JPS6047670A - Adsorbing element for tobacco filter - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an adsorption element for a cigarette filter that can adsorb and remove mutagenic substances contained in cigarette smoke.

Many reports have been made regarding the relationship between smoking and the occurrence of cancer, and Winder et al.
@rimental Carcinogen@sls+
AeadsmiePress, New York
(1967)] reported that a relatively strong carcinogenic substance was present in the neutral fraction, and animal experiments have shown that this neutral fraction is a sexually active substance. Polynomial aromatic hydrocarbons such as benzoC,)pyrene and dipentz[-,h]thianracene have been detected.

Therefore, in recent years, many studies have been conducted to improve the health of smokers by removing mutagenic substances, nicotine, tar, etc. from cigarette smoke.
(manufactured by American Drug Corporation), hemin filter (Advance 1ll), chlorella pipe (manufactured by Sinisu Kogyo Co., Ltd.), etc., but these companies are not effective in removing mutagenic substances.

Therefore, the present inventor conducted extensive research to provide a cigarette filter that can effectively remove mutagenic substances.
Liquid paraffin dissolves and adsorbs harmful substances in cigarette smoke well. Therefore, if a filter is constructed by filling solid particles coated with liquid paraffin and allowing tobacco smoke to pass through, the harmful substances mentioned above will be extremely absorbed. They found that it can be removed efficiently and completed the present invention.

That is, the present invention provides an adsorption element for a cigarette filter in which the surface of solid particles is coated with liquid paraffin.

The adsorption element for a cigarette filter of the present invention is obtained by forming a solid such as synthetic resin, glass, silica gel, alumina, cellulose, metal, activated carbon, etc. into particles and coating the surface with liquid paraffin. The particle size of the solid particles is usually preferably about 100 to 400 mesh. To coat liquid paraffin, place the solid particles in a mortar,
This is done by placing the liquid paraffin in a mixer such as a laikai or cane sugar mixer, and adding liquid paraffin dropwise or misting it to mix the two uniformly. The liquid paraffin coated needle is preferably 10 to 30% by weight of the solid particles.
The adsorption element of the present invention can be used to fill a cigarette filter or pipe. FIG. 1, which shows an example of a smoking pipe filled with the adsorption element of the present invention, will be explained as follows.

In Figure 1, (1) is the pipe body, with a suction port (
2), and a cigarette insertion part (3) into which the end of a cigarette is inserted is formed at the other end. The inside of the pipe body (1) is filled with a cavity (4) formed by partition plates (6 &) and (6b), and this cavity (4) is filled with a large number of adsorption elements (5).

In addition, the partition plates (6a) and (6b) have an arbitrary number of smoke holes (7
B) and (7b) are transparent.

In the pipe configured as described above, when a cigarette is inserted into the tobacco insertion part (3) and sucked from the mouthpiece (2), it comes into contact with the removal and adsorption element (5) that passes through the ait cavity (4), Harmful substances in the smoke are coated on the surface of the particles.
It is removed by desorption and adsorption in a fc fluid paraffin bath. Furthermore, when smoke comes into contact with the adsorption element, it is suddenly cooled down, and nicotine and tar also stick to the surface of the adsorption element and are removed.

When the adsorption element of the present invention is filled into a pipe or the like to form a filter, the length of the filter should be 5 Bm or more, particularly 10 mm or more, to give good results in removing mutagenic substances, ~90% of mutagenic substances are removed.

Next, an example will be shown in which a filter was formed by filling a pipe with the adsorption element of the present invention, and the harmful substance removal effect of the adsorption element was investigated using this filter.

Example 1 (1) Manufacture of adsorption element: 500 g of crystalline cellulose was taken as solid particles, and stirred in a Raikai kettle (manufactured by Ri Iron Works).
Liquid paraffin No. 9 was added dropwise to mix both. The average particle size of the crystalline cellulose used at this time was 300 mesh, and the mixing time was 30 minutes at room temperature. The liquid paraffin-retained crystalline cellulose obtained in this way is
It had appropriate fluidity, no scattering, good air permeability, and physical properties suitable for an adsorption element.

(11) Fabrication of a filter (hereinafter referred to as "Demta filter"): Attach a length of 5 mm to the partition plate (6a) of the pipe shown in Figure 1.
A cellulose fiber filter with a length of 5 mm is attached to it, and the adsorption element manufactured in section (1) is attached to it with a length of 5 mm.
00■). Furthermore, a cellulose fiber filter having a length of 5 mm was attached to the side of the cigarette insertion part, and the cigarette insertion part (3) was connected to this.

