JPS60237007A - Granular composition of agricultural chemical - Google Patents

Abstract

PURPOSE:A granular composition for agricultural purposes that is obtained by coating granules of agricultural chemicals including ethoprophos with a water- soluble high polymer, thus showing reduced percutaneous toxicity. CONSTITUTION:Granules for agricultural purposes which contains, as an active ingredient, ethoprophos: O-ethyl S,S-dipropyl phosphorodithioate, being active as a soil insecticide and nematocide against a variety of nematodes, gold beetles and scale insects are coated with more than 0.1wt%, preferably 0.1-5wt% of a water-soluble high polymer such as alginic acid, methyl cellulose or PVA. The granules are obtained by spraying granules of mineral support previously sprayed with ethoprophos with a solution of the water-soluble high polymer in water or an organic solvent and drying them.

Description

DETAILED DESCRIPTION OF THE INVENTION (A) OBJECTS OF THE INVENTION 1. The present invention relates to a novel invention that can be used in agriculture, particularly in the field of manufacturing agricultural chemical granules. More specifically, the present invention relates to an improved technique for reducing transdermal toxicity to mammals in a granular agricultural chemical composition containing esoprophos shown below as an active ingredient.

Esoprophos 〇-Ethyl S,S-dipropyl phosphorodithioate (JLEDJL) A method of adding linseed oil to reduce the dermal toxicity of granules containing esoprophos is known (Japanese Patent Publication No. 57-5201 Publication No.).

is trying to do it. Zhan Esoprophos has already been used in potato cyst nematode,
It is a soil insecticide and nematocide that is known to be effective against various nematodes including the sweet potato knot nematode, scarab beetles, hedge beetles, scale insects, and the like. However, esoprofos has very strong dermal toxicity to mammals, and strict care is required when handling this preparation.

Under these circumstances, the reality is that there is no satisfactory technique for reducing dermal toxicity. Therefore, the object of the present invention is to provide a new type of esoprofos granules without transdermal toxicity, instead of the conventional technology.

(B) Structure of the Invention The present inventors have conducted extensive research into techniques for reducing the transdermal toxicity of granules containing esoprophos to mammals. As a result, it was discovered that transdermal toxicity can be significantly reduced by coating esoprophos-containing granules with one type of water-soluble polymer, leading to the present invention.

That is, esoprofos is coated with a water-soluble polymer, avoiding direct contact with mammalian skin, and as a result, transdermal toxicity is significantly reduced. Furthermore, since the additive is water-soluble, when applied, it is easily dissolved or damaged by moisture in the soil, facilitating the elution of Enprophos, and is thought to exhibit high biological effects.

Examples of water-soluble polymers used in the present invention include the following.

■) Natural polymer guarcum, locust dragonfly, gum arabic, gum tragacanth, carrageenan, alginic acid, agar,
Pectin, starch, dextrin, α-cyclodextrin, β-cyclodextrin, xanthan gum,
pullulan, gelatin, etc.

2) Semi-synthetic polymeric methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, sodium alginate, ammonium alginate, etc.

3) Synthetic polymeric polyvinyl alcohol, sodium polyacrylate, polyethylene oxide, polyethylene glycol, polypropylene glycol, etc.

The amount of water-soluble polymer used in the present invention is 0.
．． If the content is 1% (wt%) or more, the effect will be exhibited, but from the viewpoint of both effectiveness and economy, 0.1 to 5% is desirable.

When esoprophos granules are coated with the water-soluble polymer of the present invention, transdermal toxicity can be significantly reduced. Furthermore, even if a water-soluble polymer is added, the biological effects that esoprofos originally has are not impaired.

The preparation method of the present invention is not particularly limited, and may be a method for preparing ordinary pesticide granules. For example, it can be prepared by the following method.

Preparation method 1 A water or organic solvent solution of a water-soluble polymer is sprayed onto a granular mineral carrier onto which esoprophos has been sprayed and adsorbed in advance, and dried to obtain granules.

Preparation method 2 Esoprofos and a mineral carrier are mixed with a binder, water is added, mixed, and then granulated using an extrusion granulator or transfer granulator, dried, and sized.

Next, the water-soluble polymer is dissolved in water or Spray the organic solvent solution and dry it to form granules. get.

As the mineral carrier used in the present invention, any carrier commonly used in agricultural chemical formulations can be used.

For example, clay, diatomaceous earth, talc, bentonite, attapulgite, vermiculite, zeolite, pumice,
Examples include cellulose powder, white carbon, etc. If a granular mineral carrier is used, these mineral carriers may be prepared in an appropriate particle size, and empty granules containing no active ingredients prepared by normal granulation methods may be used. It may also be a drug.

Furthermore, decomposition inhibitors, surfactants, and the like that do not impair the effects of the granular composition of the present invention may be used in combination, if necessary.

