JPS60130509A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:A composition for the oral cavity, obtained by incorporating a sweet perfume, e.g. anise oil, and a sweetening agent, e.g. stevioside, in combination with a composition containing a polishing agent, binder, surfactant, fluorine- containing compound, enzyme, germicide, etc., and having improved taste and feeling of use. CONSTITUTION:A composition for the oral cavity, obtained by incorporating a sweet perfume selected from anise oil, fennel oil, anethole, amyl formate, and ethyl butyrate, etc. and a sweetening agent selected from stevioside, rebaudioside, osladin, perillartine, etc. in combination with a composition for the oral cavity, e.g. toothpaste, mouthwash, prophylaxis paste, etc. The use of the above- mentioned two components provides the aimed composition for the oral cavity, capable of masking an unfavorable taste of a polishing agent, binder, surfactant, fluorine-containing compound, enzyme, antiplasmin agent and germicide, etc., and having a good taste and improved feeling of use.

Description

[Detailed description of the invention] The present invention relates to an oral composition that is comfortable to use.

Oral compositions such as toothpaste contain abrasives, binders, thickeners,
Effective amounts of surfactants, chemical compounds, enzymes, anti-plasmin agents, and bactericidal or antibacterial agents are combined, but these ingredients usually have an unpleasant taste for use in the oral cavity. Many of them have this, which may cause problems in terms of usability.

For this reason, countermeasures such as limiting the mixture t' have been taken, but this is not necessarily a sufficient solution.

The present inventors conducted extensive studies on oral compositions that have a good feeling of use even when such components with undesirable taste are blended, and found that (A) 7 varnish oil, fennel oil, anethole, at least one sweet flavoring agent selected from the group consisting of cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl 7-ohmate, amyl 7-ohmate, and ethyl butyrate; paudimezaide, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, licorice extract, phyllozultene, sweet tea extract, -2f tide ester, hexahydrofluorene derivative, 2-arylcalylbenzoic acid derivative, oxathiazinone di Abrasives, binders, thickeners, surfactants, fluorine compounds in combination with at least one sweetener selected from the group consisting of oxide derivatives, thaumatin, monellin, osladin, perilartin, and fruit extracts. , an enzyme, an antiplasmin agent, or a bactericidal or bactericidal agent.
The inventors have discovered that it is possible to obtain an oral composition with an excellent feeling of use, and have thus come up with the present invention.

The present invention will be explained in more detail below.

The oral composition according to the present invention is used as toothpaste, toothpaste, moisturized toothpaste, powdered toothpaste, liquid toothpaste, etc., mouthwash gourd, profilafsis paste, etc. (A) Anise oil, 7-ennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil,
at least one sweet flavoring agent selected from the group consisting of methyl salicylate, methyl 2-ohmate, ethyl formate, amyl 7-ohmate, and ethyl butyrate, and (B) stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate. salt, ammonium glycyrrhizinate, licorice extract, phyllodultin, sweet tea extract, guted ester, hexahydrofluorene derivative, 2-arylcarbonylbenzoic r*u conductor, oxathiazinone dioxide derivative, thaumatin, monellin, osladine, perillartin , and at least one sweetener selected from the group consisting of Seikan extract, and these are combined into an oral composition containing the required ingredients.

In this way, the present invention uses the sweet flavoring agent A and the sweetener B in combination, and as a result, these sweet flavoring agents and sweeteners effectively interact with each other. It has sufficient sweetness without the use of saccharin, which is commonly used as a sweetener, and has a good sweetness. It is possible to provide an oral composition with a good taste and a good feeling of use.

In addition, in the present invention, the blending amount of the sweetening agent A is 0.01 to 5% of the entire composition (the amount of lotus, the same applies hereinafter), and the blending amount of the sweetener B varies depending on the compound used, but usually It is preferable to set it as 0.001-10 inches of the whole composition.

In the present invention, the abrasives used together with the above-mentioned sweet flavor A and sweetener B include dicalcium phosphate dihydrate and anhydride, monobasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, and aluminum hydroxide. , alumina, silica-based abrasives such as precipitated silica and precipitated aluminosilicate, aluminum silicate, insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, suspended calcium, ? Contains methyl methacrylate, bentonite, zirconium, and synthetic resin.
i2a+JM can be used (in the case of toothpaste, 61 total amount is suitable between 20 and 90, especially in the case of toothpaste, 20 and 6
Section 0).

In particular, when dibasic calcium phosphate (dihydrate, anhydride, a mixture thereof) is used with a sweet flavoring agent^ and sweetener Bi, the bitter taste of dibasic calcium phosphate special 1 is improved, and precipitated silica etc. Silica-based abrasive (At2
When sweetener B is used in imitation leaf flavorings (containing less than 1 as O), the astringency of these is improved. Furthermore, α type,
Compared to other aluminum hydroxide and calcium carbonate, these metallic tastes and nigami tastes are improved. Further, titanium oxide containing 50 to 1001 of those having an anatase type and/or rutile type crystal structure can be added as an abrasive to the above-mentioned abrasive, but sweet flavoring agents A and t+ Combination #'i of flavoring material B Improves the golden M taste of titanium oxide.

In addition, as a silica-based abrasive, Zeo-dent ■ is used.

