JPS60105619A - Urine alkalizing food composition - Google Patents

Abstract

PURPOSE:To provide the titled composition containing citric acid, sodium citrate and K2HPO4 at specific ratios, capable of alkalizing urine without affecting the balance of Na<+>/K<+>, free from deliquescence, and useful as a remedy for hyperuricemia. CONSTITUTION:A mixture of citric acid, sodium citrate and K2HPO4 is used as a component of the titled composition. The amount of the mixture in the composition is >=1wt% and <80wt%. The molar ratios of (citric acid):(sodium citrate):(K2HPO4) (x:y:z) are, 1.7<=x<=2.8, 1.0<=y<=3.0 and 2.1<=z<=3.8, especially 2:3:3. The urine is alkalized, the dissolution of uric acid in the urine is promoted, and the precipitation of uric acid and the formation of stone can be prevented without causting the change in the balance of Na<+>/K<+> in the blood. Furthermore, it is free from deliquescence and moisture absorption, and has high storage stability. It can be administered even to a patient of hypertension.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a urine alkalizing food composition. More specifically, the present invention provides J1 containing citric acid, sodium citrate and potassium hydrogen phosphate.
The present invention relates to a deliquescent urinary alkalizing food composition.

From before, "1? JJ suffers from i-wind, urinary stones, and kidney dysfunction! It is known to administer urinary alkaline earth metals such as heavy +IIj and sodium citrate for the treatment of hyperuricemia seen in S. In other words, in hyperuricemia, the urine tends to be acidic, and uric acid precipitates in the kidneys and urinary tract, often resulting in stones.The treatment of hyperuricemia involves promoting uric acid excretion and reducing uric acid in the urine. It is desired to prevent precipitation of uric acid by increasing the solubility of uric acid. This precipitation of uric acid can be prevented by alkalinizing the urine by administering the above-mentioned sodium bicarbonate, sodium citrate, or the like. Furthermore, by alkalizing the urine, it becomes possible to dissolve uric acid or uric acid stones that have already precipitated in the body.

However, when administering the above-mentioned sodium bicarbonate, sodium citrate, etc., although it is possible to alkalinize the urine, it also leads to excessive intake of sodium, resulting in a decrease in blood Na ” /
There is a problem in that the imbalance of the K+ ratio results in side effects such as high blood pressure.

Furthermore, in recent years, drugs containing citric acid and an alkali salt of citric acid have been proposed as auxiliary drugs for the treatment of hyperuricemia. For example, on pages 56 to 63 of Uric Acid Vol. It has been experimentally proven that [Brand name: Uralit-U (CG-120), Dr, manufactured by Madaus] is useful as an auxiliary drug for IFR treatment of hyperuricemia, and its effectiveness has been demonstrated. is suggested. When administering this composition, the balance of the Na''/K ratio in the blood is unlikely to collapse as described above, but since the citric acid potassium contained in the composition has deliquescent properties, The disadvantage is that the composition itself has poor storage stability.

Undeveloped IJIJ 4+5' has been researched on urinary alkalizing foods (!!health foods) that can effectively prevent gout, urinary tract stones, etc. by regularly ingesting 1,1. As a result, we found that a composition containing citric acid, sodium citrate, and potassium hydrogen phosphate in a certain range of composition ratios to an excipient such as fructose and a stimulant suitable for daily intake can be used as described above. The inventors have discovered that the drawbacks associated with known drugs can be overcome and that they can be efficiently ingested as a preventive food, and have thus arrived at the present invention.

In other words, the present invention aims to reduce the in-body N a ”/K
``The aim is to provide a food composition that brings about alkalinization of the urine without disturbing the ratio balance and thus without affecting blood pressure.

Another object of the present invention is to provide a food composition that causes alkalinization of urine and that does not have deliquescent properties or hygroscopic properties.

