JPS60135065A - Membrane separation type serum sampling system - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Technical Field The present invention relates to a membrane separation type plasma collection system that uses a membrane plasma separator to collect only plasma and returns blood cell components to the blood donor when blood is collected from donated blood.

<Prior art> Centrifugation is one of the plasma collection systems, but it is uneconomical because it requires expensive equipment, and sedimentation using inexpensive equipment takes a long time to separate plasma, making it impractical. Not.

The membrane separation method using a membrane plasma separator is the most practical method as it does not contain formed components such as platelets in the pre-separated plasma, but the conventional method relies on forced extracorporeal blood circulation. This placed a heavy burden on blood donors.

<Purpose> The present invention reduces the burden on blood donors by returning concentrated blood from which plasma has been separated to the blood donor through an intravenous drip in extracorporeal blood circulation using a membrane plasma separator, and also simplifies the plasma collection system. The purpose is to make the

<Example> An embodiment of the system of the present invention will be described based on the drawings.

The drawing shows the flow path system of a membrane-separated plasma collection system, in which a predetermined amount of anticoagulant is passed from vein to vein on the upstream side of an extracorporeal blood circulation circuit generally made of soft polychloride. The pumped blood of the drug is pumped to an internal resistance controlled membrane plasma separator, which collects the separated plasma in a plasma container and collects the concentrated blood in a blood container. The blood is stored, and the stored blood is gradually returned to the vein by dripping in the drip chamber (see step 1).

Next, we will explain the operation of the system of the present invention. Blood from a 1J blood donor passes through the indwelling side placed in a vein, and is generally pumped by a roller pump type blood pump at 20 to 6 o y.
(15), but before entering the blood pump, the anticoagulant, e.g.
~! The injected blood is anticoagulated at a ratio of /6, flows into a membrane plasma divider, and the plasma is separated.

The membrane plasma separator is preferably of a hollow fiber type using cellulose triacetate as the membrane material.In order to prevent blood cell damage caused by internal resistance increase 11 of the membrane plasma separator due to concentration of circulating blood accompanying blood stain separation, the membrane plasma separator is preferably of a hollow fiber type. Measure the differential pressure between the inflow and outflow sides of the plasma separator, and calculate the internal resistance of the separator to 60
The rotation of the blood pump is controlled to maintain it at about +nm1-1g.

The blood separated by the membrane plasma separator is stored in a plasma container, but it is convenient to use a blood bag type container.Concentrated blood separated from 3 degrees plasma is preferably stored in a plasma container for ease of handling. Blood is drained into a blood bag-type blood container, and blood is gradually transferred from the indwelling needle placed in the vein through the drip chamber at a flow rate smaller than that into the blood donor container by adjusting the roller clamp on the downstream side. When a predetermined amount of plasma, for example approximately 400 m, has been collected to be returned to the vein of When this is reached, the operation of the blood pump is stopped, the infusion is continued until all of the blood stored in the blood container is returned to the donor's vein, and then the indwelling side is withdrawn from the vein to complete plasma collection.

Effectiveness> The present invention utilizes a pump for a specified amount of anticoagulant on the flow side of the extracorporeal blood circulation circuit extending from vein to vein, and pumps the collected blood to a membrane plasma fraction 1IIL device whose internal resistance is controlled. The plasma separated by the separator is stored in a plasma container, the concentrated blood is stored in the blood container, and in parallel with the storage, the stored blood is gradually returned to the vein by drip. This system reduces the burden on blood donors, and does not require complicated mechanisms, making the system simple and economical. 5: If you use a commercially available @liquid set as the circuit part that includes a commercially available blood bag, a drip chamber, and a Q roller clamp, the scale will not only be easy to handle, but will also be more economical. .

[Brief explanation of drawings]

The drawings show a flow path system according to an embodiment of the present invention. patent applicant Nissho Co., Ltd.

Claims (1)

[Claims] On the upstream side of the extracorporeal blood circulation circuit from vein to vein, blood pumped with a predetermined amount of anticoagulant is pumped to a membrane blood drug separator whose internal resistance is controlled, and is separated by the membrane plasma separator. Membrane separation type plasma collection characterized in that collected plasma is stored in a plasma container, concentrated blood is stored in the blood container, and the stored blood is gradually returned to the vein by drip in parallel with the storage. system.