JPS5932850A - Simplified blood analyzer - Google Patents

Abstract

PURPOSE:To easily perform the analysis of chemical ingredients of varied items in blood in a short time by such an arrangement wherein under a disk to which measuring elements can be installed, an optical means for photometry composed of a light source, filter, lens, reflecting mirror, condenser and optical fiber for transmitting reflected light is provided. CONSTITUTION:A filter 28 which conforms to the nature of a measuring element 14 to be measured is selected by turning a rotary disk 35. Desired light rays obtained from a light source 27 through the filter 28 pass through a lens 29, reflecting mirror 30 and condenser 31 and are irradiated on the back of the measuring element 14, and light beams reflected by the back of the measuring element 14 are transmitted to a light receiving element 33 through an optical fiber 32, and an analyzed value processed by a sensor and automatic arithmetic unit is digitally displayed.

Description

DETAILED DESCRIPTION OF THE INVENTION The invention is directed to a simple blood analyzer.

There are many chemical components of Φ in the blood.

The concentration of these chemical components Q', 'J--as long as the living body is healthy9, it maintains a certain range, or due to disease etc., when the equilibrium state of the living body is disrupted, -h and other components. causes a change in the concentration of For example, the rapid increase in various enzymes during acute 11T inflammation, and changes in serum glial η response during chronic hepatitis.
:'? There's somewhere. Accordingly, measuring the concentration of blood components collected from a living body at 1F (1iff) is a common method of diagnosis, introduction/overobservation, and treatment of diseases.
It is extremely difficult to perform, and has been developed as a blood analyzer for the gods.

(7) However, most of the blood analysis cores that have been commonly used in the past are blood (full surface, serum).

11'lL ji, [) was reacted with the reagent in a liquid state and the change in color of the peaks was measured. Therefore, the number of chemical components of the 1rII solution collected from the same organism (in order to carry out step 11, a large amount of blood was required)
, and the analysis takes time, and the constant value changes at the beginning and end of 1til garden-'. There was a problem with 1il-J.

In the past, devices for the purpose of phase separation of a wide variety of chemical components have been developed, and have been widely used not only in the field of therapeutic medicine but also in the field of preventive medicine. However, such a device had a complicated structure and was expensive, and only a general practitioner could fit in one hand and one shell.

In view of the above points, the book τZ Ming uses a diaphragm-shaped measuring element impregnated with a reagent that reacts with blood components to form a color, and the measuring element absorbs blood into the Daibutsu J-ru I Fuai? We have developed a blood mI easy analysis analyzer vortex that allows analysis of various chemical components in blood to be performed easily and in a short time using a small amount of blood using a simple configuration called f(II light). is intended to provide.

Next, what about this invention? An explanation will be given based on an embodiment shown in Ii.

■ is a constant temperature room that is constantly maintained at a constant temperature (30 to 40"C) by heating stage 2 of a heater, etc., and a disk chamber installed in the center of the second part of humidity room 1. , the bus 5 is exposed to the cross-section of the tray part 4 and the opening/closing lid 5 which is transparent. A ventilation hole 6 is provided in the tray part 4 of this disk chamber 3, and the inside of the greenhouse 1 is heated through the ventilation hole 6. P air is kept convecting inside the disk chamber 3.

7 (:j- iQ in the center of the tray part 4 of the disk chamber 3
If the shell holder 8 is placed in the disk holder f-↑7,
The center of icJ is supported by a shaft 9 which is shaped like ITt.

Otsu's IIl+ 4'r 9 is below as shown in the 41st N, 1 and 5! ! The j11i section is rotatably held at the bottom of the '1αγ product chamber 1 and fitted into the ilk shaft cylinder 1 (-), and is loaded into the shaft cylinder 10 and pressed downward by the screw ring 11. has been done. The shaft rod 9 is held in a vertically elongated hole 12 provided on the side surface of the shaft cylinder 10 via a pin 13 (the range of vertical movement is regulated).
The rotation of the shaft 9 is made so that it rotates in unison with the l1llllll 10.

