JPS60190977A - Method and apparatus for monitoring local heation - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and apparatus for local heating and 1:j heating using a nuclear magnetic resonance apparatus.

Recently, local hyperthermia therapy has been attracting attention as one of the cancer treatments. This treatment method focuses on the fact that cancerous tissue is sensitive to high humidity, and the cancerous tissue is locally heated by irradiation with super-combined waves, microwaves, etc. to treat the cancer tissue. However, this: There is no way to monitor L during treatment,
Currently, the intensity of the super-combined wave that irradiates the cancerous tissue is determined by relying on experience and intuition. For this reason, there were inconveniences such as applying too much heat and destroying surrounding tissue, or applying too little heat and not achieving a sufficient therapeutic effect.

The present invention has been developed with this in mind, and it is an object of the present invention to provide a novel method and apparatus for local heating and monitoring using a nuclear magnetic Jt sounding device.

The present invention supplies high-frequency waves for heating and high-frequency pulses for nuclear magnetic resonance measurement to a single coil placed close to a λ1 quadrant placed in a static magnetic field, and generates from the object after irradiation with the high-frequency pulses. The present invention is characterized in that nuclear magnetic resonance measurement is performed based on resonance signals detected by the coil. Hereinafter, the present invention will be explained in detail using the drawings.

FIG. 1 is a block diagram showing an example of an apparatus for implementing the present invention and performing 1 = local heating and monitoring. In the figure - (1 is I
41 Z'i, a treatment object 2 such as a patient or an animal is placed in the static magnetic field formed by the magnet 1, and a transmitting/receiving coil 3 is disposed on the surface of the affected area of the object 2.

4 is coupled with the coil 3 to form a tuned circuit (b); the high frequency is generated from the high frequency oscillator 5; the high frequency is supplied to the circuit 4 via the gate circuit 6 and the amplifier 7; sent to. The resonance signal generated near the transmitter/receiver coil 3 and detected by the coil 3 is transmitted to the terminal 8.
The signal is taken out via the amplifier 9 and sent to the demodulation circuit 10. Free induction decay signal (FID) obtained by demodulation
signal) is sent to the computer 12 via the A-D converter 11.
and stored in the memory 13. computer 1
2 applies appropriate data processing to the I-11) image 54 stored in the memory 13, and displays the processing result on the display V114. 15 is a control circuit for controlling 0NtOFF of the gate circuit 6.

For example, when the measurement nucleus is a hydrogen nucleus (IH), the oscillation frequency of the oscillator 5 is equal to its resonance frequency 11
is set to Then, the control circuit 15 turns on the gate circuit 6 during the first heating period T1 of 111, as shown in FIG. 2, and sends a high frequency wave of frequency f1 to the coil 3. Therefore,
The affected area absorbs the high-frequency energy irradiated from the illumination 3 and becomes feverish and humid. This initial heating period T
During the measurement 111 after 1, the control circuit 15 turns on the gate circuit 6 for an appropriate period to make a 90° pulse for measurement (a high-frequency pulse with an intensity and pulse width that tilts the magnetization of hydrogen nuclei by 90°). R90 is created and irradiated to the affected area via the coil 3. After this 90° pulse irradiation, the resonance signal detected by the same coil 3 is sent to the receiving fa circuit 10.
3, the data is extracted as an ID signal, and stored in the memory 13. The computer 12 immediately determines the °C longitudinal relaxation time T1 based on this 111) signal, and displays the value on the display device q1.
Display on 4.

By the way, in cancer tissue, the T of 1H nucleus is lower than that in iJ- normal tissue.
1 is known to be long. Therefore, J for heating,
As the cancerous tissue is destroyed, the value of T1 becomes clearer as the cancerous tissue is destroyed, and it is possible to know the state of destruction of the cancerous tissue by monitoring the value of T1.

Therefore, as shown in Fig. 2, nuclear magnetic resonance measurements are performed every time heating is performed for an appropriate JIIJ period to determine the T1 of the 'H nucleus, and whether the value of I'1 is below a predetermined value? If you stop heating when the temperature is too low, it will be less likely that you will be able to perform appropriate heat treatment.

In the present invention, since this heating and nuclear magnetism (nuclear magnetism) measurements are performed using the same coil 3, measurements can be made in exactly the same area as the heated area, and the reliability of the monitor is extremely high. Todoroki 1.

FIG. 3 is a block diagram showing another embodiment of the present invention,
Components that are the same as in FIG. 1 are given the same numbers.

In the wooden embodiment, the high frequency oscillator 5 is used exclusively for heating,
A high frequency oscillator 16 for measurement is separately provided. Accordingly, the circuit 4' is combined with the coil 3 to form a double-tuned circuit. 17 is a gate circuit, and 18 is an amplifier.

d3 in the configuration shown in Figure 3, and the measurement nucleus is, for example, 3tp.
The nucleus is selected and therefore the oscillation frequency f2 of the high frequency oscillator 16
311] is set to the resonance frequency of the nucleus.

