JPS60103970A - Dialysate supply method and apparatus in blood dialysis - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Subject of the invention/Field of industrial application) The present invention relates to a dialysate supply power method and device for hemodialysis, and relates to a dialysate supply method for hemodialysis and its device, and relates to dialysis of multiple patients using multiple dialyzers. It is used to increase the efficiency of use of dialysate in hospitals where dialysis is performed.

(Prior art) Hemodialysis, which is performed using an artificial kidney device (dialysis device), purifies the blood by eliminating waste products from the body or taking in what is needed in place of the kidneys when the human body suffers from renal failure. It is widely used to carry out.

FIG. 1 shows an example of a conventional dialysis device, which uses a positive pressure method. In FIG. 1, cannulae la, H+ are punctured into blood vessels in the limbs of body A to serve as entrances and exits for extracorporeal circulation of blood. The blood pump 2 supplies a constant flow of blood flowing out from the cannula 1a to the dialyzer 3, and the constrictor 4 supplies the blood to the tube 5.
A stenosis is created in the dialyzer 3 to generate positive pressure in the blood inside the dialyzer 3.

An air chamber 68+ is provided at the blood inlet and outlet of the dialyzer 3.
6b and pressure gauges 7a and 7b are provided as a guide to know the ultrafiltration pressure. A supply path 8a and a discharge path 8b are connected to the dialyzer 3, and a separately prepared dialysate is supplied thereto. To perform hemodialysis with this conventional dialysis device, the supply path 8
The blood pump 2 was rotated while continuously supplying dialysate from a. Adjust to

By the way, the phenomena that occur inside the dialyzer during 1 (11 fluid dialysis) are the movement of substances and water due to osmotic pressure and the movement of water due to ultrafiltration.If water is also considered a substance, these substances and It is known that there is a relationship between the movement of There is resistance due to the fluid film that exists along the membrane.Figure 2 is a diagram to explain the concentration gradient inside and outside the dialysis membrane and the fluid film, and shows the concentration of a substance W in the blood and dialysate. are Co and C (,+), respectively, and the overall mass transfer coefficient is K, the transfer rate N△ per unit area of the substance film can be expressed as NA = K (CB - Co ). If the membrane transfer coefficients of the substance on the blood side and dialysate side are respectively 1+ and K11, the diffusion coefficient of the substance in the dialysis membrane is I) 1, and the membrane thickness is 1°, then 1LI - 1 = □ + □→−□ K KB DM KO It is known that the total resistance 1/N is equal to the sum of the respective resistances of the blood side membrane, dialysis membrane, and dialysate side membrane (Artificial Dialysis Research Conference) 1L319G9, Vol. 2, No. 2, P98 onwards).

Therefore, in order to increase the dialysis rate using the same dialyzer, the flow rate of blood and dialysate should be increased to generate turbulent flow on the surface of the dialysis membrane and reduce membrane resistance. Bye. Regarding only the dialysate side, if the flow rate of the dialysate is made as fast as possible, the dialysis efficiency will increase, but this will also result in an increase in the amount of dialysate consumed. Therefore, in conventional dialyzers, dialysis efficiency,
After considering various factors such as dialysis time and consumption of dialysate, approximately 500 ml lt/min of dialysate is continuously supplied.In addition, when using multiple dialyzers, connect one dialysate supply to each dialyzer, or connect a large-capacity dialysate supply 4
Therefore, the dialysate is distributed to a plurality of dialyzers, and in any case, the number of dialysates corresponding to the number of dialyzers is continuously supplied.

As mentioned above, in the dialysate supply method and device from 17L, dialysate is continuously supplied to the dialyzer from the supply path 8a, and during that time, substances that have been dialyzed and moved to the dialysate side are Exhaust 1] Continuously discharge JA from route 1 8b with dialysate
It is supposed to be released. Therefore, in order to consume a large amount of dialysate, a large amount of pure water and dialysis stock solution, which are raw materials for dialysate, are required, and a large amount of electricity is consumed to heat the dialysate to a certain temperature. The equipment used to manufacture dialysate was becoming larger.

