JPS5932851A - Simplified blood analyzer - Google Patents

Abstract

PURPOSE:To make it possible to easily carry out the analysis of chemical ingredients of varied items in blood in a short time with a small amount of blood by such an arrangement wherein a measuring element impregnated with a reagent which reacts with an ingredient of blood and develops a color is used, and the degree of color development is photometrically measured. CONSTITUTION:Measuring elements 14, each is impregnated with a reagent necessary for the analysis of blood, are installed in piercing holes 18 of a disk 19, and the disk is set on a disk mount 17 in an isothermal chamber 1 and a small amount of blood (full blood, serum, blood plasma) is poured. The disk 19 is brought to closely contact with the tray unit 4 of a disk chamber 3 and the measuring element 14 is also brought to contact with the conelike cover 25e of a condenser 25c and by this, measuring distance is made constant. Photometric light rays obtained from a light source 27 through a filter 28 are irradiated on the back of the measuring element 14 through a lens 25a, reflecting mirror 25b and the condenser 25c, and reflected light rays are transmitted to a light receiving element through an optical fiber 25d and an analyzed value is displayed on a display window 30 through a sensor and automatic arithmetic unit.

Description

DETAILED DESCRIPTION OF THE INVENTION This invention d relates to a simple blood increment 411 device.

Blood '+'K contains various chemical components.

The concentration of chemical components in torera remains the same as long as it is living or healthy.
Although the range is maintained, if the equilibrium state of the living body is disrupted due to some disease, the amount of the towara component changes by 1ql. For example, in the case of υJ acute hepatitis, various C terms ``1' element f) rapid increase in the number of patients, the rise of chronic hepatitis, [lJl changes in the collagen reaction, etc.]. Therefore, the production of this component can be accurately determined by 6111 1 to determine
Diagnosis of disease 9M, overwatch festival, therapeutic power needle, etc. 7 in total
It is important to perform various blood phase separation devices.
It has been developed.

However, since it is small, it has not been commonly used in the past]' Shitebuko 4 (
Most of the 11 liquid analyzers are blood (all 1 rll)
, , Ir11'/Zan.

Plasma) is reacted with a reagent in a liquid state, and the color change is caused by side effects.Therefore, in order to analyze the multiple components of blood collected from the same living organism, it takes a lot of effort. Den's blood got 8 votes, not just 1, but the analysis is also]
It took 1 time, 1 time at the beginning and end of the measurement, 1 stop and 11 [(or fluctuation - 4 and 1) problems or -6 dimensions. l) I heavy equipment i
'4 is also open to the public, and the field of therapeutic medicine is also referred to as the field of therapeutic medicine.
tc /j-) Since /ξ, such electrical appliances are extremely complex, large-sized and expensive, and require a lot of energy from general practitioners.
It was not something I could resign to.

In this case, I put a disc-shaped measuring element impregnated with a reagent that gives a gray color to the blood, and the meter measuring element. 111 turns dark brown in the blood
．． t51', which is easy to measure in combination and non-photometry, was completed.
←Wl between C1 measurement element and 1lill Mr part
``Release to the deer - 11- In order to accurately measure the light in the fixed position (S A 24t, position [2 digits blood finger jμ.

l(!1 I'll provide an analyzer i'l for the purpose of IJ('l).

Next, I will remove this valve 1; 1 drawing (/(Small J-・Examples) and Illustrated by Shima Akira.

1Q" Is it always jt by the heating means 2 of the heater? Fixed (
7)? Chang degree (30-i o ”e) VXKU
Terasa f'L fl ・1tji etc. 3 has a bifurcated disk chamber in the upper center of 10 vortex chamber 1, total disk chamber 3
It consists of an ID cross-section sheet 1-shaped 1-shi--anatomy 4 and an opening/closing lid 5 for controlling transparency. Training part 4 of this life room 3
1.11・□j air bleed hole 6
Through the air, the air warmed in Yixue 1 enters the disk chamber;
3, the sentence J b'+t- is written as follows.

7 &;J: Turn the through hole 8 in the center of the tray part 4 of the disk chamber 3 (-2 in the disk chamber 3 (mortar!
Exit L7/This unit is equipped with 1 unit, and the unit is controlled by 1 unit.
The center of the stand 7cj is supported by the 11th axis of the rod.
There's one.

This ILB Fume + RJ Shi... 9 as shown in Figures 4 and 5
Child's Master"lh'.

At the bottom of the Atl note, the rotation number 141 is maintained at the bottom of the crystal room.
, R shaft cylinder 1 inch (go fk inserted, as well as
Loaded into the meter barrel 10 (and splitter) - 9i1f pressure is applied to the ground from the -pr. Note that S''' nl,
- 1st lever 9 is the axis J, I) 1ill iAi -
provided/and engaged through a vertically long hole 12 (bin '1;);
While the range of vertical movement is restricted 7, the rotation of the shaft rod 9 rotates integrally with the shaft cylinder 10.

I・1 is a reagent pot/impregnated that develops color by reaction with blood components -m-
- 1. shaped part] 115, 7 - exposed window in the center of the lower surface]
, 6, a plate-shaped measuring element held by a flat frame part 17 having a diameter of 1.6', and a meter measuring element 14&-j
The through-holes 18 of the disk 19 are arranged in a circle (circle), and each through-hole 18 (IC (4ρ) is connected to the through-holes 18 of the disk 19. Hal, 17
There are at least 18 types of reagents impregnated with different reagents, and J'L is almost always WR. The remaining measuring elements are fitted into holes in the spare disk (not shown), and are stored and preheated in a storage (not shown) provided in the constant temperature room 1 (n11).

