JPS60131456A - Data processing unit for analytical device - Google Patents

Abstract

PURPOSE:To economize the capacity of a data memory by performing data processing operation only in the time section determined by the time data relating to the peak rise and fall stored in the time data area of the memory. CONSTITUTION:The data processing unit of this analytical device is so constituted as to permit selection of two modes; a mode for analyzing a standard sample and a mode for analyzing a sample to be measured. When the mode for analyzing the standard sample is selected, the unit detects the rise of the peak, the summit of the peak and the end point of the peak, stores the respectively points of the time for the detection and calculates and stores the time width before and after the point of the time for the summit of the peak by taking the point of the time for the rise and end point of the peak into consideration. When the mode for analyzing the sample to be measured is selected, the unit takes the outputs from the detectors of the analytical device into a data memory within the certain time width before and after each peak according to the above- mentioned storage and performs prescribed data processing. The memory capacity is thus considerably decreased and further the taking in or the data processing of the unnecessary data on the sample to be measured is eliminated.

Description

DETAILED DESCRIPTION OF THE INVENTION A. Field of Industrial Application The present invention relates to a data processing device in an analytical device such as a chromatograph.

The record of the detector output of a conventional chromatograph, that is, the chromatograph, is in the form shown in Figure 1, with peaks for each sample component appearing here and there on baseline B, and from the time of sample introduction to the chromatograph to The main analytical information directly obtained by chromatography is the retention time until the peak of each component appears, peak height, peak area, etc. Conventionally, the output of a chromatographic detector was input into a recorder to draw a chromatogram, and humans calculated the retention time from that chromatogram.

The peak height, peak area, etc. were recorded. Recently, computers have come to be used for data processing in analyzes using romatographs. However, the peak of the last sample component appears in the chromatogram more than an hour after the sample is injected, so if the output of the chromatographic detector is sampled every 50 m5 and stored in memory, it will take one hour. A memory capacity of 300 bytes is required for analysis of . In addition, in some cases, when beats that do not appear in the standard sample but are unnecessary for measurement appear in the sample being measured, conventionally it has been difficult to record data such as area and other data for such peaks. There was something that happened.

C. Purpose The present invention reduces the data memory capacity of a data processing device in an analytical device that performs an analytical method such as chromatography, emission spectroscopy, mass spectrometry, etc. in which multiple peaks appear separated on the time axis. The main purpose is to
Another purpose is to eliminate unnecessary peak-related data presentation.

D. Configuration The present invention has two modes, a standard sample analysis mode and a measured sample analysis mode. When the standard sample analysis mode is selected, peak rise detection, peak top detection, peak end point detection are performed, and each The detection point is memorized and the peak rise,
If you calculate and memorize the time width before and after the peak peak point, taking into account the peak end point, and select the measurement sample analysis mode, the calculation will be performed only within the time width before and after each peak based on the above memory. The present invention provides a data processing device for an analyzer, characterized in that the detector output of the analyzer is taken into a data memory and a given data process is performed.

E. Embodiment FIG. 2 shows the configuration of an embodiment of an apparatus in a chromatograph of the present invention. 1 is a detector of the analyzer, 2 is an A/D converter that converts the output of the detector into A/D, 3 is an arithmetic control circuit (CPU), 4 is a ROM in which the operating program of CPU 3 is stored, and 5 is a ROM. 6 is a pass line for the CPU in the RAM for inputting and outputting measurement data and other data; 7 is a keyboard for manually inputting various data and specifying the operating mode; 8
is a printer plotter that records measurement results and data processing results.

Two types of analysis operation programs are prepared in the ROM 4: a standard sample analysis mode and a measured sample analysis mode.

The second figure shows the flowchart of the standard sample analysis mode. Each area is provided in the RAM 5 as shown in the memory map of FIG. When the introduction of the sample into the chromatograph is detected (a), the timing operation starts (b).
The data of channels 1 to 5 in the data channel area in FIG. 3 are transferred to the adjacent channels that are each increased by +1 (-). Since all the data in the pot channel are initially set to 0 in the initialization operation, the contents of the channel area do not change even if the steps are initially performed. Next, the average value is 1.2
(The contents of both channels are moved to the adjacent channel with +1 respectively). The same channel is also initialized and the initial content is O. Next, the output of the detector 1 is sampled and stored in the first channel of the data channel area (E). Next, the data of the five channels in the data channel area is taken out as the average value t[, and is input into the first average channel. However, the following steps will not be performed until the first to fifth data channels are filled with sampling data after the first five sampling operations.
Since the explanation is complicated, the explanation of the operation during that time will be omitted. In short, noise is removed by averaging the sampling data at five points. When the first to sixth samplings are performed, the first average value is transferred to the second average channel in steps (e) and (f), and the second average value is transferred to the first average channel. Thereafter, each time the output of detector 1 is sampled, new average data enters the first average channel, and data that was in the first average channel enters the second average channel.
Extrude the average channel data to a second average channel. At step (g), the difference Δ between the data of the first average channel and the data of the second average channel is determined,
In step (h), the absolute value of Δ is compared with the set level l. If step (h) is No, the presence or absence of flag F1 is checked in step (su). Flag F1 is a flag that indicates that a chromatographic peak is currently appearing, and when the reaction is No, the operation is A.
Jump to the point and check whether the step (analysis time (for example, 1 hour, input in advance) has ended or not. If not, the operation returns to B. If step (S) is YES, the difference Δ Since ! is below and there is currently a peak, this means that the top of the peak has been detected, and in step (wo) the presence or absence of the flag PF is checked.The PF already has a peak. If step (wo) is No, flag PF is set, and the time (time from the start of time measurement) is stored in the Sn channel of the time data area.Then, the time at the top of the nth peak is now It is memorized and the operation jumps to A.The operation for specifying channel number n will be described later.The time of the first peak top is memorized in the P1 channel.When step (H) is Y'ES, step (N) Check the presence or absence of flag F1 with
In case o), since the rising edge of the peak has been outputted ↑, flag F1 is set and the time obtained by subtracting a fixed time from that time is stored in the Sn channel of the time data area.

