JPS604729B2 - emulsifier composition - Google Patents

Description

[Detailed description of the invention]

The present invention contains as essential components one or more mixtures of N-long chain acyl acidic amino acids or their salts and one or more mixtures of polyhydric alcohol fatty acid esters, which have mild effects on the skin. The present invention relates to an emulsifier composition comprising: Conventionally, emulsions have been prepared by appropriately selecting and using lipophilic emulsifiers and hydrophilic emulsifiers. That is, two or more of anionic surfactants, cationic surfactants, and nonionic surfactants are used depending on the required hydrophilic-lipophilic balance (hereinafter referred to as HLB) of the oily components of the emulsion. Emulsions were prepared using selected combinations of compositions as emulsifiers. In particular, compositions in which anionic surfactants such as fatty acid soaps are combined with nonionic surfactants such as ether type, ester type, or amide type are widely used as emulsifiers for preparing emulsions. However, these emulsifier compositions have the following characteristics: {1- They do not irritate the skin and have a mild effect on the skin, '2} The resulting emulsion is stable and the quality of products such as creams and lotions does not deteriorate; These products fully meet all requirements such as ease of use and excellent appearance.
There wasn't. Furthermore, an emulsifier composition comprising a combination of cholesterol and/or cetyl alcohol and a sulfate ester of an aliphatic higher alcohol such as cetyl alcohol has also been proposed. An interfacial compound is formed at the interface, and a stable emulsion is formed. However, sulfate esters of aliphatic higher alcohols cause strong irritation when applied to the skin layer, and are therefore not preferred for use in cosmetics other than those intended for cleaning. The present inventors conducted extensive research in view of the above circumstances, and found that when using an emulsifier composition in which an N-long chain acyl acidic amino acid and/or its salts are combined with a polyhydric alcohol fatty acid ester, The inventors have discovered that products such as creams and lotions that fully meet the requirements of the above can be obtained, and have developed the present invention. That is, the present invention relates to an emulsifier composition that contains two components, an N-long chain acyl acidic amino acid and/or a polyhydric alcohol fatty acid ester, as essential components and can easily and reliably emulsify an oily component. . The present invention will be explained in detail below. One component used in the present invention is an N-long chain acyl acidic amino acid and/or its salts. In the present invention, one or more N-long chain acyl acidic amino acids or salts thereof or mixtures thereof can be used. N-long chain acyl acidic amino acids are composed of residues of acidic amino acids such as glutamic acid and aspartic acid and N-long chain acyl groups which are fatty acid residues having 8 to 40 carbon atoms. As the acidic amino acid, either D-form, L-form or a mixture thereof can be used. Further, as the fatty acid giving an N-long chain acyl group, there are straight chain saturated fatty acids, saturated fatty acids having a side chain, straight unsaturated fatty acids, and unsaturated fatty acids having a side chain. Suitable fatty acids for use are caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, linoleic acid, hydroxystearic acid, serotetratic acid, abietic acid, lanolin fatty acid , 2-ethylhexadecanoic acid, 2-hebutylundecanoic acid, 2-octyldecanoic acid and 12-methyl-9.1
1-octadecadienoic acid and the like. In addition, the enteric ions that form salts of N-long chain acyl acidic amino acids include alkali metals such as sodium and potassium, ammonium, and monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine. , triisopropanolamine, 2-amino-1-butanol, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1.
3-propanediol, 2-amino-2-ethyl-1.3
- alkanolamines such as propanediol, tris(hydroxymethyl)-aminomethane, morpholine, and arginine, lysine, oxylysine, 8-lysine, histidine, orthinine, trinavanine, citrulline,
Cations derived from basic amino acids such as thiolhistidine can be used. On the other hand, another component used in the present invention is a polyhydric alcohol fatty acid ester. In the present invention, one or more polyhydric alcohol fatty acid esters can be used. This polyhydric alcohol fatty acid ester is a reaction product obtained by reacting a polyhydric alcohol with a fatty acid, and is a mixture of partial esters such as monoester, diester, triester, tetraester, bentaester, etc. The mixing ratio varies depending on the type of fatty acid and the number of hydroxyl groups in the polyhydric alcohol. The polyhydric alcohol used to synthesize polyhydric alcohol fatty acid ester is
Polyglycerin (diglycerin, triglycerin, tetraglycerin, bentaglycerin, hexaglycerin,
Octaglycerin, nonaglycerin, decaglycerin, etc.), ventaeritoritol, sorbitan, sorbitol, mannitol, sucrose, etc.Furthermore, the fatty acids used to synthesize polyhydric alcohol fatty acid esters are linear saturated fatty acids. , saturated fatty acids with side chains, linear unsaturated fatty acids, unsaturated fatty acids with side chains. Preferred fatty acids for use are caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid. Acid, behenic acid, oleic acid, linoleic acid, linolenic acid, ricinoleic acid, isostearic acid, undecylenic acid, hydroxystearic acid, cerotic acid, abietic acid, isooctanoic acid, isohexadecanoic acid, 2-ethylhexadecanoic acid, lanolin fatty acid , and 12-methyl-9.11
