JPS60163663A - Skin coating composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition for use on the skin, more specifically, a composition for use on the skin that forms a thin coating film and coats the affected area after the stain agent has evaporated. Regarding.

Conventionally, it is applied to skin debris etc. to form a coating film on the application site,
Facial puncture agents, nail polish agents, etc. are well-known examples of cosmetics that are intended to be used in such a way that the coating film is removed after use.

In addition, for skin medicines, the suture site is sealed and fixed after surgery to prevent suppuration due to contamination with microorganisms, or steroid cartilage is rubbed or applied and sealed so that the entire cartilage is covered, and the volatilization of cross-agents is used. Used in so-called ODT therapy, which not only prevents the feeling of stickiness, but also allows the steroid to be absorbed and acted on locally without side effects in a small container.
For example, about 5% polyvinylpyrrolidone-vinyl acetate copolymer and about 5% β-
Ethoxyethyl methacrylic resin, about 3% maleic rosin ester, etc. are bathed in an organic bath agent such as ethanol or acetone, and then an active ingredient suitable for therapeutic purposes, such as a fungicide such as domufen bromide, is added. Liquid preparations for the skin containing steroids, such as hydrocortisone, and aerosol-type bandages made by adding propellants such as propellant-11 are known, and some of them have been put into practical use for medical purposes. It is being

However, conventional skin coating compositions using straw coating film forming agents have one or more of the following drawbacks.

(1) Since the 7-acional backing agent is water-based, it dries very slowly. If it is alcohol-based, it becomes cloudy, does not form a transparent coating, and the type of solvent is limited.

(2) The coating film dries slowly and leaves a sticky feeling not only during use but also after use.

(3) The formed coating film has weak adhesiveness and is easily peeled off.

(4) Under the influence of sweat and moisture, it becomes sticky, softens, and easily peels off.

(On the other hand, the adhesion is too high, or the releasability is still low.) Since the coating material is not flexible, it does not come off as a single film, and it is difficult to remove. In some cases, it may not be possible to remove the damaged part of Hiroshima.

Furthermore, in hairy areas where the skin is in close contact with the skin, it is painful when peeled off.

(6. Gives a strange feeling to the skin dregs.

As described above, conventional external compositions of this type have poor adhesion to skin debris, removability of the coating film, and ease of use. As a result of various studies, Honko Monja et al. &'f developed an aerosol-type coating film made by combining polyurethane, A-B-A type teleblock, and polyamide in a volatile bath agent. A skin #aided composition is proposed.

That is, when the above composition is applied to the surface of skin debris, an M film of polyurethane, A-B-AM-tereblock copolymer disstomer, or polyamide is quickly formed on the applied surface, This polyurethane, A-B-
The A-type Teleblock, N-base Nidistomer, and polyamide 4-coated film has very good adhesion to the skin, and it is durable in itself, has moderate strength, and has good adhesion to the skin. Nevertheless, it can be easily peeled off to form a single thin film. In addition, it has characteristics such as not causing any strange sensation when attached, and can be applied to external medicines, quasi-drugs, etc.

The present invention will be explained in detail below. As the polyurethane resin, A-B-A type teleblock copolymer distoner, and polyamide used in the present invention, a spoonful can be used as long as it is soluble in a volatile organic bath agent.

The blending amount of polyurethane resin, A-E-A type teleblock elastomer, polyamide varies depending on the application, etc., and is not limited. When used for products, it is preferably 0.5 to 60% by weight of the entire composition, especially 4 to 30 liters. If the coating composition has a lower concentration than this, the strength of the 4M film that remains after application will decrease. The viscosity is weak and peels off easily, and at higher elevations, the viscosity of bath grade becomes very thick, making it difficult to apply uniformly.

In addition, the bath agent of the above resin is polyurethane resin, A-B-A
Any material made of O-type elastomer or polyamide in a bath-like shape can be used.Specifically, a small amount of methanol, ethanol, isoglopanol, acetone, methyl ethyl ketone, etc. can be used.
Both types are used.

In the present invention, a surfactant and a hydrocarbon oil are blended as agents for improving the peelability of the coating film. The surfactant may be anionic, cationic, zwitterionic, nonionic, or fatty esters, and may be used alone or in combination with two or more.
In particular, nonionic activators have the effect of improving the removability of the coating film.

Specifically, as the anionic activator, fatty acid sulfate, higher alcohol sulfurized ester salt, sulfuric ester salt of cylindrical fat rib ester, nonionic ether baba ester salt, dialkyl sulfosuccinate, etc. are used. . In addition, as cationic activators, first-family amine salts, quaternary ammonium salts, those with amide bonds, etc., and as double-sided agents, alkylglycine types, betaine types, imidacillin types, etc. are used. Do 3. Furthermore, nonionic activators include polyoxyethylene type, polyoxyethylene ether type, polyoxyethylene sorbitan fatty acid ester type, polyoxyethylene alkyl ether type, holoxyethylene alkylphenyl ether type, polyoxyethylene castor oil, and hydrogenated castor oil. Oil-based, polyethylene glycol fatty acid ester, etc. are used.

