JPS6057815B2 - Anti-caries additives and anti-caries foods containing the additives - Google Patents

Description

[Detailed description of the invention] The present invention relates to the production of food products.

More particularly, it relates to Candy products which have been rendered anti-caries by the use of novel anti-caries additives.
There has long been a need for ways to counteract the cariogenic effects of foods, particularly those containing large amounts of sweeteners such as sucrose and other sugars.

It was theorized that when sugars are placed in the mouth, they cause the production of acids that promote tooth decay. Contributing factors to dental caries in children are the adhesion of highly refined sugars and their breakdown products to dental plaque after ingestion, combined with very slow oral clearance (0ra1c1earance) or the ability to produce large amounts of acid, or a combination of these factors. are involved.

In the past, many anti-caries agents have been evaluated in systems where the anti-caries agent is applied topically (ie, directly to the teeth) and consumed in the form of a toothpaste (eg, toothpaste, toothpaste).

However, the knowledge gained on the effectiveness of anti-caries agents used in such topical applications suggests that these anti-caries agents may be used in other applications, such as food products, especially food products containing a significant proportion of sugars. It was concluded that it could not be expected to be effective. Unfortunately, known anti-caries agents generally do not provide any substantial degree of protection when used in food products.

Thus, known anti-cavity agents such as fluorides, phosphates, vitamin K1 nitrofurans, ammonium compounds, iodoacetic acids, etc., when added separately to food products containing high proportions of sugars, can be used in the food environment. There are almost no direct local effects within the area. For these and other reasons, dental researchers have continued to strive to develop new anti-cavity agents that not only exhibit high levels of anti-cavity efficacy, but also are non-toxic, stable and widely available.

It has been suggested that aluminum salts may have a beneficial effect in reducing dental caries or in promoting fluoride uptake by tooth enamel. For example, a substance that can reduce the acid solubility of tooth enamel (Sn ratio TanceCapab)
leOfDecreasingtheAcidSOlu
BiIityOfTOOthEnamel), J. D
entRes. 28l6O (1948); RegOIati.et.al. 1. Effects of aluminum and fluoride on dental caries, fluorine content and dissolution in rat molars (EffectsOfAIuminurnan).
dFIuOrideOnCauis. FIuOrine
ContentandDissO1uti0n0fRa
tM01ars) JHel, DdOn. Acta. l3
:59 (1969); and Kalada,
Electrochemical properties of free and complexed fluorides in drinking water and the influence of aluminum and iron on fluoride uptake into tooth enamel (ElectrOchemicalCh
aracteristicsOfFreeandCom
plexedFluOridesinDRinking
WaterandTlleEffecLl>0fA1u
rninumandIr0n0rF1L10rideI
nc0rp0rati0nInt0T00thEnam
e1, University of Michigan paper (1972).

In vitro studies have shown that pretreatment of enamel with an aluminum solution increases fluoride uptake when subsequently treated with a fluoride solution, but combined treatment with aluminum and fluoride shows no benefits over and above the effects of fluoride alone. indicated that he would not give anything.

McCann (7) r Influence of fluoride complexation on fluoride absorption and retention in human enamel (
TheEffectOfFluOrideCOMple
xFOrmatiOnOnFluOrideUptak
eandRetEntiOninHumanEname
l)! , Archs. OralBlOl. l4:521
(1969); and Gerhardt et al.
etal. ) Fluoride absorption on natural tooth surfaces pretreated with aluminum nitrate (FluOrideUpta)
keinNaturalTOOthSur'Faces
Pretrated with Aluminum
itrate) J, J. Dent. Res. 5l:87
0 (1972). Moreover, the above techniques primarily dealt with the use of aluminum in combination with fluoride and did not focus on the effects of aluminum in the absence of fluoride. It has previously been proposed that adding aluminum sources to the diet may reduce its caries-inducing ability.