Precipitated silica, silica xerogel, silica aerogel, etc., which are sold under the trademarks Zeo ■ and 5ldent ■ and have primary particles of 500 mμv and secondary particles of 1 to 30μ, can be used. In this case, precipitated silica is particularly preferably used, with a 5lO2 content of 70% or more, preferably 90% or more, and an alkali/alkaline earth metal oxide content θ~5%.
, 5i02 bond of metal oxides such as aluminum-magnesium, calcium, etc. 1t0-10%, preferably O-5, sticking moisture content (loss on drying) 1-10, average particle size 0.5 ~30μ, preferably 1
~15μ, specific surface area of 11 (BET method) 500ff
l" or less, preferably 300 m" or less, refractive index 1
．． 44-1.47, liquid absorption j10.6-1.3 cc/
Those having properties No. 7 are preferably used. in particular,
Zeo49, Zeodent 11 from Huber, USA
3. 5ylold AL- from W, R, Graee, USA
1,63,74,404, UK J, Crossfield
Neosyl ET from d&5ons - Germany Deg
Examples include USSA's 81dent 3 and 20 Misaki.

In addition, examples of binders used together with sweet flavoring agent A and sweetener B include caradanan, cal? Cellulose derivatives such as sodium oxymethylcellulose, methylcellulose, hydroxyethylcellulose, sodium calgaxymethylhydroxyethylcellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, karaya gum, gum arabic, etc. Gums, polyvinyl alcohol, sodium polyacrylate, xyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, gluformable silica compounds such as gluformable silica, gluformable aluminum silica, vegum, laponite, etc. Inorganic binders, etc. may be used, and 1 or more of these may be used (compounding amount usually 0.3 to 5). A oxymethylcellulose alkali metal salt such as oxymethylcellulose sodium, especially a carboxymethylcellulose with an average degree of etherification of 0.7 to 1.4. Oxymethylcellulose Improves the taste of alkaline earth soils. Also, the taste of kaladanan and its salt and xanthan gum? Rivinylpyrrolidone or Cal? The powderiness of xyvinyl polymers is improved. Furthermore, the bitterness of the glucatable silica-based substance is improved. In addition, examples of the glucatable silica-based substances include Cab-0-811■,
'l'okus i l■, a gludizable macroplastic ultrafine powdered silica sold under the trademark Aerosll■;
Examples include igneous fine powder gluing silica with secondary particles of several microns or less sold under the trademarks Vitasil ■ and N1ps11■.

Further, thickening agents used with sweet flavoring agent A and sweetener B include sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, bori-propylene glycol, xylit, maltitol-lactit, etc. One or more of these glazes can be used (composition 1, usually 10 to 70%). According to the present invention, these thickening agents can be suitably used to improve the bitter taste and the bitter taste of polyethylene glycol, especially the bitter taste of polyethylene glycol having an average molecular weight of 1:400 to 1,500.

Additionally, sorbitol is a relatively good sweetener.
It is preferable to use them in combination, and since glycerin can also be used as a sweetening agent although it has a slightly bitter taste, it is preferable to use them in combination.

-Furthermore, sweet flavor A and sweetener B can be used together with surfactants to improve their taste. In this case, the surfactant may include sodium lauryl sulfate, sodium myristyl sulfate, etc. whose alkyl group has 8 to 8 carbon atoms.
Water-soluble salts of higher fatty acid monoglyceride sulfonates whose fatty acid group has 10 to 18 carbon atoms, such as sodium lauryl monoglyceride sulfonate, sodium coconut monoglyceride sulfonate, and higher fatty acid radium monoglyceride sulfonates. 2-ate, olefin sulfonate, noya rough insulfonate, radium-N-methyl-N-/! lumitoyl tauride, radium-N-lauroyl sarcosinate, radium-N-lauroyl-
anionic activators such as amide esters (acylated amino acid esters) of higher fatty acids and lower aliphatic amino acids whose fatty acid group has 12 to 18 carbon atoms;
Fatty acid alkylolamide of lauric acid mono- or jetanolamide, stearyl monoglyceride,
The number of carbon atoms in the fatty acid group of a-mono and dilaurate is 12
~18 perilla fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fat ff minister, stearic acid monoglyceride,
? Rio Φ diethylene sorbitan monolaurate, polyoxyethylene hydrogenated castor oil, ethylene glycol approx. 60
Examples include nonionic surfactants such as sorbitan monostearate condensates with moles added, polymers of ethylene oxide and propylene oxide, and derivatives such as polyoxyethylene polyoxypropylene monolauryl ester, and amphoteric surfactants such as betaine type and amino acid type. Kiere, part 1
114 or 2a or higher is recommended.
．． Sections 1 to 7), the combination of sweet flavoring agent Δ and flavoring agent B improves the bitterness, astringency, and oiliness of the alkyl sulfate ester alkali gold salt having an alkyl group having 10 to 14 carbon atoms, and also improves the fatty acid carbon The bitterness of perilla sugar fatty acid esters having 10 to 14 carbon atoms and the bitterness and astringency of acylated amino acid esters having an acyl group of 12 to 18 carbon atoms can be improved, respectively, and the taste properties can be improved. The fatty acid alkylolamide can also be used in combination with the other active agents mentioned above, but the combination of Sweet Flavor A and Sweetener B improves its bitterness, astringency, and astringency.

Therefore, according to the present invention, it is possible to effectively use these activators, especially activators that have a relatively small number of carbon atoms and are conventionally thought to have poor taste. The taste and feeling of use of oral compositions containing inferior active agents can be improved.