Note that even if a water-soluble polymer is mixed with esoprophos, a mineral carrier, etc. in advance and granulated by adding water, the effect of reducing transdermal toxicity cannot be obtained.

Examples are given below to specifically explain the present invention, but the present invention is not limited to these examples. In addition, all parts in the examples are parts by weight.

111'' (Preparation method 1) Granular attapulgite (14-48 mesh) 94.8
After adsorbing 5 parts of esoprophos by spraying onto the sample, 40 parts of a 0.5% carboxymethylcellulose aqueous solution is sprayed onto the sample.

Dry in a fluidized fluid dryer to obtain granules containing 5% of soprophos.

Granular attapulgite (14-48 mesh) 94.5
After adsorbing 5 parts of esoprophos by spraying onto the sample, 50 parts of a 1% aqueous solution of methylcellulose was sprayed onto the sample. Dry in a fluidized fluid dryer to obtain granules containing 5% esoprophos.

(Preparation method 1) After 5 parts of esoprophos is sprayed and adsorbed on 94 parts of granular zeolite (14 to 48 mesh), 33 parts of a 3% aqueous solution of polyvinyl alcohol is sprayed.

Dry in a fluidized fluid dryer to obtain granules containing 5% enprofos.

1 ship 1 (iS1 manufacturing method 1) 94.8 parts of granular diatoms (14 to 48 mesh) are sprayed and adsorbed with 5 parts of esoprophos. Sodium alginate 1
% aqueous solution. Dry in a dynamic dryer to obtain granules containing 5% esoprophos.

1 pot 1] (Preparation method 1) 5 parts of esoprophos is sprayed and adsorbed onto 94.8 parts of pumice (14 to 48 mesh). Sodium polyacrylate 1%
Spray with 20 parts of aqueous solution. Dry in a fluidized fluid dryer to obtain granules containing 5% esoprophos.

(Preparation method 2) Mix 5 parts of esoprophos, 3 parts of white carbon, 5 parts of sodium lignin sulfonate, and 86.8 parts of clay, and add 1 part of water.
After adding 5 parts and mixing, the mixture is granulated using an extrusion granulator. After drying and sizing (14 to 48 meshes), 20 parts of a 1% pullulan aqueous solution is sprayed. Dry in a fluidized fluid dryer to obtain granules containing 5% esoprophos.

(c) Effects of the invention Test examples will be given to prove the usefulness of the present invention.

In addition, samples prepared by removing the water-soluble polymer of the present invention from Examples 1 to 6 were designated as Control Examples 1 to 6, and samples prepared by the method described below were designated as Control Examples 7 and 8.

[Preparation method of Comparative Example 7] Add 1 part of carboxymethyl cellulose to 5 parts of esoprophos, 3 parts of white carbon, 5 parts of sodium ligninsulfonate, and 86 parts of clay, mix, then add 15 parts of water, mix, and extrude granulation. Granulate using a machine. Dry and size (14 to 48 mesh) and 5% as esoprophos.
Obtain granules containing:

[Preparation method of Comparative Example 8] Esoprophos granules described in Japanese Patent Publication No. 57-5201 A mixture of 5 parts of esoprophos, 1 part of linseed oil and 2.5 parts of propylene glycol was mixed with granular attapulgite (14 to 48 mesh). ) to obtain granules containing 5% of esoprophos.

Trial] Example 1 Patch test with mice Moisten the gauze part (diameter 1.5 cm) of a bandage with distilled water, and prepare a sample according to the example (mouse 1k).
5 mg of esoprophos) per g. This was then applied to the depilated skin of mice, and the number of deaths was observed over time.

Five mice were used in this test per sample.

The results are shown in Table 1.

A predetermined amount of the sample prepared according to Example 1 was applied to sweet potato knot nematode contaminated soil placed in a 115,000 are pot and mixed uniformly.

After mixing, five tomato seeds were sown, watered, and left in a greenhouse. 20 days after sowing, the tomato seedlings that had germinated and grown were taken out, the degree of Nekobu expression in the roots was examined, and the control value (%) was determined.

In addition, the evaluation of the degree of staghorn and the control value were determined by the following method. In addition, this test was conducted with 1 bottle per group and 5 repetitions. The results are shown in Table 2.

Degree of Nekobu expression O: None L: Slight 2: Slight 3: Medium 4:
High 5: Severe (%) The average degree of Nekobu expression in the untreated area was 100 8 The degree of Nekobu expression in the drug-untreated area was 4.7.

Patent applicant: Hokuko Chemical Industry Co., Ltd. 1 47-

Claims (1)

[Claims] A granular pesticide containing 〇-ethyl S, S-dipropyl phosphorodithioate as an active ingredient is added to one of the water-soluble polymers.
A granular agricultural chemical composition with reduced transdermal toxicity, characterized in that it is coated with seeds.