However, research to date suggests that aluminum is ineffective as a dietary caries preventive agent. For example, Van Reen, et al.
aries: MOlybdenum, A] Uminum
andTitanium) J, Helv. OdOnt.
1 in Acta, ll:53-59 (1967) (5 vertices)
Potassium aluminum sulfate is 10, 50 or 100p
When added to the drinking water of rats to provide pm of aluminum, it did not provide any protective effect against dental caries.・
・I conclude that. The same conclusion was reached by Wynn et al.
．． etal. Dental caries (Den) in albino rats fed high sucrose diets containing different amounts of aluminum
talCariesintheAlbinORatOn
HighSucrOseDieteContainin
gDifferEnt, AmOuntOfArunll
num) yo J. NatritlOn, 54:285-2
90 (1954), and also in the case of aluminum added to chow-fed rats, as reported by Kruger et al.
゜“Trace element’3” on experimental dental caries in white rats
TheEffectOf66TraceEle
ments53OnExperimentalDent
alCariesintheAlbirK)Rat).
J. University of Queensland Dissertation (Unin.OfQue)
enslarldPapers) 11-28 (1959
) has also been obtained with parenterally injected aluminum. The use of aluminum in toothpaste products has not shown any desirable results.

For example, French Patent No. 3610M describes a particular combination of aluminum lactate, aluminum fluoride and calcium pyrophosphate, which abrasives inhibit aluminum by reacting with it to form insoluble aluminum phosphate. Similarly, U.S. Patent No. 309
No. 5356 attempts to reduce the solubility of such abrasives and increase fluoride absorption by using aluminum salts, such as aluminum fluoride, in conjunction with insoluble sodium metaphosphate, but has no independent therapeutic effect. is not obtained from aluminum. US Patent No. 32827♀
No. 5, No. 1, No. 1, No. 1, No. 1, No. 1, 2003, describes a low PH stannous fluoride toothpaste stabilized against precipitation and oxidation of stannous ions through the use of hydroxyl-substituted di-7 and tri-carboxylic acids.

However, there is no mention in this patent of the use of aluminum in conjunction with fluoride-free systems. Similarly, U.S. Pat. No. 3,937,806 teaches an oral composition containing indium and fluoride, with the addition of malic acid to stabilize the indium; It is not recognized that advantageous results can be achieved with aluminum and carboxylic acids. Canadian Patent No. 9282η describes an acid toothpaste containing a combination of a surfactant and a protein-clotting substance, such as an aluminum or other metal salt of certain rubonic acids.

However, this patent also does not teach that significant dental health benefits are obtained with aluminum-containing foods. For example, some elements are known to prevent tooth decay (e.g., F, MO, Sr, and V), while others are known to promote tooth decay (e.g., Se,
A large amount of data on aluminum (Mg and Cd) has been published by Navia [Effect of Mir on Dental Cavities] EralsOnD.
dentalCaryS) J1 Food and Drugs vs. Dental Caries (Die
tany Chemicalsv. DentalCari
es),,A. C. S. , District of Washington (197
0) indicates that it is inactive against dental caries as classified.

U.S. Pat. No. 3,772,431 may be an effervescent countersubstance (e.g., a solid base material and a solid organic acid such as fumaric acid, citric acid, tartaric acid) and an aluminum compound that generates C when dissolved in water. (although not necessary) relates to mouthwash tablets containing a combination of analgesics and analgesics.

Additionally, this patent states that in combination with fungicides and chelating agents,
Discloses the optional use of vitamin C (ascorbic acid) as a mucin precipitating agent. However, this patent does not suggest that any anti-caries treatment effect is achieved as a result of the presence of aluminum compounds in such compositions. In fact, the other essential ingredients in the tablets are incompatible with aluminum, making them of no therapeutic use. In short, the prior literature has to date taught nothing about therapeutically effective systems that provide bioavailable aluminum in foods in the absence of fluoride.

The first object of the present invention is therefore to provide a means to overcome the drawbacks of the prior art means for reducing the caries-inducing power of sugar-containing foodstuffs.

A related object is to provide an effective aluminum-containing anti-caries additive for use in sweetened foods such as candi.

Another object is to provide a caries-preventing food compounded with an aluminum-containing caries-preventing additive having the above-mentioned characteristics.

