JPS5988404A - Iodophor composition - Google Patents

Abstract

PURPOSE:To provide a iodophor composition having high long-term stability and useful as a disinfectant, by adding a halogenated isocyanuric acid or its salt to iodine, an iodine carrier and an iodide, and adjusting the pH of the mixture to a specific range. CONSTITUTION:The objective iodophor composition is an aqueous solution containing 0.5-5wt% of iodine, 5-50wt% of an iodine carrier, 0.1-3wt% of an iodide, and 0.1-3wt% of a halogenated isocyanuric acid (salt) and having a pH of 4-7. The iodine carrier is preferably a surface active agent [preferably a nonionic and/or anionic surface active agent having (poly)oxyalkylene chain], polyols or polyvinyl pyrrolidone. USE:Sterilization of the wall and floor of medical, dairy, food processing, environmental sanitation or public building, sterilization and cleaning of cattle shed and cattle, disinfection of cooking utensils, disinfection and sanitation of the skin of animal and human body, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to iodophor compositions. More specifically, the present invention relates to a bactericidal iodophor composition with improved storage stability.

Iodophor compositions have the properties of iodine as a bactericidal agent, and have many advantages such as lower vapor pressure, less odor peculiar to iodine, and less irritation than iodine, so they are used in medical, dairy, etc. It is used in the field for purposes such as sterilization, disinfection, and cleaning.

Conventionally, there has been an iodophor composition which is an aqueous solution of iodine and an iodine carrier, contains iodine ions and iodate ions, and has PII adjusted to a predetermined range. However, it is difficult to obtain a product with good long-term stability depending on the iodine content and the type of iodine carrier.

The inventors of the present invention have arrived at the present invention as a result of intensive studies with the aim of solving the problems mentioned in section 2. That is, the present invention is a water bath solution containing iodine, an iodine carrier, an iodide, and a halogenated inocyanuric acid (Hanawa).

The iodophor composition is characterized in that the Pl and I values are in the range of 4 to 7.

In the iodophor composition of the present invention, the halogenated isocyanuric W <salt> is a compound in which 1 to 8 of the 8 hydrogens of isocyanuric acid are substituted with a halogen such as chlorine, iodine, or bromine, and/or I can give you the salt. Examples of salts include alkali metal salts (lithium, sodium, potassium salts, etc.). Specific examples of halogenated isocyanuric acid (salt) include chlorinated isocyanuric acid (salt) (monochloroisocyanuric acid).

Dichloroisocyanuric acid, trichloroisocyanuric acid,
Sodium dichloroisocyanurate].

Examples include iodinated isocyanuric acid (at), (potassium short isocyanurate, etc.), etc. Among these, chlorinated isocyanuric acid (converted) is preferred, and particularly preferred is from the viewpoint of good solubility in water. Dichloroisocyanuric acid or its alkali metal salt.

Elemental iodine can be used as iodine.

Iodine carriers include surface-active substances and non-surface-active substances. The surfactant is usually a lekylene chain ((
Mention may be made of nonionic, anionic, cationic and amphoteric surfactants having (poly)oxyethylene, (poly)oxypropylene and/or (poly)oxybutylene chains). This nonionic surfactant is poly(8-40
mole) oxyalkylene (02-4), alkyl (Os
-Cl8) ether, polyoxyethylene alkyl (0
8-1□) Phenyl ether (polyoxyethylene alkyl or nonylphenyl ether), polyoxyethylene/polyoxypropylene block copolymer (Pluronics from Wyandotte, etc.).

Examples include polyoxyethylene alkyl phenyl ether formalin condensates.

Examples of anionic surfactants include sulfuric ester salts of nonionic surfactants [polyoxyethylene alkyl (08-
C+s) ether sulfate ester salts (alkali metal salts, ammonium salts and amine salts, hereinafter referred to as anionic activators are the same), polyoxyethylene alkyl (
08-12) Phenyl-ether sulfate salt, etc.]
, phosphate ester salt [polyoxyethylene alkyl (Q
+-qs) ether phosphate ester salt, polyoxyethylene alkyl (ql-CI2) phenylnylic acid ester salt, etc.].

As a cationic surfactant, polyoxyalkyl (q~
Examples include C4) alkyl(012-Q+s)trimethylammonium halide (iodite, etc.).

Preferred among these surfactants have (poly)oxyalkylene chains. Nonionic and/or anionic surfactants.

In addition, examples of non-surface-active substances used as iodine carriers include low-molecular or high-molecular weight water-soluble or water-solubilizable substances. Specific examples include water-soluble polyols (low-molecular-weight polyols such as ethylene glycol, propylene glycol, glycerin, and sorbitol, and their alkylene oxide (ethylene oxide, etc.) adducts such as polyethylene glycol) and polyvinylpyrrolidone.

The iodine carrier may be a mixture of two or more types.

Iodides are not particularly limited as long as they are compounds that dissociate into iodide ions in an aqueous solution, and metal iodides such as alkali metal iodides (potassium iodide, sodium iodide, etc.), alkaline earth metal iodides (calcium iodide, iodide, etc.) magnesium oxide, etc.) and non-metal iodides such as ammonium iodide, hydrogen iodide, etc. Preferred among these are alkali metal iodides and hydrogen iodide.

In the iodophor composition of the present invention, the content of each component in the two compositions is as follows. In other words, iodine is usually 0
．． 1 to 1% by weight, preferably 05 to 5% by weight, and the iodine carrier is usually 1 to 80% by weight, preferably 5 to 50% by weight.
, iodide is usually 0.05 to 5% by weight.

