JPS604900A - Reactor for synthesizing radioisotope liquid - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to the synthesis of radioisotopes, and more particularly, to condensing and trapping synthesized radioisotope vapors;
By washing and dissolving the condensed synthetic liquid with a solvent,
This invention relates to a reactor for recovering radioactive isotopes in concentrated solution.

For example, CYr'RIS
The following reaction itself for synthesizing H21N□ using the radioactive isotope (1?I) produced by H21N□ is well known.

2H2+”Oa-2H2’ too.

In the above reaction, palladium (Pd) is used as a catalyst.
It is also known to use a reaction temperature of 150°C. In this way, the radioactive isotope H2
When synthesizing ``<), the key point is the recovery method. That is, if water (H2O) is present in an unnecessary location in the recovery system, H21cO will be trapped in that area and cannot be recovered.

For this reason, conventionally, synthesized) I 2 "O (gaseous! f3) was introduced into the H20 cell and converted into H2"
The so-called bubbling method was used to collect the

However, this bubbling method requires a sufficient amount of water to cause the bubbling phenomenon.

Therefore, the concentration of H2'SO after bubbling is extremely reduced. On the other hand, in order to perform bubbling, it is important to increase the flow rate of the raw material gases 'b2 and H2.
The recovery efficiency of 21Go itself also decreases.

Furthermore, the recovery system, which inherently dislikes water, requires bubbling into the water, so it gets contaminated with water and must be replaced frequently, making it difficult to repeatedly synthesize and recover H2''O. It's impossible.

Furthermore, as another conventional example, the following reaction itself for synthesizing H''CN in an electric furnace is also known.

"C114+ Nll a→f-1"CN In this reaction, platinum (Pt) is used as a catalyst, and the reaction temperature is 1000"C. By changing the type of solvent, various H"CNN liquids can be obtained. . For example, +lcl autylamine ((:113(CI+21G”C112NII□
), conventionally, the trapped II”CN
is washed with water and melted to recover it as an aqueous solution. Next, after this aqueous solution was steam-dried, DMSO (dimethyl sulfoxide) was added as a solvent and recovered as a DMSO solution. As a result, complicated and troublesome operations are required to evaporate the washing water and dry and solidify H'HiN.

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a reactor with a simple structure capable of continuously synthesizing and recovering radioactive isotopes in a concentrated solution state any number of times in view of the above-mentioned drawbacks of the prior art.

According to the present invention, the radioactive isotope vapor after synthesis is not recovered by hubbing, but is condensed and trapped in a trap, and the condensed radioactive isotope solution is washed and dissolved with a solvent. , which is recovered in the form of a concentrated solution.

According to the main features of the present invention, there is provided a reaction section that synthesizes a radioisotope in a vapor state using a mixture of radioisotopes as a raw material gas, a radiation section that synthesizes the radioisotope in this reaction section, and a trap section in which the radioisotope is synthesized. and a conduit for injecting a vapor solvent, and the synthetic liquid trapped in the trap section is
A reactor for synthesizing a radioactive isotope liquid is provided, which is characterized in that the injected solvent washes, dissolves, and recovers the radioactive isotope liquid.

According to another feature of the present invention, the trap section maintains a temperature lower than the condensation point of the radioisotope vapor and has a relatively large effective internal surface area. A reactor is provided.

According to still another feature of the present invention, the toranobop section for condensing and tramping the toranoisotope vapor is a bell-shaped funnel that hangs down from the downstream end of the reaction vessel defining the reaction section. A radioactive substance comprising a container and a flexible pipe that hangs down in a coil shape from a lower mesh pipe of the funnel container, and traps the radioactive isotope vapor that has flowed down from the funnel container by condensing it on its inner wall surface. A reactor for isotope liquid synthesis is provided.

According to another main feature of the present invention, the 1-lamp section includes a cylindrical container that is vertically arranged and that can communicate with the reaction container defining the reaction section; A reaction for synthesizing a radioactive isotope liquid, characterized in that the glass wool is filled in the bottom of a funnel-shaped container and condenses and traps the radioactive isotope vapor flowing down from the funnel container on its outer surface. Equipment will be provided.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

First, referring to FIG. 1, the main parts of a reactor IO for synthesizing an abrasive isotope liquid according to the present invention are illustrated. This reactor 10 includes a reaction vessel 11, a catalyst stopper 12, and a funnel vessel 1.
3. It mainly consists of an atmosphere section 14 heated by constant temperature heating means, a flexible pipe 15, and a conduit 16. The reaction vessel 11 is arranged substantially horizontally, and defines therein a relatively elongated reaction section 11a containing a catalyst. Catalyst stop 1
In No. 2, the reaction section 11a is arranged near the downstream end of the reaction vessel 11 so as to be cold.

