JPS6058500A - Light-resistant antibacterial soap - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a soap having a wide range of antibacterial properties and excellent light resistance.

2.4.4'-)dichloro-2-hydroxydiphenip ether, V (hereinafter abbreviated as TCHDPE)
has a wide range of nupectrum against microorganisms such as Gram-negative bacteria, Durham-positive bacteria, and yeast, and has low resistance to irritation to the skin and mucous membranes, so it suppresses harmful microorganisms that adhere to the skin and hair. For the purpose of washing, use soap and shampoo,
It is a promising antibacterial agent with wide applications in cleaning agents and cosmetics. However, when the above-mentioned TCHDPE is simply blended into a soap base, the soap turns dark brown when exposed to sunlight, reducing the product value.
is well known.

Conventional techniques that cannot be improved on this point*! :t, for example, a method of blending aromatic diabonic acid (or an alkali metal salt thereof) (US Pat. No. 3,284,362),
Method of blending fatty acids (Special Publication No. 47-20629),
Those who combine organic acids such as malonic acid, succinic acid, lactic acid, malic acid, tartaric acid, maleic acid, fuma/I/acid, citric acid (equity number 1852-43207), those who combine jJ acid & ( Although methods such as HtnI] 55-86900) are known, there is no method that is satisfactory in various respects.

As a result of extensive research in order to obtain even better products, the inventors found that when a specific 1-hydroxyethane-1,1-diphosphonic acid compound described below is combined with phosphoric acid, the discoloration prevention property is remarkable. The present invention was completed based on the discovery that the present invention has the following effects.

ffxb, the present invention i 2.4.4'-trichloro-2
In soaps containing 7-hydroxyphenylene ether p, 1-hydroxyethane-1,1-diphosphonic acid (hereinafter referred to as HF1DHA), 1-human p-xyecune-1,1-diphosphonic acid at least one of a 1-hydroxyethane-1゜1'-diphosphonic acid-based compound (hereinafter abbreviated as HgDHA-based compound) selected from the group consisting of alkali metal fences, ammonium salts, and lower alkanolamine salts; It is an antibacterial soap with excellent light resistance (q), characterized by the fact that it contains an acid.

Preferred are the alkali metal salts and potassium salts of 11F and DMA in the HEDBA-based compounds, and examples of the lower alkano-μamine salts include monoethanolamine salts, jetanorμγmine salts, and triethanolamine salts. Salt, monoisopropanol amine salt, diisopropanol amine HA1 triisopropanol amine salt, etc. are preferred l/-I.

The above-mentioned HEDHA compounds are used +fII-t or in combination of two or more. The amount added varies depending on the type of soap product, but in general, it is based on the weight of the soap base.
[j, preferably 03 to 50% by weight 1c.

5. If the weight of the product is 006, it will not be possible to provide sufficient protection against discoloration (light resistance) as a product. O% If it is more than 31%, the moldability during soap production will be poor.

The amount of phosphoric acid to be used in combination with HEDHA and other compounds is preferably 0.06 to 5.0% by weight based on the weight of the soap base. If the amount is less than 0.03% by weight, the anti-discoloration effect (light resistance) will be reduced, and if the amount exceeds 5.0% by weight, the moldability of the soap will be poor.

The amount of the antibacterial agent T CHD PE is 0-05 to 5.0% by weight based on the weight of the soap base. 0.05
If it is less than 5.0% by weight, it will not be able to provide sufficient antibacterial properties as an antibacterial soap, and if it is more than 5.0% by weight, even if it is placed in the presence of the above-mentioned HEDHA compound and phosphoric acid. May discolor easily.

The antibacterial soap of the present invention is the above-mentioned TCHDPI.

! (In addition to EDHA and phosphoric acid, K, fungicides as necessary (
For example, 3,4,4-trichlorocarbanilide, isozolomethymuphenol, etc.), anti-inflammatory agents (e.g., allantoin, dipotassium glycyrrhizinate, diammonium glycyrrhizinate, etc.), superfat trIJ (e.g., fatty acids, higher alcohols, lanolin, lanolin derivatives, higher fatty acid esters, etc.), antioxidants (e.g., taba, toco7 yellow μ)
, L-ascorbic acid or its ester or salt,
Known and commonly used additives such as BEIA% BIT, etc.), chelating agents (for example, ethylenediaminetetraacetic acid or its alkali metal salts, citric acid, tartaric acid, etc.), fragrances, and pigments can also be used.

The antibacterial soap of the present invention does not affect the physical or chemical properties of soap, does not irritate the skin, sufficiently retains its antibacterial action, and can significantly improve light resistance. The action and effect are extremely excellent.

Examples will be described below. % by weight shown in the examples, parts means parts by weight.

In addition, the Hunter White Skin shown in the Examples was measured using a Nippon Heavy Color Difference Meter (manufactured by Nippon Kameiro Co., Ltd.) @ Example 1 Soap base (beef tallow/coconut oil - 30/20) K: Add 5 parts of the above R+, appgD, to a soap base containing 0.1 part of titanium dioxide and 1.0 part of fragrance, and add the required amount of phosphoric acid shown in Table 1 below and the above. Hunter white charcoal after HgDHA irradiation and Hunter white charcoal before irradiation were measured, and the degree of discoloration was observed with the naked eye.

For comparison, a sample without the addition of a washing light fastness imparting agent was also produced in the same way (AI sample).The degree of discoloration when observing appearance 1 with the naked eye was evaluated and the results were as shown in Table 1 below. are shown in Table 2. Table 2 shows the measurement results for Hunter white charcoal.

