JPS60155109A - Liposome pharmaceutical - Google Patents

Liposome pharmaceutical

Info

Publication number
JPS60155109A
JPS60155109A JP991084A JP991084A JPS60155109A JP S60155109 A JPS60155109 A JP S60155109A JP 991084 A JP991084 A JP 991084A JP 991084 A JP991084 A JP 991084A JP S60155109 A JPS60155109 A JP S60155109A
Authority
JP
Japan
Prior art keywords
fatty acid
higher fatty
lecithin
chemicals
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP991084A
Other versions
JPS6354684B2 (en
Inventor
Haruo Honda
Teppei Maruyama
Noriko Saito
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP59009910A priority Critical patent/JPS6354684B2/ja
Publication of JPS60155109A publication Critical patent/JPS60155109A/en
Publication of JPS6354684B2 publication Critical patent/JPS6354684B2/ja
Application status is Expired legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes

Abstract

PURPOSE:The titled stable pharmaceutical, obtained by incorporating a higher fatty acid with a lipid used as a membrane material, and having improved affinity for the living body, retention of chemicals in the interior thereof and sustained release property of the chemicals. CONSTITUTION:A liposome pharmaceutical obtained by incorporating >=5wt%, preferably 10-15wt% higher fatty acid with a lipid, particularly phospholipid as a membrane material in a liposome pharmaceutical for retaining chemicals. A 10-20C higher fatty acid is preferred for the higher fatty acid, and particularly an 18-20C unsaturated higher fatty acid (optimally oleic acid) having 1-4 double bonds is preferred. A hydrogenated natural lecithin such as hydrogenated soybean lecithin, egg yolk lecithin or corn lecithin is preferably used as the phospholipid.
JP59009910A 1984-01-23 1984-01-23 Expired JPS6354684B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP59009910A JPS6354684B2 (en) 1984-01-23 1984-01-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59009910A JPS6354684B2 (en) 1984-01-23 1984-01-23

Publications (2)

Publication Number Publication Date
JPS60155109A true JPS60155109A (en) 1985-08-15
JPS6354684B2 JPS6354684B2 (en) 1988-10-28

Family

ID=11733259

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59009910A Expired JPS6354684B2 (en) 1984-01-23 1984-01-23

Country Status (1)

Country Link
JP (1) JPS6354684B2 (en)

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61501897A (en) * 1984-04-19 1986-09-04
JPS62132819A (en) * 1985-12-04 1987-06-16 Roehm Pharma Gmbh Skin acting agent
JPS6396193A (en) * 1986-10-14 1988-04-27 Saburo Senoo Novel ribosome
JPH01180245A (en) * 1988-01-12 1989-07-18 Terumo Corp Liposome
WO1990014078A1 (en) * 1989-05-17 1990-11-29 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
US5043164A (en) * 1989-01-17 1991-08-27 The University Of Tennessee Research Corporation Blood-stable, cholesterol-free liposomes
WO1995012386A1 (en) * 1993-11-04 1995-05-11 Schering Aktiengesellschaft Charged liposome preparation
US5656289A (en) * 1988-09-29 1997-08-12 Patralan Limited Pharmaceutical formulations that have a biologically active hydrophilic phase and a chylomicra-containing hydrophobic phase
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
WO2003015753A1 (en) * 2001-08-20 2003-02-27 Terumo Kabushiki Kaisha Liposome preparations
JP2005531595A (en) * 2002-05-31 2005-10-20 ペリコン, ニコラス ブイー Local drug delivery to use phosphatidylcholines
WO2005123078A1 (en) 2004-06-18 2005-12-29 Terumo Kabushiki Kaisha Liposome preparation containing slightly water-soluble camptothecin
US8668937B2 (en) 2011-03-17 2014-03-11 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
JP2016503773A (en) * 2012-12-21 2016-02-08 ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA Gas-filled micro vesicles
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9585931B2 (en) 2013-03-13 2017-03-07 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9597401B2 (en) 2013-03-13 2017-03-21 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9597400B2 (en) 2013-03-13 2017-03-21 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US10034914B2 (en) 2013-03-13 2018-07-31 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US10226511B2 (en) 2013-03-13 2019-03-12 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5287221A (en) * 1976-01-07 1977-07-20 Ajinomoto Co Inc Preventive for chicken dinfections
JPS5931707A (en) * 1982-02-17 1984-02-20 Parufuyuumu Kurisuchiyan Deioo Powdery lipid component and hydrophobic component mixture and manufacture, hydrated lipid layer plate phase and manufacture, medicinal composition or cosmetic composition containing same phase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5287221A (en) * 1976-01-07 1977-07-20 Ajinomoto Co Inc Preventive for chicken dinfections
JPS5931707A (en) * 1982-02-17 1984-02-20 Parufuyuumu Kurisuchiyan Deioo Powdery lipid component and hydrophobic component mixture and manufacture, hydrated lipid layer plate phase and manufacture, medicinal composition or cosmetic composition containing same phase