Therefore, when the raw material gas mixed with the radioactive isotope gas is supplied upstream of the reaction vessel 11 by the carrier gas, the raw material gas flows downstream while its reaction is promoted by the catalyst inside the reaction section 11a. In this case, since the catalyst stopper 12 is disposed near the downstream end of the reaction vessel, the vapor of the synthesis liquid generated by the reaction passes through the catalyst stopper 12 and flows further downstream, but the catalyst in the reaction section lla is Passage is prevented by a stop 12. Catalyst stopper 12
The vapor of the synthesis liquid that has passed through flows into the funnel container 13.

This funnel container 13 hangs down from the downstream end of the substantially horizontal reaction container 11, and has a morning glory shape consisting of an upper large diameter portion 13a and one thin tube 13b. Here, as surrounded by a dashed line frame, reaction vessel II and funnel vessel 13 are shown.
Both are maintained at a predetermined temperature by the constant temperature heating means 14, so that in the reaction section 11a of the former 11, the reaction of the raw -l gas is promoted, while in the latter 13, the vapor of the synthesis liquid floats down inside. and reaches the thin tube 13b. This thin tube 13
From b, the above-mentioned flexible pipe 15 hangs in a coiled manner. This corrugated pipe 15 is a trap collecting means which is a main component of the present invention, and is maintained at a temperature of about 100.degree. Condensation is trapped on the inner wall surface. Furthermore, since the aforementioned conduit 16 opens approximately at the center of the large diameter portion 13a of the funnel container 13, the synthetic liquid trapped in the flexible tube 15 is removed by injecting the cleaning solvent from the conduit 16 into the large diameter portion 13a. It is collected and discharged outside. After discharging the radioactive isotope liquid, the carrier gas is transferred from the conduit 16 to the large diameter section 1.3a.
When the reaction solution is introduced into the reactor, all of the reaction liquid remaining in the funnel container 13 and the flexible tube 15 is recovered and discharged to the outside.

The reactor 10 for radioisotope liquid synthesis according to the present invention is prepared using N2I
Examples applied to the synthesis of 50 are shown in Figures 28 to 2C below.
This will be explained in detail with reference to the drawings. Reference numerals already explained in FIG. 1 are omitted.

First, reference is made to Figure n, which shows the reaction/trap operating mode. From the left of the figure, the raw material gas (2
H2→-+52) was added to reaction vessel 1 at a flow rate of 500 cc/min.
1 into the reaction section 11a. Here, reaction vessel 11
The diameter is about 12 dragons φ and the total length is about 1001. The introduced raw material gas passes through the internal palladium (Ild) catalyst (150
°C), it reacts to form N21SO. N2 after synthesis
Since the reactor A:i 11 is heated to about 150'C by a constant temperature heating means 14 such as an electric furnace or a mantle heater, it passes through a catalyst stopper 12 made of sintered glass and has a capacity of about 100% in a vapor state. It flows into a 3 cc funnel container 13.

This f(2'も0 vapor continues to flow into the downstream flexible pipe 15 in a suspended state.) Since this flexible pipe 15 has been left at room temperature, the N21SO vapor that has flowed in is condensed on the inner wall surface. This trapped N2'
The supply of raw material gas (J) continues until the desired amount of O is reached, so leave valve 3 open and unreacted raw material gas is discharged outside as waste gas containing radioactive gas ("02"). The outer diameter of the flexible tube 15 is approximately 6 mm and the length of the coiled portion is approximately 40 cm. Observe with a sensor such as a radiation meter when the trapped N2"O reaches the desired amount. After that, stop supplying the raw material gas and close valve 3.

Next, reference is made to FIG. 2B showing the washing/separation/recovery operation mode F. Normally, after about 5 minutes of operation/trap mode, valve V
2 and valves 5 and V6 alternately to operate the syringe 17 and air cylinder 18, distilled water, which is a cleaning solvent, is pumped into the conduit 16 with an outer diameter of about 6 mm φ.
Pour into the large diameter portion 13a of the funnel container 13 over approximately medium heat.