Another object is to provide a caries-preventing food having the above-mentioned characteristics and incorporating a non-cariogenic nutritive sweetener.

Yet another object is to provide a new anti-caries candy.

The above and other objects, advantages and features of the present invention are to prevent dental caries by adding at least one soluble aluminum ion-containing salt and an ingredient selected from the group consisting of adipic acid, ascorbic acid and mixtures thereof into foods. This can be achieved by incorporating amounts that are both effective and non-toxic.

When such additives are added to Candy products, it has been found that even at very low additive contents (e.g., aluminum levels as low as about 100 ppm), repeated intake of small amounts of the anti-cavity agent has a cumulative effect. It is effective because there are Desirably, such additive-containing foods also include at least one primary sweetener selected from the group consisting of sorbitol, xylitol, and mixtures thereof, and at least one selected from the group consisting of dextrose, fructose, and mixtures thereof. A non-cariogenic nutritive sweetener consisting of a mixture of secondary sweeteners.

The mixture contains at least about 75% by weight of the mixture the first sweetener when dextrose is the second ingredient and at least about 60% the first sweetener when fructose is the second ingredient. . The sweetener is provided in the food in an amount effective to sweeten the food. The use of the anti-cavity additive of the present invention reduces the acid solubility of tooth enamel, and when the sweetening system of the present invention is also used, there is little detrimental reduction in plaque PH when placed in the mouth. ,or,
(which means that the production of oral acids that cause cavities is minimized), has little or no harmful demineralization of tooth enamel, and has rapid oral A product showing removal is obtained.

The present invention will be explained in more detail. According to the invention, food,
In particular, sweet foods such as Candy contain one or more soluble aluminum ion-containing salts and an ingredient selected from the group consisting of adipic acid, ascorbic acid, or a mixture thereof in an amount that is effective and non-toxic for preventing dental caries. ing.

1 Foods used herein
) The term J refers to virtually any wide range of food products suitable for human consumption, including candy, baked goods, chewing gum, manufactured beverages, fruit preparations, etc. However, it is not limited to these.

AscOrbicacid J as used herein refers to its isomeric epimers, isoascorbic acid, known as erythropic acid and D-erythrohexy-2-enoic acid gamma-
It also includes lactones, which may be used in place of ascorbic acid for purposes of the present invention.

Adipic acid and/or ascorbic acid can be present in any convenient content of greater than 0 and less than about 6% by weight of the food product.

Preferably, the acid is present at about 3% by weight. The particular soluble aluminum salt used is not critical; virtually any non-hazardous water-soluble aluminum ion-containing salt can be used. Suitable aluminum salts include aluminum potassium sulfate, AlK(SO,)2·12H20; aluminum chloride AlCl3·6H20, aluminum sodium sulfate AlNa(SO4)2●12H20, aluminum ammonium sulfate AlNH4(SO4)2·12H
20, Sodium aluminum phosphate NaAl3Hl4
(PO4)8-4H20: Aluminum sulfate Al2(S
O4)2・181120, aluminum nitrate, Al(N
O3)3 and sodium aluminate NaAlO2. Potassium aluminum sulfate and sodium aluminum sulfate are preferred because they are widely available and have established safety. An amount of soluble salt that is both caries-preventing and harmless is about 100 to 1000 ppm aluminum ions (calculated as aluminum ions, 0
．． 01 to 0.1%).

For example, when potassium aluminum sulfate monohydrate or aluminum chloride hexahydrate is used, each salt has approximately 0.
2-2% by weight and about 0.1-1. It exists in a range of 10%. The caries-resistant additives of the present invention can be used in all types of sweet foods such as hard candies, toffee and caramel, chocolate and chocolate coatings and other candies products. However, preferably this additive is used in tabletted and baked hard candies. When a Kyan Day product is manufactured from a variety of separate ingredients (for example, in the case of a Kyan Day product that has a toasted sugar-based filling topped with chocolate), the additives of the present invention may be used in one or more of these ingredients. It may be used for any or all. An important feature of the present invention is that ascorbic acid and adipic acid are relatively safe compared to other commonly used carboxylic acids such as citric acid and malic acid, and the rapid The discovery is that it does not demineralize teeth when it remains in the mouth during the period of intraoral removal.