Cited By (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
JPS61501897A (en) * 1984-04-19 1986-09-04
JPS62132819A (en) * 1985-12-04 1987-06-16 Roehm Pharma Gmbh Skin acting agent
JPH0512352B2 (en) * 1986-10-14 1993-02-17 Saburo Senoo
JPS6396193A (en) * 1986-10-14 1988-04-27 Saburo Senoo Novel ribosome
JPH01180245A (en) * 1988-01-12 1989-07-18 Terumo Corp Liposome
US5656289A (en) * 1988-09-29 1997-08-12 Patralan Limited Pharmaceutical formulations that have a biologically active hydrophilic phase and a chylomicra-containing hydrophobic phase
US5043164A (en) * 1989-01-17 1991-08-27 The University Of Tennessee Research Corporation Blood-stable, cholesterol-free liposomes
US5503850A (en) * 1989-05-17 1996-04-02 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
WO1990014078A1 (en) * 1989-05-17 1990-11-29 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
JPH05501855A (en) * 1989-05-17 1993-04-08
WO1995012386A1 (en) * 1993-11-04 1995-05-11 Schering Aktiengesellschaft Charged liposome preparation
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US7238366B1 (en) 1995-06-06 2007-07-03 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
WO2003015753A1 (en) * 2001-08-20 2003-02-27 Terumo Kabushiki Kaisha Liposome preparations
JP2005531595A (en) * 2002-05-31 2005-10-20 ペリコン, ニコラス ブイー Local drug delivery to use phosphatidylcholines
US9060925B2 (en) 2002-05-31 2015-06-23 Transdermal Biotechnology, Inc. Methods of delivering stable topical drug compositions
US9050248B2 (en) 2002-05-31 2015-06-09 Transdermal Biotechnology, Inc. Methods of delivering stable topical drug compositions
JPWO2005123078A1 (en) * 2004-06-18 2008-04-10 テルモ株式会社 Poorly water soluble camptothecin-containing liposomal formulation
JP4874097B2 (en) * 2004-06-18 2012-02-08 テルモ株式会社 Poorly water soluble camptothecin-containing liposomal formulation
WO2005123078A1 (en) 2004-06-18 2005-12-29 Terumo Kabushiki Kaisha Liposome preparation containing slightly water-soluble camptothecin
KR100847626B1 (en) * 2004-06-18 2008-07-21 가부시끼가이샤 야구르트혼샤 Liposome preparation containing slightly water-soluble camptothecin
US8668937B2 (en) 2011-03-17 2014-03-11 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
US9517179B2 (en) 2011-03-17 2016-12-13 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
US9937202B2 (en) 2011-03-17 2018-04-10 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US9198854B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US9198970B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US9198930B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US9198933B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US9198853B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US9198931B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US9198932B2 (en) 2012-09-19 2015-12-01 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US9205043B2 (en) 2012-09-19 2015-12-08 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US10034897B2 (en) 2012-09-19 2018-07-31 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US9480707B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US10034896B2 (en) 2012-09-19 2018-07-31 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US10034898B2 (en) 2012-09-19 2018-07-31 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US9295638B2 (en) 2012-09-19 2016-03-29 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US9968634B2 (en) 2012-09-19 2018-05-15 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US9968635B2 (en) 2012-09-19 2018-05-15 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US9950004B2 (en) 2012-09-19 2018-04-24 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US9844565B2 (en) 2012-09-19 2017-12-19 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US9827266B2 (en) 2012-09-19 2017-11-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US9795632B2 (en) 2012-09-19 2017-10-24 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US9480710B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US9480705B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US9480709B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US9480711B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US9480706B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US9480708B2 (en) 2012-09-19 2016-11-01 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
JP2016503773A (en) * 2012-12-21 2016-02-08 ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA Gas-filled micro vesicles
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9439926B2 (en) 2013-03-13 2016-09-13 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9480642B2 (en) 2013-03-13 2016-11-01 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
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