JPS5953426A - Remedy for psychogenic asynodia - Google Patents

Abstract

PURPOSE:To provide the titled remedy for psychogenic asynodia, containing the extract of EZOUKOGI as an active component. CONSTITUTION:EZOUKOGI (Acanthopanax senticosus [Rupr. et Maxim.] Harm.) is extracted with water or hydrous or anhydrous 1-3C lower aliphatic alcohol (e.g. methanol), and the obtained defatted extract is fractionated with water and butanol (e.g. n-butanol, i-butanol, etc.). The obtained fraction is used as the active component. Nowadays, the psychosomatic disorder and neurosis are often caused by the complicate human relations and works in the modern society acting as a psychological stressor; and the neurosis, above all the asynodia, is deemed as one of the serious modern diseases. It has been recognized by animal experiments using mouse that EZOUKOGI is effective to recover the psychogenic asynodia by continuous administration.

Description

DETAILED DESCRIPTION OF THE INVENTION (1) Background Technical Field of the Invention The present invention relates to the use of Acanthopanax 5
entico-sus (Rupr, et Maxi
This invention relates to a psychogenic sexual behavior disorder recovery agent containing extract's proboscis as its active ingredient.

In modern society, as the social life of the society becomes more severe, interpersonal relationships in the workplace and complicated work contents become psychological stressors, causing so-called psychosomatic disorders and neuroses. In case of psychosomatic illness.

The pathological condition is generally manifested as physical symptoms, and urinary system diseases are one such symptom. Among these, lifelong behavioral disorders are considered to be one of the serious problems of modern disease. Therefore, if a drug for restoring psychogenic sexual behavior disorders that can be easily taken is developed, it would be possible to eliminate mental stressors.

By the way, in general, there has been a lot of interest in crude drugs recently, and Eleuthero is known as one of the crude drugs, and its therapeutic effects include prevention and comprehensive treatment of nervous system diseases, atherosclerosis, and cancer. It is known to have therapeutic effects.

m) Tetrarchism of the Invention The present invention relates to a new use of Eleuthero extract, ie, use as a recovery agent for psychogenic sexual behavior disorders.

In other words, one aspect of the present invention is to develop a method that only causes a decline in sexual behavior using the "hanging method" (details will be described later), and administering Eleuthero extract after stress loading, which has the effect of recovering from sexual behavior disorder. It is based on the discovery of a small fire called Atsuichiko.

Therefore, the psychogenic sexual behavior disorder diluting agent according to HonzuNmei is effective against Acanthopanax 5entico.
suS[Rupr.

et Maxim, ] Harm, ) with water or a lower aliphatic alcohol with a carbon content of 1\3 containing water or no water.
It is characterized by subjecting the 1114-defatted extract to partitioning with water and citanol and using the resulting fraction as an active ingredient. .

Eleuthero is a member of the same family Araliaceae as the Korean silkworm), and is one of the most well-known things in Korea. It is also known that the components of both plants are quite A.
otbeker-Zeitung 117, No.20
, 19.5 (1977)].

Currently, Eleuthero is attracting attention as a substitute for Korean ginseng. In addition to the four physical properties mentioned above, this Eleuthero also has the effect of sexual behavior disorder 1v, a discovery that even Nagisa in the field had never thought of, making a significant contribution to modern disease countermeasures.

Detailed Explanation of the Invention 1. Although it is already stated that the eleuthero itself is well known, a summary thereof is as follows.

1) Distribution and chemical components of Eleuthero j1. The north is the middle reaches of the Amur River, and the east is Saba 1.
Ginseng grows above 800 m above sea level in South Korea and China's Shanxi and Hebei provinces in the south, and its distribution almost coincides with the absolute boundaries of Korean ginseng. Like Korean ginseng, Eleuko gi is a plant of the Araliaceae family.

Its chemical components are glycosides, glucose, and sucrose.

Mixtures of non-glycoside polar conjugates and dyes are included.

The glycoside components are eleytheroside A and B.

C, D, E%F and G are known, and their content ratio is also known to be 8:30:12:24:2:1. The first five eleitherosides are monocyto or biocyto, which are obtained in crystalline form. In addition, as sugars, eleutheroside A, B%D
and E have glucose and C has galactose. All eleitherosides contain a methoxy group. These, including genin, are highly unstable compounds.

2) Pharmacological properties of Eleuthero The toxicity of eleuthero preparations is extremely low (, its LD).