Additionally, fluorine compounds impart an undesirable taste to oral compositions, but the combination of sweet flavoring agent A and sweetener B improves the bad taste of such fluorine compounds. B can be suitably blended into a fluorine compound-containing oral composition. 7. The elementary compounds include sodium fluoride, potassium fluoride, lytecum difluoride, cesium fluoride, zirconium fluoride, and ammonium fluoride.
7A, and water-soluble inorganic fluorides such as sodium monofluorophosphate and potassium monofluorophosphate, silver diamine fluoride, hexylamine hydrofluoride, laurylamine hydrofluoride, cetylamine hydrofluoride, glycine hydrofluoride, Water-soluble organic fluorides such as lysine hydrofluoride and alanine hydro70lide, as well as tin fluoride, cyclized stannous fluoride,
Examples include tin-containing fluorides such as tin monofluorophosphate, and two or more of these may be used, but monofluorophosphates, metal fluorides, and silver diamine fluoride are particularly sweet. When used together with flavoring agent A and sweetening phase B, the characteristic sour taste and golden pA taste are improved respectively. When the above-mentioned fluorine compound is added to an oral composition, the amount of the fluorine compound is not particularly limited, but it can be usually added in an amount of about 0.01 to 10%. In addition, it is preferable that the amount of fluorine is 1,001,000 pp or less per 1 cup of acid for scooping.

In addition, when blending enzymes into oral compositions, even if the enzyme itself does not have an unpleasant taste, various impurities may be mixed in during the production process of the enzyme, resulting in a bitter taste or bad odor. The combination of sweetener A and sweetener B can eliminate the bitter taste and bad odor of enzymes and produce an oral composition with a good feeling of use. In this case, the enzymes used together with the sweet flavoring agent A and the sweetener B include dextranase, lytic enzyme, lysozyme, oxidoreductase, mutanase, etc., and amylase, f-rothiase, lytic enzyme, etc. are also used. .

In addition, even if one of these enzymes is used alone, 2υ
Even if the above are used in combination, the amount of vinegar added is not particularly limited, but it can be 0.01 to 5.

Furthermore, by adding sweet flavoring agent A and sweetener B to anti-plasmin agents such as epsilonamitsukazolonic acid, tranexamic acid, and their derivatives, it is possible to reduce the bitterness and characteristic powderiness of these anti-plasmin agents. The quality is improved. In addition, examples of derivatives of epsilonamitsukazolonic acid and tranexamic acid include alkyl esters and aryl esters of these compounds such as hexyl esters, heptyl esters, and 2-enyl esters. Further, when these antiplasmin agents are added to an oral composition, the amount thereof is usually 0.005 to 3%.

Furthermore, bactericidal or bactericidal agents may be added to oral compositions, but bactericidal or bactericidal agents usually exhibit an off-taste such as bitterness or astringency. The combination of sweet flavoring agent A and sweetener B eliminates the astringency, powderiness, dryness, and off-taste of such bactericidal or antibacterial agents, and makes the oral composition have a good feel when used. In this case, the bactericidal or antibacterial agents used with sweet flavoring agent A and flavoring agent B include biguanide compounds such as chlorhexidine and its salts (hydrochloride, gluconate, etc.), quaternary compounds such as distearylmethylethylammonium chloride, etc. Examples include phenolic compounds such as ammonium salts, methanol extract of mace, bactericidal agents extracted from plants such as rose manol, and rose hydroxybenzoic acid alkyl esters having an alkyl group of 1 to 5 carbon atoms. , hinokitiol, etc. can also be used. These bactericidal or antibacterial agents are 12j
lt may be used alone or in combination of two or more types, and the amount added is not limited, but usually 0.00
Sections 1 to 5.

The oral composition of the present invention is manufactured according to a conventional method by appropriately selecting and using the above-mentioned components depending on the type thereof, and combining them with the above-mentioned sweet flavoring agent A and sweetener B. The inventive oral composition further contains menthol, carvone, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methylodugnol, cineol. , linalool, ethyl linalool, vanilin, chitun, spearmint oil, penomint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, viment oil,
Flavoring agents such as cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil may be used alone or in combination to give a total range of 0.00 to 5.0, preferably 0.00.
In addition, saccharin sodium,
Neohesberidyl dihydrochalcone, glycyrrhizin,
As/ya lathylphenylalanine methyl ester, p-
Sweeteners such as methoxycinnamic aldehyde (θ~2
(preferably 0.01 to 1%), aluminum chlorohydroxylalantoin, dihydrocholesterol,
One or two kinds of active ingredients such as glycyrrhetinic acid, glycyrrhetinic acid, chlorophyll, sodium chloride, calopepitide, and water-soluble inorganic phosphoric acid compounds may be blended.

In addition, when the oral composition of the present invention is in a linear or liquid form, it may be prepared to have a pH of 2 to 10;
As regulators, citric acid, tartaric acid, malic acid, malonic acid,
Organic acids such as maleic acid, cono-phosphoric acid, acetic acid, and phosphonic acid and their salts of alkali metals and alkaline earth metals, inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid, and alkali hydroxides can be blended. .

9 below, Examples and Comparative Examples are shown to further specifically explain the present invention.

[Example, comparative example]

The sweet flavoring agents shown in Table 1 and the sweeteners shown in Table 2 were all blended into the following oral compositions, and the sensation of use (taste) was sensory evaluated. In this case, all oral compositions were evaluated by a panel of 10 experts based on a comprehensive evaluation of bitterness, off-taste, bitterness, metallic taste, etc., and the results were determined to be good taste. Shown in numbers.

1　°゛ [Note] 1) Hexahydrofluorene derivative Δ CH.

2) Hexahydrofluorene t1. Body BCH.