Furthermore, these acids (1) do not inhibit aluminum ions like many other acids, and (2) have a pH value of 3 in the mouth, where aluminum ions are most actively incorporated into tooth enamel.
．． 5 to 4.5 temporarily, and (3
) Opens the apatite crystal lattice of the enamel somewhat to allow aluminum ions to react better with the enamel. The Candy products produced according to the method of the present invention have the advantage that, thanks to the addition of the caries-resistant additive of the present invention, the Candy products can be safely consumed without inducing or promoting tooth decay. Otherwise, it is essentially identical to prior art Candy products.

Thus, the anti-cavity candy products prepared in accordance with the present invention contain additives such as colorants, flavoring agents, milk fat and vegetable oils, blowing agents, and mouth-feeling additives such as crunchy rice grains, stone fruits, etc. It may also contain the usual and customary supplementary ingredients normally found in standard Candy products.

However, some common candi components are undesirable from a dental standpoint. For example, significant amounts of fat and mouth-feeling additives such as crunchy rice grains adversely affect oral clearance of the candi. Nevertheless, by using the additives of the present invention, candi becomes less harmful to the teeth. Candy made in accordance with the present invention can be manufactured using conventional manufacturing techniques.

Additive l can be added at any convenient time so long as it is present in the desired content in the final product. The composition of an exemplary anti-caries candy made in accordance with the present invention is shown in the Examples below.

Example 1 Tabletted Candy Example 2 Baked Hard Candy Preferably, the anti-cavity additive of the present invention is combined with anti-caries nutritive sweetening systems, i.e. sorbitol, xylitol, instead of sucrose or other cariogenic sweeteners. and a mixture of at least one first sweetener selected from the group consisting of dextrose, fructose, and mixtures thereof; secondary sweetener;
and at least about 60% of the mixture weight contains the first sweetener when fructose is the second sweetener. Used in sweetened foods containing

4. Sorbitol is the preferred first agent in terms of cost and availability, and dextrose is the preferred second agent. Desirably, a homogeneous mixture of the first and second agents is used. 75% sorbitol and/or xylitol-2 when using sorbitol-rudextrose or xylitol-3-rudextrose mixtures
A 5% dextrose mixture is preferred.

If fructose is used, somewhat higher amounts of the secondary sweetener can be used. For example, about 40% fructose is preferred for sorbitol-fructose and xylitol-fructose mixtures. Generally, the sweetening mixture of the present invention is used at the same content as the sugar or other cariogenic sweetening system was used.

For example, when a non-cariogenic nutritive sweetening system is used in accordance with the present invention in a 4 Kyan Day product, it is preferably used at a content of about 40 to 100% of the Kyan Day product. Candy products made in accordance with the present invention are safe to consume with reduced incidence and severity of dental caries, thanks to the addition of caries-resistant additives and the substitution of non-cariogenic nutritive sweetening systems.

Candy produced in accordance with the present invention can be produced using conventionally used non-cariogenic nutritive sweetening systems as described above.
The manufacturing technology is generally the same, although some changes are necessary due to the use of sorbitol or xylitol as the main ingredient in the sweetening system. Thus, in the case of tablets, the same techniques are used to mix the ingredients and form them into tablets, but somewhat more extensive humidity control must be provided since sorbitol and xylitol are desiccant agents. .

Magnesium stearate may also be added in small amounts to aid in removing the tablet from the mold. Knowing these properties of sorbitol- and/or xylitol-containing sweeteners, those skilled in the art can readily adapt existing Candy processing technology to produce other Candy products in accordance with the present invention.

The ingredients of an exemplary anti-cavity candy prepared using a nutritive sweetening system in accordance with the present invention are shown in the Examples below.

