JPS5946123A - Preparation of gel like emulsion and oil in water type emulsion - Google Patents

Abstract

PURPOSE:To prepare an oil-in-surfactant type gel like emulsion, by gradually adding an oil phase component to a surfactant continuous phase having an aqueous phase component consisting of a water soluble solvent and water and a nonionic surfactant dissolved therein. CONSTITUTION:An aqueous phase component wherein a water soluble solvent selected from one kind of more glycols or a derivative thereof (e.g., propylene glycol) and water are within a range of 3:7-8:2 and a nonionic surfactant (e.g., sorbitan fatty acid ester) are dissolved to prepare a surfactant continuous phase. In the next step, an oil phase component (e.g., squalane) is gradually added to prepare an oil in surfactant type gel like emulsion. Because thus obtained gel like emulsion is resistant to agglomeration, it is hardly restricted by various conditions during a production process and a stable O/W emulsion can be easily prepared and, at the same time, the gel like emulsion itself can be utilized as a product.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing a novel gel-like emulsion and an oil-in-water emulsion. When the ionic surfactant is dissolved,
1] A manufacturing method for obtaining a gel-like emulsion consisting of oil in a surfactant by gradually cooling the oil phase components, and by adding an aqueous phase to the emulsion? T) This is a method for producing an oil-in-water emulsion with a constant η.

Generally, the conventional method of adding surfactants is the so-called agent-in-oil method, in which a surfactant is added into the oil phase in advance.
) method, or conversely, the nee- ient inno water (agent
There is a method in which a 731 water-based surfactant is dissolved in an aqueous phase and a lipophilic surfactant is dissolved in an oil phase. Conventionally, gel emulsions have been used, such as by utilizing the heavy viscous state immediately after the phase inversion in the agent-in-oil manufacturing process, or by using the paste method, in which an emulsifier is added to a small amount of the aqueous phase and the oil phase is added little by little. However, it is said that it is extremely difficult to adjust IIL13, which is used for both the phase inversion method and the paste method.

For example, in the former phase inversion method, if it is tilted toward the lipophilic side, it will not be reversed even when water is added, and a gel-like emulsion cannot be obtained. On the other hand, if 11LB is tilted toward the hydrophilic side, the oil phase will not be dispersed in the gel emulsion and will separate immediately after inversion. In the latter paste method, in the case of the lipophilic side, the dispersibility of the surfactant in water is poor, and even if an oil phase is added, an emulsion/yellow state is not obtained, but a mere separation system is formed. On the other hand, on the hydrophilic side, the surfactant is completely dissolved in the water phase, and when the oil phase is added, the oil droplets are large and tend to coalesce and separate instantly.

From these backgrounds, as a method for producing stable gel-like emulsion, surfactant J) hydrophilic-oleaginous balance (HL
It has been pointed out that it is important to strictly adjust B) and to dissolve the surfactant in the oil phase in advance. In selecting an emulsifier, the concept of IILIi value established by Griffin is utilized. Ill□ suitable for producing gel-like emulsion based on this concept
The 13 value is said to be in the range of 8 to] 3, but in order to actually obtain a stable emulsion, it is safe to adjust the HLB value with high accuracy depending on the type and composition of oil (11:).Furthermore, this Gel-like emulsion products offered up to
Under such severe conditions, the resulting product /l/ tended to break down and exhibit fluidity.

On the other hand, as a method for producing a stable oil-in-water emulsion (1), the agent-in-oil method described above has been reported to be superior to date. This agent-in-oil method is a method in which a nonionic surfactant is dissolved in an oil phase, and then an aqueous phase is added to this oil phase to obtain an oil-in-water emulsion through phase inversion. In the production of oil-in-water type, including the above-mentioned gel emul/yono problem,
Even with this method, there are some f11 points. It is the addition of water during the emulsification process [1F, stirring 11.1 setting,
Regarding the conditions for setting the amount of water for inversion, 41
14) Careful attention is required, and the raw materials used, especially the surfactants Hl and Lt, have a large influence, and reproducibility tends to be poor due to quality fluctuations such as lot fluctuations and lack of skill on the part of the operator. ′And it is. However, it is still affected by the compatibility between the surfactant and the oil phase, and whether the compatibility is good or bad, a good emulsion can be obtained.
There is one short point such as "no".