(Purpose of the Invention) The present invention has been made in view of the above-mentioned circumstances, and it is possible to significantly reduce the consumption of dialysate, improve the utilization efficiency of the device for producing dialysate, and make it possible to downsize the device. It is intended to.

(Technical Means of the Invention) When performing hemodialysis on a plurality of patients using a plurality of dialyzers, the method of the present invention supplies dialysate to the plurality of dialyzers in a time-sharing manner from a dialysate supply device. The apparatus of the present invention is characterized in that the dialysate supply paths of a plurality of dialyzers are connected to one dialysate supply device, In the inlet, electromagnetic supply on-off valves are inserted, and in order to operate each of the above-mentioned supply on-off valves, a transmitter is installed to output a pulse signal to each of the intake on-off valves in a time-sharing manner. The dialysate supply device is characterized in that each of the supply opening/closing valves is configured to perform an opening operation only for a required time in synchronization with a pulse signal from the pulse generator. In addition, time-sharing in the present invention refers to a state in which a plurality of dialyzers use one (flit) or one dialysate supply device at different times, and the use by these plural dialyzers is mutually exclusive. It doesn't matter whether it's equal or not.

(Example) Hereinafter, the present invention will be described by way of an example with reference to the drawings.

First, in order to explain the present invention in detail, a dialysis apparatus for one dialyzer is shown in FIG.

In Figure 3, la and lb are cannulae, 2 is a blood pump, 3 is a dialyzer, 4 is a squeezer, 5 is a tube, and 6a
, 6b is an air chamber, and 7a, 7b are pressure gauges. Blood flowing out from the cannula 1a passes through the tube 5a, is sent into the dialyzer 3 from the tube 5b by the blood pump 2, and flows out from the duplex 5C. The dialyzer 3 is connected to a dialysate supply path 9 and a dialysate discharge path 10 . The supply path 9 is provided with a supply on-off valve 11, and the dialysate supplied from the dialysate supply device 12 at a pressure of about 0.3 to 0.6 kg/cJ is passed through the supply on-off valve 11. When the dialyzer 3 is occluded, it is cut off from the dialyzer 3. The discharge path 10 is provided with a metering flow path 10a and a cleaning flow path 10b branching off. A metering on/off valve 13 is inserted into the metering channel 10a, and a meter 14 is connected to the tip of the valve to measure the amount of dialysate flowing out.
A cleaning on-off valve 15 is inserted into the cleaning channel 10b, and its tip is connected to a drainage tank or the like. Supply on-off valve 11, metering on-off valve 13 and cleaning on-off valve 1 used here
All of the valves 5 are electromagnetic two-way valves that are closed during operation and open when energized.

FIG. 4 shows the measuring instrument I4 shown in FIG. 3 in detail. In this figure, the tank 16 has a cylindrical body 17 made of heat-resistant glass or the like whose upper and lower ends are closed by a lid 18 and a bottom body 19. , bolts 20 . . . and nuts 20 a . The center of the bottom body 19 is recessed in a loose groove shape, and a discharge passage 21 is connected to a discharge port 19a at the center. An electromagnetic on-off valve 21a is inserted into the discharge passage 21, and an over-half 1''-pipe line 2 opens slightly below the lid I8 to prevent overflow in the tank 16.
1b joins a discharge passage 21 downstream of the on-off valve 21a, and the tip of this discharge passage 21 is connected to a drainage tank or the like. The metering flow path 10a from the dialyzer 3 is connected to the bottom body 1.
9 is connected to the inlet 19b. A level switch 22, 23 is attached to the lid body 18, which operates according to the internal liquid level. , for example 100m
j! The other level switch 23 is set to operate when the liquid level in the tank 16 flows into the overflow pipe 21b above the level switch 22. There is.