Reference numeral 14 denotes a disc-shaped measurement element 1, which holds a tape-like part 15 impregnated with a reagent that develops color by reacting with blood components by a flat frame part control 7 having exposed windows 16 and 16' at the center of the top surface. The measuring element 14 is fitted into each through hole 18 of a disk 19 in which a plurality of (six in the figure) through holes 18 are equally arranged on the same circle. This i′lli constant element −f−υ
, JI'lI liquid impregnated with different reagents for each chemical component is prepared, but at least 18 types are generally satisfactory.7.-1. The measuring element is placed in the through hole of the spare disk (not shown).
The thorns were attached and stored in a storage (171 not shown) provided in the constant temperature room (1), and heated to be preheated.

The disk 19 engages with a center hole 20 that can fit into the head 9' of the disc 90 that protrudes from the center of the disk mounting table 7, and a protrusion 2 that projects at an eccentric position of the disk mounting table 7. 111. Engagement holes 22 are provided, one in the disk chamber 3; and 111. This ensures accurate positioning when However, in this embodiment, the disk 19 may be partially rotated by protruding from the front notch 23 of the opening/closing lid 5, so that it can be rotated manually or by being activated. Great, disk 19 is that hole 1.
8, the rotation can be stopped at every 4' angle. As a means for this, in this embodiment, as shown in the fourth figure, a notch means 24 is provided on the lower surface of the 1llll cylinder 10 which rotates integrally with the shaft rod 9.

With the pipette insertion part provided on the opening/closing lid 5 of the 25υ disk chamber 3, insert the pipette into the pipette insertion part 2 (not shown) to insert the pipette into the disc 19.
Two through holes], 811C Φ, are located in the center of the measurement element 14 and are elevated so that blood can be dispensed accurately.

26 is the optical means for photometry where the measuring element 14 measures the 1λ (coupling) of 41 colors in blood. A light source 28G is a filter thrown in front of the light source 27 to separate the light from the light source 27 into the photometric light &1 of the desired wavelength.29
The photometric rays obtained by passing through 28 filters are made into 7 lines, and the photometric rays pass through the 30-member lens 29 and become parallel.

It is a reflector that bends light in the vertical force direction. Partial reflector:
Measurement bent by 30) Y, original side is condensing lens; 3
1 and tl! ,l? I2 disk 19
The light is irradiated onto the sensor 5j-' element 14σ) 111'+ fitted in one of the through holes 18. The irradiated/measured two points ζZj
' + The back of 4...L is the reflected light j, 1) Inside the 11th condensing lens 31 + L4 Sada + lji l, optical fiber thread (
432: The light receiving element 33 k<transmission j,) is transmitted."
, is becoming a sea urchin. The light-receiving element f 33 k(, - this receiving, is / this optical appearance l+lψphantom Jln 1 j・shioi ten'-rio', hi automatic ('Iit calculation system [displayed through the item Small window/16 to 1-=small J1/[).

1#-^i' Fj-+F(/L meta-8C4,531
The chemical composition of the blood that I try to change)
Measurement of zeta-impregnated A・R19 (matches the φ class (also) L (1σ) is also available), and it is necessary
Photometry of wavelength)'(: 11! Set/C multiple 1 hard forest, hole: 3G k(-1+:t〈additional JjiC.However, the through hole 3 of the rotating circle
6 V fl; swampy filter 28 or more σ+r+
It is pivotally supported on the front surface of 27 by a non-circular Jji 1'Qj'lu joint IS37' of horizontal Φ1 + 37 so that (i'/+6).
,”+AAl17:+,l, and iL:lJ/ε double major?
71′.

38) Publication costs? j each 11″ 1 and 7, -
'1 see 111', -C101, there are 10 Ej groups, (-i:c).
nself 1 yellow 11111137 other parts +・i'i'Lj
i Crystal chamber l polarization 1' (・(-stop 11
-,,-1 Formwork: Turn around 39 1・Note 1 and keep 1r 1r
/ζ times 1%, shaft f foil 40U, 1t each, '41) L1
Revised rotation 11 information 1 I 40's 11th surface ((-sue 7 ) to print 1ii1 as shown in j() -C.

