JPS605166A - エンドトキシン中和剤 - Google Patents

エンドトキシン中和剤

Info

Publication number
JPS605166A
JPS605166A JP58112695A JP11269583A JPS605166A JP S605166 A JPS605166 A JP S605166A JP 58112695 A JP58112695 A JP 58112695A JP 11269583 A JP11269583 A JP 11269583A JP S605166 A JPS605166 A JP S605166A
Authority
JP
Japan
Prior art keywords
endotoxin
polymyxin
agent
neautralizing
fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58112695A
Other languages
English (en)
Other versions
JPH0738880B2 (ja
Inventor
小玉　正智
徹 谷
花沢　一芳
岡藤　太郎
和雄 寺本
西海　四郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP58112695A priority Critical patent/JPH0738880B2/ja
Priority to EP84106810A priority patent/EP0129786B1/en
Priority to DE8484106810T priority patent/DE3481280D1/de
Publication of JPS605166A publication Critical patent/JPS605166A/ja
Priority to US06/833,421 priority patent/US4661260A/en
Priority to US07/022,960 priority patent/US4771104A/en
Priority to JP5002625A priority patent/JPH0749052B2/ja
Publication of JPH0738880B2 publication Critical patent/JPH0738880B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28028—Particles immobilised within fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B01J20/28038—Membranes or mats made from fibers or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Medicinal Preparation (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 （発明の技術分野） 本発明は、エンドトキシンの毒性を減刑させる中和剤に
関する。
（従来技術とその問題点） エンドトキシンは、＠乳動物の血中に入ると発熱を起す
物質であり、その量が多いときには致死作用すら示ず。
このエンドトキシンが血中に入る機会は、肝Ｗ：４瘍、
胆のう炎などの重度の細菌感染症、胃穿孔や外科手術後
の感染症のときであるが。
そのほか最近では人工透析や輸液の際にも、器具等のエ
ンドトキシン汚染によって起りうる。ポリミキシンはエ
ンドトキシンの中和作用を有する抗生物質であるが、血
中に入ると腎毒性が強いのでその使用は経口投与あるい
は局所投与に限られ。
その使用ｍにも制限がある。
〈発明の目的） ポリミキシンのエンドトキシン中和作用を生かしつつ、
副作用を減刑すること。
（本発明の構成） 本発明は、ポリミキシンを繊維状担体に固定化してなる
エンドトキシン中和剤を１２供づるものである。
本発明でいうポリミキシンとは、　３　ａｃｉ　ｌ　ｌ
ｕｓｐｏｌｙｍａｘにＪ：り産生される抗性物質であり
、ポリミキシンＡ、ポリミキシンＢ１．ポリミキシンＢ
２．ポリミキシンＤ１．ポリミキシン「１およびポリミ
キシン上２笠の、グラム陰性菌に対づる抗菌作用を有づ
−るものを意味づる。
本発明で君う繊維状担体とは、０．１〜１００ｍ２　／
（Ｉの表面積を有するＩｌｉ維状成型物であり。
使用条件下において、化学的Ｊ３よび物理的に安定であ
るとともに、ポリミキシンを化学的に固定しうる官能基
を有するものを意味ブる。イの一例をあげると、α−ハ
ロゲン化アシル基、ハロゲン化ベンジル基またはイソシ
アン酸基を有するポリスチレン繊維または架橋ポリスチ
レン繊維、アクリル酸・アクリロニ１〜リル共重合体繊