Preferably 0.1 to 8% by weight, halogenated isocyanuric acid (salt) usually 0.01 to 6% by weight, preferably 0.1 to 8% by weight.
The weight is N%.

The effective iodine content in the iodophor composition is not particularly limited, but is usually 0.1 to 10% by weight.

Preferably it is 0.5 to 5% by weight.

Further, the weight ratio of the iodine carrier to the iodine in the iodophor composition is usually 1:1 to 50. Preferably l:5~s
o, the weight ratio of halogenated isocyanuric acid (salt) to iodine is 1:0.01. ~5. Preferably 1:0
．． It is 1 to 0.5. The equivalent ratio of iodide and halogenated isocyanuric acid (salt) is usually 1:O,' to 10°, preferably i:o, 5 to 5.

The iodophor composition of the present invention can be obtained by conventional methods. For example, an iodine carrier and an iodide are dissolved in water, the pH of the solution is made acidic (eg, 5 or less), and iodine is added, stirred, and dissolved. After completely dissolving, halogenated isocyanuric acid (salt) is added and uniformly dissolved. These dissolutions are usually performed at room temperature. It can also be dissolved by heating.

It is also preferable to avoid unnecessary heating - to avoid sublimation loss of iodine during melting. Next, adjust the pH to a range of 4-7. The pH adjustment can be carried out using an organic acid, etc., and it is preferable to use citric acid, sodium hydroxide, and potassium hydroxide.

The iodophor composition of the present invention is a solvent and a foaming agent.

It may contain compounding agents such as foam suppressants, thickeners, and PH buffers. These compounding agents may be added before dissolving iodine, or may be added after dissolving iodine.

The iodophor composition of the present invention is usually diluted with water so that the effective iodine concentration ranges from several pptn to 150 ppm. High concentrations (e.g. o, i
~1% by weight).

The iodophor composition of the present invention has excellent storage stability, particularly long-term storage stability, and has good long-term stability even if the iodine content and the type of iodine carrier in one composition are changed. Furthermore, the pH is in the weakly acidic range of 4 to 7, which means that metal products such as iron are less likely to rust, and are less irritating to the skin.

In the iodophor composition of the present invention, 9 hypochlorous acid or its salt (K, Na, Li, Mg, C!a, NH,
If an acid salt (such as sodium iodate) is used, it may not be possible to obtain a product with good long-term storage stability depending on the iodine content and the type of iodine carrier.

Because it exhibits the following effects, the iodophor composition of the present invention can be used in fields such as medical care, dairy farming, food processing, and environmental hygiene; disinfection of walls and floors of public buildings; cleaning of livestock sheds and animal streets; and cooking utensils and equipment. Disinfection; Used to sterilize and disinfect the skin of animals and humans.

The present invention will be further explained below with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

Example 1 Sodium iodide 1.6f, polyoxyethylene/polyoxypropylene block copolymer (polyoxypropylene chain average molecular weight 1750, 1% aqueous solution, cloud point of liquid 11)
5°C) 40f and citric acid 1. J' was dissolved in 200 y of water, and then elemental iodine Bf was added and stirred to dissolve. After completely dissolving, sodium dichloroisocyanurate 1.2
After dissolving, adjust the pH to 5 with a 10% aqueous solution of caustic soda.
and water was added to obtain a total amount of 800 g of an iodophor composition. For comparison, an iodophor composition not containing sodium dichloroisocyanurate (
A') was obtained in the same manner.

All operations were performed at room temperature.

1/I of the obtained iodophor composition immediately after preparation
Table 1 shows the effective iodine content that can be titrated with ON sodium thiosulfate, the pH value, and the effective iodine content after being left at 50'C for 2 weeks and 6 months. As is clear from Table 1, the iodophor composition of the present invention has significantly better stability than the comparative product.

Table-1 Example 2 Example 1. Using the same method as above, an iodopol composition having each component ratio (weighted portion) listed in Table 2 was prepared. The effective iodine content of these iodophor compositions immediately after preparation,
Table 2 shows the pH value and the available iodine content after being left at 50'C for 2 weeks and 6 months.

Note 1: Example 8 for pal adjustment Sodium iodide o, 5g, polyoxyethylene (n=
14) Nonylphenyl ether 15 dato' citric acid 05
g was dissolved in 70 f of water, and then 1/1 of elemental iodine was added, stirred, and dissolved. After completely dissolving 2 halogenated isocyanuric acid (m) listed in Table-3 0. In place of 'gt bamboo shoots, 04 g of sodium hypochlorite or sodium iodate was added and dissolved, the pH was adjusted to 5 with a 10% aqueous sodium hydroxide solution, and water was added to obtain a total amount of 100 g of an iodopol composition. All operations were performed at room temperature in all cases.

Table 3 shows the effective iodine content of the resulting iodophor composition immediately after preparation, III (value), and the effective iodine content after being left at 50'C for 2 weeks and 6 months.

Claims (1)

[Scope of Claims] 1. An aqueous solution containing iodine, an iodine carrier, an iodide, and a norogenated isocyanuric acid (salt), and
) I(Iodopol composition characterized in that the value is in the range of 4 to 7. 2. The content of halogenated isocyanuric acid (j%) is 0.01 to 5% by weight in the composition J) 3. The composition according to claim 1 or 2, wherein the content of iodide is 0.05 to 5% by weight in the composition. 4 Claim 1 in which the iodine carrier is a surface-active substance
The composition according to any one of Items 1 to 3. 5. The composition according to any one of claims 1 to 8, wherein the iodine carrier is a polyol and/or a polyhinylpyrrolidone.