As a result of intensive research to solve the above-mentioned problems, the present inventors have found that by using KAI 1M1 activator oil-in-gel emul/Yono, the particles are uniform, extremely fine, and stable even under harsh conditions. A gel-like emulsion and an oil-in-water emulsion can be obtained, and a simple manufacturing method with better reproducibility than ever before has been completed.

The present invention is glycol 4j size [zo0 poem conductor 1ilt
i kadad, part 1. f55 part 1 stroke or (・:j, 2
From a water-soluble R'r medium selected from XI and water 7'I:
Dissolve the filtered water phase components and the nonionic surfactant) and prepare a continuous phase by removing the interfacial layer +1, and then add the oil phase components 6- and 1-.
From surface-active phase-resistant medium oil:
The present invention relates to a method for producing gel-like r-, -jl'7.1, which is characterized in that ノ1'7:1.

Furthermore, 'i(1!?ii, law!# 1)
．． ', ) 11, -Kel (In-1 Add aqueous phase to Furunyono to change the continuous phase from the interface/, I'i l'l removed phase to water to create oil-in-water type - '-2 L/. The present invention relates to a method for producing oil-in-water it,'!, :r-l/'-1, characterized in that 1) is reduced to 1.

To describe in detail the method for producing the gel-like knee gel according to the present invention; 7 to 8 parts;
! Dissolve the J1 polymer surfactant in the aqueous phase component consisting of 2 parts and slowly add the oil phase to the surfactant phase while stirring, and remove the surfactant from the oil in the surfactant phase. Gel emul/yo/ is formed f'1 (11'' or [) Naru 3, Kinoshita 4:' [! Odor, Q-1, oil phase is slowly added, and the interfacial packing property is increased in 1 minute. 1. Add 1 layer of oil phase to the drug continuous phase.
-Share and Ura's 71! - Surface tension is as small as 1.11s
Fl, the same phase is water, 1 no, ) sound, I- Comparatively finer milk f is I'j, (7,, I do/, -me,
11 different ho 1 - game noi 11 ゛ - down 11 machine (11 (
ShibyouI'/1'6-1・11wa4: <-Ci1.4
@j , V') and detailed 1"1'↓: +-,・le,・
・Insuke'Taniyoshi C〈-I: I can come 1, this 7t
h IN "l', i<+, ・Water/1 remaining 41 solvent. 1-Ratio of water tit the above ill'l, 37 parts"
) 8', 2nd part IV Yasukaa; 2], water is 7
1) +I good/) fortune telling 1.・、Lhi-＼
Girigo (liquid crystal appears 1, water τ' 170%, [good and Kaikyu story + l agent l11.l + candy 7~1'2
31 ratio 1 is low, A1 go I1/I Meller acupuncture phase 11° 4, Nmen'no play crystal Q-shi!・:1;
L, 1, just add oil phase &:t W side l
l'l l' l l l l-, l l l-, i value is 12.
The higher the Jll + j + J1, -\ Girigono 1, the -jl of the liquid crystal always appears, and the dispersion of the oil phase therein is Jl always % Ill L, I1, - force, the water relative to the water-soluble solvent. 4. The ratio is 2/1ν. ra (・-
"1. Surface active t" decreases association in water-aqueous f1 solvent ゛J-
It seems that there is a possibility of micelle formation. : 4', 1.1:
σ) /, -me, oil phase / \'s suction 4''
, : , 1/l or low l-1, fibrous (1) W 1rl
l story ('l removal phase oil: +: -,) /L /1-6
river? Sei-11-J゛, (1 (1'lll oil content 11 thread or f!) l'+ :11/:, u) Horn-"C-11
..., 1 takes 2 IJ, , ;, 1 for l, j. ·hair/
[) 7 volumes in the aqueous phase, t/,)] thickness] 1'i for rivers (
'I'? 'l r, 12()mon:1:%]゛tsu,1
．． -'C8Fl中111 1・-C7(・)/:、ノ1<・'下が5ら/′)、、′! () Medium・1: % or more 1・
Ca;:), L: W-lii story 1'l cut (eye 111 layer jl "t) (ll?; Formation 1- /C, Kotokade J-
1 water solution ('l solution II, 1 (, - song (11 is the molecule!'f
l-7+-like pj1: (1, 2, heteshish7-11i, Uno [组-1°・ノ[/!7・tl, piece 3 formation bar\i+
/': 3. Nol'/! '1' in 80: z to I, h'[''menran□-II cut i1.S C/L, meeting?
1l11. ．． I' ko, l car(, %; 4. I;:
I think Jl, Kel-like upper circle/-I] 11, formation t~) 1
Ro“i,.