維、カルボキシル阜をイボするポリビニルアルコール繊
維等がある。本発明中和剤に固定化されているポリミキ
シンの吊は、少なすぎるとエンドトキシンの中和ができ
な（なるので、１０ｍｇ／（Ｊ担体以上、より好ましく
は５０ｍｇ／ｑ担体以上であることが必要である。
本発明中和剤の調製は、繊維状担体とポリミキシンを混
合することにＪζす、あるいは、さらにベプヂド縮合剤
（ジシクロへキシルカルボジイミド。
１−エチル−３−（３−ジメチルアミノプロピル）−カ
ルボジイミドなど）を添加づ−ることにより容易に達成
できる。
本発明中和剤の用途は、輸液および透析液中のエンドト
キシン除去のほか、エンド１ヘキシン血症忠者の治療な
どがあり、その使用方法の代表例として、該中和剤を充
填したカラムに輸液、透析液または血液を循環させる方
法がある。
（発明の作用機構） 本発明の土ンドｌ〜キシン中和剤の作用賎（１へは明確
ではないが、エンド１−キシンの吸着作用よりも分解作
用に基づくと考えられる。
（発明の効果） 本発明のエンドトキシン中和剤は、ポリミキシンを高い
密度で固定化しているため、溶液中のＬンドトキシンを
分解・無毒化りるとともに、ポリミキシンが溶液中に溶
出しないため、該中和剤で処理された溶液が毒１７Ｉを
小さ４１いことにｆｊ徴を有する。
以下に実施例を示す。
実施例１゜ ポリプロピレン（三井゛ノーブレン“”Ｊ３１１Ｇ）５
０部を島成分とし、ポリスチレン（パスタイ［］ン”６
６６）４６部、ポリプ［１ピレン（イ］友“′ノーブレ
ン”ＷＦ−７２７−Ｆ）４部の）昆合物を尚成分とする
海鳥型複合繊維（島数１６．中糸繊度２．６デニール、
引張強度２　、９　ｇ／ｄ　、　（１１［印５０％、フ
ィラメント数４２）５０ｇを、Ｎ−メチロール−α−ク
ロルアセトアミド５０（］、ニトロベンゼン４００（１
，９８％硫酸４００（ＩおよびパラホルムアルデヒドＯ
，，８５ｇからなる温合溶液中に浸し、２０℃で１時間
反応させた。繊維を反応液から取り出し、０℃の氷水５
ｕ中に投じて反応停止させたのら、水で洗浄し１次に、
繊維にイ」着している二［・ロベンＵンをメタノールで
抽出除去した。この繊維を５０℃で真空乾燥して、クロ
ルアレ１−アミドメチル化繊維（繊組Ａ＞７１ｇを得た
。
ポリミキシンＢフフイザー（含糖ファイＩｆ−ａ式会社
＞４．８ｇ　（５０万中位のもの８０本）を４．００ｍ
１の水にとかし、この中に８ＪＪ　ｉｌｌ△１１ｇを加
え、５時間振どう後、酸化マグネシウム１．５ｇを添加
し、室温で６０時間振とうした。
つぎに、この反応母液からとり出し、クロマトカラムに
つめて、０．１Ｎ−塩酸４８００ｍ１で洗浄した。この
洗浄液と反応母液を混合した溶液について、ミクロビユ
レット法で溶液中のポリミキシン量を算出した。一方２
反応した謀層１はさらに水２５αおよび生理食塩水６α
て洗って、ポリミキシンＢ固定化繊維（繊維Ｂ）を１５
１だ。固定化ｍは残存法から１１０ｍｇ／ｇであった。
実施例２ Ｅ　５ｃｂｅｒｉｃｈｉａ　Ｃｏ１１　Ｏ１１１：　［
３／Ｉのリボ多糖体（ディフコ・ラボラ［−リーズ社製
、）］−ノール抽出法）の０．５　ｍｇ／ｍｌの水溶液
２０ｍ１に繊維Ｂ２（＋を加え、３７℃で６０分振と°
）後、上澄を１　ｍｌ　リ”つ、ＢΔＬ、　＋３　／　
Ｃマウスに尾静脈から投与して、４８時間後の死亡率を
調べたところ。
１３匹中４匹（３１％）が死亡した。織組］３の代りに
繊維Ａを用いて同様な実験を行ったところ。
マウス１１匹中１１匹（１００％）が死亡１ノだ。
この実験からポリミニ１；シン固定化繊維がリボ多糖体
を１１１（毒化していることがわかる。
実施例３ Ｅ　５ｃｌ）ｅｒｉｃｉａ　Ｃｏ１１　Ｏ２６：　１３
６　（デイフニ１φラボラトリーズ社製、フェノール抽
出法）の０２５　ｍｇ　／１の水溶液に繊維Ｂ２（］を
加え、３７°Ｃで６０分間振どう後、上澄を１　１１１
１ずつ、’ＢＡＬＢ／Ｃマウスに尾静脈から投与して、
４８時間後の死亡率を調へたどころ、８匹中１四（１２
，５％）が死亡した。対照として、　１８雑Ｂで処理し
なかった水溶液について同様の投与を行ったところ。
１３匹中１２匹（９２％）が死亡した。この実験からポ
リミギシン固定化繊維がリボ多糖体を無毒化しているこ
とがわかる。
実施例４ ］三ｓｌ＋ｅｒｉｃｈｉａ　Ｃｏ１１　Ｏ１１１：　Ｂ
　４のリボ多糖体（Ｄｏ、　５　ｍｇ／ｍｔ水溶液、　
０．２５　ｍｇ／ｍｌ水溶液ｄ５よび０．１２５　ｍａ
／ｍｌ水溶液２０　ｍｌｌ、：。
繊ＩＢ２ｇを加え、３７℃で６０分間振とうしたのち、
上澄をＢ　Ａ　Ｌ　Ｂ　／　Ｃマウスに尾静脈から１１
ずつ投与して、４８時間後の死亡率を調べたところ、０
．５ｍｇ／＋＋＋ｌでは１５匹中１５匹。
０、２５　ｍｇ／ｍｌでは１３匹中１匹、０．１２５ｍ
ｇ／ｍｌでは１３匹中Ｏ匹の死亡率であった。
特許出願人　東　し　株　式　会　社 −４ζへ−

