JPS6058160A - Heart blood storage tank - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention ■1 Background of the Invention (Technical Field) The present invention relates to a cardiac blood reservoir (cardio I/M reservoir) used in a human T heart 1 capture circuit during extracorporeal circulation associated with open heart surgery. It is something.

(Prior art and its problems) In the world cardiopulmonary circuit, as illustrated in Figure 1 1',
The blood drawn from the vena cava of Shizuo is IB.

After passing through the surface line 1, the blood from Yamano passes from the suction line 2 and pump 3 to the centripetal blood reservoir 4 and line 5,
The pump 8 enters the vein 7 housed in the regulating means 6, and then pumps the heat exchanger I/J.
9, where the oxygenated blood is sent to blood supply line 1
It is configured so that it goes through 0 and returns to the store name's body.

By the way, in addition to the defoaming and blood storage functions of the blood aspirated in the 1h cavity and the 11th heart cavity, the centripetal blood reservoir has the function of defoaming and storing blood that is aspirated in the 1h cavity and the 11th cardiac cavity. Incorporates a filter that filters out foreign substances such as micro-aggregation tissue and micro aggregation.

Products designed to perform the three important functions of filtration, foaming, and blood storage have come into widespread use. On the contrary,
l! It has been pointed out that the cardiac blood reservoir, which is classified as ``Flower stool II+'', has various problems in terms of function, etc., as listed in 1-.

(1) it'd be overfunctioning 1. Problem: When blood containing many foreign substances such as tissues and microaggregates is passed through the filter, there is a tendency for clogging to occur before the filter is used effectively. In addition, in the case of pleated quills, the fill is circularly shaped +r&! A lumen is created in the relationship that is set, so that 11 of these? ! A blood V+) accumulation occurs in the blood, and there is a certain amount of blood in the heart! It becomes difficult to grasp the 1jl of blood in the tank.

Therefore, the actual blood storage is marked on the housing of the centripetal blood storage tank. 11.2, and there is also the problem of not being able to read the actual 1fil 7Il 'i' when needed.

(2) Eliminator I Function 1: Problem The blood that has entered the blood tank is filtered and defoamed by a filter and an antifoaming agent, and is then filtered and defoamed inside the housing (7H°
)1? ! At that time, the filtration and defoaming section 4 (the blood 7f (or briming solution) that flows out from the filtration and defoaming section 11') foams and drips onto the surface of the stored blood.
■ 111 odor bubbles occur, which is undesirable. In such a case, the patient will also be supplied with blood containing cyclohub, and there is a risk of peripheral vascular occlusion and severe brain injury.

Some structures have a structure in which the filtration and defoaming member is in contact with the bottom of the housing to avoid the phenomenon described above. The knee/-solonk phenomenon in which the air in the tube cannot be expelled and is left behind is likely to occur. There is a great danger of air leakage to the joints and the patient.Air block phenomenon refers to the +fu f (outflow bow) - case where the clamp 1. is connected to the blood level inside the tube. When the inflow surface liquid flows into the multiplant, the air cannot be discharged,
- Experience the phenomenon of staying in the tube.

In addition, due to the resistance of the filter, which has a built-in filter, the inflowing air has no choice but to defoam after +l has passed due to the resistance of the filter. When filtering 1 person + 1 + self tl k M, positive pressure filtration is used. Positive pressure l skin I+! In 1, the positive pressure air from the filter causes blood 'It? (E) As a result of producing bubbles in the surface liquid, it is likely to be disadvantageous for subsequent defoaming.In such a case, the pressure 1yj in the filter is also large, and the filter volume tends to be 1 °C (1 ton). To avoid this, some use +fi+ttW inflow 1) cyclone type air 5) chain structure as a pillow, but it is not possible to deal with 1 saw for 11 pieces of 4 pieces of air, and the soil It is easy to invite A, and 111d・I ('lability or aspect>: J, H leads to the result of being loyal -C).

++ Second aspect of the invention 1. This was done in view of the current situation described above, and the purpose of this is to increase blood flow from 1- to 1-. -C
An object of the present invention is to provide a centripetal blood storage tank which is constructed so that air and blood can be quickly separated from human blood when it passes through a filter, and which has antifoaming and filtration functions superior to those of the prior art.