7 gel emuls of the present invention 1'1 composition C (1,・I-
(Used 71 filtrate phase components as water soluble 1'1 solvent v, 1
, l11 glycol injected / 1-shij, 1, guide 1 kany・ge"+71, for example, bu [l bire/gri: no 11.11, 3-) II badge all ,l, ;3
-buta/diol, 1,1-tukunonol, 1.5
-Penkun/all, +-f-re/Krikor to Y? Dari = 1-l, zo;■-Chile/Cli-I-/l/,l
These include glycol derivatives such as -lyx-f-lene glycol, polyethylene glycol (average molecular weight: 300 or less), and diglobyreno glycol, and one or more of these can be selected and used. In addition to the water-soluble solvent as an essential ingredient, any other water-soluble solvent that is blended into various products such as cosmetics and food may be added as necessary, as long as it does not disintegrate the gel emulsion. can be used.

Nonionic surfactants d1, tl 1 applied to the present invention
The one with the correction value adjusted from 5.5 to 18 is used in combination with one type or more than 2 seconds. H1 edition (value is 5.5 or less)
In this case, the oil phase dissolves in the surfactant phase, and a gel-like emulsion cannot be obtained. On the other hand, if it exceeds 18, the adsorption to the oil phase decreases, and this also does not result in a gel-like emulsion. Specific nonionic surfactants include sorbitan fatty acid ester, polyquine ethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, ethylene oxide 1.4 conductor of glycerin fatty acid ester, and ethylene oxide derivative of propylene glycol fatty acid Nisder. , propylene glycol fatty acid Nisder, polyethylene/dalini! -3 fatty acid ester, polyethylene alkyl ether, polyethylene alkyl ester, ho1)-), -゛/
Globylene alkyl ether, H') O'r/N-1-lene alkyl phenyl ether, Poly-G/n-Tyrene castor/Oil derivative, Polyoxy/Edilene hydrogenated castor/Oil derivative, Polyoxy/N-1-Lenoinoitostanol, Phytosterol r1) 7- is 1-11, and if you can't get the desired thing (!) B:) by changing these - or 14, it's no good to use two or more of them together. , the use in the present invention h4°d, compared to the conventional emulsification method, may be less than 0. ] “J fl(
CF, Jlji' as an oil agent used for small oil phase components.
7;'I of I.

So, squalane, liquid paraffin, Vaseline, olive oil, glycerol tris-2-ethylhexanoe~1, Mic oil, inozolovir myristate, myristyl myristate, octyl totecanol oleinoate, hopoha? Among them, hydrocarbon-based and ester-based oils are particularly preferred, and these are used in combination with triglyceride.