3) 2-Arylcarginylbenzoic acid derivative A4) 2-
Aryl Cal to Nylbenzoic Acid Derivative B5) Oxathiazinone Dioxide Attractant 6) Oxathiazinone Dioxide Deductor B [Example 1] Dentition Dibasic Calcium Phosphate Dihydrate 45.1 Cal? Sodium oxymethylcellulose 1.2 Veegum l・0 Glycline 20.0 Propylene glycol 3.0 Sodium lauryl nitrate 1.5 Lauroyl diethanolamide 0.3 Sodium monofluorophosphate 0.75 Flavoring 1 1.0 Sweetener Section 10.3 Tertiary magnesium phosphate 1.5 Methyl hydroxybenzoate 0.1 total 100.0
[Example 2] Number of people who showed uniformity and good taste: 9 people [Example 2]
Houma dicalcium phosphate dihydrate 30. (1 Calcium phosphate anhydride 15.0 Sodium caldexymethyl cellulose 1.0 Lagunan 0.5 Glycerin 10.0 Lumitol 15.0 Polyethylene glycol 4000 1.0 Sodium lauryl sulfate 1.0 Sucrose) 9 Lumityl mono Ester 1.0 Sodium monofluorophosphate 0.76 Dextranase 1.0 Flavor A2 1.0 Sweetener 30.4 Magnesium tertiary phosphate 0.3 Methyl monofluorophosphate 0.1 Made by Dai-13 water
Remaining total: 100.01 Mokushi Nagisa 11L - Number of panels showing good taste: 10 [Example 3]
Toothpaste dicalcium phosphate dihydrate Th 40.0% Sodium carboxymethyl cellulose 1.0 Lagunan 0.5 Glycerin 15.0 Sorbi σ) 15.0 Polyethylene glycol 400 5.0 Sodium lauryl sulfate 1. O N-lauroyl sarcosinate o, 3 Sodium monofluorophosphate 0.76 Oxidoreductase 2.0 Butyl hydroxybenzoate 1.0 Flavor store 31. .

Sendai Soni 4o, 1 Magnesium phosphate 3.3 Total 300.0% Usability evaluation Number of panels showing good taste: 10 [Example 4]
Toothpaste Dicalcium Phosphate Dihydrate 45.0% Sodium Carboxymethyl Cellulose 1.0 Lagunan 0
．． 5 Glycerin 5.0 Sorbit 20.0 Propylene glycol 1.0 Sodium lauryl ff2p 1.0 Lauroyl diethanolamide 0.3 Sig sugar lauryl diester 0.1 Dextranase 1.0 Mutanase 1.0 Tranexamic acid 0201 Flavor & 4 1.0 Hajimi 60.2 Sodium benzoate 0.2 Total ioo, o% Usability evaluation Number of panels showing good taste: 10 [Example 5]
Toothpaste Dicalcium Phosphate Dihydrate 5.0 Dibasic Calcium Phosphate Anhydride 35.0 Sodium Oxymethyl Cellulose 1.2 Sorbit 15.0 Polyethylene Glycol 400 5. ON-lauroyl sarcosinate 0.3 ShiM 1m-4 lumityl monoester 0.5 Sucrose lauryl diester 0.5 Retituque enzyme 0.5 Lysozyme 0.5 Flavoring A5 10 Sweetener A 8 0.1 Salt 10.0 Total 100.0% Number of panels showing good taste after use 10 people [Example 6]
Toothpaste dicalcium phosphate dihydrate 50. (1 cal-xymethyl cellulose sodium 1.2 glycerin 1
0.0 Sorbitsu 10.0 Sodium lauryl sulfate 1.0 6-aminocasolonic acid 02 Tranexamic acid 0.2 Chlorhesijin mum O11 Flavoring 1 0.3 Flavor & 5 0.7 Sweetener )ra 1 0.2 Sweetness A2 0.2 Sodium benzoate 005 Total 100.0% Number of panelists who evaluated good taste for use: 10 [Example 7]
Toothpaste dicalcium phosphate dihydrate 35. (1 Dibasic calcium phosphate anhydride 10.0 Xanthan gum 1.
0 Glycerin 20.0 Propylene Glycol 3.0 Sodium Lauryl Sulfate 1.5 Lauroyl Diethanolamide 0.3 Sodium Monofluorophosphate 0.75 Flavor Black 11.0 Sweetener AI 0.3 Magnesium Tertiary Phosphate 1.5 Rose Methyl hydroxybenzoate 0.1 Feeling of use (showed good taste) Number of 4 channels: 10 [Example 8]
Toothpaste dicalcium phosphate dihydrate 10.04 Precipitated silica 10.0 Titanium chloride 20 Xanthan gum 1.0 Glycerin 20.0 Propylene glycol 3.0 Sodium lauryl sulfate 1.5 Lauroyl diethanolamide 0.3 Monofluoroline Sodium fluoride 0.75 Sodium fluoride 0.1 Flavoring Al 1.0 Sweetener A 1 0.3 Magnesium phosphate 1.5 Methyl hydroxybenzoate 0.1 Usability evaluation Good taste Number of panels shown: 10 people [Example 9]
Toothpaste dicalcium phosphate, dihydrate 15.01 Dicalcium phosphate, anhydride 20.0 Precipitated silica ] 0.0 Titanium oxide 1.0 Calxyvinyl polymer/neutralizing agent (1,5 Veegum)
1.0 Gly7rin 20.0 Propylene glycol 3.0 Sodium lacryl sulfate 1.5 Lauroylzoethanolamide 0.3 Sodium monofluorophosphate 0.75 Flavoring Al 1.0 Sweetener A 1 Q, 3 Tertiary phosphorus Magnesium acid 1.5 Methyl hydroxybenzoate 0.1 total 100.0
User impression evaluation: Number of glossy nails that showed good taste: 8 people [Example 10]
Toothpaste dicalcium phosphate dihydrate 50.0% aluminum hydroxide 1.0 titanium oxide i.