According to the present invention, the top 741 has a 1rl'l liquid inflow hole in the center, and the bottom has a hollow nozzing that slopes toward the blood outlet, and an antifoam agent is provided in the bottom. A one-stage filtration/defoaming knife consisting of a filter, a defoaming member disposed to enclose the filter, and an outer bag enclosing these is placed in the housing with the +InIn liquid. The bottom 7;ll of the first stage of the filtration and defoaming knife is located at the bottom 7 of the filtration defoaming knife by the inclined bottom of the above-mentioned /＼Using. By supporting them, you can achieve goal 1 of L.

■ Detailed Description of the Invention Below, a small drawing of the centripetal blood reservoir of the present invention is shown.
A preferred embodiment will be described in detail.

Figure 2 shows the uninvented centripetal blood reservoir I0, partially broken and removed.
It is shown as a partial cross-section, and it can be seen that the filtration and defoaming part 4422 is supported and built into the housing 21 which is shaped like a circle. The housing 21 is a hard transparent body made of hard plastic materials such as polycarbonate, acrylic-styrene co-Φ1 combination, polyester, polyamide, TPX, PVC18BS! -1, if/appropriately 1.1 is made by integral molding. A blood inflow boat 27 having a blood inflow 1J23 for collecting blood from Yamano, a priming 1J24, a rapid briming 1126 with a connector 25, and a blood inflow boat 27 on the inside of the housing 211, and in addition to these, there is a blood inflow boat 27 having a blood inflow 1J23 for collecting blood from Yamano, a priming 1J24, and a rapid briming 1126 with a connector 25. Turn right at Air + Jl exit 29 etc. The 11th part of the housing 21 is approximately cylindrical and hollow. The bottom of the housing 21 is eccentrically formed 5 +1+ eyes Il flow 11 radially 11/! Diagonal 4: Forms four sides.

Housing 211 size mold production-1 may be composed of 21 parts, but from the viewpoints of +RU liquid leakage, D filleting, lapels, etc., it is necessary to mold them as a single piece except for the +CJ part. Or preferable. In particular, it is necessary to prevent blood from accumulating at the bottom, so it would be better if there were no adhesive parts. The blood M provided at the bottom of the housing 21 is 11 degrees 30, and the blood M provided at the bottom center of the housing 21 is 11 degrees, ILI
I! 1! Housing 2
It is preferable to place it eccentrically near the outer periphery of h. Therefore, it is preferable to make the shape of the 1r11 liquid flow 11 eye 130 into a funnel-like shape with a smooth curved surface. It's easy.

In this way, when blood flows into the 1-ya pulse reservoir through the tube connected to the llj>4-shaped blood flow i, li l-J, which has a smooth curved surface, the m+ fluid flows into the blood outflow 1130 and Because it flows along the walls of the tube, the air block phenomenon, which is a series of problems, does not occur. This is inside the body which is constantly monitored +fil in'
When the blood level drops by 1- below the blood outlet due to the movement of the central circle 1 (++) on the reservoir surface 4n or the fluctuation of the inflow of 1000 and θ from Yamano during the adjustment operation of the reservoir for the optimization of i', In the same way, the phenomenon of air protrusion is also prevented.

The anti-foaming member 22 mounted in the double housing 21 is supported between the housing bottom and the IIIJI 32 that protrudes downward from the blood inflow boat 27 in the housing 21. The filtration and defoaming member 22 has various functional elements arranged concentrically outward from the center, and sequentially passes through the air introduced into the center and defoams. This allows defoamed blood to be stored at the bottom of the housing again without generating bubbles. As shown in FIG. 2, the filtering and defoaming member 22 includes a filter 34,
The defoaming member 35 disposed around the defoaming member 35 and the outer bag 36 enclosing them are removed. Although the functional arrangement of these components is not limited to that shown in FIG. can.

Examples of the filter 34 include a screen type with a mesh having a pore diameter of about 20 microns, a depth type with an adsorption effect, and the like.

In the intracardiac blood reservoir with a built-in filter, blood is subjected to positive pressure, but the positive pressure may cause the blood to eject from the filter and form bubbles, making subsequent defoaming disadvantageous. As mentioned above. To prevent this, it is best to treat the filter with an antifoaming agent in advance. As an antifoaming agent, silicone for anti-7Ω (combalan F type mixed with silica, oil type) etc. is generally used, and for the filter structure, nylon, polyester, etc. are preferable.

By attaching an antifoaming agent to the filter, when blood comes into contact with the filter, bubbles are defoamed and separated into blood and air, which prevents soil A from filter 13 and at the same time improves the filtration performance of the filter. is maintained.

In order to confirm the antifoaming effect of attaching an antifoaming agent to a filter, the following experiment was conducted.