The above purpose consists of citric acid, sodium citrate and potassium hydrogen phosphate, the composition ratio of which is x:y:z(
Citric acid: Sodium citric acid, potassium dihydrogenate,
molar ratio) of a mixture of 1 to 80% by weight (however, 80%
%), where X, y and 2 representing the composition ratio of the mixture are respectively
1.7≦X≦2.8.1.0≦y≦3.0 and 2.1
This can be achieved by the urine alkalizing food composition of the present invention having a numerical value in the range of ≦2≦3.8.

Next, the present invention will be explained in detail.

The present invention effectively realizes the prevention of gout, stone formation, etc. using a food composition containing citric acid, sodium citrate, and potassium hydrogen phosphate in the above composition ratio. In other words, the food composition for undeveloped IJ increases the solubility of uric acid in urine and prevents the precipitation of uric acid by promoting alkalinization of the urine, and prevents the formation of stones due to the precipitation of uric acid. be.

In addition, these ingredients, especially sodium citrate (Na3
C (31 summer 507) and potassium hydrogen phosphate (K z I
By mixing IPOa) with the composition ratio within the above range, it is possible to alkalinize the urine and increase the solubility of uric acid in the urine without disturbing the balance of the Na''/K+ ratio in the blood. Therefore, since it has almost no effect on blood pressure, it can be taken even by people who tend to have high blood pressure.

Furthermore, the urine alkalinizing food composition of the present invention can increase urine volume and uric acid excretion amount. That is,
By alkalinizing the urine, it is possible to increase the uric acid concentration in the urine and increase the amount of urine, thereby promoting the excretion of uric acid.

Furthermore, the urine alkalizing food composition of the present invention has not only deliquescent properties but also almost no hygroscopic properties.Therefore, there is no problem with its preservability during daily use, and it can be used as a food. Further, no special molding process is required.

The urine alkalizing food composition of the present invention having the excellent properties as described above has the following structure.

The urine alkalinizing food composition of the present invention contains a mixture of citric acid, sodium citrate, and potassium hydrogen phosphate in an amount of 1 to 80% by weight.

(excluding 80%).

In this mixture, the composition ratio (molar ratio) of citric acid: sodium citrate potassium hydrogen diphosphate (x:y:z)
x, y and 2 in are respectively 1.7≦X≦2.
The numerical values are in the range of 8.1.0≦y≦3.0 and 2.1≦2≦3.8. From the viewpoint of hygroscopicity, preferably 1
．． 9≦X≦2゜7.1.5≦y≦2.5 and 2.4≦
It is a numerical value in the range of 2≦3.2. Urine alkalinization effect and blood electrolyte balance (N a ” / K ”
More preferably, from the viewpoint of the influence on
．． 9≦X≦2.2.1.8≦y≦2.2 and 2.8≦
It is a numerical value in the range of 2≦3.1, and the above M1 ratio is 2:2
:3 is most preferred.

To prepare this mixture, for example, add rice to the above composition ratio + g
This is carried out by weighing the amounts of citric acid, sodium citrate, and dipotassium hydrogen phosphate, dissolving them in water, and dehydrating and drying them.

fi) Various additives known as food additives, such as excipients made of sugars such as fructose and lactose, stabilizers, and flavoring agents, can be added to the resulting mixture. The content of the above mixture in the product is 1 to 80% (
However, it should be within the range of 80% (excluding 80%).

It is particularly preferable that the content of the mixture is in the range of 20% by weight.

Thereafter, it can be molded into any desired shape such as granules or solids (pellets, etc.) using known formulation methods or food processing methods to produce food. Although there is no particular limitation on its shape, it is preferably a pellet-shaped solid with a diameter of 20 mm or more.

Next, Examples and Comparative Examples of the present invention will be described.

However, each of these aspects does not limit the invention.

[Example 1] 0.42 g of citric acid (C6HgO7), 0.588 g of sodium citrate (N83CaHaOy), and 0.522 g of potassium hydrogen phosphate (K2HPO4) were dissolved in 20 m of distilled water, and then heated to 80°C. The mixture was stirred for 15 minutes in a water bath at a temperature of .