Polyvinylpyrrolidone 0.5 Veegum 1.0 Glycerin 20.0 Propylene glycol 3.0 Sodium lauryl sulfate 1.5 Lauroyl diethanolamide 0.3 Sodium monofluorophosphate 0.75 Flavoring Boiled 11.0 Sweetener x, 10.3 Tertiary magnesium phosphate 1.5 Methyl hydroxybenzoate 0.1 Used #Evaluation Good taste/4'Number of 10 people [Example 1
1] Toothpaste dicalcium phosphate dihydrate 20.04g diphosphoric acid lucicum anhydrous ] O10pa? Rivinylpyrrolidone 0.5 Veegum (), 5 Glycerin 20.0 Propylene glycol 3.0 Sodium lauryl sulfate 1.5 Lauroyl diethanolamide 0.3 Sodium monofluorophosphate 0.75 Fragrance Al l. 3 Tertiary Magnesium Phosphate 1.5 Methyl Bara Hydroxybenzoate 0.11 Water Residual Feeling Evaluation Number of panels showing good taste: 10 [Example 12]
Toothpaste precipitated silica 10.0 Sodium carboxymethyl cellulose 1.0 Glycerin 30.0 70% sorbitol solution 30.0 Propylene glycol 1.0 Polyethylene glycol 1000 2.0 Sodium lauryl sulfate 1.0 Sodium fluoride 0.4 Tranexam @ 0.1 Perfume 30.5 Perfumery 40.5 A 8 "" Methyl Rose Hydroxybenzoate 0.3 Stone Usage Evaluation Number of panels showing good taste: 10 [Example 13]
Toothpaste precipitated silica 15.0 Modulus ladanane (), 5 Sodium powder 0.76 Chlorhexidine digluconate 0.01 Flavoring agent 0.7 Sweetener 70.1 No9 Rahido a-methyl oxybenzoate 0.01 Usability Ff
Senj Number of panels showing good taste: 1o [Example 14]
Toothpaste precipitated silica 20. Cl carboxyvinyl polymer/neutralizer O5 glycerin 4
5.0 Sorbit 70 solution No. 10.0? Lietelene glycol 400 1.0 Sodium lauryl sulfate 1.0 Lauroyl sarcosinate 0.3 Sodium monofluorophosphate O4 Sodium fluoride, 0.2 Flavoring A2 0.8 Sweetener A 6 0.1 Noyara hydroxybenzoic acid Methyl 0.02 Usability evaluation: Number of panels showing good taste: 10 [Example 15]
Toothbrushing silica 25.0% Sodium Calgaxymethylcellulose 1.0 Polyvinylpyrrolidone 0.2 Glycerin 20.0 Sorbitto 70% solution 15.0 Polyethylene glycol 400 5.0// 1000
10.0 lauroyl sarcosine) (1,2 lauroyl diethanolamide 0.5 sucrose) 9 lumityl monoester 1.2 dextranase t.

Mutanase 0.5 Kosoya 3 0.7 Sweetener Grave 502 No+Rahit 70 xybenzoic methyl 0. o3! l 1
0o, o% Usability evaluation: Number of panels showing good taste: 9 people [Example 16] Toothpaste precipitated silica Zeodsnt, 113■ 10. (1
〃 Vitasll■ 5.0 Kara rnan o5 Veegum 0.5 Glycerin 20.0 Nrubitsu 70-chi solution 20.0 Polyethylene glycol 400 5.0 // 1000
10.0 Sodium lauryl sulfate 1.0 Sodium monofluorophosphate 0.76 Flavor) [4
0.6 Sweetener A 4 0.1 Salt 5.0 Carnosic acid 0.2 Total 100.0 Use sensitivity value Number of panels showing good taste: 10 [Example 17]
Toothpaste precipitated silica 5ident 3■ 10.0%tt
Zoo 49■ J00 Polyvinylpyrrolidone 0.5 Veegum 0.5 Glycerin 10.0 Ruby, Ton 70% solution 30.0 Polyethylene glycol 1000 15.0 Sodium lauryl sulfate 1. .

Silver diamine fluoride (), 2 Lysozyme ()1 Oxidoreductase 0.3 Chlorhexidine salt #, salt 0.01 1 fragrance plate 51. .