Each of the on-off valves IL 13.15 is electrically controlled by a control device (not shown), and the timing of their operation will be explained next. Figure 5 shows the supply opening/closing button f.
f1il, lIi The operation sequence of the quantity on-off on-off valve 13 and the cleaning on-off valve 15 is shown in Mac 1.1.
3 and the cleaning opening/closing valve 15 are closed or opened, respectively, approximately in synchronization with this. That is, in one cycle time tc, the supply on/off valve 11 is opened only for a relatively short period of time, and at the same time the metering on/off valve 13 is closed, the cleaning on/off valve 15 is opened, and the remaining relatively important For a long period of time td, the respective operating states are opposite to each other.

Therefore, during the time tev, the dialysate from the dialysate supply device 12 flows into the dialyzer 3 through the inlet path 9 and the inlet valve 11, and through the outlet path 10, the cleaning channel iob, and the cleaning valve 11. It is discharged through valve 15. Further, during the time td, the dialysate is not supplied to the dialyzer 3, and the increased amount of dialysate as a result of water removal in the dialyzer 3 is sent to the discharge path 10, the metering flow path 10a, and the metering opening/closing. It flows through valve 13 into meter 14 .

Here, the time period tw will be referred to as a cleaning process, and the time period td will be referred to as a regular seating process. In other words, in the cleaning process,
The dialysate flows into the dialyzer 3 and the inside of the dialyzer 3 is washed, and in the fixed seat process, the flow of the dialysate into the dialyzer 3 is stopped and dialysis is performed inside the dialyzer 3, The dialysate increased by water removal flows into the nI meter 14. 6. So that these cleaning steps and regular steps are repeated. Second, there is. Next, the cleaning process and the regular process will be explained in more detail, including their functions.

As mentioned above, one of the factors that reduces the dialysis efficiency is the resistance caused by the membrane on the dialysate side of the dialyzer 3, but the cleaning process described above cleans the inside of the dialyzer 3 to reduce the resistance. This is a process that destroys the fluid film that is present. Therefore, the flow rate of the cleaning solution in the cleaning process should be such that it generates turbulence on the surface of the dialysis membrane in the dialyzer 3 and destroys the fluid boundary film. The dialysate supplied from the supply device 12 is pressurized by a pump to a pressure of about 0.3 to 0.6 kg/cl. In order to reduce the resistance of the flow path as much as possible and increase the flow rate, the water is directly discharged through the discharge path 10, the cleaning flow path 10b, and the discharge on/off valve 15. In addition, the amount of dialysate flowing through the intercostals necessary for the cleaning process is slightly larger than the amount of priming on the dialysate side of the dialyzer 3, and the cleaning process can be performed in a short time enough to replace the dialysate. When the resistance of the membrane on the dialysate side decreases as a result of the washing process, sufficient mass transfer is carried out in the regular processes such as the setting process where the inflow of the dialysate is stopped, and dialysis is performed. In this step, water is removed and the amount of dialysate increases, so the amount of water removed can be measured each time the increased amount is measured. Therefore, in this step, the discharge path 10 communicates with the meter 14 through the metering flow path 10a and the metering on/off valve 13.

However, in the regular process, a fluid film will eventually form again, so cleaning processes must be performed periodically. According to tests conducted by the inventor, Briming 180
When dialysate heated to about 36 degrees and pressurized to about 0.3 kg/cnl is supplied from the dialysate supply device 12 to the dialyzer 3 of m# for 3.3 seconds, a total flow rate of 90 mβ is generated during this period. was gotten. This 3.3 second washing process is performed twice in 1 minute, and the rest is a steady process, that is, the cycle time is t.
By repeating these steps with c set to 30 seconds, 5
It was possible to obtain a dialysis efficiency equivalent to or higher than that obtained by supplying 00 m j2 /min of dialysate. The times of the cleaning process and the steady process, that is, how many times the cleaning process is performed at a certain time of light opening, and the amount of cleaning solution and the duration of the cleaning process are not necessarily uniquely determined. , the performance of the dialyzer, the capacity of the dialysate supply device, the equipment and personnel of the hospital where hemodialysis is performed, and the individual case. Further, in the washing step, a pressure of 0.3 to 0.6 kg/ca is applied to the dialysate, but such pressure may be changed depending on the structure of the dialyzer. Importantly, while the flow of dialysate to the dialyzer is stopped, all or
Most of the dialysis is performed, and the dialyzer is washed by intermittently injecting 1774II' solution, and as long as these are performed, conditions such as time, number of times, flow rate, etc. are arbitrarily determined. Is possible. As a result, the amount of Pl consumed by the dialysate is significantly reduced, and the consumption of pure water and dialysis solution, which are the raw materials for the dialysate, as well as electricity for heating, is reduced. It becomes possible to downsize the equipment to be manufactured and supplied.