Example 3 Tablet-type candy implementation i'-4 Tablet-type candy Example 5 Tablet-type candy Example 6 Tablet-type candy Example 7 Tablet-type candy implementation i-8 Tablet-type candy Example 9 Baked hard candies Day Example 10 Tofui. -ElJ
″r ) − ′ = ri
υ●u Example 111-V-? Attack? ? l-FlPl2V! --1j Experimental Evaluation The anti-caries properties of the products produced according to the present invention were demonstrated by the following experimental studies.

The main criterion for evaluating anti-caries agents is their ability to reduce the solubility of tooth enamel, i.e. enamel solubility (lower enamel solubility).
ESR).

In vitro REsRJ studies are performed in the following manner.

Healthy bovine incisors are embedded in self-hardening acrylic resin with the labial surface exposed, and treated with pumice powder to prevent spores.
Next, one window (WindOw) J is formed on the incisor surface by pouring wax onto an aluminum foil circle with a radius of 1 cm.

A stylus is then used to draw a border around the foil window, which is then pulled away to expose a circular area of enamel of reproducible size. This windowed tooth was prepared using a 0.2N acetic acid solution using an ESR stirrer at a stirring speed of 60 rpm.
PH4. Demineralize four consecutive 25 ml aliquots of 25 ml of 200 ml of 100 ml of 200 ml of 200 ml of 200 ml of 200 ml of aliquots. By the fourth demineralization, the amount of calcium and phosphorus deionized from the tooth reaches a certain level. The teeth were then injected with approximately 60 mL of 25 ml of Candy supernatant (1 part Candy diluted with 3 parts double-distilled water to mimic the dilution that occurs in the mouth after ingestion).
The mixture was stirred and treated at a speed of 'Pm. After treatment, add 4 more teeth
Deashing was performed with 25 ml of acetic acid buffer every two times. The fifth and eighth demineralization solutions are referred to as the first post-treatment demineralization (first PTD) and the fourth post-treatment demineralization (4thPTD).
The difference between the amounts of calcium and phosphorus in the fourth demineralizing solution before treatment and their amounts present in the fifth and eighth demineralizing solutions after treatment is divided by the amount of fourth demineralizing, and the first PTD and Four PTDEs
Use 100x to determine the SR value.

Calcium was determined using atomic absorption spectroscopy and phosphorus was determined using Fiske-SubbarOw.
) method. Since repeated short-term ingestion of Candy containing the caries-resistant additive of the present invention has been shown to have a cumulative effect in reducing the solubility of tooth enamel,
The tooth is treated multiple times with relatively short dwell times (eg, 5 minutes, or the intraoral removal time for this type of candice).

Using this technique, a grape flavored candy tablet having the formulation shown in Example 3 was evaluated. For comparative purposes, Kyandi with the same formulation but without the addition of aluminum salts was tested as a control. ESR data for Candy of Example 3 was measured after 10 5 minute treatments and also after 2 5 minute treatments. The ESR data shown in Table 4 shows that repeated 5 minute treatments with this lysis candy have a significant cumulative ESR effect. After such processing nod, ESR of 70%
was gotten. Although the ESR evaluation indicates the effectiveness of the anti-caries agent, it is also highly desirable to determine the amount of the anti-caries agent actually absorbed into the tooth enamel in order to further establish its efficacy.

Healthy cow incisors with 6 windows were soaked 1:3 in double distilled water.
The sample was treated with the Candy of Example 3 diluted to . 25 teeth
It was treated with Candy solution of m1 twice in a row at an interval of 5 minutes each. After treatment, the tooth was washed with 15.0 m1 of 2.0NHC104.
The amount of calcium and aluminum was determined. Calcium was measured by atomic absorption, and aluminum was measured by the AluminOn method. The data presented in Table 2 clearly show that significant amounts of aluminum ions react with and are absorbed into the tooth enamel. When teeth were treated with double-distilled water in a similar manner, the aluminum absorption value became zero. These accumulated aluminum absorption values correspond to the accumulated ESR values shown in Table 1 and should be correlated. In summary, these demonstrate the anti-caries effect of the additives of the invention. The anti-caries effect of the additive was also demonstrated in an in vivo rat study conducted as follows.

