JPS60197622A - Bacteriocidic composition - Google Patents

Abstract

PURPOSE:A bacteriocidal composition that is obtained by adding sodium laurylsulfate as a surface active agent to a silver salt of sulfa drug, thus markedly increasing the bactericidal effect of the sulfa drug which has been used as a bactericidal or bacteriostatic agent. CONSTITUTION:The objective composition is obtained by adding sodium laurylsulfate to a silver salt of sulfa drugs such as compounds of formulas I and II. The amount of the sodium laurylsulfate is 0.01-1% based on the composition and 6.5-20,000 at a weight ratio. When the drug is not heat-treated, the addition of more than 0.01% of sodium laurylsulfate increases the bactericidal effect 8- 250 times.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a disinfectant composition, and more particularly to a disinfectant composition containing a sulfur drug silver salt and sodium lauryl sulfate.

The present inventors were conducting various studies to further improve the efficacy of sulfa drugs, which are widely used as bactericidal and bacteriostatic agents along with antibiotics. The present invention was completed based on the discovery that the same effect can be applied to sexes.

Accordingly, the present invention provides a disinfectant composition containing a sulfonate silver salt and sodium lauryl sulfate.

Examples of the sulfur agent silver salt used in the present invention include those represented by the following formula.

Compound 1゜Compound 2゜Compound 3゜Compound 4゜Compound 5゜Compound 6゜Compound 7, Compound 8, Compound 9, Compound 10゜Compound 11゜Compound 12゜Compound 13゜Compound 14゜Compound 15゜Compound 16゜Compound 17° Compound 18° Compound 19° Compound 20° Compound 21° Compound 22° Compound 23° Compound 24° Compound 25° Compound 26° Compound 27° Compound 29° Compound 30° Compound 31° Compound 32° Compound 33° Compound 34 Compound 35° Compound 36° Compound 37° Compound 38° Compound 39° Compound 40° These silver salts are prepared by a conventional method, for example, by dropping silver nitrate onto the sodium salt of the sulfa drug.

The bactericidal composition of the present invention can be made into a cream, ointment, sterile effervescent tablet, etc. by a known method, and the dosage is generally the same as that of a bactericidal agent using a conventional sulfa drug. It is determined by

In order to prepare the disinfectant composition of the present invention, sodium lauryl sulfate may be blended in the composition in a weight ratio of 0.0011 or more, or 0.001 or more per 1 of sulfur agent silver salt. Among these, a particularly preferred amount of sodium lauryl sulfate is 0.01 to 1% in the composition, and a coulometric ratio of 6.5 to 20,000 per 1 of sulfur agent silver salt.

Next, the results of testing the bactericidal action of the bactericidal composition of the present invention will be shown.

[Bactericidal action test]

Test Example 1 Sodium lauryl sulfate was dissolved in sterile water and 100w/
#LIf', 2QIv/a/, 2#l/+117.0,
Make a solution of 24/m and 0.92M97-. Amounts of each of these are dispensed into different test tubes, and a solution 5d of the compound (1) dissolved or suspended in sterilized water at each concentration is added to prepare composition sample solutions of various concentrations. After keeping each sample solution in a 37°C constant temperature bath for about 3 hours, it was added to N. coli 0-1 and Pseudomonas aeruginosa I, which had been previously cultured at 37°C for 20 to 24 hours.
FO13736 and Stahylococcus aureus AT
Add 1wLl of each culture solution of CC65389, and after 1 hour, inoculate one platinum loopful of this solution into a normal bouillon culture medium.
The presence or absence of bacterial growth was observed 48 hours after inoculation. Further, in order to examine thermal stability, the same test was conducted for each sample solution that had been autoclaved at 120° C. for 20 minutes.

The results are shown in Table 1.

Table l Test Example 2 Dissolve sodium lauryl sulfate in sterile water to make a 2 da/- solution. Dispense 5 ml of these into different test tubes, add 5 d of sulfa drug silver salt solution dissolved or suspended in sterile water to each E degree, and add composition sample solution of each concentration. M against Staphylococcus J. thalaeus ATCC65389 was prepared in the same manner as in Test Example 1.
LC values were determined. The results are shown in Table 2.