Next, the measuring device 14 will be explained in more detail along with its function.

The on-off valve 21a is normally closed, and the dialysate flows into the tank 16 from the inlet 19b and accumulates, and when a certain amount, here Loom j2, is reached, the on-off valve is closed by the operation of the level switch 22. 21a is opened for a certain short period of time, and the dialysate in the tank 16 is discharged through the discharge passage 21. During this time, the metering on-off valve 13 is closed to prevent dialysate from flowing into the tank 16. Each time the on-off valve 21a operates, 1 is added to a counter (not shown), and from the count value of this counter, the total amount of water removed per 100 m unit can be measured, and this can also be visually measured on the scale 17a. By adding readings, you can get a more precise amount of water removed. When the dialysate in the tank 16 reaches an abnormal level due to a failure of the on-off valve 21a, etc., it is discharged from the overflow pipe 21b to the discharge path 21, the level switch 23 is activated, and an alarm lamp or alarm buzzer is activated. In addition, if necessary, water removal is performed by closing the metering on-off valve 13 or the like.

According to the above-mentioned measuring device 14, all the amount of water removed in the regular process is measured, so it is possible to accurately measure the amount of water removed despite having a simple configuration. In the washing process, as mentioned earlier, considerable pressure is applied to the dialysate, so it is thought that not much water is removed during this time, and the time of the washing process is shorter than that of the regular process. As a result, even if the amount of water removed in the cleaning process is ignored, it is possible to measure the amount of water removed with considerable accuracy. However, ignoring the amount of water removed in the cleaning process, i! ? If not, or if you want to measure the amount of water removed with even higher accuracy, you can do the following, for example. Zunawaji is equipped with a time counter to measure the operating time of the metering on-off valve 13 and the cleaning on-off valve 15, and the metering on-off valve 13
Calculate the amount of water removed per unit time from the operating time of and the amount of water removed measured by the meter 14, and multiply the amount of water removed per unit time by the operating time of the cleaning on-off valve 15 and an appropriate coefficient. is added to the amount of water removed measured by the measuring device 14. In this case, each on-off valve 13, 1
Either the operation time shown in step 5 is displayed and the above calculations are performed by the operator, or the above calculations are automatically performed using a microcomputer and appropriate sensors, and the results are displayed. In addition to displaying the information, the progress of water removal may be monitored. For example, it can be configured to switch to the cleaning process when the speed of water removal decreases below a certain value, or when the speed of water removal increases above a certain value or when the total amount of water removed reaches a certain level. It can also be configured to stop water removal when the

By the way, the on-off valve 11 that switches between the cleaning process and the regular process
．． 13.15 has been described as being performed simultaneously in FIG. 5, but this is not at all simultaneous, but with a slight time lag between them as will be explained next. That is, FIG. 6 shows each on-off valve II, 13 near the cleaning process.
．． 15. As shown in this diagram, when switching to the cleaning process, the metering on/off valve 1
3 is closed, the cleaning on-off valve 15 is opened twI, and the supply on-off valve 11 is opened tw2 after that. The opposite is true when switching to a steady process. Therefore, the metering on-off valve 13 is never opened at the same time as the other two on-off valves, especially the supply on-off valve 11, and dialysate other than the amount of water that has been removed flows into the meter 14. Guaranteed not to. Such a time lag occurs when the on-off valve 11.1
3. , taking into consideration the operational response speed of 15, etc., it is usually one-tenth
You can choose from a range of seconds to a fraction of a second, for example, L
+u = 0.2 seconds, tw2 = 0.5 seconds, tw3-
0.2 seconds, Lu4=0.2 seconds.

