JPS605570B2 - Manufacturing method of disintegrant - Google Patents
Manufacturing method of disintegrantInfo
- Publication number
- JPS605570B2 JPS605570B2 JP54129149A JP12914979A JPS605570B2 JP S605570 B2 JPS605570 B2 JP S605570B2 JP 54129149 A JP54129149 A JP 54129149A JP 12914979 A JP12914979 A JP 12914979A JP S605570 B2 JPS605570 B2 JP S605570B2
- Authority
- JP
- Japan
- Prior art keywords
- producing
- disintegrant
- acid
- aqueous solution
- polymerization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Description
【発明の詳細な説明】 本発明は、使用制限のない崩壊剤の製造法に関する。[Detailed description of the invention] The present invention relates to a method for producing a disintegrant with no restrictions on use.
現在販売されている崩壊剤は、セルローズの水中の膨潤
性を高めるため極性基のカルボキシメチル化を行ない、
更に品質の安定性を確保するためにカルシウム塩とした
所謂繊維系グリコール酸カルシウム、又は繊維系グリコ
ール酸を微粉砕したもので、いうまでもなくエーテル誘
導体である。Disintegrants currently on the market carboxymethylate polar groups to increase the swelling ability of cellulose in water.
Furthermore, in order to ensure stability of quality, it is a so-called fibrous calcium glycolate made into a calcium salt, or a finely ground fibrous glycolic acid, and it goes without saying that it is an ether derivative.
これがため、前者は食品添加物法により使用基準が定め
られている（食品に対 ２％以下）。一方後者は食品添
加物には指定されていない。本発明は、標示義務及び使
用制限の無い、崩壊剤を天然物の配合によって（必要に
応じては食用界面活性剤を徴量添加）製造する事を特徴
とするもので、平均重合度２００〜５００のセルローズ
パウダーと、分解率１２〜４２の糖類とを混合し、軸３
〜５の水溶液を添加鷹拝し、一定時間放置熟成後、乾燥
し、粉砕する崩壊剤の製造法に関する。For this reason, the use standards for the former are set by the Food Additives Law (2% or less of food). On the other hand, the latter is not designated as a food additive. The present invention is characterized by producing a disintegrant by blending natural products (with the addition of an edible surfactant if necessary), without labeling obligations or restrictions on use, and having an average degree of polymerization of 200 to 200. 500 cellulose powder and sugars with a decomposition rate of 12 to 42 are mixed, and the axis 3
The present invention relates to a method for producing a disintegrant, which comprises adding an aqueous solution of 5 to 5, allowing it to mature for a certain period of time, drying it, and pulverizing it.
本発明に使用するセルローズパウダーは、７０％が結晶
領域で、約３０％が非結晶領域であるから酸加水分解に
よってこの非結晶領域を破壊して、結晶部分を取り出し
たもので、平均重合度２００〜５００のセルローズ分子
から成りたち、セルローズの含有量が９９．５％以上の
ものである。The cellulose powder used in the present invention has a crystalline region of 70% and an amorphous region of about 30%, so the amorphous region is destroyed by acid hydrolysis to extract the crystalline portion, and the average polymerization degree is It is composed of 200 to 500 cellulose molecules, and the cellulose content is 99.5% or more.
また、使用したセルローズパウダーのメッシュは５０〜
３００のものである。本発明に使用する糟類とは、デキ
ストリンを指し、酵素分解及び酸分解による分解物で、
分解率Ｄ．Ｅ．（ＤｅｘＵｏｓｅＥｑｕｉｖａｌｅｎｔ
）が１２〜４２迄のものである。In addition, the mesh of the cellulose powder used is 50~
300. The pulp used in the present invention refers to dextrin, which is a decomposed product by enzymatic decomposition and acid decomposition.
Decomposition rate D. E. (DexUoseEquivalent
) are from 12 to 42.
本発明に使用する舟３〜５の水溶液とは、天然物又は有
機酸にて調整したもので、天然物又は有機酸とは、クエ
ン酸、リンゴ酸、乳酸、酒石酸、酢酸、リン酸及びフィ
チン酸である。The aqueous solutions of boats 3 to 5 used in the present invention are those prepared with natural products or organic acids, and the natural products or organic acids include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, and phytic acid. It is an acid.
本発明に使用する食用界面活性剤とは、非イオン性のも
のを指し、各種脂肪酸モノグリセラィド祭糖脂肪酸ェス
テル、ソルビタン脂肪酸ェステルである。The edible surfactant used in the present invention refers to a nonionic surfactant, and includes various fatty acid monoglycerides, sugar fatty acid esters, and sorbitan fatty acid esters.