Sweetener A 3 0.4 Methyl rose hydroxybenzoate 0.01 Usability evaluation: Good taste. Number of samples: 10 [Example 18]
] Toothpaste precipitated silica 20.0% titanium oxide 0.01 Cal xyvinyl polymer/Medium 5Fil agent 1.0 Solbi, 70% solution 50.0 Lauroyl sarcosinate 0.1 Sucrose palmitermodiester 1.2 Sucrose lauryl diester 0.5 Retituque enzyme 0.2 6-aminocasolonic acid 0.2 Dilauryl methyl ammonium chloride 0.1 Flavor Al 1.0 Sweetener &2 05 Methyl parahydroxybenzoate 0.002 Usability evaluation Number of panels showing good taste: 10 [Example 19]
Toothpaste precipitated silica] 0.0 Titanium thioxide 0.01 Beamum 1.0 Nlubit 70% solution 60.0 Sodium lauryl sulfate 0.1 Lauroyl sarcosinate (), l Si1 sugar ururyl diester 1. 5 Flavor shop 20.4〃A4 0.2 Sweetener A I 0.3 Purified water Poor evaluation of residual use showed good taste / Number of mother tongues 10 people [Example 20
] Toothpaste precipitated silica Neogil E'lN seconds 5.0 superior t
/ Zeo 49 J5,0 Aluminum hydroxide 2.0 Xanthan fum 1.0 Glycerin 30.0 Sorbit 70% solution 15.0 I-lyethylene glycol 1000 2.0 Sodium lauryl sulfate 0.5 C-am-4-lumityl Monoester 05 sugar lauryl diester 0.5 Flavor Boiled 50.8 Sweetener 9 0O5 Usability evaluation Number of panels showing good taste: 10 [Example 21]
Spread precipitated silica Zeo 49■ 5.0% // Zeo
dent 114 15.0 Titanium oxide 0.01 Sodium carboxymethylcellulose 160 Caradanan 0.5 Glycerin 15.0 Sorbit 70 solution 30.0 H? Liethylene glycol 400 2.0 Sodium lauryl sulfate 1.0 Lauroyl sarcosine) 0.2 Lauroyl diethanolamide 0.2 Fragrance A4 0.
9 Sweetener AIO0,1 8 Ice making Evaluation of residual feeling after use Number of panels showing good taste: 10 people [Example 22]
Abrasion-resistant silica 15.0 Caldexymethylcellulose sodium 1.0 Carragnan O5 Glycerin 5.0 Sorbit 70% solution 45.0 ? Liethylene glycol 400 10.0 Sodium lauryl sulfate 1.0 Silosaccharide halothermodiester 01 Sucrose lauryl diester 0.1 Flavor A3 1.0 Sweetener 11 0.1 1-1.Feeling evaluation Good taste Number of participants shown: 9 people [Example 23]
Toothbrushing precipitated silica ZeO49■ 5.0T Zeodent 113■ 5.0 Titanium oxide 0.1 Cal? Xyvinyl polymer/neutralizer 1.0 Sorbit 7
0 solution 60.0 Polyethylene glycol 400 2.02 Sodium uryl sulfate 0.1 Lauroyl sarcosinate 01 Lauroyl diethanolamide 0.1 Halmitylmodiester 0.1 Lauryl diester 0
．． 1 Flavor shop 21.0 Sweetener shop 10.1 A 2 0.1 A 3 0.1 ・Total 100.0 Chi Usage evaluation Number of panels showing good taste properties 10 people [Example 24]
Toothpaste Aluminum Hydroxide 45.0% Cal? Sodium oxymethylcellulose 1.0 Glycerin 5.0 Sorbit 15.0 Sodium lauryl sulfate 1.0 Sodium monofluorophosphate 0.76 Dextranase 1.0 Flavor jffa 3 0.7 Sweetener 40.1 Good usability evaluation Number of people who showed good taste: 10 [Example 25]
] Tooth brushing Aluminum hydroxide 50.0 Sodium dexymethylcellulose 0.5 Caradanan 0.5 Sorbi, Tol 20.0 Sodium 2-uryl sulfate 1.2 7-Sugar palmitylmodiester 0.5 Dextranase 1.0 Fragrance 41.2 Sweetener 44 0.12 Carnosic acid o2 Number of panels showing good taste 1o Aluminum hydroxide 57.0 Thixanthan gum 1.0 Glycerin 5.0 Sorbitto 15.0 Sodium lauryl sulfate 1.0 Lauroyl Diethanolamide O72 Dextranase 1.0 Mutanase 1.0 Flavor Shop 51.5 Sweetener Mu10 0.08 Methyl Hydroxybenzoate 0107 Feeling of Use Evaluation Number of panels showing good taste: 9 people [Implemented] Example 27] Toothbrush Aluminum hydroxide 39.0 Titanium polyoxide 3.0 Sodium methyl cellulose 1.0 B
Muum O.2 Glycerin 15.0 Sorbit 5.0 Globylene glycol 1.0 Polyethylene glycol 5.0 Sodium lacryl sulfate 1.0 Lysozyme 0.5 Spicy 162 1.0 Sweetener 43 0.41 Salt 5.0 Total 100.0chi Usability Evaluation: Number of people who showed good taste: 10 people [Example 2B
] Toothbrushing Aluminum hydroxide 50.0' Carboxyvinyl I Limer-0.2 Veegum 1.0 Sorbit 15.0 Polyethylene glycol 5.0 Sodium lauryl sulfate 1.0 Lauroyl dercosinate 0.1 Lytic enzyme 0.5 Flavor Phase A 1 0.7 Sweetener j660.1 Carnosic Acid 0.1 Methyl Rose Hydroxybenzoate 0105 Feeling of Use Evaluation: Number of i4 channels showing good taste: 9 people [Example 29]
Toothpaste Aluminum hydroxide 50.0 Thypolyvinylpyrrolidone 0.3 Veegum 0.5 Sorbi, ) 20.0 Polyethylene glycol 1.0 Sodium lauryl sulfate ], 0 Silica saccharide halomitylmodiester 0.1 Silucrose lauryl diester 0.2 Oxidoreductase 0.2 Chlorhexidine digluconate o,ot dilauryldimethylammonium chloride 0.01 Fragrance mul 1 (
)7 Sweetener Ya9 0.06 i92 Methyl hydroxybenzoate 0.01 Usability evaluation Number of panels showing good taste: 10 [Example 30]
Toothpaste aluminum hydroxide 45. o Titanium thioxide 1.0 Cal? Sodium oxymethylcellulose 1.2 Sorbit 20.0 Sodium 2-uryl sulfate 1.0 Sodium monofluorophosphate 0.3 Sodium fluoride 0.2 Thymol 0.2 Flavor shop 10.5 Sweetener Hiro 1 0.52 Usability evaluation Number of panels showing good taste: 10 [Example 31]
Tooth brushing calcium carbonate 50.0q6 Cal? Sodium oxymethylcellulose 1.0 Glycerin 15.