Next, the moisture in this solution is distilled off under reduced pressure at a temperature of 70 to 80°C and dehydrated to dry it, so that the composition ratio of citric acid and sodium citrate is 2. :2:3 (molar ratio) crystalline mixture was obtained.

Furthermore, only the molar ratio of citric acid was varied within the range of 1.0 to 3.3 to obtain 41 compounds consisting of various citric acids, lium citrate, and potassium hydrogen phosphate.

[Example 2] Example 1 except that only the molar ratio of sodium citrate was changed in the range of 0.2 to 3.0.
A mixture consisting of citric acid, sodium citrate, and potassium hydrogen phosphate from each company was obtained by carrying out the same treatment as in the method described above.

[Example 3] Example 1 except that only the molar ratio of potassium hydrogen phosphate was changed in the range of 1.0 to 4.0.
A mixture consisting of various citric acids, sodium citrate and potassium hydrogen phosphate was obtained by carrying out the same treatment as in the method described above.

The hygroscopicity of each of the mixtures obtained in Examples 1 to 3 was evaluated.

First, the weight of the mixture immediately after drying under reduced pressure was measured, and then the weight after being left for 48 hours at a temperature of 24 to 32°C and a humidity of 60 to 80% was measured, and the weight change (increase) was measured.
was calculated.

The obtained results are shown in FIGS. 1 to 3.

Figure 1 shows the molar ratio X of citric acid plotted on the horizontal axis for various mixtures in which the composition ratio of mixtures consisting of citric acid, sodium citrate, and potassium hydrogen phosphate is x:2:3 (molar ratio). , is a graph showing the relationship between weight change (%) and weight change (%) on the vertical axis.

Figure 2 shows that the composition ratio of the above mixture is 2:7:3 (
This is a graph showing the relationship between the molar ratio y of sodium citrate on the horizontal axis and the weight change (%) on the vertical axis in various mixtures with different molar ratios.

Figure 3 shows that the composition ratio of the above mixture is 2:2:z (molar ratio).
This is a graph showing the relationship when the horizontal axis represents the molar ratio of potassium hydrogen phosphate (2) and the vertical axis represents the weight (a, *o-, r%) of various mixtures.

From Figures 1.2 and 3, x, y, and 2 representing the compositions of citric acid, thorium citrate, and potassium hydrogen phosphate are 1.7≦X≦2.8, 1.0≦y≦, respectively.
It is clear that for values in the range 3.0 and 2.1≦2≦3.8, the resulting mixture is excellent in hygroscopicity. Furthermore, if the above x, y and 2 are numerical values in the range of 1.9≦X≦2.7.1.5≦y≦2.5 and 2.4≦2≦3.2, respectively, It was found that it showed almost no hygroscopicity.

Next, the composition ratio of the citric acid, I-lium citrate, and potassium hydrogen phosphate obtained in Example 1 was 2 = 2:
3' (molar ratio) of the mixture on urine PH, J3 and urine -1,1- were evaluated by the following measuring force υ at I/1.

l) Urine p! After oral administration of 1000 mg/kg and 1500 mg/kg of compound 14 to rats,
The pH of the urine was measured after 9 hours.

2) Effect on urine output The above mixture was administered to rats at 1000 mg/kg and 150 mg/kg.
Urine volume was measured for 3 hours after oral administration of 0 mg/kg.

The obtained results are shown in FIGS. 4 and 5, respectively, together with the measured values of rats to which the above mixture was not administered at all (control group).

FIG. 4 is a graph showing the relationship between measurement time on the horizontal axis and urine pH on the vertical axis.

1: Rats administered at 1000 mg/kg (administration group) 2
: 1500+ig/kg administered rats (administration group) 3
: Non-administered rats (control group) FIG. 5 is a graph showing the urine output from 0 to 3 hours after administration in the rats 1 to 3 above.