The evaluation points are as follows, and as a standard product, a soap (unchanged in color) that was made as a prototype at the same time as the try-on and stored in a cool, dark place was used.

The evaluation points and dignity are as follows.

Table 1 Evaluation points Degree of discoloration Grade 5 Same as standard product Pass 4 Slightly discolored compared to standard product 6 Significantly discolored compared to standard product Fail 2 Significantly discolored compared to standard product 1 Same level as without addition of light resistance imparting agent ・l Table 2 Table 2 Q Thinness Example 2 Soap base example in which 0.1 part of titanium dioxide and 10 parts of fragrance were blended with soap base (beef tallow/yang oil 80/20) + 00 parts, the above TcaDpgO, 5 parts Combine this with the following,
Each required amount of phosphoric acid (!: !(FJHA
A sample A2-A20 was prepared as a prototype using the usual soap manufacturing method by adding tetrasodium salt of A2-A20), and after irradiating it for 2 days in direct sunlight on a clear day in spring, Hunter white charcoal and Hunter white charcoal before irradiation were measured. The degree of damage was observed with the naked eye. For comparison, a sample without the addition of a light resistance imparting agent was also produced in the same manner (AI sample).

In addition, the evaluation score of the degree of discoloration when observing the appearance with the naked eye and the measurement results of Hunter white charcoal are as shown in Table 6.

The evaluation points are as follows, and as a standard product, a soap (uncolored) that was prepared at the same time as the sample and stored in a cool, dark place was used.

Table 6 Example 6 The above TCHDPε1. [ ] parts, added 3 parts of phosphoric acid and 5 parts of agDaAO, and made a prototype based on the normal soap manufacturing method. After irradiating it with direct sunlight for 2 days on a sunny day in spring,
Hunter White Melon Oki 1'&l, /ζ.

As a result, it was found that #'4J had a small change in 674 height compared to 703 before irradiation, and had excellent light resistance despite the TCHDPE content.

Example 4 0 parts of the above rcHDpal was added to a soap base containing 100 parts of soap base fII8 (beef tallow/coconut oil = 80/20), 015 parts of titanium dioxide, and 1.0 parts of fragrance, and 0 parts of phosphoric acid was added to this soap base. .1 part, 02 parts of HEDHA's tetrasodium were added, ≠Rakuminato each part Hitomi Sasakite was prototyped based on the usual soap manufacturing method, and after irradiating it with sunlight on a clear day in spring for 2 days, Hunter's white skin was measured. . As a result, compared to 71.5 before irradiation, the result was 6.
It was clear that the light resistance was excellent despite the addition of TCFIDpg.

Example 5 Soap base (4-fat/coconut oil = 80/20) + 00 parts, 01 parts of titanium dioxide, and 10 parts of fragrance were added to the soap base, 0 parts of the above TCHDPE1 were added, and 01 parts of phosphoric acid was added to the soap base. A prototype was made by adding 0.2 parts of dipotassium salt of HgDHA and 0.2 parts of dipotassium salt of HgDHA.
We measured Ritsu and Hunter white melon that were irradiated for days. the result,
There is little change at 671 compared to 706 before irradiation (TCH
rJJ was impressed by the fact that it had excellent light resistance despite the inclusion of DPE.

Example 66 5 parts of the above TCHDPB O was added to a soap base made by combining 100 parts of soap crucible (beef tallow/coconut #] = 80/21), titanium dioxide O, +S, and 15 parts of pigment. Add 06 parts of tetraammonium salts of 0ROUB, I(F, DHA) and make a prototype based on the usual soap manufacturing method.
Hunter white melon was measured after being irradiated with 1fij of sunlight for 2 days during sunny spring weather. As a result, 71,2 of irradiation +1・I
Even compared to that, it's 68! : Little change, T CHD P
It was found that the light resistance was excellent regardless of the addition of ε.

Example 7 Soap soap containing 100 parts of stone ffi base (beef tallow/coconut oil -80/2 [+), 02 parts of titanium dioxide, and 10 parts of fragrance.
Blend 5 parts of Cjii 2 T CHD P [E O, 06 g of veric acid (!, 06 parts of tetratriethanolamine salt of HEDHA), and mix with ordinary soap-making I.
A prototype was made based on the H method, and the I0 was determined by irradiating it with sunlight on a clear day in spring for two days (Hunter 0 degrees). As a result, irradiation M
Compared to fi's 709, 685 has less y conversion, and T C
*J-man found that all HDP formulations had excellent light resistance regardless of the strength.

Claims (1)

[Scope of Claims] (112,4,4'-trichloro-2'-hydroxydiphenyl ether, a soap containing 1-
Hydroxyethane-1,1-diphosphonic acid, 7-potassium salts of 1-hydroxyethane-1,1-diphosphonic acid, ammonium salts, and 1-hydroxyethane-1, selected from the group consisting of lower vulcanolamine blocks. An antibacterial soap with excellent light resistance, which is formulated with at least one 1,1-diphosphonic acid compound and phosphoric acid. f21 At least one of the above-mentioned 1-hydroxyethane-1,1-diphosphonic acid compounds is present in 006 to 5. The antibacterial soap with excellent light resistance according to claim (1) rE1, which contains OWj in an amount of %. (6) The amount of phosphoric acid is 0 relative to the amount of ffi in the soap base.
．． The antibacterial soap with excellent light resistance according to claim (1), wherein the antibacterial soap has a weight distribution of 03 to 50%. (4) Secret RF claim B, in which the 2.4.4-trichloro-2-hydroxydiphenyl ether is blended in an amount of 0.05 to 5.0% by weight, based on the weight of the soap base. Antibacterial soap with excellent light resistance as described in item 1).