JPS60199809A - Cosmetic base - Google Patents

Abstract

PURPOSE:The titled base, containing sterol ester of lanolin fatty acid as an active constituent, having improved emulsifiability, water holding and humectant properties, easily compatible with the skin, giving softness and moisture to the skin, and readily adsorbable without allergic problems. CONSTITUTION:A cosmetic base containing sterol ester of lanolin fatty acid as an active constituent. The above-mentioned active constituent is obtained by esterifying lanolin fatty acid with sterol. The esterification reaction is carried out by heating a mixture of the lanolin fatty acid with the sterol at about 100- 250 deg.C in the absence or presence of a catalyst, e.g. p-toluenesulfonic acid or tin chloride. The lanolin fatty acid has about 21 average carbon atoms and about 320 average molecular weight, and consists of a branched fatty acids such as isofatty acids or anteiso fatty acids and hydroxy fatty acids. Cholestero is preferably used as the sterol.

Description

[Detailed description of the invention] Technical field The present invention relates to a base material for cosmetics.

Lanolin has excellent properties for the skin and is widely used as a base material for cosmetics. However, depending on the person applying the base material, although it is very rare, it is said that the base material has allergenic properties such as irritating the skin. Additionally, there are still some problems with Furin, including its unique odor and stickiness. Much research has been carried out to improve these drawbacks of furin, and it has now become possible to obtain products that are almost satisfactory in terms of allergy, color, odor, etc.

On the other hand, many efforts are being made to develop a base material for cosmetics that has properties equal to or superior to those of lanolin, and is free from skin irritation, color, odor, and stickiness.

In view of the current situation, the present inventor completed the present invention as a result of intensive research to develop a base material for cosmetics that has properties equivalent to or better than lanolin and does not cause allergic problems. reached.

Object, Structure, and Effects of the Invention The object of the invention is to provide a material that has excellent emulsifying properties, water-retaining properties, and moisturizing properties, easily blends into the skin, imparts flexibility and moisture to the skin, and is easily absorbed into the skin without leaving any stickiness on the skin. First, it is an object of the present invention to provide a base material for cosmetics that is free from allergy problems.

The base material for cosmetics of the present invention is made of fluorinated fatty acid 9-sterol ester.

Lanolin fatty acid, which is a constituent of sterol esters of fluorinated fatty acids, has an average carbon number of about 21 and an average molecular weight of about 820.The crude product is a pale yellowish brown solid, but when highly refined it becomes white. It is a known substance. Lanolin fatty acids are mostly composed of branched fatty acids such as isofatty acids and antiisofatty acids, and droxy fatty acids, and there is very little normal fatty acid, which is often found in ordinary natural fatty acids, and almost all even and odd numbered acids. They are contained in similar proportions. In the present invention, it is of course possible to use conventionally known thunorin fatty acids as they are, but it is also possible to use thunorin fatty acids divided into specific carbon number ranges by fractionation, distillation, etc. Since about 178 of them are hydroxy fatty acids, it is possible to use a lanolin fatty acid in which part of the lanolin fatty acid is oligoesterified by intermolecular esterification with the hydroxyl group and carboxyl group present therein. The reaction conditions for this oligoesterification are not particularly limited, and conventionally known reaction conditions for hydroxyesterification can be widely applied. For example, thunorine fatty acid is heated to 100 to 2
A method can be adopted in which the acid value is measured during the reaction, and the reaction is stopped when the desired acid value is reached. In addition to this product, a partially lactidized product can also be obtained, but even if this product remains, it does not pose any problem in the present invention.

The sterol, which is another component constituting the sterol ester of lanolin fatty acid, is a conventionally known sterol, and is not particularly limited, and may be of animal origin, plant origin, or synthetic sterol. Examples of such sterols include cholesterol, isocholesterol, phytosterol, sitosterol, 7-dihydrocholesterol, and hydrogenated products of these sterols. In the present invention, these sterols may be used alone or in combination of two or more. Particular preference is given to using cholesterol according to the invention.

The sterol ester μ of thunorin fatty acid, which is a component of the base material for cosmetics of the present invention, is obtained by esterifying the above-mentioned lanolin fatty acid and sterol. There are no particular restrictions on the reaction conditions for the esterification reaction. (A wide variety of conventionally known reaction conditions for esterification reactions can be adopted. The sterol mixture may be heated to about 100 to 250°C. The end point of the reaction can be determined by measuring the acid value. In addition, without oligoesterifying lanolin fatty acids in advance, by simultaneously charging and reacting an excess of thunolin fatty acids with a certain amount of sterols, we can conduct an oligoesterification reaction of lanolin fatty acids and an esterification reaction between the fatty acids and sterols. The sterol ester of thunorin fatty acid obtained in this way can also be used as the base material for cosmetics of the present invention. In addition, if lower alkyl esters of fluorinated fatty acids, such as evamethyl esters and isopropyl esters, are easily available, the fatty acids may be oligoesterified in the presence of a transesterification catalyst such as sodium methylate as necessary. By transesterifying a lower alkyl ester and a sterol in the presence of the above transesterification catalyst,
It can also be a sterol ester of fluorinated fatty acid, and in the present invention, this ester can also be used as a base material for cosmetics.

The base material for cosmetics of the present invention has excellent emulsifying properties, water-retaining properties, and moisturizing properties, is easily compatible with the skin, is easily absorbed into the skin, and does not leave any sticky feeling on the skin.

EXAMPLES The present invention will be further clarified by presenting production examples, formulation examples, and usage examples below.