4] 31 g/Kg (oral administration to mice)
It is.

The pharmacological properties thereof are listed and briefly explained as follows (excluding those related to the present invention).

11) Activating and tonic effects Eleuthero has revitalizing and tonic effects.

Activation effect means that a single drug administration VC increases biological activity f.
ft'i Kakahiishi Maruyo 5 The tonic effect refers to the effect of a drug, and the tonic effect is the effect of maintaining the active ability of the living body and each organ for a long period of time, not just immediately after taking the first drug, as a result of taking the drug every day for a long period of time. say.

(2) It acts as a daptogen (a drug that enhances the body's ability to adapt to stress), an agent that enhances the body's resistance to adverse conditions.

(31 Effects on metabolism 'FJ4 #J additive effects, appetite-stimulating effects, etc.)
It has the effect of exerting ap.

As for therapeutic effects, as mentioned above, it has a preventive and curative effect that is one of the most effective in comprehensive treatment of nervous system diseases, atherosclerosis, and cancer.

2. Extraction and Extract 1) Process Extraction of Eleuthero and obtaining the desired extract can basically be carried out by any means used for the extraction of herbal medicines.

First, the target for extraction is any part of the Eleuthero plant, including the vine, but the root is most preferred.

The extraction operation according to the present invention consists of the following unit steps 7-).

(1) Extraction Extraction is carried out using water, water or water-containing or non-hydrous C1-C5 alcohol.

The lower alcohol to be used as a extraction liquid has 1 carbon number.
~3 (usually a monohydric alcohol).

%VC preferred are methanol and ethanol, especially the former.

Extraction can be carried out either under Kj or at room temperature.

At room temperature, the extraction time is long and usually takes several days.

It goes without saying that it is preferable that the target plant be crushed in order to increase extraction efficiency.

(2) Degreasing The extract obtained as described in 81.1, either as it is or in a liquid phase, or after distilling off the extractant alcohol,
Some water-insoluble solvents include ether, acetate,
Treat with other ingredients to extract l1tj '1↓ in the extract.

Preferable practice for oil and fat A) is from early extraction T4.1
Water is added to the solid content from which the 6J medium has been removed from the strained solution or the solid matter, and this aqueous suspension is extracted with a degreasing solvent.

11iT T, I also usually fire firearms at room temperature.

(3) Minutes Song 1 After defatting σ) Add the extract to 0 mark 1 with water and citanol and put out 1 song.

As butanol (well, do the partitioning)'r, any one of which has marginal solubility in water, especially n-, i-, and 5ec-butanol, can be used. Particularly preferred is n-butanol or i-butanol (the former #HC). n-Butanol has a finite solubility in water1! Something with V, lb, so n
- If a sufficient amount of butanol is used, degreasing treatment] Obtain the target fraction by partitioning between the aqueous layer and the sitanol layer (both layers are saturated with other layer components) of the Taji extract. I can do it.

This fractionation is also usually carried out at room temperature.

To separate the desired fraction from water A4+, the solvent can be distilled off or other suitable means can be used.

2) Extraction example A specific example of Eleuthero extract I proboscis production is shown below.
It is 1. 1- That is, eleuthero σ) 50 g of roots were ground and immersed in 200 ml of methanol for 3 days.

The obtained extraction tube was suspended in 5 ml of water, and 50 ml of ether was added thereto. Take 1 liter of water from this mixed bath liquid σ] and add 5 Qml of butanol to this 1 t.
I added it.

The produced waters 1. and 4 were collected and evaporated to dryness to obtain a eleuthero extract fraction (approximately 1 g C9i:).

3. Psychogenic Sexual Behavior 111 Disorder Recovery Agent In the present invention, psychogenic sexual behavior disorder recovery agent - Eleuthero extract itself or water extract is dried according to 8 requirements and used as an excipient for preparation as appropriate; It can be mixed with a binder, a diluted drug, and administered in the form of a powder, tablet, capsule, syrup, injection, etc. by freezing or divisibly.俟11; means age and body size.

The amount may be increased or decreased depending on the symptoms, but the oral dosage is usually 1Jv.
20mg-5g of extract is recommended per day.

A preferred embodiment of the present invention is one consisting of Eleuthero extract and formulation auxiliary ingredients. 1. Another preferred embodiment of the present invention is a dosage form in which the above-mentioned daily dose is divided into one or several times and administered for IJR.