43 O, nii 'A*horizontal medium+II :'i 7 no suri 411 lever, 訃" suri jllil shi z bar 131c
1 group 1'll, : or bottom 4 of thermostatic chamber 1 1'IiC central danger Jl, Free State 11 or IT'-T+,, l+ 'i',
) 111 Ten Ente 1 Heat Out) 1) Long Groove 3
Naganuma 1.16 song (with 71 external VC protruding), which was perpendicular to 1. 1 - To the right as shown by the two-dot chain line -
] 11 biu 7 no -, 7j □ 1.1 part is 1) 11 Rotating disc: From 3.1 take out Tawara & J, Fushin 1 Tar 28 is rotated, circle bear and exchange J 婂 come I/i 2 I'm at 7. Agency, this fu 4, JL Jitter 8 is i'lII Yagi Keiho to Soi 3
3's ilj is X'! Even if I let it get worse, yes.

47.4i; i, iii in note + i 4'l No. 1 of 9; Medium solid/ζΦ゛; Two swinging levers with free gear h: locked on the 11th surface of skin body 4 () So;, Chiwa”, 1l
Il Ruba -47, /18 group ☆; 11. U111 (clap to the base 4 noso 50' set up in the crystal room l: +1 FIL
, both) II1σ) Bin 511/This pivot 71i is -
1, 52 1-・force 4) τ′1Φj, lever 17
1st pushbutton to make one stab, s 3 V swinging lever 48 of external force - do not move down - 12 pushbutton (').

These first and second pushbuttons 52, 53C1, ci+
By pressing , (n i,Φ!■-bar'17
゜ Lower the shaft 9 by -1 at 7 through 18, tick, ri 1
9 U-1 Inisukku: 3σ) l・shi・−a4 ni 1 nusaseru/[menoi, noma, aru 1, this disk l 9
Or the disk chamber It71le is densely lengthened to part 4ttt: 1% 1-IIchi,;'4)8t) Small like 1
・Part 41・(”Jike/(]Kun)J sword 11 lJ:
l11j + hole 8', city space: 3 inside (' (protruding L
Cone-shaped cover for condensing light 1, -31 34
(Wa) Blind part U (2l'Ai ~ ryo's back side should be lined up in the same way). Hold the press ζ～) and get 7. Nama 1, [111 1st pushbutton 52 翰en)・Point)・
2 pushbuttons 531 for assay;
If you push the rough l/bar 54 and the 241°2 pushbutton 53 further than the fully pressed state, you will be able to hold the shaft in the pressed state. - so that the rotating lever 55 that acts on
! : 'AI2 Press 5, 5: This is the switch of the light metering light 111 that closes when 3 is pressed.

Next, I will talk about the construction rl-1k.

Douzu, soak 5 of the necessary reagents in blood U analysis 14 / 2. 7 missing, Isk 10 1 [1 Disc chamber installed in the soil of greenhouse 1: 3 open/close λ, 5 open as shown in 11th 17J Power is output from the center of the mounting table 7, and -C is located at the irt'i part 0' of the shaft 4'+9 inside the disk 19) +L
Possible L 2 (L is 1 (Odai I and same II';'1 (7+
, the second engagement hole 22 is engaged with the protrusion 21 . Once the disk 19 is set in this way, close the opening/closing lid 5 of the disc chamber 3, insert a pipette into the pipette insertion part 25 of the opening/closing lid 5, and dispense blood (whole blood y, 1flLr+'i, blood solution). do. This dispensing &d, disk 19 manually (city motion) C
(Yori 1 Go - 17 Tsutsutsu Okino to Ijwa Jshi/). Measure the degree of reaction (10) of the blood that is dispensed into (1), or measure the degree to which the blood reacts (10). Together with Finosi〃-
28S-Turn the rotary disk 35 to select
11 Punishment) l method or J-7 point-to-point assessment or shi-1
・-ノ't+-crab-decided, M! l '8 Ta;71
．． il: il"i:'21 Press button 52, K person presses the second push button 5:3. This is Vtl.
J: So, the swing is 41 degrees, the lever is 47. /18 is 1・dynamic L
7.1 combined, 19 valves up φlb ('t9S-F''I
r. ”・,1′1・
31 cone-shaped (Zl cover: 34)
〉Tokc'-Jru. Buhuisk 1q or Tisfu room: 3's training part 11 and flowers 1',! - If you enter ゛1, it will be N (September 1 switch 57 or C for 1), so (interval star
1. ``Switch 5G'' Kotori (from -) v: Ryo 2
7 emits light, condenses the light, and traces it through the filter 28.
The desired light beam is irradiated with red light from the lens 292, reflecting mirror 30° condensing lens 31, as shown in Figure 8, on the back surface of the external measuring element 14. -Reflected light from the back side of January 1 (・; 1 optical fiber wholesaler: 32 to ilG,
L,, i: Two elements A: -33 Jl, shown] 7 + Sealy and 0 automatic reproduction 14 - 11"l through L = analyzed in the display window 46 (1jj is de, / Tanoshi is displayed.