Now, in the dialysis apparatus shown in FIG. 3, in the normal process, the supply on-off valve 1j and the washing on-off valve 15 are closed, and the metering on-off valve 13 is opened to perform normal dialysis, but in an abnormal state, the C In addition, the metering on-off valve 13 is also closed, and the dialysate in the dialyzer 3 is cut off from the outside, so that water is not removed. The abnormal situation referred to here is, for example, a case where there is no adverse effect such as a drop in blood pressure on the patient due to each transient water removal, or a case where there is a risk of such adverse effect. The inventor previously proposed a method for detecting such anomalies in a patent application issued in 1983.
-57147, and by applying this to this embodiment, it is possible to achieve even higher safety and labor-saving. In other words, to explain it simply, an air chamber or the like is provided in the middle of the tube 5a between the cannula 1a and the blood pump 2 in FIG. If the value is below, the metering on/off valve 13 may be forcibly closed. As a result, it is possible to prevent a drop in blood pressure due to transient water removal and perform stable dialysis, and it is also possible to increase patient safety and save labor by reducing the occurrence of human error.

In addition, as mentioned above, even when the metering on-off valve 13 is closed and water removal is stopped in the event of an abnormality, the movement of substances due to osmotic pressure continues, so the cleaning process is performed at the same cycle in this case as well. This is desirable. However, if an abnormal situation occurs that requires stopping all of these actions, it goes without saying that control should be taken so that appropriate measures are taken.

In the explanation so far, an example using one dialyzer 3 has been explained, but next, an embodiment of the present invention in which hemodialysis is performed simultaneously on a large number of patients using a plurality of dialyzers. I will explain about it.

FIG. 7 shows a circuit in which dialysate is supplied from one dialysate supply device 1.2a to ten dialyzers 3a, 3b, . . . 3j, and illustration is omitted. However, a blood side circuit necessary for performing dialysis is connected to each dialyzer 3a. Further, in this embodiment, a case will be described in which a measuring device for measuring the amount of water removed is not provided. On the dialysate side of each dialyzer 3a..., a supply on-off valve 11a... is inserted into the supply path 9, and a cleaning on-off valve 15a... and a flow sensor 24a are inserted into the discharge path 10, respectively. Each of these supply on/off valves 11
a..., washing on/off valves 1.52..., and flow sensors 24a... are housed in individual control panels 25a... and are arranged near each patient together with each dialyzer 3a... ing. The flow sensors 24a... detect whether or not the dialysate has flowed in each discharge path 10, and for example, an ultrasonic sensor or the like can be used. Discharge path 1
The dialysate discharged from 0 is led to a drainage tank 26.

Each individual control panel 25a... is connected to the central control panel 28 by control wires 27a...

The central control panel 28 is provided with a transmitter that outputs an assignment signal So in a time-sharing manner to allow each individual control panel 25a to perform the cleaning process, and ... is the assignment signal S from the central control panel 28
The cleaning process can be performed only while o is being sent. In addition, each individual control panel 25a...
A timer is provided to individually adjust the time width of the cleaning process, and adjustment is possible within the time allocated to each individual control panel 25a.

FIGS. 8 and 9 show examples of these tannings. FIG. 8 shows how the state of the assignment signal SO output to each control wire 27a changes over time, and shows how the state of the assignment signal SO output to each control wire 27a... changes over time.
time is allocated to each individual control panel 25a. 9th
The figure shows each individual control within the allocated time tc/10! 25a... shows a state in which the time tw of the cleaning process is determined by the timer. Each supply opening/closing valve 11'a... is opened only during the time of the respective washing process to supply dialysate to the dialyzer 3a... to perform the washing process. The cleaning on-off valve 15a... is
It is always open, and during the regular process, the dialyzer 3a.
The amount of dialysate that has been removed in the . F1: I-sensor 24a...
・Detects whether a certain amount of dialysate has flowed during the washing process, and issues an alarm if it is not flowing. Further, the cleaning opening/closing valves 15a are closed at 7 o'clock in case of abnormalities such as a drop in blood pressure, and water removal is stopped. Even in this case, the cleaning process is performed synchronously as described above.