Next, the first step of the present invention (creation of gel emul/yon)
Regarding the reason why the use of water is effective in Jj1, the difference in solubility between when using water and when not using it is shown in Figure 2 by using a phase equilibrium diagram to calculate the individual hetadion MJ: i〈l −]. . As a surfactant, polyethylene ethylene ((shi)oleyl ether), oil agent (fluid Hala 7in), water-soluble g6F:j:
], :(-g'7-ol, - was used. Figure 1i is a phase diagram of a system using 1,3-fritnool as the aqueous phase.
G+ oleyl ether dissolves into each other, giving a colorless and transparent solution. When liquid paraffin is added to this, it will initially dissolve, but the saturation
(The liquid paraffin and 1,3-butane are separated into liquid paraffin and liquid paraffin.There is no definite gel-like emulsion in this branch/singing area.) water)
1iliT of water and 1,3-butanoneol as 111
When used in l-ii-i- ratio, ],;]3-fuku/
When Saw Seal Water Kai + RN Activator Solution Liquid Bacify/Rei is added, it initially forms a colorless and transparent phase (same as Dimension 1).
1. Then, the liquid paraffin is further cooled.
:lt 'iiJ''When it comes to J area, -7<1 in this area
i (,・Lnickel-Jnotonyo1] 6, kel-like - "maru/;1" is colorless and transparent or bluish-white and transparent,)1 '7: ; indicates a state of high viscosity. By adding an aqueous phase to this, a fine oil-in-water emul/con is produced ('V',+). Oil in water Lζ1j Emma 几／YO7ノ(r
l: I can't do it. JJ when only a water-retaining solvent is used as the aqueous phase and when a water-soluble solvent and water are used as f, If river and Y-
The difference in uψ is due to the association of nonionic surfactants (/(=, L
This is thought to be due to the difference in the effects of water on the surface of the oil. This will force the gel-like emulsion to form fine oil droplets. At the same time, the surfactant m1 active agent phase is expanded in the low concentration range.

It has been reported in the literature that nonionic surfactants are difficult to form micelles in water-soluble solvents. (+
'(, Rigamont+, M, T, Ceret
i Mazr, a.

Hiv, Ttal, 5oStanze 0rass
e+ 4L 532 (1970)).

J) J As shown above, a water-soluble solvent and water are mixed to increase adsorption of the surfactant to oil droplets and form a fine gel-like emulsion. (On the other hand, if there is only water, the surfactant will combine indefinitely and form a sweet liquid crystal.Liquid crystals have very high hardness and poor coalescence stability, so the oil phase is mixed into enemy crystals.) Uniform dispersion is often difficult.

) Thus, since the gel-like emulsion according to the present invention is stable against coalescence, it is less subject to restrictions on various conditions in the manufacturing process, such as stirring speed, time, temperature, equipment, etc., and it is easier to create a stable gel. It is possible to manufacture gel-like emulsions and at the same time produce the gel-like emuls/yellows themselves as products. It is an oil-in-water type oil-in-water type produced by adding an aqueous phase to the oil-in-water type, which has even more excellent characteristics. Gel-like cleaners such as CLENE/NCCLINO 3, COOLTO CLEAN, etc. contain a large amount of oil and surfactant 1'1 agents, so this should be wiped off after applying VC to the skin. ironically, it is impossible to wash it off with water, and it is usually only by using water-41-facial cleansers that the remaining chemical-41
You can wash off the contents of one item/) 1. Along with this,
In the case of the present invention, it is possible to easily wipe away internal substances by using only water, instead of using such an aqueous method.

The following is a method for producing an oil-in-water emulsion/container, which is another target of the present invention. If necessary, dissolve the water-soluble additives, add the aqueous phase, and continue to heat the phase for 11 hours.
This is a method of converting a surfactant into water continuously to create an oil-in-water emul.