In this way, Konogi 1. Meiil J, +: Wa Q, 1, Place the disc-shaped measuring element; Turn several through holes into the section-C, 7↑, center the array, and rotate the disk freely. 311
I/(7, 1. In the l force of the disk,) Y, the source, and the) °C4 source 1) set on the 11th plane υ-y and Isui
Photometry of the desired wavelength)', a lens that makes the light 1i11'4 parallel, and photometry to trace the wavelength)Y-condensation. City IL1 direction (
The reflecting mirror 5 has a bending angle of 1, and the reflecting mirror 5 has a bending angle of 1-
7 / this measurement), focus the light and - Z) (7
1. A condensing lens that irradiates the back surface of the 51-element with 11j attached to the through hole, and 2.
Hi'jr+ 1 optical means for side light from an optical fiber assembly that transmits the reflected light from the back surface of the 311 constant element A to the light receiving element f]. A measurement element impregnated with a reagent that develops a reaction color (Ufiffi 7il-i[,
5. This 1llll juice - white liquid on the element (full surface, serum, face serum)
4-Dispensing 7, detail 1111 constant element]' is derogatory to 1
1 ill part fr : 1 pile (norrige r, things to do
7 (more than 171% of sweat serum in the blood)
It is customary to hold a memorial service between the 1st and 6th of the year.

-f/ζ, (1 Motoko Kawaoki's current 11 (1 body: 11 dll [1-! I-) Y, system] The reflected light is efficiently taken out by bending the center 41' of the condensing lens and the palm fiber, which has the effect of increasing the measurement accuracy. .

[Brief explanation of the drawing]

Figure 1 shows an embodiment of the figure +-;
Q;) A perspective view of the external appearance with the opening/closing lid of the test chamber opened.
Measuring Pui 114 (Danger/And Buisuf's printed map, No. 41)
Sentence 1d A front cross-sectional view of the state in which the food is placed in the food room. Parent, Itsu 1, No. (5N41 &, l Store in 2nd push button) l/bar, rotation (1 bar, 1j (shallow 2 state blue) 1, 92z1 glare, in) 7 tnu ike photometry r
+1+1 light film 191゛ top view, Fig. 8+(j times, 1st i
u'+i +trnr 1)≧1, FIG. 3... Tisfu room, 4... Part of l/re, 1/1
...Measuring element, 18...) Front hole, 1! )・
...-Hooisuk, 26...Photometry 111 Optical 1 stage,
27... Hikari East, 28... Neuter +29.
...Lense. :30...reflector, :31...collection) 1'7 le...
:32...Optical A navy blue, 33...Photodetector-r. lPJ Applicant Konishiroku Photo Industry Co., Ltd. Figure 4 Figure 6 Figure 3

Claims (1)

[Claims] A number of through-holes into which a disc-shaped measuring element can be fitted are made at the same 1'i.
-,,,h (rt-tongue arrangement setting (2, Puotode, isk can be rotated freely (7-Water-installed in the prison, one of the disks is light OI; Rehabilitation game 1. (eight people) 011 plane, and the desired - 2 l chairperson's 11 river light/field filter, photometry) 11 - lens that crosses the parallel Q', and the total ton's 5. A reflective nail λ that bends the light beam for d in the vertical direction, a reflective nail λ that bends the light beam for d in the vertical direction, a reflective nail λ that focuses the bent photometric light beam with the reflective mirror
[ζ] For photometry, consisting of a condensing lens that illuminates the back surface of the measuring element, an optical fiber that passes through the center of the condensing lens and transmits the reflected light from the back side of the measuring element to the light receiving element. A simple blood type 4J1 package with an optical means as an A9 key.