Wistar rats, 35 days old and exposed once, were randomly distributed into two equal groups according to sex, body weight, and littermate.

A second group of rats served as controls and received a low fluoride cornmeal diet and fluoride-free water ad libitum. The first group of rats received a corn diet of 3% adipic acid and 1% A
The same diet was maintained except fortification with lCl, 6H20. After one month, the rats were sacrificed and the acid solubility of their mandibular molars was measured.

The data are shown in Table 3. These data show that in rats fed a diet containing the caries-resistant additive of the present invention,
Phosphorus and calcium ESRs of 40% and 35% are shown, respectively.

The caries-preventing effect of the caries-preventing Kyanday of the present invention is also as follows:
Effects of caries preventive agents in rats using the 1 initial caries injury method by Francis (Tlle
EffectivenessOfAnticaries
A? NtsinRatsUsinganIncipie
ntCariOusLesiOnMethOd)J,A
rch. OralBlOl. ,ll:141-148(
in rats using the method described in (1966).

100 weaned (21 days old) Wistar
All rats of the ter) species were randomly divided into five equal groups according to sex, body weight, and litter size.

Parents of weaned rats were fed a non-cariogenic fluoride corn diet and fluoride-free double-distilled drinking water for one week prior to mating. Female rats were kept on this same diet during 21 days of gestation, birth and 21 days of weaning to prevent the pups from being exposed to external sources of fluoride during development. After weaning, 21-day-old rats were fed a high sucrose cariogenic diet and fluoride-free double-distilled water ad libitum. Once a day,
Both the left and right mandibular molars were each locally polished for 5 days every week for 4 weeks with each local caries-preventing Candy solution for 6 days. The solution was applied to the molars by using a cotton swab and dipping it freshly into Candy solution each time at ratio second intervals. The topical candy solutions used in the treatment were prepared by dissolving 1 part by weight of each experimental candy in 3 parts by weight of double-distilled water. The basic candy formulation of Example 3 was used with the following modifications.
Group 1 - Control group - Example 3 without AlK(SO4)2.12H20 Example 3 Group 3 with 6% AlK(SO4)2.12H20 Example 3 Group 4 Instead of sorbitol Example 3 Group 5 using dextrose in all cases Group 3 using dextrose instead of sorbitol The rats were placed in an air-conditioned room inside a fence set on a raised wire mesh floor, and when handling laboratory animals. Normal hygiene measures were strictly observed.

The lighting was timed to ensure 1 turbid period of bright light and 1 turbid period of dark light. Rat body weights were measured initially and at the end of the one month study.

There was no statistically significant difference in weight gain between the experimental group and the control group. Furthermore, no animals died during the experiment. At the end of the experiment, the animals were killed by chloroform inhalation, and the teeth were stained with 1% silver nitrate.
3 containing 0.2% A1(SO4)2.12H20
The 11% reduction in caries incidence observed in group 3 (6% Al(SO4)
) 18% or less obtained with 3:1 sorbitol-dextrose scan (containing 2.12H20) is 99%
It was effective at a certain level.

The 10% and 7% reductions seen in Groups 4 and 5, respectively, were not statistically significant. These latter two were the same as Groups 2 and 3 except that all of the sorbitol in the Candy was replaced with dextrose. While Group 4 had on average about the same number of injuries as Group 2, the injuries in Group 4 were significantly more severe. Data is A1 (SO.).・12H. It has been shown that the 3:1 sorbitol-dextrose yandi containing 0.0% has a significant effect on reducing dental caries in vivo. These also show that all candies benefit to some extent from the caries-resistant additive system of the present invention. The criticality of the use of adipic acid and/or ascorbic acid in combination with aluminum salts has also been demonstrated experimentally.