In other words, the best way to add the aqueous phase component in Unit 4'1'' is to gradually add it.
t V? : In case of failure, assistance such as gentle stirring for a long period of time and strong mechanical force is required, and it is not necessarily effective.
Not only will it no longer be possible to say that it is a typical particle, but the Emul 737 particles that can be used will become larger. r as a water phase component
ll, water alone or a mixed aqueous solution of d2 water and other water-soluble components. As the basic water-soluble 4-component -C,
In addition to the water-soluble solvent used as an essential ingredient in IT, iiLi one-stage gel emul/Yoshi, ordinary water-soluble ingredients used in each product may be used, such as glycerin, diglycerino, sorbitol, and malt. -ol, ethanol, mucopolysaccharide triglyceride, sodium lactate, pantethyl, pyrrolido 7carboxylic acid, and the like.

In this way, the oil-in-water emul/reed obtained through the first step of ``T and 1st'' has uniform particles and is extremely fine.
F'j r'i: A fairly stable formula is provided even under 'ii. frl, some, 'I
Suru 1, 1ri 1j;, Kashi 11, JP-A-1978 5578
．． '(Shijini', ifl, stable A゛Oil-in-water type extremely/Yono's production J<1□10'1'' water-soluble 1'l melted)
1) Make a medium oil emul/reed, then; 7+, "f+)
He uses a method called water test interpretation. Furthermore 1. X11
9. :1・;l n11. + tLi', 'i for the emulsion in the water aqueous solvent ('1., i /+1.1 1, JP-A-51-5578: No. 3)
1! 1, make a middle oil 1 (reemul 7'-J) [-1 using a water-soluble solvent] 3, on the other hand,
In the present invention, water and a water-soluble 1/1 solvent are used [one purpose is to reduce the surface activity by 1/1 and cause the micelles to associate, and to create a continuous phase at the interface without forming liquid crystals. 1, therefore, the gel-like emul/Yoshi V1 represented by (4) in [-E7] is an oil type in the interfacial case, and the water-soluble solvent Nakaura type-T-Mal/Eln is its menononizl.
, are different. 3. Furthermore, the manufacturing method according to the present invention and JP-A-51-5578. The mechanism of method No. 3 is a cat d1, the use of water is an essential condition in the first step, and the use of oil in a water-soluble solvent1. Because it is not Riemal/Yono, Kai [f1 eyes 1'! Glycols and their derivatives that promote the association of I-sex drugs are particularly useful, and the method of JP-A No. 51-5578:3 uses water-soluble compounds and oil in the solvent, so that glycols and their derivatives can be used as essential components. Considering that all water-soluble solvents such as methanol, ethanol, and glycerin can be used, it can be understood that the mechanism of the present invention is different. Thus, the present invention provides a method for producing a good oil-in-water type emul/reed by a unique new method.

In order to subtly demonstrate how fine the oil-in-water emulsion according to the present invention is, an electron micrograph (magnification 4
< : ] (1,000 times) is shown in Figure 3 (omitted).

The composition uses polyoxine ethylene oleyl ether as a nonionic surfactant, 1 paraffin as an oil phase component, and 1. : Tamo (7) using 3-butanediol. As shown in the photo, Yunowa “'71”
&-: extremely fine emulsification of about 0.2μIll
1% I'5 yJ, 6, - Also, the emulsification system is in a closed back state.・Why does this form a gel?

Furthermore, water was added to the oil in the surface-activated cutting phase to form an oil-in-water emulsion /=+7J:L/i-, a microscopic photograph of IIr+ of the J mixture is shown in Figure 1 (omitted). O・111
1' Emulsify using Hatake's 1'--/Et-in-oil method, and further add 10,00081' with a homomixer.
．． Emulsify for 5 minutes and observe the emulsion under a microscope in Figure 5 (omitted). If we compare b' true in Figures 1 and 5 with the ratio axis -1, it is clear that the power of the present invention is several orders of magnitude superior in terms of the size and homogeneity of the proofreading. ,.