Example 2 The removal of aerobic substances was carried out using the method of Ames et al. [Mutation Rol,
31, 34 (1975)), Salm
Onalla typhlmurlum TA98 strain was used for investigation in a metabolic activation system in the presence of S9 mix.

(Preparation of il 89 mixes) An olive oil solution of filter-sterilized polychlorinated biphenyls (1ce400.Dose: 500*/9 body weight) was administered intraperitoneally to Wistar male rats (body weight 140-1602). 4 days after rat administration. The liver was fasted on the 5th and rotated on the 5th.The liver was removed at angles and homogenized 3 times using sterile isotonic KC1 solution.This homogenate was
Cool and centrifuge at 000XIF for 10 minutes and collect the supernatant fraction.
There were 9 fractions.

For these 89 cars, 0.3-1MgC128μmol, KC43
3μmol, G-6-P (manufactured by Orient Yeast Co., Ltd. 5Pmol,
NADP (manufactured by Orient Yeast Co., Ltd.) 4 μmol and 0.1
An S9 mix ft consisting of 0.7-M II phosphate buffer (pH 7,4) was prepared. Furthermore, G-6-P and NAD
It was used after sterilization with a Pld Millipore filter.

(4) Mutagenicity test method 7'CSalmonella Ly
Phim-urium TA98 culture solution (approximately 109 bodies/d) 0.1- was placed in a stoppered test tube, and the above 89 mix and the test substance dimethyl sulfoxide (DMSO) 1
Add m solution (sterilized through a Millipore filter), stir quickly, and incubate at 37°C for 20 minutes. Soft agar 2- was added to this m mixture, and stirred (7
Afterwards, M layer F2 was placed on an agar medium and cultured at 37°C for 48 hours. The mutagenicity of the test substance was determined by counting the number of 176 His revertant colonies that appeared.

(ii) Tobacco smoke trapping method Using the device shown in Figure 2 [7. Insert a commercially available Cefunstar (with the filter part removed) into a Temtar filter (8) with a filter length of 5 mm17, ignite it, and aspirate it. This was done on 3 to 10 cigarettes, and the tar captured in the tar trapping tube (i51t DMSO2dK soluble calcanyl,
Te collection 1. ．． , test m-1) and 17. Further, the tar trapped in a portion of the filter was dissolved in DMSO2 and used as sample 17 and test sample 2. In Figure 2, (9) is DM
Cleaning tube containing SO04+, 01J is a three-way cock, (1
2+ is aspirator-1Q31 is a rubber tube, I is a cigarette. In addition, the results without the pipe were used as a control (1v) The results are shown in Table 1.

Table 1 shows each dilution ratio when the amount of tar collected from one Seven Star from which the present filter was removed is 1.0.

As shown in Table 1, by using Temta filter,
It can be seen that 60-70% of mutagenic substances are removed.

Example 3 In the same manner as in Example 2, mutagenic substances in tar (15) were investigated using the Temta filter with filter lengths f 5 mm and 10 mm. The results are shown in Table 2. It is as follows.

Table 2 As shown in Table 2, Temta filter and [7 5 m
When +n length was used, about 60-70% of mutagenic substances in tobacco smoke were removed, and when 1OInn length was used, about 80% was removed. Therefore, it is better to have a longer Temta filter.

) Example 4 Using the same equipment as Example 2, test pipe (8) 1
．． Using Temta Filter, Aqua Filter, Hemin Filter, and Chlorella Pipe with a filter length of 5 mm, the ability of each to remove mutagenic substances was investigated. That is, a commercially available Seven Star (with the filter part cut out) was inserted into the test pipe (8), and the smoke from three cigarettes that passed through the pipe was trapped [7 and tar 05].
The tar αH1 was collected by passing smoke from three cigarettes through the pipe, and the number of B mutant colonies was counted in the same manner as in Example 2. Ta. The results are shown in Table 3.As is clear from Table 3, the absorption
Compared to commercially available pipes, the Temta filter has superior ability to remove mutagenic substances.

[Brief explanation of the drawing]

FIG. 1 is a cross-sectional explanatory view showing an example of a smoking pipe filled with the adsorption element of the present invention, and FIG. 2 is a schematic explanatory view of a test device for confirming the effectiveness of the adsorption element of the present invention. 1-11 Pipe body 5-m-Adsorption element 8--Demta filter 9--Washing tube containing DMSO 10-m
-Tar capture tube 11---Three-way cock 12-11 Asbilator and above Applicant: Nissui Pharmaceutical Co., Ltd. Patent attorney Nobuo Ono 1. ．． ．． .゛、゛. ;、゛7：・・：・、1

Claims (1)

[Claims] 1゜ An adsorption element for cigarette filters made by coating the surface of solid particles with liquid paraffin.