Next, in step (wa), 1 is added to the designated number n of channel numbers.

When n=1 is initially set in the initialization operation, the time obtained by subtracting a certain period of time from the rise time of the first peak is memorized in the 81 channel. When step (N) is YES, the peak of the chromatogram is in progress, and the operation jumps to point A. If both steps (su) and (tsu) are YES, it means that the end point of the peak has been detected because it is in the middle of the peak and has passed the top of the peak, and Δ is smaller than j. Add a certain amount of time to the time data area and store it in the Jiin channel of the time data area, and set the flag F.
'l, turn off PF and move to point A.

As a result of the above operations, the time data area of RAM5 has the following information:
The time slightly before the rise of each peak in the chromatogram (
time from sample introduction) is 5n (n=1..2...)
The peak top time is stored in the Sn channel, and the time slightly after the peak end point is stored in the Sn channel.

FIG. 5 is a flowchart of the operation in the sample analysis mode. After the initialization operation, when sample introduction is detected in step (a), time measurement is started (b) and 1 is added to the designated number n of channel numbers (c). Since n=o is set in the initialization operation, initially it becomes n-1 in step (c). step) in the time data area of RAM5! 'n(n=
1.2...) Check whether the time stored in the channel (time from the time of sample introduction) has arrived. Initially, n==1, and a time slightly before the rise of the first peak is stored in the S1 channel. At first step) is No, then moves to step (e) and F1
Check for presence of flag. In the measurement target sample analysis mode, the flag Fl means that the measurement data is being taken in, and is set when step (2) becomes Y and BS. Initially, there is no F1 flag and step (e) is NO, the operation returns to point A, steps (e) are repeated, and eventually when step (d) becomes yEs, flag F1 is set.
, and the operation returns to point A. After that, the time stored in channel 81 has passed, so step ) becomes No again, and step (e) flags F.
1 is present (YES), so in step (G), RAM5
It is checked whether the time is stored in the Sn channel in the time data area of . Initially, n=1, so l
This is a judgment as to whether it is the time of the IC1 channel or not, and this is a judgment as to whether the first peak has ended or not.If step (卜) is No, it means that the first peak has not ended yet. First, in this case, the output of detector 1 is sampled and stored in the measurement data area of RAM, and the operation is as follows.
Back to the point. In this way, the detector output is captured only during a time width with some leeway added to the time width in which the peak of the chromatogram exists. If you repeat the above actions,
Eventually, the result of step (G) becomes Y, ES, and in step (S), flag F1 is erased, and the operation returns to point B. In step (c), 1 is added to n, so the second The acquisition of the output data of the detector 1 is stopped until a moment before the peak appears, and the output data is acquired from a little before the rise of the second peak until slightly after the peak end point, and the acquired data is stored in the RAM 5. is stored in the measurement data area. The operation ends when the preset analysis time has elapsed.

In the preferred embodiment described above, the detector output is stored in memory only for the determined time interval, but it is also possible to perform data processing such as integrating the detector output for the same time interval.

Effects According to the present invention, since measurement data is stored in memory only during the peak existence period of the detector output, the memory capacity can be significantly reduced. Data processing such as data acquisition or integration of peaks that do not need to be measured is also eliminated, so without using a standard sample, simply analyze the sample to be measured, detect the rise of the peak, and start acquiring measurement data. However, the memory capacity can be partially reduced compared to the case where data acquisition is stopped after detecting the end of the peak. It is also possible to avoid complicating data recording by printing out unnecessary data such as areas for peaks that do not appear in the standard sample and are unnecessary for measurement.

[Brief explanation of the drawing]

FIG. 1 shows an example of a chromatogram obtained by a gas chromatograph, FIG. 2 is a block diagram showing the configuration of an apparatus according to an embodiment of the present invention, and FIG. , FIG. 4 shows R of the above device.
FIG. 5 is a flowchart of the operation of the above apparatus in the sample analysis mode. Agent Patent Attorney Kosuke Agata

Claims (1)

[Claims] It has a standard sample analysis mode and a measured sample analysis mode.The standard sample analysis mode detects the rise and fall times of the peak of the detector output, and detects the time slightly before the rise time and the time slightly before the fall time. The subsequent time is stored in the time data area of the memory, and in the measured sample analysis mode, the detection output is stored in the memory only for the time period determined by the time data regarding the peak rise and fall stored in the time data area of the memory. 1. A data processing device for an analyzer, characterized in that an operation program is set to perform data processing operations such as importing or integrating data.