食用界面活性剤は全固型分に対し０．０１〜０．１％添
加する。次に、本発明を工程を追って説明する。The edible surfactant is added in an amount of 0.01 to 0.1% based on the total solid content. Next, the present invention will be explained step by step.
まず、平均重合度２００〜５００のセルローズパウダー
４０〜８０％とＤＥ１２〜４２の糖類６０〜２０％とを
混合する。次いで、ｐＨ３〜５の水溶液を混合粉体の１
５〜２５％添加鷹拝し、６〜２独特間放置熟成する。そ
して、乾燥機にて１２０〜１５０ｏｏの加熱条件で含有
水分５％以下まで乾燥し、最後に２００〜３００メッシ
ュに粉砕して製造とする。得られた崩壊剤は、食品、医
薬、農業、化粧品、洗剤、製紙等に広く用いられる。以
下、本発明を実施例により詳述する。〔実施例〕
上記の通り粉体の混合比により９種類を作り、次の方法
で製造した。First, 40-80% of cellulose powder with an average degree of polymerization of 200-500 and 60-20% of saccharides with a DE of 12-42 are mixed. Next, add an aqueous solution with a pH of 3 to 5 to 1 part of the mixed powder.
Add 5-25% and leave to mature for 6-2 hours. Then, it is dried in a dryer under heating conditions of 120 to 150 oo to a moisture content of 5% or less, and finally pulverized to 200 to 300 mesh for production. The obtained disintegrants are widely used in foods, medicine, agriculture, cosmetics, detergents, paper manufacturing, etc. Hereinafter, the present invention will be explained in detail with reference to Examples. [Example] As described above, nine types were made according to the mixing ratio of the powders, and they were manufactured by the following method.
１ デキストリンをＰＨ４．５の水溶液で溶解する。1 Dissolve dextrin in an aqueous solution of pH 4.5.
２ 上記溶解液をセルローズパウダーに混合蝿梓を行い
全粉体が平均にウェット化するまで放置する（熟成）。2. Mix the above solution with cellulose powder and leave until the entire powder becomes evenly wet (ripening).
３ 食用界面活性剤を温湯溶解し、この溶液を更に混合
粉体添加、混合損拝する。４ 上記混合粉体を乾燥板に
て乾燥を行う。3. Dissolve the edible surfactant in warm water, add the mixed powder to this solution, and mix. 4 Dry the above mixed powder using a drying plate.
５ 乾燥後粉砕し、フルィにかけメッシュをそろえる。5 After drying, crush and pass through a sieve to align the mesh.
得られた崩壊剤の分散、崩壊テストを日本薬局方、崩壊
試験ｍ錠剤の項に従って行なった。その結果を下記に示
す。１ 常温の水溶液に投下した場合
崩壊、分散作用の最も顕著であったのは
Ｎｏ．＆Ｎｏ．９ついでＮｏ．１〜Ｎｏ．７であった。The dispersion and disintegration test of the obtained disintegrant were carried out in accordance with the Japanese Pharmacopoeia, disintegration test m-tablet section. The results are shown below. 1 When dropped into an aqueous solution at room temperature, No. 1 had the most pronounced disintegration and dispersion effect. &No. 9 then No. 1~No. It was 7.
２ 熱湯（１００００）に於けるテストに於てはその崩
壊分散速度は倍加されたが、効果は常温水溶液の場合と
同じであった。３ 冷却水（５００）に於けるテストも
熱湯に於ける場合と同じであった。2 In the test in hot water (10000), the disintegration and dispersion rate was doubled, but the effect was the same as in the case of room temperature aqueous solution. 3. Tests in cooling water (500) were the same as in boiling water.
４ ｐＨに対する影響
解３〜ｐＨ８の各々溶液２００ｃｃに上記と同じ条件で
テストした結果、ＮＯ．８、ＮＯ．９、ＮＯ．１〜Ｎｏ
．７各々の崩壊作用には全く影響がなかった。4 Effect on pH When 200 cc of each solution of pH 3 to pH 8 was tested under the same conditions as above, NO. 8.No. 9.No. 1~No
．． 7 had no effect on the disintegration action of each.
本発明の組成物と日本薬局方に記載された結晶セルロー
スとの比較崩壊試験を行なった。A comparative disintegration test was conducted between the composition of the present invention and crystalline cellulose described in the Japanese Pharmacopoeia.