Although the above-mentioned measuring device is omitted in this embodiment,
It can be provided as required, and the control of the cleaning on-off valves 15a... may be changed or changed accordingly.

In this embodiment, each supply on-off valve 11a... is sequentially opened in accordance with the allocation signal So from the central control ff12B, and dialysate is supplied to each dialyzer 3a... from the dialysate supply device 12a in a time-sharing manner. It will be supplied to In addition, each dialyzer 3 is controlled by a timer provided in each individual control 125a...
a... In other words, the cleaning process can be performed at the necessary time according to each case, and dialysate is not supplied to dialyzers that are not in use by setting the timer to zero, etc. be able to.

Therefore, even though the dialysate is supplied to a large number of dialyzers 3a, the total amount of dialysate to be supplied by the dialysate supply device 12a is significantly reduced, and the amount of dialysate per hour is reduced. Since the flow rate is averaged, the J rate used by the dialysate supply device 12a is dramatically improved. As a result, the amount of dialysate consumed is significantly reduced, and the piping equipment for the dialysate supply device 12a and the supply channel can be downsized, making it possible to significantly reduce the equipment costs and expenses required for these. becomes. For example, in the past, l 1lla
Compared to the case where dialysate was continuously flowing at 500 mβ/min for each dialyzer, the conventional dialysate supply device 12a required a supply capacity of 577 mβ/min for 1 dialyzer, but this is an illusion. However, in this example, if the cycle time tc is 60 seconds and 100 mL of dialysate is to flow in one cleaning process of one dialyzer, the dialysate supply device 1.22 is 17! This means that the supply capacity is only 1/min, which is actually one-fifth of the conventional supply capacity.

Even when the number of washing steps is increased by shortening Lc between cycles 1 and 11 to 30 seconds or 20 seconds, the amount of dialysis lll< consumed in each case is 2j! /m
In, 37! /min, which is much less than the conventional method. As mentioned above, how long the cycle time should be set can be determined depending on the hospital's equipment, personnel situation, and individual cases. Please adjust the cycle of the device.
It's good. In addition, in the double embodiment, a case has been described in which dialysate is supplied from one dialysate supply device 12a to ten dialyzers 3a, but these combinations can be made arbitrarily. .

In the above-described embodiment, the assignment signal So is continuously output during a period corresponding to the assignment time, but as shown in FIGS. 10 and 11, at the start of the assignment time, A trigger signal SL for notifying the timing may be output, and the allocated time and other necessary IN information may be indicated by a separate signal.

In addition, the assignment signal so for each individual control panel 25a...
.

The period and allotted time of st do not necessarily have to be equal. For example, the central control panel 281JIJ may be set based on the data for each patient, such as the progress state of water removal in each dialyzer 3a, the required total amount of water removal, etc. Then, the time and timing of the cleaning process required for each dialyzer 3a can be determined. Therefore, as a transmitter for the central control panel 28, in addition to a fixed-cycle transmitter using hard logic, there is also a transmitter that uses a microcomputer or the like to perform various calculations and outputs a signal equivalent to a pulse signal as a result. It can also be considered.

The individual control panel 25a used in this embodiment is equipped with the above-mentioned timer so that the time for the cleaning process can be easily set using a dial. A connection port, an indicator light to indicate that a cleaning process is in progress, an indicator light and alarm buzzer to indicate that an abnormality has occurred, and a stop button for the alarm buzzer are provided. In addition, if you decide to install a measuring device, you will need display devices i, l, l to display the amount of water removed, a gauge to set the displayed value to zero, a scheduled water removal amount setting device, etc. It is sufficient to provide the following. moreover,
It is also possible to provide a device to prevent transient water removal as described above, and the equipment required for this is $11:
Just set it up. In FIG. 7, the central control panel 28 is shown as an independent one, but this is
It is also possible to accommodate it inside one of 25a...