Table 2: Table 2 As is clear from the above results, sodium lauryl sulfate is 0.5% when no heat treatment is performed. The bactericidal effect of cisulfur agent silver salt is improved by 1 to 64 times by adding more than 100 ml of sodium lauryl sulfate.
By adding 01S or more, the bactericidal effect of the sulfur agent silver salt is improved by 8 to 250 times.

Next, the present invention will be described with reference to reference examples and examples.

Reference Example 1 2.78y- of sulfamethacin was suspended in 20-y water,
Drop a solution of 0.40F sodium hydroxide dissolved in 201+11 water. Stir for 5 to 30 minutes and filter the insoluble portion. Add 1.70y- of silver nitrate dissolved in 20+111 water to the P solution, then add 4017 of water for 30 minutes.
Stir for 1 hour. The precipitated crystals were washed sequentially with water, ethanol, and ether, and air-dried to form sulfamethacine silver salt (
Compound 5) 3.27F (yield: 85%) is obtained. Melting point 300℃ or higher.

Reference Example 2 2.86f of sulfamerazine sodium salt is dissolved in 20-ml water, and the insoluble portion is passed through. Silver sulfate 1.70 in f solution
A solution of f- dissolved in 26 mt of water is added dropwise, then water 4011j is added and stirred for 30 minutes to 1 hour. The precipitated crystals were sequentially washed with water, ethanol, and ether, and air-dried to yield sulfamethacine silver salt (compound 4) at 3.275%! −(
A yield of 88 h) is obtained.

Melting point 272-275°C (decomposition).

Example 1 (Hydrophilic ointment) Hydrophilic ointment 100? was manufactured.

Sulfabenzamide silver 11 Sodium lauryl sulfate 1.5 White Vaseline 14y- Stearyl alcohol 22? Propylene glycol 15y- Inglopanol ester 8? Total amount is 100 with purified water? shall be.

Example 2 (Macrogol ointment) Macrogol ointment 100 with the following ingredients and amounts according to the usual method
g- was produced.

Sulfabenzamide silver l? Sodium lauryl sulfate ILt Globylene glycol IO? macro goal 4000 44t Macrogoal 400 44) Example 3 (sterilized effervescent tablet) One tablet having the following ingredients and quantities was prepared according to a conventional method.

Nl acetylsulfanilamide ° Silver 500 Q Sodium lauryl sulfate 1000 # Citric acid 700 Da Bisodium carbonate 1000 + 19 Hydroxyglobil cellulose 101 V Mannitol makes the total amount 400 (19).

Written amendment to the above procedure (voluntary) 1. Indication of the case Patent Application No. 53921 filed in 1982 2. Title of the invention: Fungicide composition 3. Relationship with the case by the person making the amendment Applicant's address: Nihonbashihama-cho, Chuo-ku, Tokyo 2-chome 12-4 name
Name: SA Yoshiyaku Co., Ltd. Representative Yasushi Michi Naokata 4, Agent 6 Column 7 of "Detailed Description of the Invention" of the specification to be amended, Contents of the amendment α) In the specification, line 2Jj, line 4, (Ibid., 5th member, line 4, (3) 6th member, line 6, ←) Ibid., page 11, line 12, "Eng. FO13736 and" stop, "Eng. yo137!16 or" I am corrected.

(5) Identical, same, lines 13-14 are corrected to "Culture solution 1- of each of MuT0065389, culture solution 1- of rATa06538F."

(6) Minimum lethal concentration (MI,
O) In the right column of (μf/Wrt), ``Stahi 4 Putskasuau V Kusum TO065389J Toru is corrected to ``Stahirokotsu Force Aureusum TO006538P J.''

(η Same, page 13, line 8, rATOc! It says 65389J, "M T (306538P J and 1 correct.

(8) Same, line 163 rFll [in, sulfur] gold, rFi [ni, nitsu] is corrected.

Claims (1)

[Claims] 1. A disinfectant composition containing a sulfur agent silver salt and sodium lauryl sulfate.