As the carbonized ice cream oil, vaseline, parayne, olefin, alkylbenzene, squalane, squalene, etc. are used.

The amount of surfactant and carbonized ice cream oil is usually 0.1 to 301%, especially 0.2 to 2% of the total content,
A great effect is exhibited in this range of distribution friends.

When using an aerosol-type skin-covering composition for a skin-covering composition for pharmaceuticals and quasi-drugs, etc., the ingredients and effective JW content should be adjusted as appropriate depending on the type and use of these products. It is blended. In addition, these products are prepared by dissolving the ingredients in a polyurethane resin, A-B-A type teleblock copolymer elastomer, and polyamide bath to form a solution. fi
Adjust to a non-gas spray that does not use a propellant, or an aerosol that uses a propellant such as dimethyl ether or dichlorodifluoromethane. In this case, the coating agent can be a volatile bath agent such as ethanol or acetone.

'4i on the coated surface, the coating drying time is very short at about 30 seconds (therefore, it is formed quickly, does not leave a sticky feeling, and forms a completely colorless transparent F3A'in film. I can do it.

Furthermore, since this coating itself is flexible, it can stretch with the movement of the skin, and has appropriate adhesion without feeling stiff or strange, and does not fall off during use. Not at all. In addition, the film that is formed is breathable and moisture permeable, so it does not prevent physiological effects such as skin debris breathing, does not swell or cause rashes, and is water resistant, so even if you sweat, you can not bathe. Even if you do not apply physical force such as rubbing,
The temporary covering film will not come off.

The polyurethane resin, A-B-A teleblock copolymer elastomer, and polyamide solution according to the present invention can be cured by adding active ingredients such as anti-inflammatory analgesics, anti-inflammatory drugs, steroids, and nonsteroidal drugs. When used as a formable external composition, it can be expected that the effect of the active ingredient will be both immediate and long-lasting due to the action of the coating film formed.

The present invention will be specifically explained in detail below by showing examples and comparative examples.

Example 1 = TJ containing To-/I/ To-10 Cariflex TR1107 was dissolved in a liquid halafine and acetone mixture, and component B was added thereto to prepare an aerosol agent.

Example 2 Nisocol HCO-605f Methyl ethyl ketone) Nisocol HCO-605f)
60 was dissolved in methyl ethyl ketone and filled into a non-gas spray container.

Example 3 Example 4 Methyl ethyl ketone 14 B [Trichlorofluoromethane 707 Example 5 Example 6 Example 7 B [Trichlorofluoromethane 60 9 Example 8 Bll) IJ Dichlorofluoromethane 30 ? Comparative Example BE Dichlorodifluoromethane 60 5'Example 3~
8. The product of Comparative Example was prepared in the same manner as in Example (2).

Next, the products of Examples 1 to 8 and comparative examples were examined for adhesion, film releasability, and film uniformity. The results are shown in Table 1. The evaluation criteria are as follows.

Adhesiveness Q: Very dense and sticky to skin debris, difficult to peel off even when in contact with water.

△ Does it have good adhesion and adhesion to skin debris? It may be rotated by movement or contact with water.

× Adherence to skin 1+Q is long, but adhesiveness is poor.

Peelability ◎ Can play the Yoj well.

Δ Hard to peel off.

× Part of the film remains on the skin and is difficult to peel off.

Non-soft (he) It has elasticity as the skin moves, and there is no feeling of tightness or discomfort.

Δ There is some elasticity associated with the encouragement of sarcasm, but there is also a sense of normalcy.

X There are cracks in the film and removal of IA+f due to the presence of skin debris.

uniformity C. It was found to be a uniform sheet by microscopy.

△ There is some unevenness due to speculum.

× There is a lot of unevenness on the sheet due to speculum.

Table 1 Adhesiveness Peelability Flexibility Uniformity implementationfl11 ◎ ◎ ◎ ◎ ◎ ◎ 〃 3 ◎ ・ ◎ ・ 〃 4 ◎ ・ ◎ ◎ ri 5 (to) Δ △ × 〃 6 ◎ Δ × 〃 7 ◎ × △ × 〃 8 △ Δ
) in terms of adhesion to the skin, releasability, flexibility, and uniformity.
In both cases, it was recognized that the time required for satisfaction was compromised.

Applicant: Sato Hiroyaku Co., Ltd. Representative Patent Attorney Kabuji Tashiro

Claims (5)

[Claims] (1) Skin surface-D1. 1. An aerosol-type composition for a skin wave layer, which contains a non-water-bathable polymer compound as an abdominal agent. (2) A molecular compound consisting of at least one of polyurethane, A-B-A type ten block co-articulated distomer, and polyamide. (3) The composition as described in the first or second paragraph of the Special Edition, wherein the amount of the molecular additive is 0.5 to 601% by weight. (4) Scope 1 of the patent that self-assembles an interfacial agent and a hydrocarbon oil as a peelability improving agent.
The composition according to item 1, 2 or 3. (5) The blending amount of surfactant and hydrocarbon oil is O21~
30. The composition according to claim 4, which is 30 years old.