Claims (1)

    【特許請求の範囲】
  1. ｍｌ状担体にポリミキシンを固定化してなるエンドトキ
    シン中和剤。
JP58112695A 1983-06-24 1983-06-24 エンドトキシン血症治療剤 Expired - Lifetime JPH0738880B2 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP58112695A JPH0738880B2 (ja) 1983-06-24 1983-06-24 エンドトキシン血症治療剤
EP84106810A EP0129786B1 (en) 1983-06-24 1984-06-14 Endotoxin detoxifying material
DE8484106810T DE3481280D1 (de) 1983-06-24 1984-06-14 Endotoxin detoxikationsmaterial.
US06/833,421 US4661260A (en) 1983-06-24 1986-02-21 Endotoxin detoxifying process
US07/022,960 US4771104A (en) 1983-06-24 1987-03-06 Endotoxin detoxifying material
JP5002625A JPH0749052B2 (ja) 1983-06-24 1993-01-11 エンドトキシン中和剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58112695A JPH0738880B2 (ja) 1983-06-24 1983-06-24 エンドトキシン血症治療剤
JP5002625A JPH0749052B2 (ja) 1983-06-24 1993-01-11 エンドトキシン中和剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5002625A Division JPH0749052B2 (ja) 1983-06-24 1993-01-11 エンドトキシン中和剤

Publications (2)

Publication Number Publication Date
JPS605166A true JPS605166A (ja) 1985-01-11
JPH0738880B2 JPH0738880B2 (ja) 1995-05-01

Family

ID=26336059

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58112695A Expired - Lifetime JPH0738880B2 (ja) 1983-06-24 1983-06-24 エンドトキシン血症治療剤
JP5002625A Expired - Lifetime JPH0749052B2 (ja) 1983-06-24 1993-01-11 エンドトキシン中和剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5002625A Expired - Lifetime JPH0749052B2 (ja) 1983-06-24 1993-01-11 エンドトキシン中和剤

Country Status (3)

Country Link
US (2) US4661260A (ja)
EP (1) EP0129786B1 (ja)
JP (2) JPH0738880B2 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023008490A1 (ja) 2021-07-29 2023-02-02 ジャパン・ヘモテック株式会社 不織布基材、液体浄化用繊維材料、当該材料の製造方法および当該材料を備える洗浄器

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192633A (en) * 1986-06-13 1988-01-20 Royal Postgrad Med School Endotoxin removal
US4870158A (en) * 1987-01-05 1989-09-26 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymyxin lipopolysaccharide antigen and associated method
US5101018A (en) * 1989-06-12 1992-03-31 International Minerals & Chemical Corp. Method for recovering recombinant proteins
US5047511A (en) * 1989-08-28 1991-09-10 Pitman-Moore, Inc. Method for recovering recombinant proteins
IT1279209B1 (it) * 1995-05-16 1997-12-04 Bellco Spa Filtro dializzatore/reattore atto ad effettuare la cattura di endotossine, e procedimento per la sua realizzazione.
US5928633A (en) * 1995-05-16 1999-07-27 Toray Industries, Inc. Material for elimination or detoxification of super antigens
US5952092A (en) * 1997-01-30 1999-09-14 Aqf Technologies Llc Fibrous structures with labile active substance
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
CA2322000C (en) * 1998-12-24 2008-07-29 Toray Industries, Inc. Hemocathartic method and hemocathartic column
ES2325304T3 (es) 1999-04-28 2009-09-01 Toray Industries, Inc. Materiales para eliminar canabinoides y columnas para la eliminacion de canabinoides con el uso de los mismos.
US6774102B1 (en) 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
JP4945876B2 (ja) 2000-04-05 2012-06-06 東レ株式会社 ハイモビリティーグループタンパクの吸着材および体液浄化カラム
JP2009500019A (ja) * 2005-07-01 2009-01-08 プロメガ・コーポレーション 生体分子の精製のための浮遊性粒子のネットワーク、及び生体分子の精製のための浮遊性粒子又は浮遊性粒子のネットワークの使用
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
GB0621452D0 (en) 2006-10-27 2006-12-06 Ucl Business Plc Therapy for liver disease
GB0621454D0 (en) 2006-10-27 2006-12-06 Ucl Business Plc Goal directed therapy for liver failure
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
AT509192B1 (de) * 2010-06-24 2011-07-15 Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems Sorptionsmittel für endotoxine
EP2679302A1 (de) 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Selektives Sorptionsmittel für die extrakorporale Blutreinigung
CA3069402A1 (en) 2017-08-31 2019-03-07 Toray Industries, Inc. Sea-island composite fiber, carrier for adsorption, and medical column provided with carrier for adsorption
GB202004775D0 (en) 2020-03-31 2020-05-13 Ucl Business Ltd Apparatus
GB202307837D0 (en) 2023-05-25 2023-07-12 Yaqrit Ltd Dialysis method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52123986A (en) * 1976-04-13 1977-10-18 Toray Ind Inc Adsorption of ionic or polar substances
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2175017B1 (ja) * 1972-03-07 1976-11-05 Toray Industries
US3959128A (en) * 1974-12-27 1976-05-25 Preventive Systems, Inc Process for removing endotoxin from biological fluids
DE2601089A1 (de) * 1976-01-14 1977-07-21 Preventive Systems Verfahren zur entfernung von endotoxinen aus biologischen fluiden
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
CA1148872A (en) * 1979-04-06 1983-06-28 Eugene A. Ostreicher Filter with inorganic cationic colloidal silica
US4276050A (en) * 1980-01-10 1981-06-30 Abbott Laboratories Method for systemic endotoxin detection
US4488969A (en) * 1982-02-09 1984-12-18 Amf Incorporated Fibrous media containing millimicron-sized particulates
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52123986A (en) * 1976-04-13 1977-10-18 Toray Ind Inc Adsorption of ionic or polar substances
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023008490A1 (ja) 2021-07-29 2023-02-02 ジャパン・ヘモテック株式会社 不織布基材、液体浄化用繊維材料、当該材料の製造方法および当該材料を備える洗浄器