-octadecadienoic acid, etc. The weight ratio of the N-long chain acyl acidic amino acid and/or its salt to the polyhydric alcohol fatty acid ester used in the present invention is 20:1 to 1:20, preferably 10:1 to 1. : The range is 10. The emulsifier composition of the present invention can be produced by reacting an N-long chain acyl acidic amino acid with the intestinal ion and mixing the salt produced by the reaction with the polyhydric alcohol fatty acid ester. However, it goes without saying that it can also be produced by simultaneously mixing the three components of N-long chain acyl acidic amino acid, the above-mentioned intestinal ion, and polyhydric alcohol fatty acid ester. The emulsifier composition of the present invention, which is composed of the above N-long chain acyl acidic amino acid and/or its salts and polyhydric alcohol fatty acid ester, can be used to synthesize mineral oils, animal oils, vegetable oils, waxes, etc. Although oily components such as esters can be sufficiently emulsified and a sufficiently stable emulsion is formed, a surfactant having any HLB can be added as an optional component if necessary. It is surprising that a well-emulsified emulsion can be formed even when added independently of HLB. In addition, as shown in the Examples below, the emulsifier composition of the present invention can stably emulsify various oily components regardless of the required HLB of the oily component, and can extremely efficiently obtain various types of emulsions during emulsion preparation. be able to. Furthermore, stable emulsions can be obtained in any pH range, alkaline, neutral, or acidic, and both O/W type and W/O type emulsions can be obtained freely. Furthermore, preservatives, heat-preserving agents, thickeners, bactericidal agents, ultraviolet absorbers, pigments, medicinal agents, fragrances, and other additives are added to the emulsion obtained by emulsifying oily components with the emulsifier composition of the present invention. They are added in appropriate combinations to form creams such as vanishing cream, cleansing cream, make-up cream, W/○ type cream, Eimyo Ku IJ cream, lotions such as milk lotion, and medicinal products such as hydrophilic cartilage. can. As explained above, the emulsifier composition of the present invention contains an N-long chain acyl acidic amino acid and/or its salt, and a polyhydric alcohol fatty acid ester. By using the emulsifier composition of the present invention, oily components can be emulsified extremely easily and reliably. Since an interfacial compound is formed by the above two components, the emulsion formed using the emulsifier composition of the present invention has extremely good stability. In addition, emulsions obtained using the emulsifier composition of the present invention or products such as creams and lotions obtained by adding appropriate additives to the emulsions do not substantially cause irritation to the skin. The action is mild. Furthermore, the resulting products such as creams and lotions have excellent usability and appearance. Examples of the emulsifier composition of the present invention are shown below. These Examples are provided to explain the present invention in more detail, and do not limit the scope of the present invention, and various changes are possible. In addition, all "%" in the examples indicates weight %. Example 1○/W emulsion% {11 Liquid paraffin (HLB12-14) 2
0.0{21 Sorbitan monostearate
4.0'3} N-acyl (C.2-C,8) glutamic acid disodium salt
0.5{41 Purified water 7
5.5 total 100.0
[1] After adding the above components m to (2) into a beaker, they were heated and melted on a water bath to form a mixture of 8000, and then the above glue components were added and dispersed thereto to form a mixture. [0] After adding the purified water from {4} above into another beaker, preheat it to 80 qo, and then change the shape from [1] above.
After adding the mixture to the prepared mixture, it was heated at 80 qo for 5 minutes to uniformly emulsify it, and then cooled under a frame. The resulting emulsion was slightly alkaline. A portion of this was taken out and left in a constant temperature bath at 40 qo to examine the heat resistance stability of the emulsion, and the emulsion was not destroyed even after 30 days had passed. This shows that a stable emulsion was obtained. Examples 2 to 6 ○/W Emulsion Instead of liquid paraffin as the oily component in Example 1, isopropyl myristate (HLBIO), cetostearyl 2-ethylhexanoate (HLBIO), squalane (HLBI0, 1), saturated fatty acid ( C8-C,2) triglycerides (HLB15) and castor oil (HLB
7 to 9) were emulsified in accordance with Example 1 using 20% each. Like the emulsion obtained in Example 1, the emulsions obtained in Examples 2 to 6 were weakly alkaline, sufficiently emulsified, and had sufficient stability. Example 7 Vanishing cream (0/W type) % {1'MC stearic acid 5.0
(2) Parafine wax (1350F)
2.0 legs tuna 5
．． 0'4) Cetyl alcohol
2.0 (5l cetyl isooctanoate
5.0{6} Isopropyl myristate
2.0'7} Sucrose fatty acid ester (Sugar Estel S-110 manufactured by Daiichi Kogyo Seiyaku)
2.0 legs Butyl paraoxybenzoate 0
．． Monopod N-acyl (C,2-C,8) glutamic acid monosodium salt 1.02{10
} Methyl paraoxybenzoate 0.1 plate Glycerin 5.002
Purified water 70.603
Fragrance 0.2 total
100.03 [1
] The above components {1} to leg were added into a beaker, and heated and melted on a water bath to form a mixture of 8000, and then the above components ① were added and dispersed to form a mixture. Note that the HLB of the oily components '1} to [6} is 10.5. 3