As is clear from FIG. 4, when the mixture of citric acid, sodium citrate, and potassium hydrogen phosphate in the composition ratio of 2:2:3 (molar ratio) according to the present invention was administered, none of them were administered. The urine pH was higher than that of the control group, indicating an alkalinizing effect. Also, from Figure 5, when the above mixture was administered, urine pH 1, 0 to 3 hours after administration was higher than that of the control group. It is clear that t increases.

[Example 4] 0.9 g of fructose was added to 0.1 g of the mixture obtained in Example 1, in which the composition ratio of citric acid, sodium citrate 11, and potassium hydrogen phosphate was 2:2:3 (molar ratio). After mixing, pellet-shaped tablets were produced by a conventional method.

[Example 5] The composition ratio of citric acid, sodium citrate and potassium hydrogen phosphate obtained in Example 1 was 2 = 2:3 (molar ratio)
After mixing 9.95 g of fructose with 0.05 g of the mixture, pellet-shaped tablets were produced by a conventional method.

[Example 6] The composition ratio of citric acid, sodium citrate and potassium hydrogen phosphate obtained in Example 1 was 2:2:3 (molar ratio)
After mixing 0.85 g of fructose with 0.15 g of the mixture, pellet-shaped tablets were produced by a conventional method.

[Brief explanation of the drawing]

FIG. 1 shows the mole Jtx of citric acid on the horizontal axis in various mixtures in which the composition ratio of mixtures consisting of citric acid, sodium citrate, and potassium hydrogen phosphate is x:2:3 (molar ratio). It is a graph showing the relationship when weight change (%) is plotted on the vertical axis. FIG. 2 shows that the composition ratio of the mixture according to FIG. 1 is 2:y:3 (
This is a graph showing the relationship between the molar ratio y of sodium citrate on the horizontal axis and the weight change (%) on the vertical axis in various mixtures with different molar ratios. FIG. 3 shows that the composition ratio of the mixture according to FIG. 1 is 2:2:z (
2 is a graph showing the relationship between various mixtures having a molar ratio of 2 and a molar ratio of potassium hydrogen phosphate of 2 on the horizontal axis and weight change (%) on the vertical axis. Figures 4 and 5 are graphs showing the relationship between measurement time on the horizontal axis and urine pH on the vertical axis, and graphs showing the urine volume for 3 hours after administration, respectively. . 1: Rats at 1000+*g/kg (administration group) 2: Rats at 1500mg/kg (administration group)
3: Non-administered rats (control group) 41f, jM Applicant: Kuchiki Chemipha Co., Ltd. Agent Patent attorney: Yasuo Yanagawa

Claims (1)

[Claims] A mixture consisting of 10 citric acid, sodium citrate and potassium hydrogen phosphate, whose composition ratio is x:y:2 (molar ratio), is 1 to 80% by weight (however, 80% is ), and X, y and 2 representing the composition ratio of the mixture are each 1.7≦X
≦2.8.1.0≦y≦3.0 and 2.1≦2≦3.
A urine alkalinizing food composition having a numerical value in the range of 8. 2゜ It is confirmed that x, y and Z representing the composition ratio of the above mixture are 1.9≦X≦2.7.1.5≦y≦2.5 and 2.4≦2≦3.2, respectively. A urine alkalizing food composition according to claim 1, characterized in that: 3. x, y and 2 representing the composition ratio of the above mixture are 1.9≦X≦2.2.1.8≦y≦2.2 and 2.8≦2≦3.1, respectively. The urine alkalizing food composition according to claim ff12. 4.Contains about 1 and 2 compounds in the range of -20% by weight1
4- The urine alkalizing food composition according to claim 1, characterized in that: 811. The urine alkalizing food composition according to claim 1, wherein the 5°1.2 group acid contains a saccharide. 6゜'', 4, characterized in that the 2-set acid is in solid form.
11. The urine alkalizing food composition according to claim 1.