So11t 5.0 Sodium lauryl sulfate 1.0 Sodium monofluorotetraphosphate 0.76 Tranexamic acid 0.1 Flavor A5 0.8 Sweetener 45 0.19 Number of samples showing good taste 9 people [Example 32]
Toothpaste Aluminum hydroxide io, o% Calcium carbonate 30.0 Titanium oxide i,.

Sodium carboxymethylcellulose 0.5 Caragnan 05 Glycerin 15.0 Sorbit 5.0 Sodium lauryl sulfate 1.0 7-day sugar zf lumityl monoester 0.16-aminocaproic acid 0.5 Flavoring 161 1.2 Sweetener 48 0. 1 Total i o o, ochi Usability evaluation: Number of panels showing good taste: 10 [Example 33]
Years Old Calcium Carbonate 50.0 Thixanthan Gum i.

Glycerin 5.0 Solubiy) 15.0 Sodium 2uryl sulfate 1.0 Tranexamic acid 0.2 Chlorhexidine hydrochloride 0.01 Flavor A 5 0.6 Sweetener AI 0.33 Total 100.0 Number of panels showing good taste: 1o [Example 34]
Iil Polished Calcium Carbonate 50.0 Polyvinylpyrrolidone 0.3 Calxyvinyl Polymer 0.2 Veegum 0.2 Sorbit 20.0 Sodium Lauryl Sulfate 1.0 Lauroyl Sarcosinate 0.1 Sodium Monofluorophosphate 0.76 fragrance 45 0
．． 8 Sweetener AI 0.26 Total 100.0 Chi Usage Evaluation Number of panels showing good taste: 9 people [Example 35] Toothpaste Calcium carbonate 50.0 T Sodium oxymethyl cellulose 1. .

Veegum 0.2 Sorbit 20.0 Sodium 2-acrylic sulfate 1.0 Savings J165 0.9 Sweetener Genus 10.3 A? Butyl 5-hydroxybenzoate 0.06 Methyl 5-hydroxybenzoate 0.007 Usability evaluation Number of panels showing good taste: 10 [Example 36]
Mouthwash Glycerin 5.096 Sorbit 15.0 Sucrose Halmitylmodiester 1.0 Sodium Monofluorophosphate 0.76 Chlorhexinone Diglucon e1m 0.2 Flavor By A I 0.8 Sweetener A I 1.3 Ethanol 15.0 Usability evaluation: Number of panels showing good taste: 10 [Example 37]
Mouthwash Sorbi, 15.0 Polyethylene glycol 4000 5.0 Polysaccharide lauryl diester 0.2 Flavor shop 50.8 Sweetener A 3 0.6 Ethanol 0.5 I-lyoxyethylene (a-3) hardening Castor oil 1.0 meter
100.0chi'' East m quiet dヱjL Number of flats showing good flavor properties 10 people [Example 38
] Mouthwash Sodium fluoride 0.4% Mutanase 0.2 Tonexamic acid 0.1 Flavoring agent 108 Sweetener 20.5 Colors o, o o i Total 100.0% Good taste after use Number of panels showing gender: 10 people Examples 1 to 38
All of the oral compositions had a good feel when used.

Applicant Lion Corporation Agent: Patent Attorney Takashi Kojima

Claims (1)