Approximately 2 cc of injected distilled water drips from the opening of the conduit I6 and flows into the lower capillary tube 13b of the funnel container and the convoluted tube 15 following it.
The trapped II2'O is separated from the gas.The separated N21'O flows down the snake pipe 15 together with distilled water, and when the valve V4 is opened, the outside collected and discharged.

Here, the operations of the syringe 17 and the syringe cylinder 18 will be briefly explained. The air cylinder for operating the syringe 17 is operated by introducing pressurized N2 by switching valves 5 and V6. That is, when N2 is alternately introduced into the upper and lower chambers as seen from the drawing, the piston of the air cylinder 18 slides up and down, causing the piston of the syringe 17 to move vertically and southward by the common piston rod. . As a result, the syringe 17 performs its sucking and discharging operations to supply distilled water to the conduit 1G.

Now, after the recovery mode of I]21゜O, the valve ■1 is opened and the valve ■4 is also opened at the same time. Then, as shown in FIG. 2C showing the purge operation mode, purging N2 is supplied to the conduit 16 through the valve 1. Supplied N2, conduit 16
The gas is ejected from the opening toward the thin tube 13b of the funnel container 13 at high speed, and not only the gas but also the liquid remaining in the funnel container 13 and the flexible tube 15 is recovered through the valve 4.

By repeating the three operation modes as described above, II2'ゝ0 can be continuously synthesized and recovered any number of times. According to a test using the above-mentioned reactor, more than 600 mCi of EO3 was produced in less than 5 minutes with d-50μ8 operation using phosphorus produced by a small medical zychrotron, CYPLYS, as a raw material. It has become possible to synthesize and recover 112"0. Also, since the reactor itself has a simple structure, by replacing the wash water tank with one of alcohol or sterile distilled water, the trap/recovery system can be easily The sterilization process will also become easier.

Furthermore, the reactor for synthesizing radioactive isotope liquid according to the present invention is not limited to the one for synthesis/recovery of "21.0".

For example, a second embodiment in which the present invention is applied to the synthesis and recovery of H''CN will be explained with reference to FIG. It is mainly composed of a reactor 2I, a trap section 22, and a guide bamboo 23.The reactor 21 is a reaction section inside thereof, and
H"CN is synthesized in a vapor state using a mixture of CI+4/N2 and N113 supplied through solenoid valves V1' and V2', respectively, as a raw material gas. In this case, the reactor 21 is heated to 1000'c. This electric furnace uses platinum as a catalyst.The H''CN vapor synthesized in the electric furnace 21 flows down into the cylindrical container 24 of the L/wrap section 22 via the solenoid valve V3'. , cylindrical container 2
It condenses on the outer surface of the glass wool 25 filled at the bottom of the container 4 and is L-wrapped. In order to promote this trap reaction, the glass wool 25 is impregnated with a suitable alkali. The supply of raw material gas continues until the trapped H"CN synthetic liquid becomes the desired counterfeit, so the solenoid valve V
5' is left open, and unreacted raw material gas is discharged to the outside as waste gas containing radioactive gas 'tl:+14. After enough cards, open solenoid valve V4' and open conduit 23.
A solvent DMSO (dimethyl sulfoxide) is injected through the glass wool 25 and dropped onto the glass wool 25. Then, the H'lCN synthetic solution trapped on the outer surface of the glass wool 25 is washed and dissolved by the injected DMSO, and when the solenoid valve V6' is opened, it is recovered in a concentrated solution state.

After recovery, the solenoid valves V3° and V5'' are closed, and the purging N2 gas is jetted into the cylindrical container 24 at high speed through the conduit 23.The inside of the cylindrical container 24 is caused by this high-speed jet of N2 gas. Not only the gas but also the liquid remaining on the surface of the glass wool 25 is recovered through the solenoid valve.

In this way, by repeating the reaction/1-lap operation mode, the washing/7-dissolution/recovery operation mode, and the purge recovery mode, the can be recovered as a concentrated solution of DMSO. Using this 18 solution, 1lc-octylamine (C1
13(CI+2) s"C112Nl12) can be synthesized. In the experiments of the present inventor, 1 with a radiochemical yield of 39%
1C-octylamine was obtained. This is because by using the reactor 20 shown in Figure 3, CN can be recovered anhydrously and the complicated and troublesome evaporation to dryness can be omitted.As a result of combining this reactor with a small medical zychrotron CYPRYS. , EO5T: up to 760 mC1 I("CN was synthesized.