[By circulating blood using a filter made of 5-layered iron non-woven fabric with a maximum weight of 100 g/m', the difference in antifoaming properties between those with and without silicone cordon and the suitability of silicone coated stars was evaluated. I set the range. Note that in this experiment, only a filter was used, and no antifoaming part was provided on the outer periphery.

The silicone coating was done by dipping the filter in a silicone solution.

Figure 3 shows the silicone coating using 11 blood (1 pot to 3] 1 coat) for the non-coated product (dotted line curve) and the 6-coat product (solid line curve). The results of the confirmation of the 7+'l foam effect by Koh I. FIG. 4 shows the antifoaming effect of different silicone concentrations in an example using /1 blood (after blood collection 2+1).

From these results, it can be seen that coating a filter with silicone is very effective in improving antifoaming properties, and that the silicone C degree to be coated is preferably about 0.5 to 3 v/v%. . If it is less than 0.5 v/v%, the filter will be wet and air bubbles will not be removed easily, resulting in a pressure of 151%.
If the concentration exceeds 3%, clogging of the filter by silicone is likely to occur, making it difficult to prevent leakage, and leaching of the silicone becomes a problem.

7. The extinguisher 714 member 361 on the outer periphery of the ailter 34 is for defoaming the blood that has been filtered or filtered and defoamed by the noilter 34 on the 1st stream side, and is made of foamed horsetail/tan, stainless steel ribbon, A polypropylene mensch lumber 1 is coated with the antifoaming agent mentioned above.

The outer bag 36 is generally a tricot I bag, but
Any material may be used as long as it does not generate phlegm and there is no risk of elution or blood cell θ destruction (including body activity).

In addition, there are also problems with the shape and structure of the housing in terms of blood storage function. For the housing, it is easy to make a mold by making a lower part with a flange and gluing it at the middle part. However, with such a structure, there is a possibility of blood leakage at the bonded portion, and at the same time, labeling is troublesome, and the marking at the flange portion is likely to be inaccurate.

In addition, in response to open heart surgery cases, the vent line is passed through the -C circulation abnormality, and the bu is insufficiency! To understand high i.

+m ttl, Qt is often measured. In other words, the heart is IJ, 3 blood! As stated in C;, when there is pulmonary venous return, blood accumulates in the left ventricle, and that! i) makes it possible to understand the level of Kairai. Also, if there is caval valve insufficiency, this is also determined by the amount of blood stored in the left ventricle. That is, in order to determine these points through the vent line, a detailed 11 blood display is required. Therefore, it is preferable that the shape of the bottom of the housing and the blood outflow boat be configured so that the blood (h) can be easily read.

IV. Basic Effects of the Invention The use of the cardiotovascular blood vessel of the present invention will be explained.

The cardiac blood reservoir is constructed and used as shown in FIG. Blood aspirated from the cardiothoracic cavity during open-heart surgery passes through the duplex 2 connected to the Ifi[1j'i, IL inlet 24] and is transferred from the white liquid inflow boat 27 to the filter 34's device. be provided.

The filter 34 also filters out -1- substances such as tissue and microaggregation-1 contained in the blood 7+fi supplied from the blood inflow boat 27 or in the transfused blood 1r)+1+. In order to effectively filter out this foreign material,
It is sufficient to form a certain amount of void surrounded by the filter 34, thereby preventing clogging or channeling due to foreign matter, and making it possible to utilize the effective surface 1 of the filter to a large extent.

If there is a risk of blood gushing or bubble generation in the filter 34 due to excess positive pressure, it is preferable to coat the filter 34 with an antifoaming agent as well. With this configuration, even if there is a problem described above due to positive pressure filtration, the blood rlJ is defoamed at the same time as it contacts the filter 34, and the blood flows to the filter 34 side, while the air The air is discharged from the cavity via the outlet 29 at the top of the housing, so that the filtration pressure can be kept low.

In this way, the blood that has been filtered or filtered and defoamed by the filter 34 is completely defoamed while passing through the defoaming section old 35 and gradually flows downward in the X direction, and finally passes through the outer bag 36 and is filtered to the housing 21. The blood leaks into the blood storage space 46 between the antifoaming member 22 and the blood storage space 46 .

The leaching takes place mainly near the eccentric bottom 39 of the filtering and defoaming member 22, but since the eccentric bottom 39 is in contact with the sloping bottom 40 of the housing 21, there is a +R problem in which the leached blood drips and generates bubbles. Not at all.