Bovine teeth with windows were processed by the described 'ESR method. However, 37 ppm aluminum ion (AIK (SO
. ), 12H. The difference is that the teeth were treated once in two batches with a solution containing 0. Calcium and phosphorus ESR data are shown in Table 5, and in contrast to other acids that either kill aluminum or significantly reduce its effectiveness as an enamel solubility reducer under such conditions, adipine Acids and ascorbic acid are compatible with aluminium, especially during the quaternary after-treatment with minimal influence. Although the present invention has been described above with particular reference to food products, these techniques are also intended and useful with respect to other food products in which the additives of the present invention can be used.

Claims (1)

[Scope of Claims] 1. Food containing at least one soluble aluminum ion-containing salt and one component selected from the group consisting of adipic acid, ascorbic acid and mixtures thereof in an amount effective and non-toxic for preventing tooth decay. Anti-cavity additives for products. 2 The aluminum salt is present in a content of about 0.01 to 0.10%, calculated as aluminum ions, based on the weight of the food, and the selected ingredient is present in a content of more than 0% and less than about 6%. Additives according to scope 1. 3. Claim 1 in which the selected component is adipic acid
Additives listed in section. 4 Aluminum salt is aluminum potassium sulfate 12
The additive according to claim 1, which is a hydrate AlK(SO_4)_2.12H_2O. 5 Aluminum salt is aluminum chloride hexahydrate Al
The additive according to claim 1, which is Cl_3.6H_2O. 6. A caries-preventing food containing at least one soluble aluminum ion-containing salt and one component selected from the group consisting of adipic acid, ascorbic acid and mixtures thereof in an effective and non-toxic amount for preventing dental caries. 7. A patent claim in which the aluminum salt is present in a content of about 0.01 to 0.10%, calculated as aluminum ions, and the selected ingredient is present in a content of more than 0% and less than or equal to about 6%, based on the weight of the food product. Foods listed in item 6 within the scope of 8. Claim 6, wherein the selected component is adipic acid.
Foods listed in section. 9 Aluminum salt is aluminum potassium sulfate 12
The food according to claim 6, which is a hydrate AlK(SO_4)_2.12H_2O. 10 Aluminum salt is aluminum chloride hexahydrate A
The food according to claim 6, which is lCl_3.6H_2O. 11 A mixture of at least one first sweetener selected from the group consisting of sorbitol, xylitol and mixtures thereof and at least one second sweetener selected from the group consisting of dextrose, fructose and mixtures thereof is used as a nutritional sweetener. and the mixture further contains at least about 75% by weight of the mixture as a first sweetener when dextrose is the second sweetener and at least about 60% by weight of the mixture when fructose is the second sweetener. 7. The food product of claim 6, wherein the food contains a first sweetener and the mixture is present in an amount effective to sweeten the food product. 12. The food according to claim 11, wherein the first sweetener is sorbitol and the second sweetener is dextrose. 13. The food according to claim 11, wherein the first sweetener is sorbitol and the second sweetener is fructose. 14. The food according to claim 11, wherein the first sweetener is xylitol and the second sweetener is dextrose. 15. The food according to claim 11, wherein the first sweetener is xylitol and the second sweetener is fructose. 16 About 0.1 to 1.0% by weight of a soluble aluminum ion-containing salt, based on the weight of the product, up to about 6% of one component selected from adipic acid, ascorbic acid and mixtures thereof, and at least about 1% by weight of the mixture. An anti-cavity candy product containing at least about 40% of a nutritive sweetening mixture of sorbitol and dextrose, 75% of which contains sorbitol. 17 Adding at least one soluble aluminum ion-containing salt and one component selected from the group consisting of adipic acid, ascorbic acid and mixtures thereof in an amount that is effective and non-toxic for preventing dental caries. A method of imparting preventive properties. 18 A mixture of at least one first sweetener selected from the group consisting of sorbitol, xylitol and mixtures thereof and at least one second sweetener selected from the group consisting of dextrose, fructose and mixtures thereof is used as a nutritional sweetener. the mixture comprising at least about 75% by weight of the first sweetener when dextrose is the second sweetener and at least about 60% by weight of the mixture when fructose is the second sweetener. 18. The method of claim 17, wherein the mixture contains a first sweetener and the mixture is present in an amount effective to sweeten the food product.