その結果を下記に示す。供試品名：ＫＣフロツク
ＪＡＦ−Ｚ
試験項目：崩壊試験
結晶セルロースとの比較
ァスコルビン酸の錠剤を下記のように２種類調製し、そ
の崩壊性を日本薬局方崩壊試験｛１｝錠剤試験に行って
、行なった。The results are shown below. Test product name: KC Flotsu JAF-Z Test item: Disintegration test Comparison with crystalline cellulose Two types of ascorbic acid tablets were prepared as shown below, and their disintegration properties were tested using the Japanese Pharmacopoeia disintegration test {1} tablet test. , I did it.
（水を加えて混合、成形、乾燥、１錠は、１５５の９、
径９肌、厚さ４側）その結果、成形した固型製剤が試験
溶液中で消失する時間はＪＡＦ−Ｚ添加のものは１５〜
２０分であり、結晶セルロース添加のものは２０〜２５
分であった。(Add water, mix, mold, dry, 1 tablet is 9 of 155,
As a result, the time for the molded solid preparation to disappear in the test solution was 15 to 15 minutes for the one containing JAF-Z (diameter 9 skin, thickness 4 side)
20 minutes, and 20 to 25 minutes for those containing crystalline cellulose.
It was a minute.
ここでいう「ＫＣフロツク」とは山陽国策パルプ株式会
社製の「セルローズパウダー」の商品名であり、さらし
パルプのセルロース構造体の約７０％が結晶領域で約３
０％が非結晶領域であるから、酸加水分解によってこの
非結晶領域を破壊して結晶領域を取り出した結晶セルロ
ース製品である。"KC Flotz" here is the trade name of "Cellulose Powder" manufactured by Sanyo Kokusaku Pulp Co., Ltd. Approximately 70% of the cellulose structure of bleached pulp is a crystalline region with approximately 3
Since 0% is an amorphous region, this crystalline cellulose product is obtained by destroying this amorphous region and extracting a crystalline region by acid hydrolysis.
Claims (1)
、分解率１２〜４２の糖類とを混合し、ｐＨ３〜５の水
溶液を添加撹拌し、一定時間放置熟成後、乾燥し、粉砕
することを特徴とする崩壊剤の製造法。 ２ 平均重合度２００〜５００のセルローズパウダー４
０〜８０％と、分解率１２〜４２の糖類６０〜２０％と
を混合することを特徴とする特許請求の範囲第１項記載
の崩壊剤の製造法。 ３ ｐＨ３〜５の水溶液は天然物又は有機酸にて調整し
たものであることを特徴とする特許請求の範囲第１項記
載の崩壊剤の製造法。 ４ 天然物又は有機酸がクエン酸、リンゴ酸、乳酸、酒
石酸、酢酸、リン酸及びフイチン酸であることを特徴と
する特許請求の範囲第３項記載の崩壊剤の製造法。 ５ 平均重合度２００〜５００のセルローズパウダーと
分解率１２〜４２の糖類との混合物に対し、ｐＨ３〜５
の水溶液を１５〜２０％添加することを特徴とする特許
請求の範囲第１項記載の崩壊剤の製造法。 ６ ６〜２４時間程度放置熟成することを特徴とする特
許請求の範囲第１項記載の崩壊剤の製造法。 ７ １２０〜１５０℃の加熱条件で含水率５％以下まで
乾燥することを特徴とする特許請求の範囲第１項記載の
崩壊剤の製造法。 ８ ２００〜３００メツシユに粉砕することを特徴とす
る特許請求の範囲第１項記載の崩壊剤の製造法。 ９ 平均重合度２００〜５００のセルローズパウダーと
、分解率１２〜４２の糖類とを混合し、ｐＨ３〜５の水
溶液を添加撹拌し、一定時間放置熟成後、混合粉体の１
５〜２５％の水溶液に食用界面活性剤を混合粉体の０．
０１〜０．１％添加、加熱溶解した溶液を加え、撹拌し
、乾燥し、粉砕することを特徴とする崩壊剤の製造法。 １０ 平均重合度２００〜５００のセルローズパウダー
４０〜８０％と、分解率１２〜４２の糖類６０〜２０％
とを混合することを特徴とする特許請求の範囲第９項記
載の崩壊剤の製造法。１１ ｐＨ３〜５の水溶液は天然
物又は有機酸にて調整したものであることを特徴とする
特許請求の範囲第９項記載の崩壊剤の製造法。 １２ 天然物又は有機酸がクエン酸、リンゴ酸、乳酸、
酒石酸、酢酸、リン酸及びフイチン酸であることを特徴
とする特許請求の範囲第１１項記載の崩壊剤の製造法。 １３ 平均重合度２００〜５００のセルローズパウダー
と分解率１２〜４２の糖類との混合物に対し、ｐＨ３〜
５の水溶液を１５〜２０％添加することを特徴とする特
許請求の範囲第９項記載の崩壊剤の製造法。１４ ６〜
２４時間程度放置熟成することを特徴とする特許請求の
範囲第９項記載の崩壊剤の製造法。 １５ １２０〜１５０℃の加熱条件で含水率５％以下ま
で乾燥することを特徴とする特許請求の範囲第９項記載
の崩壊剤の製造法。 １６ ２００〜３００メツシユに粉砕することを特徴と
する特許請求の範囲第１項記載の崩壊剤の製造法。[Claims] 1. Cellulose powder with an average degree of polymerization of 200 to 500 and saccharides with a decomposition rate of 12 to 42 are mixed, an aqueous solution of pH 3 to 5 is added and stirred, and the mixture is left to mature for a certain period of time, then dried and pulverized. A method for producing a disintegrant, characterized by: 2 Cellulose powder with an average degree of polymerization of 200 to 500 4
The method for producing a disintegrant according to claim 1, characterized in that 0 to 80% of saccharide and 60 to 20% of saccharide having a decomposition rate of 12 to 42 are mixed. 3. The method for producing a disintegrant according to claim 1, wherein the aqueous solution having a pH of 3 to 5 is adjusted with a natural product or an organic acid. 4. The method for producing a disintegrant according to claim 3, wherein the natural product or organic acid is citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, and phytic acid. 5 For a mixture of cellulose powder with an average degree of polymerization of 200 to 500 and saccharides with a decomposition rate of 12 to 42, pH 3 to 5