Then, the C1 control circuit 15 turns on the gate circuit 6 as shown in FIG.
)'15 Start heating the affected area. Next, while heating, the control circuit 15 turns on the gate circuit 17 for an appropriate period as shown in FIG. 11'b frequency pulse) R9
0 and irradiates it to the affected area via the coil. The resonance signal detected by the same coil 3 after the 90' pulse Qi is extracted as the FIIIM signal by the receiving circuit 10 and stored in the memory 13. computer 12
By stealing this F I I signal, a nuclear magnetic buzzer is generated, and the display device i14 is
to be displayed.

In addition, cancer tissue, normal tissue, ATP (adenosine triphosphate), creatine phosphate. The abundance ratio of phosphoric acid compounds such as inorganic phosphoric acid is different. Therefore, by determining the abundance ratio of phosphoric acid compounds based on nuclear magnetic resonance spectra, it is possible to know whether cancer tissue remains undestructed or not.

Therefore, as shown in Figure 4, nuclear magnetic resonance measurements were performed every time heating was performed for an appropriate period to obtain spectra, and the abundance ratio of phosphoric acid compounds determined based on the spectra was different from that of cancer tissue. If you can stop heating when the baby arrives, it will be possible to perform appropriate heat treatment. In this example as well, since this heating and nuclear magnetic resonance measurement are performed using the same coil 3, it is possible to perform measurements on exactly the same area as the heated area. Furthermore, in this example, since heating is performed using a high frequency wave having a frequency different from that of the high frequency wave for measurement, it is possible to perform measurements without interrupting heating.

FIG. 5 shows the configuration of still another embodiment of the present invention, and this embodiment differs from the embodiment of FIG. 3 only in circuit 4". That is, circuit 4" is a double-tuned circuit. Control 111 using a single tuned circuit (with ``, which controls switch 19 and 1 path 1F)
By switching the number to J, the capacitor connected to =1 and 3 is switched, thereby increasing the frequency at the contact A side [
1, and when the contact is on the B side, it is tuned to frequency f2. Therefore, during the heating period T1, the switch 19 is turned to the contact Δ side, and heating is performed at -(, % frequency of the frequency f1. During the measurement period T2, the switch 19 is turned to the contact B side, and the -C frequency is 2. The 906 pulses of
Although heating is performed in the 9th position, measurement can be performed using the same frequency as the heating frequency.

In the above embodiment, the measurement was performed using a single pulse, but it is possible to use a pulse train consisting of a plurality of high-frequency pulses.

[Brief explanation of drawings]

Fig. 1 is a block diagram showing an example of a device for local heating and monitoring that implements the present invention, Fig. 2 is a timing diagram for explaining its operation, and Fig. 3 is a detailed implementation of the present invention. FIG. 4 is a block diagram showing an example of a 114 configuration, FIG. 4 is a timing diagram for explaining the operation of the system, and FIG. 5 is a block diagram showing a 4M configuration of still another embodiment of the present invention. 1: Magnet, 2: Object, 3: Transmitting/receiving coil, 4: Circuit that is combined with the transmitting/receiving i-coil to form a tuned circuit, 5, 1 (5: l!'11 frequency oscillator, 6.17: Gate circuit, 10 ：f 4 circuits, 11': A-D converter, 12: 21 mm, L-ta, 13: memory, 1/1:
Human head, 15: Control circuit, 19: Switch. 4M applicant JEOL Ltd. representative Mr. Ito

Claims (6)

[Claims] (1) Supply high-frequency waves for heating, nuclear magnetism No. 1, and sound measurement Tabata frequency pulses to a single coil placed near the target placed in a static magnetic field, and after irradiating the high-frequency pulses, remove the pulse from the target. A method for local heating and monitoring, characterized in that nuclear magnetic resonance measurements are performed based on resonance signals generated and detected by the coil. (2) Means for blocking the static magnetic Jg, including a transmitting/receiving coil placed close to an object placed in the static magnetic field, and a first optical oscillator that generates a first high frequency wave for heating. and means for extracting the second high frequency wave in a pulsed manner, such as a 20th frequency vibrator, which generates a second high frequency wave having a predetermined resonant frequency of the measurement nucleus; a coupling circuit for supplying the second high-frequency wave extracted from the second high-frequency pulse to the transmitting/receiving coil; a receiving circuit to which the nuclear magnetic resonance signal detected by the coil is supplied; and a processing circuit to process the output signal of the receiving circuit. Equipment for heating and Tanabata. (3) The coupling circuit is a double tuning circuit that tunes to the first high frequency and the second high frequency.
The device according to I. (4) The device according to claim 2, wherein the coupling circuit includes a switch that switches between the first high frequency wave and the second high frequency wave and supplies the same to the transmitting/receiving coil. (5) The apparatus according to any one of claims 2 to 4, wherein the processing circuit includes storage means and means for determining relaxation time. (6) The 5D processing circuit is an apparatus according to any one of claims 2 to 4, which comprises a storage means and a Fourier transform means.