4. The effect of increasing psychogenic behavior The following are the experimental methods and results of investigating the effects of stress on sexual behavior disorders after applying stress using the ``hanging method''. "Hanging method" includes Bull, Exp, Blol, Med,
84.

(Q), 375-377 (1977) and Cat
echolaminesand 5tress volume 8 (
1980) [H71sevler North-Ho
This is an improved method of the method described in [11and] (details will be described later).

1) Experiment! 'Jb! The mouse used for the snout (IV-C8 Itoo, 9 weeks old, 2g-3
2g: Animal breed Mr. rilf) wo01 person fit 1
After being kept in individual cages (10 x 20 x IO cm) for 1 week, normal mice with single behavior were separated into 2A. In other words, estranool (emitted +?
Hormone) 1 (lμg/Kg) was administered subcutaneously to 3 mice each time.■ Males that successfully underwent intromission (details 1 later) within ( ) minutes were selected for 5 or more successful intromissions during the week. I used it sparingly.

2) It was carried out using the actual measuring method and the ``hanging method''. That is,
The mouse is suspended by its tail at approximately 6.5 crn pfl above the water surface. Fix the mouse with its head down at an angle of 4'4 degrees, where the tip of the mouse's lion touches the water surface. Even if you use this method to relieve stress for 10 days,
Weight loss,・′! 1 movement 1τ shoulders,...' 1 motion fatigue, a decrease in trunk muscle tone and circumferential muscle tone, and a decrease in spontaneous movement and exploratory movement. 791).

111 of each 1 subtractor at that time. When we measured the same components in the blood and serum, there was no change in the weight 9 of the Suimaru and prostate of the stressed animals (the adrenal glands were enlarged and the tyrosine hydroxylase activity was increased.Table I K serum components (glucose, Table 2 shows the change in body weight (total protein, inorganic phosphorus, aldimine).

Table 2 Changes in body weight (g) As can be seen from Table 1.2 above, even when stress was applied using the "suspension method", there were not many changes in the internal components and body weight.

Using the above-mentioned "suspension method", we conducted the following experiments. Do the stress load every day from the time you quit (00:00 in the afternoon). The load time is increased for the 11th day, and extended by 10 minutes for the 1st and 1st bags, and from the 4th day onward, the load is applied for 1 hour. Immediately after loading, Eleuthero extract (500+n
g/Kg) every day 1] and examine sexual behavior the next morning. The method involved placing one male mouse in a cage (30X 4tl) containing 10 female mice administered with estranol.
x 30 cm). And within 10 minutes,
Sniffing (licking the female's genitals).

The number of times each action was performed, mounting (Ishikawa υ, where j4i is on top of the female but does not lead to insertion) and introduction (vaginal insertion), the time (minutes) until the action occurs,
and measured the number of behaviors over a 10-minute period.

The results of the following H are shown in Figures 1'41-3.

3) Recent and ancient times - Rino/p7'
To0 I tried sniffing, but after 7H 1;
1 Ma, Han Tawara, and a small H1 direction were seen. The decreasing tendency was particularly remarkable in the stress-loaded control group.On the other hand, although the number of strikes decreased in the Eleuthero extract-administered group, the number of strikes in the stress-loaded control group was similar to 40 in the normal group.

Regarding the time it takes for the first behavior to occur, there was a sex difference between the normal group and the stress-loaded control group, with the stress-loaded control group taking longer to initiate the behavior. 1, Eleuthero Extract 49 Target! Although the time required for the "r+" to act is longer than that of the normal group, there is a tendency for the time to be significantly shorter than that of the stressed control group.
Ta.

Regarding the number of times performed in 10 minutes, F6 (・te 1
．． On the 2nd and 6th day, I could not see my arm, and Eleuthero extract was administered! (An increase in the number of times was seen in 1. Also, the sealed mushroom bar?
11) Although it was not possible, the number of drops in the Eleuthero extract-administered group approached that of the normal group.

(2) Mounting line Il! Regarding the number of times IJ was performed, the stress-loaded control group had a decreased number of four edges compared to the other two groups.

Eleuthero extract administration! Hiroshi showed the same tendency as the 1E regular group, although there were some irregularities.

I sled? Regarding the time it takes to start -1 movement and 1-,
The eleuthero extract-administered group showed the same feQ direction as the normal group during days 4 to 9, although there was no difference between 1f and 1f at tani:lj+1.