In the case of forming the gel-like emul/yono component of the present invention,
As mentioned above, the aqueous phase components 11C, t.
Water, nonionic surfactant, etc. Each component should be adjusted accordingly. Such a composition ratio of 72 minutes, ('C1 water-soluble solvent: 30 to 80 parts, water 20 to 70 parts, interface talk 4'1 ratio 11
:J~80 parts, preferably 210~70 parts each;
U() to ()0 parts, 30 to 60 parts. This range is the optimum amount for obtaining a gel-like emulsion by adding the oil phase; otherwise, it is difficult to form a gel-like emulsion. The amount of oil phase added in the first step is 130 to 95% by weight based on the surfactant continuous phase.
The weight ratio is preferably 70 to 00. This range also provides a gel-like emulsion. but,
From the viewpoint of the purpose of the surfactant, it is important to be able to emulsify the oil phase in a small amount and in a large amount, so a limited range is important in order to obtain a good oil-in-water emulsion. (If a large amount of surfactant is used, an oil-in-water emulsion can be easily formed without using water droplets). ) When adding the aqueous phase components in the second step, it should be noted that, as already mentioned above, it is preferable to gradually add the aqueous phase to the gel emulsion. By gradually adding the aqueous phase components, it is possible to prevent the gel from being dispersed in the aqueous phase in a lumpy manner, and also to suppress the growth of emulsified droplets.

Also, there is no need to set a range for the amount of water phase components added, but oil-in-water emulsions are recommended! The optimum amount tolerated by the patient is used.

The oil-in-water emulsion prepared as described above has very fine emulsified particles of almost 0.95 μl or more, and is generally stable;
Due to the method of δ, it is much more stable compared to IIII Rareda Emarunoko/, especially at high temperatures. int (1111Kfu・
Its stability is unprecedented.

The method for producing an oil-in-water emulsion of the present invention is a simple method that does not require careful and strict setting of the amount of each raw material used and the stirring HJ, and does not require strong mechanical stirring power. There are no current problems of <4+1 due to lot variations in the raw materials used or lack of technical skill among the workers, and it is possible to perform lit production on an industrial scale.

Owing to its advantages, the oil-in-water emulsion according to the present invention can be used in cosmetics, food products, baldness medicines, paints, and various other applications.

Next, an example of the method for producing a gel-like emulsion of the present invention and an oil-in-water emulsion will be described.The content ratio is based on the amount of 7Ir.

Example 1 A water phase component consisting of 4 parts of 1.3-butanediol and 3 parts of n-made water, 1.0% of bitan monostearate, polyogine ethylene (20), sorbitan monostearate-1-71,
A continuous surfactant phase is prepared by heating and dissolving 0% at 100C. Separately, an oil phase component prepared by adding an appropriate amount of preservative to 30% squalane and 20% glycerol tris-2-ethylhexanoate was heated to 70°C, and this was gradually added to the surfactant continuous phase. Create a surfactant continuous phase gel emulsion! Niru.

Example 2 Polyoxyethylene (15) oleyl ether 4 was added to an aqueous phase component consisting of J, 3-butanediol 2, 2% polyethylene glycol (200), and 2% purified water at 70°C.
A crown that is heated and dissolved to create a surfactant continuous phase. Separately, an oil phase component consisting of 60% Squagun, 5 parts olive oil, 5 parts beeswax, and appropriate amounts of preservatives and antioxidants was dissolved by heating at 70°C, and this was gradually added to the surfactant continuous phase. Medium oil gel emul for surfactant/Yono 6-i Uru.

Furthermore, 20 parts of purified water of 7 (1"C) was gradually added to this gel-like emul to form an oil-in-water emulsion.

Example 3 A water phase component consisting of L3-butanediol and 6% purified water was added with polio:quinoethylene (6rl) hardened castor/
4 parts oil, 1 part glycerin dearylphate, 80℃
Prepare a surfactant continuous phase with vortex melt angle (r). Separately, add a preservative of 111° to 0% squalane and 2 parts batyl alcohol, and heat the oil phase components to 80°C. Dissolve it warmly and gradually add it to the surfactant continuous phase to prepare a medium oil gel emulsion for the surfactant.Furthermore, add 50 parts of purified water at 70°C and 4 parts of glycerin to this gel emulsion. A mixed aqueous solution of H is added to obtain an oil-in-water emulsion.