[Claims] 1. Consists of anise oil, 7-ennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, metersalicylate, methyl formate, ether 2-ohmate, amyl 2-ohmate, and hyethyl butyrate. At least one sweet flavoring agent selected from among the group; stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, grass extract, phyllodultin, sweet tea extract, peptide ester, hexahydrofluorene derivatives,
at least one sweetener in which the 2-arylcal is selected from the group consisting of a nylbenzoic acid derivative, an oxathiazinone dioxide derivative, thaumatin, monellin, osurason, perilartine, and Luohan Guo extract; -W-fE m
1. An oral cavity composition characterized by containing J-. 2. The oral composition according to claim 1), which uses dibasic calcium phosphate as an abrasive or brightener. 3. Claims using silica thread abrasive as an abrasive or brightener, Item 1 nL: Soft oral composition-04, Claims using aluminum hydroxide as an abrasive or brightener 1') Oral composition according to Jj. 5. The composition for oral cavity according to item 1, which uses calcium carbonate as an abrasive or brightener. 6. The oral cavity composition according to any one of claims 2 to 5, which further contains titanium oxide as an engraving agent or brightening agent. 7. At least one selected from the group consisting of anise oil, fennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl formate, ether 7-ohmate, amyl formate, and ethyl butyrate. Stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, licorice extract, phyllodultin, sweet tea extract, peptide ester, hexahydrofluorene derivative,
2-arylcal is at least one sweetener selected from the group consisting of nylbenzoic acid derivatives, oxathiazinone dioxide derivatives, thaumatin, monellin, osladine, herraltin, and Luohan unextracted; and a binder. An oral composition comprising: 8. The oral composition according to claim 7, wherein the binder is a carboxymethyl cellulose alkali metal salt. 9. The oral composition according to claim 8, wherein the carboxymethyl cellulose alkali metal salt has an average degree of etherification of 0.7 to 1.4. 10. The oral composition according to claim 7, wherein the binder is carragnan or a salt thereof. 11. The oral composition according to claim 7, wherein the binder is xanthan gum. 12. The oral composition according to claim 7, which is caking i1!11 polyvinylpyrrolidone. 13. Is the binder carboxyvinyl? The oral composition according to claim 7, which is a remer. 14. The oral composition according to claim 7, wherein the binder is a gluformable silica compound. 15. At least one selected from the group consisting of anise oil, fennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl 7-ohmate, amyl 7-ohmate, and ethyl butyrate. Sweet flavoring agents, stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate salt, ammonium glycyrrhizinate salt, licorice extract, phyllodultin, sweet tea extract, peptide ester, hexahydrofluorene derivative,
The 2-arylcal contains at least one sweetener selected from the group consisting of nylbenzoic acid derivatives, oxathi7nonone dioxide derivatives, thaumatin, monellin, osladine, heliraltene, and Luohan unextracted extract, and a thickening agent. An oral composition characterized by: 16. The oral composition according to claim 15, wherein the mucus agent is propylene glycol. 17. The oral composition according to claim 15, wherein the thickening agent is polyethylene glycol. 18. Polyethylene glycol has an average molecular chain of 400 to 1
18. The oral composition according to claim 17, which has a composition of 500. 19. At least one selected from the group consisting of anise oil, fennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl formate, ethyl 7-ohmate, amyl 7-ohmate, and ethyl butyrate. Sweet flavoring agents, stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, ttMt+b, phyllozulti, sweet tea extract, peptide ester, hexahydrofluorene derivative, 2-aryl carbunylbenzoic acid derivatives,
At least one flavoring agent selected from the group consisting of oxathiazinone dioxide conductor, thaumatin, monellin, osladin, Kliraltin, and Luohan unextracted material, and a surfactant. Characteristic composition for oral cavity. 20, rf surface properties agent 1# prime number of alkyl group 10-1
4. The composition for oral cavity according to claim 19, wherein the alkali gold ester of No. 4 is 1j4tM. 21. The oral composition according to claim 19, wherein the surfactant is a sucrose fatty acid ester of fatty acid having 10 to 14 carbon atoms. 22. The oral composition according to claim 19, wherein the surfactant is an acylated amino acid ester having an acyl group having 12 to 18 carbon atoms. 21. The oral cavity composition according to any one of claims 20 to 22, which additionally contains a fatty acid alkylolamide. Anise oil, fennel oil, anethole, cassia oil,
at least one sweet flavoring agent selected from the group consisting of cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl formate, amyl 7-ohmate, and ethyl butyrate; and stevioside, rebaudioside, stevio. extract, potassium glycyrrhizinate salt, ammonium glycyrrhizinate salt: JIL extract, salt of potassium glycyrrhizinate,
Sweet tea extract, peptide ester, hexahydrofluorene derivative, 2-arylcal yJ? at least one sweetener selected from the group consisting of nylbenzoic acid derivatives, oxathiazinone dioxide derivatives, thaumatin, monellin, osthrazone, perilartine, and Luohan Lai extract; and a fluorine compound. Characteristic composition for oral cavity. 6. The oral composition according to claim 24, wherein the fluorine compound is a monofluorophosphate. The oral composition 627.7 according to claim 24, wherein the fluorine compound is a metal distide. 25. The oral composition according to claim 24, wherein the elementary compound is silver diamine fluoride. Ejaculation, anise oil, fennel oil, anethole, cassia oil,
at least one sweet flavoring agent selected from the group consisting of cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl formate, amyl 7-ohmate, and ethyl butyrate; and stevioside, rebaudioside, and stevio. extract, glycyrrhizinate potassium salt, glycyrrhizinate ammonium salt, licorice extract, phyllodurten, sweet tea extract, peptide ester, hexahydrofluorene derivative,
and an enzyme. A composition for oral cavity having a characteristic of being opaque. The enzyme is dextranase q′! 1. The composition for oral cavity according to Claim 28 of Misaki Kaiji. 28. The oral composition according to claim 28, wherein the enzyme is Quenzyme. 31. Dispute in requesting permission for enzyme to be lysozyme, disciple 28
Oral composition as described in . 32. Claim 28, wherein the enzyme is an electroreductase
Oral composition as described in . 33. The oral composition according to claim 28, wherein the enzyme is mutanase. 34. A group consisting of anise oil, fennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl formate, amyl 7-ohmate), and ethelbutyrate; at least one sweet flavoring agent, stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, licorice extract, phyllodultin, sweet tea extract, peptide ester, hexahydrofluorene i%1
at least one sweetener selected from the group consisting of 2-arylcargenyl benzoic acid derivatives, oxathiazinone dioxide derivatives, thaumatin, monellin, osladin, keratin, and Luohan Guo extract; and an antiplasmin agent. An oral composition comprising: 35. The oral composition according to claim 34, wherein the anti-plasmin agent is epsilonamitsukagulonic acid or a derivative thereof. 36. The oral composition according to claim 34, wherein the antiplasmin agent is tranexamic acid or a derivative thereof. 37. At least one of the group consisting of anise oil, fennel oil, anethole, cassia oil, cinnamic aldehyde, wintergreen oil, methyl salicylate, methyl 7-ohmate, ethyl 7-ohmate, amyl 7-ohmate, and ethyl butyrate. Stevioside, rebaudioside, stevio extract, potassium glycyrrhizinate, ammonium glycyrrhizinate, licorice extract, phyllodultin, sweet tea extract, peptide ester, 84 hexahydrofluorenes,
at least one sweetener selected from the group consisting of 2-arylcarbonylbenzoic acid derivatives, oxathiazinone dioxide derivatives, thaumatin, monellin, osladine, perilartine, and Luohan Guo extract; and sterilization or An oral cavity composition characterized by containing a bacteriostatic agent. A. The oral composition according to claim 37J, wherein the bactericidal or antibacterial agent is chlorhexidine or a salt thereof. 39. The oral composition according to claim 37, wherein the bactericidal or antibacterial agent is a quaternary ammonium salt. 38. The oral composition according to claim 37, wherein the bactericidal or antibacterial agent is a plant extract. 41. Oral composition O according to claim 37, wherein the antiseptic or antibacterial agent is a heptadol compound.