In the embodiment shown in FIG. 7 described above, it has been explained that only the dialysate is supplied intermittently to each dialyzer 3a in a time-sharing manner. Similarly to the dialysate, it is also possible to supply it in a time-divided manner. Before performing hemodialysis, the dialysate is washed with pure water, disinfected with hot water or chemicals, and cooled with the dialysate before being supplied to the dialyzer, and after dialysis is completed, the same process is repeated. Cleaning and disinfection are common.

In the past, each liquid was flowed continuously in each process, but each liquid was flowed intermittently in each process, preferably at a faster flow rate than before. By supplying each dialyzer in a time-sharing manner, it is possible to significantly reduce the amount of LTL required for each dialyzer.

According to the present invention, it is possible to measure the amount of water removed at a very low level C11, and although the δ1 meter shown in FIG. 4 has been described as an example of the δ1 meter for this purpose, other meters may also be used Moraron ijj Noh. For example, the flow rate flowing through the metering flow path 10a may be continuously measured with a positive displacement integrating flowmeter, or an ultrasonic flow meter that measures the flow rate n1 flowing through the discharge path 10 may be installed, and the flow rate in the regular process may be measured. It can be configured to integrate the outputs of the sensors.

- As mentioned above, dialysate is intermittently supplied to the dialyzer,
Moreover, one dialysate supply device can be used to supply multiple dialyzers in minutes.
'II, monitor the progress of water removal by measuring the amount of water removed, and detect the blood pressure to stop water removal.
By preventing transient water removal and also performing various two-step procedures before and after dialysis in a time-sharing manner,
Toru 4Ji with excellent safety and economic efficiency, with a rate of +1j<
- Can be a device.

(Results of the Invention) According to the present invention, the consumption of dialysate can be significantly reduced, and the dialysate can be manufactured and delivered.
i! Improve the efficiency of use and downsize the jJ analysis lik feeder! J
fil L can be rubbed.

[Brief explanation of drawings]

Figure 1 shows an example of a conventional 1JJIi' device, Figure 2 shows an example of a conventional 1JJIi'device;
Figure 3 is a diagram illustrating the principle of dialysis, Figure 3 is a diagram showing a dialysis apparatus for explaining the present invention in detail, Figure 4 is a cross-sectional side view of the meter, and Figure 5 is the operation of the on-off valve. Figure 6 is a diagram showing the timing macroscopically, Figure 6 is a diagram showing the vicinity of the cleaning process in detail, Figure 7 is a diagram showing an example of the dialysate supply device, and Figure 8 is the central control of Figure 7. Assignment output from the board °
A diagram showing the state of the ζ signal, FIG. 9 is a diagram showing an example of the relationship between the assigned signal and the cleaning process, FIG. 10 is a diagram showing the state when the assigned signal is the trigger signal, and FIG. 11 is the trigger signal. It is a figure which shows an example of the relationship between and a cleaning process. 3, 3a, 3b,...3j...Dylyzer, 9
... Supply road, 11. lla, llb, -----・
1lj-supply on/off valve, 12... dialysate supply device, 28.
...Central control panel (pulse transmitter). Applicant: Japan Medical Engineering Co., Ltd.
, I li 2.・+ 2 j +1 1・1. 5t,++? 1.61/I °,'2 7 iJ(',,8 1t1 .91(c d,・10 1・1 ;-,,IIth

Claims (1)

[Claims] / Blood method 17 using multiple dialyzers for multiple patients
A dialysate supply method characterized in that, when performing this, dialysate is supplied to the plurality of dialyzers in a time-sharing manner from a j3 precipitate supply device. 2. Dialysate supply paths of a plurality of dialyzers are connected to one dialysate supply device, and a supply opening/closing valve of an electromagnetic i is inserted into each of the supply paths, and In order to operate each of the above-mentioned supply on-off valves, a transmitter is provided which outputs a pulse signal to each supply on-off valve in a time-division manner, and the above-mentioned number feeder on-off switch receives a pulse signal from the above-mentioned pulse transmitter. A dialysate supply device characterized in that the opening operation is performed only for a required period of time in synchronization with J-. The dialysate supply device according to claim 1, wherein the opening operation is performed only while the signal is on and for a certain period of time set for each supply opening/closing valve.