Example 4 4% polyoxyethylene (15) oleyl needle was added to a water phase component consisting of 2% propylene glycol, 2% polyethylene glycol (200), and 2 parts purified water.
A surfactant continuous phase is prepared by heating and dissolving at 0'C. Separately, an oil phase component consisting of squalane fiO%, olive oil 5%, and beeswax 5% to which suitable preservatives and antioxidants were added was dissolved at 70'C for 1N, and this was added to the above-mentioned surfactant continuous phase. Gradually add the medium oil gel emulsion for surfactant.

Actual example 5 Pyrene glycol 2 and 1. :Aqueous phase components consisting of 2 parts of 3-butanediol and 3% of purified water, 1 part of sorbitan monostearate, and 4% of polyoxygen/ethylene (2(1) norbitan monostearate) were dissolved by heating at 70"C. Separately, add an appropriate amount of preservative to 30% Sufuwara 7, 20% glycerol 1-IJ susu-ethylhexanoate, and heat the oil phase components to 70°C. This is gradually added to the surfactant continuous phase to form an oil-in-surfactant gel emulsion.
I. Furthermore, this gel-like emulsion was made into an oil-in-water emulsion by adding 4 JJt+ L of an aqueous solution consisting of 33% purified water at 70'C and 5 parts of 7 norbiol (!)
Le. .

[Brief explanation of drawings]

Figure 1 shows the phase equilibrium diagram at 10°C for the polyoxy/ethylene 7 ((il @leilneydel), :] 3-book/diol fluidity... rough-in system, and Figure 2 1, polyoxy/ethylene (6) oleyl. The phase equilibrium diagram of the ether/17.3-book/diyl/water/liquid paraffin system and the region of gel-like emul/yo/ are shown. Procedural Amendment (Form) December 2, 7, 1980 Director General of the Patent Office Waka 4': Mr. Kazuo Ni ■Indication of the Case 1962 Patent Application No. 93g7 No. 2, Name of the Invention Relationship with Emul/Yo/ and the Case of Person Who Amends Manufacturing Method for Oil-in-Water Emulsion 3 Patent Applicant Address Rokutohe, Yayoi-cho, Shizuoka City, Shizuoka Prefecture Street Name Pola Chemical Industries, Ltd. (Same Date Patent Applicant Name Change Notification (Submitted) 4th Director Address: 3-chome, Kojimachi, Chiyoda-ku, Tokyo Address: First Building Telephone: (26S) 9 Otsu 11.95 Date of amendment order (Japanese: July 30, 1962) 6. Subject of amendment Application, summary 1 ``t + complete description and drawing 7, content of amendment Application μ +, purification of specification and drawings iIF (no barley history in content) Up

Claims (1)

[Claims] 1. One type of glycol or its derivative or d. 2.
A surfactant continuous phase is prepared by dissolving a nonionic surfactant in a water-soluble solvent selected from a water-soluble solvent having a water content ranging from 37 to 82, and then adding an oil phase component. A method for producing a gel-like emulsion comprising obtaining a gel-like emulsion consisting of an oil in a surfactant. 2. Glycol or one of its derivatives or 21
A surfactant continuous phase is prepared by dissolving a nonionic surfactant and an aqueous phase component consisting of a water-soluble solvent selected from 1,000 or more and a water content ranging from 3.7 to 82%, and then adding an oil phase component. At least surfactant A, 1" Gel-like Emano V consisting of medium oil
A method for producing an oil-in-water emulsion, which comprises obtaining an oil-in-water emulsion by adding an aqueous phase thereto to change the continuous phase from a surfactant phase to water to obtain an oil-in-water emulsion.