[Brief explanation of the drawing]

FIG. 1 is a schematic diagram showing the arrangement of essential parts of a reactor for synthesizing a radioactive isotope liquid according to the present invention. Figures 28 to 2C are schematic diagrams showing the overall arrangement of the reactor of the present invention, Figure 2Δ shows the reaction/trap operation mode of the reactor, and Figure 2B shows the water washing, minute δ11, and recovery modes. FIG. 2C is for explaining the operation mode, and FIG. 2C is for explaining the purge operation mode. FIG. 3 is a schematic diagram showing the overall arrangement of a reactor according to another embodiment of the present invention. (Main reference number) 10, , , reactor for radioisotope liquid synthesis, ii,
, Reaction container, 12, , Catalyst stopper, 13, , Funnel container, 14, , Constant temperature heating atmosphere section, 15, , Corrugated tube, 16, , Conduit, 17, , Shringe, 18, , Air cylinder, 20, , Reactor for radioisotope liquid synthesis, 21,
, Reaction container, 22, , Trap part, 23, , Conduit, 24, , Cylindrical container, 25, , Glass wool, vi~V6. ,, Valve, Vl' ~ V6', , , Valve, Applicant Sumitomo Heavy Industries, Ltd. Sub-Agent Patent Attorney Masahiko Arai

Claims (1)

[Claims] (1) A reaction section that synthesizes a radioisotope in a vapor state using a mixture of radioisotopes as a raw material gas, and a trap section that condenses and tramps the radioisotope vapor synthesized in this reaction section. and a conduit for injecting the solvent for the radioactive isotope vapor into the trap section, and the synthetic liquid trapped in the trap section is washed and washed by the injected solvent.
A reactor for synthesizing a radioactive isotope liquid, which is characterized by melting and recovering. (2. The radioisotope liquid synthesis reactor according to claim 1, wherein the trap section is maintained at a temperature lower than the condensation point of the radioisotope vapor and has a relatively large effective internal capacity. A reactor for synthesizing a radioisotope liquid, characterized in that the reactor has a surface area.(3) The reactor for synthesizing a radioisotope liquid according to claim 2, wherein the Trump part defines the reaction part. A morning glory-shaped funnel vessel hangs down from the downstream end of the reaction vessel, and a coiled funnel hangs down from the lower mesh pipe of the funnel vessel, and the radioisotope vapor flowing down from the funnel vessel is absorbed into the inner wall of the funnel vessel. A reactor for synthesizing a radioisotope liquid characterized by comprising a flexible tube that condenses on the surface and traps it. (4) A reactor for synthesizing a radioisotope liquid according to claim 2, which comprises: After recovering the synthetic liquid, the conduit is configured to eject a purge gas into the trap section to remove the synthetic liquid.
- A reactor for synthesizing radioactive isotope liquids, characterized in that all unreacted raw material gas remaining in the wrap section, including liquid, is recovered. (5) A reactor for synthesizing a radioisotope liquid according to claim 3, wherein the raw material gas is a mixture of 15□ and N2 using N2 as a carrier gas, and therefore the radioisotope vapor is 112'sO. (6) A reactor for synthesizing a radioisotope liquid according to claim 3, comprising a valve means for switching between the solvent and the carrier gas and supplying the synthesis liquid and the raw material gas to the conduit. A reactor for synthesizing a radioactive isotope liquid, further comprising valve means for switching and discharging. (7) The reactor for synthesizing a radioisotope liquid according to claim 5, wherein the solvent is distilled water. (8) A reactor for synthesizing a radioisotope liquid according to claim 2, wherein the trap section is capable of communicating with a reaction vessel defining the reaction section and is arranged vertically. a cylindrical container, and glass wool filled in the bottom of the cylindrical container to condense and trap the radioactive isotope vapor flowing down from the funnel container on its outer surface. A reactor for synthesizing a radioactive isotope liquid, characterized by: (9) A reactor for synthesizing a radioisotope liquid according to claim 8, wherein the raw material gas is a mixture of CH4 and NH3 with N2 as a carrier gas, and therefore the radioisotope A reactor for synthesizing a radioactive isotope liquid, characterized in that the steam is H"CN. (10) A reactor for synthesizing a radioisotope liquid according to claim 8, characterized in that the glass wool of the trap section is impregnated with an alkali equivalent to 1 ffl. vessel. (11) The reactor for synthesizing a radioisotope liquid according to claim 8, wherein the solvent is DMSO (dimethyl sulfoxide).