[0] After adding the ingredients of the above dish ~OU to the purified water of above 03 in another beaker, they were heated and dissolved to prepare 80 oo of aqueous solution. [m] Then the above

After adding the aqueous solution prepared in [0] to the mixture formed in [1] above, it was stirred at 80 qC for 5 minutes to uniformly emulsify it, and then cooled under a fly pestle. of flavor was added at 4500. The obtained vanishing cream was a stable weakly acidic emulsion and had a mild effect on the skin. Example 8 Cleansing cream (0/W type) % ○} MC stearic acid 3.0 [
21 Parafine wax (1350F) 2
．． 0 legs Millou 5
．． 041 Cetyl alcohol
2.0 [5} Liquid paraffin
30.00'61 Palmitic acid isoph. Lopil 10.0 (7} Sorbitan monostearate 2.0'8} N-acyl (
C,2-C,8) Glutamic acid monosodium salt
3.0[91 Butyl paraoxybenzoate 0.15 seeds Methyl paraoxybenzoate 0.100 Propylene glycol
5.002 Purified water
37.603 Fragrances
0.2 total
100.00 The HLB of the oily components [1) to {6} above was 12, and when each of the above components was added and emulsified according to Example 7, a stable weakly acidic emulsion was obtained. This emulsion-type cleansing cream had a mild effect on the skin. Example
9 Milk lotion (0/W type) % '1} Apocado oil 7.
5{2) Cetyl alcohol
2.0'3} Sorbitan mono/gulmitate
2.0 ■ N-acyl (C,2-C,8) glutamic acid disodium salt 1.0
{5} Butyl paraoxybenzoate 0.1
■ Methyl paraoxybenzoate 0.1 [7
} Altitol (50% aqueous solution) 5.0 feet Purified water 82.1'9}
Fragrance 0.2 total
100.0 Above '1--
The HLB of the oily component of {21 was 14, and when the above-mentioned components were added according to Example 7 and emulsified, a stable weakly alkaline emulsion was obtained. This milk lotion in the form of an emulsion had a mild effect on the skin. Example 10 Make-up cream (0/W type) % m Whale wax 5.0 (
2) Cetyl alcohol 2.
0{3} Liquid paraffin 15
．． 0'4} Myristic acid isof. Lopil 5.0'5) Sorbitan monostearate 5.0'6) Titanium oxide
5.0{7} Iron oxide pigment
0.5{8} N-acyl (C
,2-C,8) Glutamic acid monosodium salt
1.0'9} Maltitol (50%
Aqueous solution) 5.0 tl Butyl paraoxybenzoate 0.1 dish Methyl paraoxybenzoate 0.102 Purified water
56.103 Flavorings
0.2 total
100.0 The HLB of the oily components (1) to {4} above is 11.5, and each of the above components was added according to Example 7 except that titanium oxide and iron oxide pigments were added and dispersed in the oily component. When emulsified, a stable weakly acidic emulsion was obtained. This emulsion form makeup cream had a mild effect on the skin. Example 1
1 W/○ type cream% {1} Parafine wax (1350F)
5.0 (2) Beeswax
10.0{3} Liquid paraffin
30.0 [4] Sorbitan monooleate
3.0{5} N-acyl (C, 2-C,
8) Glutamate monosodium salt
1.0 [6) Butyl paraoxybenzoate
0.1(7) Methyl paraoxybenzoate
0.1 [8) Purified water 5
0.6 legs Fragrance 0
．． 2 total 100.0 The HLB of the oily component of the above tl)~'3} is 4.7,
When the above components were added and emulsified according to Example 7, a stable emulsion was obtained. This W/O cream in emulsion form had a mild effect on the skin. Example 12 Hydrophilic cartilage (0/W type) % '1' White petrolatum 25.
0 [21 Stearyl alcohol 2
0.0 legs Sucrose fatty acid ester (Sugar Ester S-20 manufactured by Daiichi Kogyo Seiyaku) 2.0 [4'
N-acyl (C,2-C,8) glutamic acid monosodium salt 1.0 ■ Propyl paraoxybenzoate 0.2'61 Methyl paraoxybenzoate 0.2 (7) Propylene glycol 12.0'81 Purified water 39.6 total
100.0 [1] According to the manufacturing method of hydrophilic ointment according to the Ninth revised Japanese Pharmacopoeia (Part 2)
The ingredients were melted on a water bath and then stirred to form a 75 oz mixture. The HLB of the oily components [1] to [21] above is 12. [D] After adding the components of ① to '7} above to the purified water of ① above, they were heated and dissolved to prepare a 75o0 aqueous solution. [m] Then the above