A method for producing a disintegrant according to claim 1, characterized in that 15 to 20% of an aqueous solution of is added. 6. The method for producing a disintegrant according to claim 1, which is left to mature for about 6 to 24 hours. 7. The method for producing a disintegrant according to claim 1, which comprises drying to a moisture content of 5% or less under heating conditions of 120 to 150°C. 8. The method for producing a disintegrant according to claim 1, wherein the disintegrant is pulverized into 200 to 300 meshes. 9 Cellulose powder with an average degree of polymerization of 200 to 500 and saccharides with a decomposition rate of 12 to 42 are mixed, an aqueous solution of pH 3 to 5 is added and stirred, and after aging for a certain period of time, 1 of the mixed powder is mixed.
Mix powder of edible surfactant in 5-25% aqueous solution.
1. A method for producing a disintegrant, which comprises adding a heated and dissolved solution of 0.01 to 0.1%, stirring, drying, and pulverizing. 10 40-80% cellulose powder with an average degree of polymerization of 200-500 and 60-20% saccharide with a decomposition rate of 12-42
10. The method for producing a disintegrant according to claim 9, which comprises mixing the following. 11. The method for producing a disintegrant according to claim 9, wherein the aqueous solution having a pH of 3 to 5 is prepared using a natural product or an organic acid. 12 The natural product or organic acid is citric acid, malic acid, lactic acid,
12. The method for producing a disintegrant according to claim 11, wherein the disintegrants are tartaric acid, acetic acid, phosphoric acid, and phytic acid. 13 For a mixture of cellulose powder with an average degree of polymerization of 200 to 500 and saccharides with a decomposition rate of 12 to 42, pH 3 to
10. The method for producing a disintegrant according to claim 9, wherein 15 to 20% of the aqueous solution of No. 5 is added. 14 6~
10. The method for producing a disintegrant according to claim 9, wherein the disintegrant is aged for about 24 hours. 15. The method for producing a disintegrant according to claim 9, wherein the disintegrant is dried to a moisture content of 5% or less under heating conditions of 120 to 150°C. 16. The method for producing a disintegrant according to claim 1, which comprises pulverizing the disintegrant into 200 to 300 meshes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54129149A JPS605570B2 (en) | 1979-10-06 | 1979-10-06 | Manufacturing method of disintegrant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54129149A JPS605570B2 (en) | 1979-10-06 | 1979-10-06 | Manufacturing method of disintegrant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5653624A JPS5653624A (en) | 1981-05-13 |
| JPS605570B2 true JPS605570B2 (en) | 1985-02-12 |
Family
ID=15002342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54129149A Expired JPS605570B2 (en) | 1979-10-06 | 1979-10-06 | Manufacturing method of disintegrant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS605570B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57188526A (en) * | 1981-05-14 | 1982-11-19 | Takeda Chem Ind Ltd | Peptide-containing pharmaceutical preparation |
| JPS60200933A (en) * | 1984-03-22 | 1985-10-11 | Seiko Epson Corp | Brass for die casting |
-
1979
- 1979-10-06 JP JP54129149A patent/JPS605570B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5653624A (en) | 1981-05-13 |
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