The eccentric bottom part 39 of the 7-y excessive defoaming member 22 and the housing 21
1&touch de/l with the tilting angle 41fl140 is the outer peripheral edge of the bottom 40 of the housing 21 which is largely eccentric from the medium heat part.
1 formed across the line of symmetry on the opposite side from the blood outflow port 30. Lm within the range 11+1 of the angle α (within 906)
Made by I, M-J-if, immersion bleeding f(f, l*1.
r\r') -”;' 7 'jノM1Ne11戊tIl
! 40,, I- is ν1) on the lit plane, and the flow is
Blood I is discharged from the confluence outlet 1130 and transferred to the venous reservoir 7.
There will be an influx into

Also, +1 direction 1 effect f output ll30 is housing 21
The bulge is not formed at the center of the bottom, but near the outer periphery, and its shape is a smooth curved surface like the fIζ shape.
If you configure H5, even if you have a small amount of blood at the time, the blood flow will be 11 days - 130 degrees (11 days - 130 degrees) (you can easily read 1 on the scale. In this way, the exudate blood By forming preferably a swirling flow on the 11? surface and ensuring a smooth flow of blood in the 5th outlet 30, Since the fluid flows along the wall of the outflow port 30 and the tube connected thereto, the air block phenomenon is prevented, and there is a risk that bubbles may circulate into the body via the venous reservoir. It completely disappears.

Although the top portion of the housing 21 may be separate, it is preferable that the body portion and the bottom portion be constructed as a single piece. When constructing a housing with the glued halves, the joint [in 1]
11 Fluid may leak, the label may be difficult to read, and the blood level scale display may be inaccurate. This one-piece housing eliminates this further problem.

■Specific Effects of the Invention Since the centripetal blood storage tank of the present invention has a built-in super-defoaming stage, the tissue and microorganisms contained in the blood flowing in from the inflow boat or in the transfusion 1r11 are It is possible to effectively remove foreign substances such as aggregates, and even if there are bubbles in the liquid, the bubbles are defoamed and the deflated blood is not dripped at the bottom of the housing. Since the iH is in contact with the filtration and defoaming stage, there is no possibility of foaming again.

Positive pressure filtration is performed at the built-in cardiovert blood storage IO port n, and this Ft, 41:: 1f! However, in the present invention, the filter also contains an antifoaming agent (silicone).
I would like to avoid this kind of situation because I have no intention of asking anyone (which is appropriate). Therefore, not only the defoaming performance but also the filtration performance is improved.

The defoamer 14 member is placed in contact with the upper part of the housing, and the defoamed blood is transferred to the bottom part of the housing. There is no risk that this will lead to an explosion and create a bubble.

[Brief explanation of the drawing]

FIG. 1 is a diagrammatic perspective view of an example of an artificial heart-lung circuit, and FIG. 2 is a partial cross-sectional view of an hr-suitable embodiment of the centripetal blood storage 4a of the present invention.
Figure 3 is a small graph showing the antifoaming effect of the silicone coating, and Figure i+54 is a graph showing the antifoaming effect of the thick silicone coating. Explanation of line numbers 1...Blood removal line, 2...Zanker line, 3.8
...-19・l+IA,)111.11. IP'! l
L,, 1/ll to -2, y G,, 6 volume regulating means, 7... venous reservoir/to, 9... heat exchanger visitor extraction, 10... blood supply line, 21... ...No\Using, 2
2... Filtering and defoaming member, 23... Blood inflow [1, 24
゜28... Priming ['', 25... Connector,
26... Rapid priming port, 27... tli+liquid inflow boat, 29... Air utilization ['', 30... Blood outflow port, 32... Leg, 34... Filter, 35
... Defoaming member, 36... 1 bag, 37... Adhesive, 38... Support, 39... Eccentric bottom, 40...
Bottom, 46...Blood storage space Patent applicant: Chirusen Co., Ltd. 1 Agent: Nozomi Watanabe (valve)

Claims (2)

[Claims] (1) ``;B The blood flow boat is placed in the middle, and the bottom part is 1 year old! A first stage of filtration and defoaming, which is composed of a filter, a foaming part disposed to enclose the filter, and an outer bag enclosing these, is placed in the housing. 1-' force of inflow ball 1 into the f device, and its inside and 1
A centripetal blood storage tank having a 4'+- feature in that it is provided so as to communicate with the f11 liquid inflow boat, and the bottom of the II basin vortex defoaming stage is supported by the inclined bottom of the housing. (2) The centripetal blood reservoir according to claim 1, wherein the antifoaming agent is silicone.