The difference between the normal group and the stressed control group was 8.9 and 100 for the number of occurrences during the phase.
In the stress-loaded control group, there was a marked decrease in repetition. On the other hand, in the Eleuthero extract administration group and the stress-loaded control group, continuous administration was started on the 6th and 8th day, and WN9:: was observed from the firefly half, and the growth rate approached that of the normal group.

3) Regarding the number of times the intro mission row 1 was performed, the Jl group also had the same 1
1; Indicates direction. Is the decrease in the number of times of stress 1 load comparison A 11' only a little)? It was written by i. Eleuthero extract administration 11.1 to 1.5 times (1)
It showed 41 directions.

Maximum f force ((row tr, time at which h was caused and times performed in 10 minutes > g vc 1lkl), and no difference in T4 was obtained between each group. ;-1, the Eleuthero water extract 49 group tended to approach the normal group from the latter half in both time and rotation θ.

From the above data, it can be concluded that administration of Eleuthero extract's proboscis #31 has a great effect on restoring psychogenic sexual behavior disorder.

[Brief explanation of drawings]

The number of times sniffing was performed to the tfth figure 8 is shown in the 11th-
Figure 1 shows the number of sniffs performed in 0 minutes (test day/rz), respectively (test day/rz). Figure 2 shows the number of times the mounting was performed, and the time until the 21st mortar B starts mounting. The number is exactly as shown in At R*#J. ! , l! : 3111 A li mini intro mission, j, l! ,' Figure 3 H&”l time at the neck to start the cointromission, ffi+>,
3 + 4c indicates the number of times the introduction was performed in 10 minutes, respectively, in trials 1-2: Fl hJ. The notation in the figure -gwo:r-, with the lower A close, has a taste. 0 Positive', Ii'+ (Str/Su Misaki+' 1AIi:
+) IP4・Stress 1'1 control right r △ Stressed area Eleuthero extract administration group (+), *,
(**) and * indicate the results of T test>i. That is, (*14.t P < 0, 1, *th,
P<(1,05, (**)) is P<(1,02, and *
* indicates P < 0. The old addition water Iψ becomes military [7, ■ Gender difference finger (・; Mi. By the way, *(N, S,) in the diagram
Toaha Bakone eyes, the difference between normal life and normal life is P<0
．． 05, and * (S, C,) indicates that the difference between the stress load control group and the stress-loaded control group is P<0.05, and ■・). I’ll be out! Person Ino Mata Kiyo Diagram 1 A Test Mao Day Diagram 1 B Diagram 1 C Second Garden B Trial Horse Moxibustion Day Examination Day Diagram 3 B Type 8 Mao Day Procedure Amendment Form December t, 1980 Mr. Kazuo Wakasugi, Commissioner of the Patent Office1, Indication of the case, 41/1980 Patent Application No. 1642702, Name of the invention, Psychogenic sexual behavior disorder recovery agent3, Person making the amendment Relationship with the case 4. I'rt'r Applicant Kuei Pharmaceutical Co., Ltd. Column 8 of "Detailed Description of the Invention" in the Att Document .”
After that, add the following. [In addition to the above, there are also Eleutero
-coccus 5enticosus (Rupr,
et Maxim, ), but since this is synonymous with the former E, 1111 is used in the present invention. ] (2) Delete "8 which is a glycoside" from lines 7 to 16 on page 5 and add the following. Eleutherozide A and B are 1-glycoside components. B, , C, D and E have been found (see the above document D).
eutsche Apothelcer Zeitun
etc.), sugars include eleuterozide A, B, and B.
It is said that 1, J, 2 and E have glucose, and C has galactose. ”

Claims (1)

[Claims] 1. Acantbopanax 5ent
icosus [Rupr. et Maxim,] ilarm,) is extracted with water or a lower aliphatic alcohol containing 1 to 3 carbon atoms, and the extracted extract is subjected to a defatting treatment [1].
2. A psychogenic sexual behavior disorder recovery agent, characterized in that the resulting defatted extract is partitioned between water and butanol, and both components obtained are used as active ingredients. 2. The psychogenic sexual behavior disorder recovery agent described in claim 1, wherein the lower aliphatic alcohol is dissolved in methanol. 3. Any one of claims 1 to 2, wherein the butanol is n-butanol or i-butanol,
A single-dose 1ν drug for psychogenic sexual behavior disorder as described. 4. An agent for restoring sexual behavior disorder of ijQ lit: according to any one of claims 1 to 3, which uses the roots of Eleuthero.