Production Example 1 Molecularly distilled lanolin fatty acid (acid value 1B8.1, hydroxyl value 54.4, melting point 54.2°C) was added to lkF in a 81 4-tubular flask equipped with a stirrer, thermometer, nitrogen gas suction tube, and water separator. Add 01% of para-toluenesulfonic acid as a catalyst, react under reduced pressure F at 120 to 200°C while stirring well under nitrogen gas blowing, and continue to react until the acid value reaches 100 while measuring the acid value. The reaction was carried out for 5 hours to obtain the desired oligoesterified lanolin fatty acid 990f.

Next, 700 t of Cholestero-IV was added, and the mixture was reacted under reduced pressure at 120 to 200° C. for about 5 hours while stirring well and blowing nitrogen gas. After the reaction is complete, neutralize the catalyst with sodium carbonate,
After decolorizing using activated clay, the clay and catalyst are removed by F5 filtration, followed by deodorization by blowing steam under reduced pressure at 200°C, and at the same time, a trace amount of unreacted cholesterol remaining is removed to obtain the desired oligomer. Cholesterol ester 1600f of esterified lanolin fatty acid was obtained.

Production Example 2 Production Example 11 Molecularly distilled low melting point lanolin fatty acid (acid value 188.1, hydroxyl value 72.8, melting point 4) was placed in a Ti3-mounted flask.
2.5°C) and reacted for about 5 hours according to the method described in Production Example 1 until the acid value reached 180 to obtain the desired oligoesterified Wonolin fat 1! I! Obtained 990F. Next, Cholestero-/I/900f was added, and in the same manner as in Production Example 1, the desired oligoesterified low-melting point Thunorin fatty acid cholesterol ester 1800F was obtained.

Production Example 8 The flask described in Production Example 1 was charged with high melting point lanolin fatty acid (acid value 107.7, hydroxyl value 16.7, melting point 78.4°C) lkf and cholesterol 750t, which were purified by solvent fractionation, and the amount of fatty acid charged as a catalyst was iX puffed toluenesulfonic acid was added thereto, and the reaction and post-treatment were carried out according to the esterification method of Production Example 1 to obtain the desired high melting point lanolin fatty acid cholesterol ester 1701.

Table 1 shows the general properties of the lanolin fatty acid cholesterol esters obtained in these preparation examples.

All of the obtained samples were pale yellow, odorless, pasty solids.

The skin irritation was measured using the Japanese Industrial Skin Hygiene Association method (combination method, Dermatology Bulletin-6,
6, 161-181, 1971), visual judgment was performed on five men and women each through a patch test, and a microscopic observation of a replica of the skin a after the patch test using the sump method. No abnormalities were observed in humans, and the results were negative.

As sterol esters, Ml) No. 1 to 8 in Table 1
Cosmetics of Formulation Examples 1 to 5 were produced by blending other ingredients as appropriate. All had good properties.

Formulation example 1.1'-W10 type skin cream "Sample NL)
, 2 1.0 (wt%) Lecithin 0.5 Vaseline 15.0 YOFCOFE-1 (Note 1) 10.0 Water Remaining Note 1: Molecularly distilled ester of Wonorin fatty acid and 2-octyldodecanol was fractionated and purified. Nenephrine fluid.

Formulation example 2. "0/W type emulsion J Sample No. 10.2 (wt%) Liquid buffin 8.0 Lecithin 2.0 Water Balance example 8゜"Skin care cream" Sample No. 21.5 (wt%) White petrolatum 1. 5 YOFCOFE-101 (Note 2) 1.5 Beads wax 2.0 Stearic acid 10.0 Triethanolamine 1.5 Glycerin 8.0 Magnesium stearate 20.0 Water Remainder Note 2 Bimolecularly distilled Wonorin fatty acid and 2-octyl dodeca A paste-like part obtained by separating and refining the ester with nol.

Formulation example 4. "Cold cream" Style: MJJ paraffin 50.0 (wt%) wax 1
5.0 Sample No. 15.0 Borax 0.8 Water Balance fragrance Appropriate amount Blending example 5. "Lipstick" Oleyl alcohol 25.6 (441%) Setanol 5.0 Castor f-based 81.0 Beeswax 6.0 Petrolatum 5.0 Carnauba wax 5.0 Sample No. 84.0 Lanolin 10.0 Eosinic acid 0.4 Pigment 8.0 Fragrance Appropriate amount Usage example As a way to understand the performance of the product of the present invention, 10 women were asked to perform a trial test on the product of sample No. 091.

The test method is to apply a sample to the back of the hand before going to bed, and check the expandability of the sample when clothed, its absorption into the skin, the presence or absence of an unpleasant oily feeling that remains on the skin surface, and the smoothness of the skin surface when you wake up the next day. After surveying people about their impressions about the suppleness and moisturizing feel of the product, all of them said that it absorbs well into the skin when applied, so it doesn't leave an unpleasant oily feeling, and that it does not leave an unpleasant oily feeling on the skin surface when you wake up. It was found that the intended purpose of the present invention was achieved as a good feel was observed.

(Above) May 28, 1980 Commissioner of the Japan Patent Office Kazuo Wakasugi 1, Indication of the case 1988 Patent Jaw 57105 May 2, Name of the invention Base material for cosmetics 3, Person making the amendment 4, Agent 10 Sawa no Tsuru Hill, Hirano-cho 2, Higashi-ku, Osaka Phone: 06-203
-0941 Voluntary Voluntary Voluntary No. 6, Contents of Amendments to the Number of Inventions Increased by Amendment 1. On page 7, line 6 of the specification, the phrase "nitrogen gas suction pipe" is corrected to read "nitrogen scum injection pipe."

2. In Table 1 on page 10 of the middle part of the specification, the phrase "human 000 syl value" is corrected to read "hydroxyl value."

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Claims (1)

[Claims] (1) A base material for cosmetics consisting of lanolin fatty acid sterol ester μ.