The aqueous solution prepared in [0] was added to the above [
After adding it to the mixture formed in step 1), it was stirred well until it solidified. The obtained hydrophilic bone was slightly acidic and had a mild effect on the skin. Example 13 ○/W emulsion% om Liquid paraffin (HLB12-14) 20
．． 0 [2] Sorbitan monostearate
4.0 legs N-acyl (C,2-C,8) glutamic acid 0.45'41 Sodium hydroxide
0.05{5} Purified water
75.50ta total
100.00 [1] The above components [11 to 3-] were heated and melted to form a mixture of 80 qo.

[0] The above component '4' was added to the purified water of component (1) and then heated and dissolved to prepare an 80 oo aqueous solution. After adding the aqueous solution of [D] to the mixture of 0 [m] and [1], it was heated for 5 minutes at 80:00 to uniformly emulsify it, and then cooled under the lamp. The obtained emulsion exhibited heat resistance stability similar to that of the emulsion of Example 1, was weakly alkaline, and had a mild effect on the skin. Example 14 Cream (0/W type) % [1] Glycerin trisooctanoate (HLB16) 3
0.0'2) Cetyl alcohol
2.0 (3' sorbitan monopalmitate
3.0'4} Sucrose fatty acid ester
2.0'5) N-stearoyl-L-glutamate monosalium 1
．． 0[6] L-Arginine
0.5 [71 Purified water
61.5 total 1
00.0 [1] Heat and melt the above components '11 to '3},
After forming a mixture at 80° C., components '41 and '51 were added and uniformly dispersed. [0] The above component [61] was added to component [71' and dissolved by heating to prepare an aqueous solution at 80°C. [0] was added to [m][1], and the mixture was stirred at 80°C for 5 minutes to uniformly emulsify it, and then cooled under a takazu, yielding a stable emulsion.

Claims (1)

[Scope of Claims] 1. An emulsifier composition comprising an N-long chain acyl acidic amino acid and/or its salts and a polyhydric alcohol fatty acid ester as essential components. 2. The composition according to claim 1, wherein the ratio of the N-long chain acyl acidic amino acid and/or its salt to the polyhydric alcohol fatty acid ester is 1:10 to 2:1 by weight. 3. The composition according to claim 1, wherein the acidic amino acid constituting the N-long chain acyl acidic amino acid and/or its salts is glutamic acid, aspartic acid, or the like. 4 Polyhydric alcohol fatty acid ester has 8 to 40 carbon atoms
The composition according to claim 1, which is a polyhydric alcohol ester having a fatty acid group of . 5 The polyhydric alcohol fatty acid ester is polyglycerin, pentaerythritol, sorbitol, sorbitan,
The composition according to claim 1, which is a fatty acid ester of mannitol or sucrose.