Also Published As

Publication number Publication date
EP0129786A2 (en) 1985-01-02
EP0129786A3 (en) 1986-01-22
US4661260A (en) 1987-04-28
JPH05329207A (ja) 1993-12-14
JPH0738880B2 (ja) 1995-05-01
EP0129786B1 (en) 1990-02-07
US4771104A (en) 1988-09-13
JPH0749052B2 (ja) 1995-05-31

Similar Documents

Publication Publication Date Title
JPS605166A (ja) エンドトキシン中和剤
Sawada et al. Leukocytapheresis in ulcerative colitis: results of a multicenter double-blind prospective case-control study with sham apheresis as placebo treatment
WEIL et al. Shock caused by Gram-negative microorganisms: Analysis of 169 cases
Stricker et al. Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin)
US4649134A (en) Pharmaceutical composition containing defibrotide for the treatment of states of acute renal insufficiency
Fox Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome
Wise et al. Candidal cystitis: management by continuous bladder irrigation with amphotericin B
Hersle et al. AUTDERYTHROCYTE SEXSITIZATION SYNDROME (PAINFUL BRUISING SYNDROME): REPORT OF TWO CASES AND REVIEW OF THE LITERATURE
Hazen et al. Acute febrile neutrophilic dermatosis in children: report of two cases in male infants
McGovern The pathophysiology of gram-negative septicaemia
Anderson et al. Herpes encephalitis in pregnancy.
McFadzean et al. Hypoglycaemia in suppurative pancholanghtis due to Clonorchis Sinensis
Eschwege Generalized moniliasis with localization in the brain
Hendrickse et al. Lactulose in baby milks causing diarrhoea simulating lactose intolerance.
Atchley Annual Graduate Fortnight:“Disorders of Metabolism”, October 23 to November 3, 1933: Dehydration and Medical Shock
Metz Observations on the mechanism of the haematological changes in the haemolytic uraemic syndrome of infancy
O'Hickey et al. Phaeochromocytoma associated with adult respiratory distress syndrome.
Eisinger The postpartum haemolytic uraemic syndrome
Agranat A near-fatal case of Coxsackie B1 myocarditis (with pericarditis) in an adult
Ruml et al. Activation of tuberculosis during prednisone therapy
Kullavanijaya Recovery from overdose with glibenclamide.
Kyle et al. Evaluation of tryptophan mustard (NSC-62403) in patients with plasmacytic myeloma
Etzwiler Effect of glucagon hydrochloride on hypoglycemia of juvenile diabetics
Farr et al. Anuria due to cystine stones in a baby.
Berkson et al. FULMINATING MENINGOCOCCEMIA (WATERHOUSEFRIDERICHSEN SYNDROME): REPORT OF TWO PATIENTS SUCCESSFULLY TREATED WITH CHEMOTHERAPY, VASOPRESSORS, AND ADRENAL STEROIDS