[) 11th disc 1! A center hole 20 that can fit into the head 9' of the shaft rod 9 protruding from the center of the IJ disk mounting base 7, and a protrusion 2 protruding from the eccentricity M'' bl of the disk mounting base 70. The engagement holes 22 that engage with the respective holes 22 are arranged so that ]゛, A, isk chamber 3f<4', L, k
When the disk I9 rotates, it should be sunk exactly 6''!Iζ1 (1?'-). Part 2:
3 so that it can be moved in one motion, but it may also be made to be able to rotate with the electric motor 1111. ′! It's F.
The disk 10 is adapted to be able to rotate and stop at the corner of the through hole 18 thereof. ζ, and [-2 in this embodiment, the shaft cylinder 1.0 (7
) A lower ini V /tch means 24 is provided.

25i (J through the hole 26 of the shell 110 of the photometer 1 provided in the tray part 4 of the tisf chamber 3 [7, as shown in FIG. 7, the target of the through hole 18 of the disk 19 .

In the photometering section 25 provided, the light is emitted from a light source 27 and is separated by following a filter 28 as shown in Figure 8, and the photometering light beam of a certain wavelength is received by a lens 25a and converted into parallel light beams. , reflecting mirror 251], and the measuring element 14 is focused by the condensing lens 25cV.
The light reflected from the back surface of the irradiated measuring element 14 is collected by the optical fiber assembly 25d which passes through the center of the lens 25c and is taken out to the light receiving element 29. (/(becomes.

：口）kJ, the light is received by the light-receiving element 29, and the received optical information is sent to the computer.
1'' is a display window that displays measured values digitally.

: At 31, there was oil on the pipette insertion part of the opening/closing lid 5 of the J Tisfu chamber 3.
Pipette with the inside (1 1 mark 44-L) or disc 1! -) is fitted into one of the through holes 18 of /
It is positioned at the center of the tube so that blood can be accurately dispensed.

32, 1 the said take 19 in the disk chamber 3 1.1, .
Actuating means for bringing the part 4 into close contact with the first part 4 are shown in FIGS. This disk 19 is secretly placed in the tray part 4 of the vouching chamber 3;
A constant element A 14 is provided in the tray part 4 of the disk chamber 3 as shown in No. 81i''1.
1. The top of the cone-shaped cover 25e that covers the surface of the condensing lens 25c that protrudes from Always keep it constant.
ijE' mountain [19] Fixed L jr R body 35 No1-m1 Vt1 lit mountain Dji, i, , , on the way.

With two swinging tonneaus locking the swinging bars 33 and 34, the bases of the swinging bars 33 and 34 are
l:''Both on the front and rear surfaces of the wall plate 36 installed in the old vortex chamber 1,
j-j! It is pivotally connected via the /37. 31
Swing lever that moves to the front side: 3; 3-
The first push button is moved by 1.'Φj, and the second push button is moved by the swinging lever 3.14 on the rear side by 30V. The first pushbutton 38 is a slide plate that has been lowered along the 111th wall or: U6 t) 11 h > j (1'1 -
Body&lCJAM (=I' kJ et al. note t1, second pusher, / 39 kInlf FtL: ``The slide that hung from the rear of the f-shape 3G (Ah to the upper wheel j of the anti-41,...!, 4. Two numbers A, one digit, 11 integrated through 17
ing. 1) Slide No. 11 on version 40 and 41 (・
: 4, - 1.1・part (/long hole 42, 42' is 1
A bottle 43.
1. Engage with 43'. I'm here. Sliding l-'840 and 41 kl (the protrusion installed at the -F' end) ↑44 and the bottle 15 shelled on the wall plate 3G (-7 b, -spring 4G) 13111 pressure is applied in the m V j direction by
Tell the fl-.

i/r-9-C1 1st pushbutton: 38 in the l-direction V with the line link 16U (if you press it against the resistance, the slide/10
1 Snori: / 49 include A11 frill swing 1 shi bar; U; Chigi: 35 and 1 group 14'19': v Jinshin 11 and Buisuf 1!-
) to the disk chamber; 3 tray part 4 (/(-dense 49'-
)Jru-・Force, 4jii 2nd pushbutton: Press 39) and slide illu・11 to move the rocking bar of (iill); (4 or -1・Direction K 4'5: Dynamic (~, ^11
Part 4 of the training of 19 Rei-Day Squeak 3
υ('X dense 42 -C is. 50 &,
j: a・, 6 As shown in the diagram <r'+i1 2nd Yoshihotan:
] 0 and 1 at the appropriate place on the slide 841;
The stock 1/bar 17 that engages with the concave notch 51 at the ψ1'1^ part, the stop lever 50, and the hole 5()'
l no (' iiu 7 On the back of wall 4 of 36, several phrases are rotatably written on girder bottle 52. 53 (2 I
, strike 7g 1, bar 50's 1, 'rent 1]; slide the part/I, 1 i/? 2L [2J It is a spring that rotates one force in the direction of entering. 54 to 1 said stoff/bar 50's +, radius 11t'c quiet thrust) -1, metering ha 54 &, t,'i') it "B'll + wall 1y
:', To 61 d(・Rita Banono hole 55 i!3
′! Shift and dry 1': 7T protrudes in front of Kiji 3G.

5 (5 pieces: J', Off '7 self 2nd press button 39
Ponna 57 Shiko Free X'tj"1
．． ; Jumen Rei - Spring 58 Shoji, so I-E throw and 77'?
In the two-turn renomy, its base, ), ji; d, bin 56
′ is connected to the wall 36 of the 11th ladle through 2. Count times! li; Lower surface of the free end of the lever 56 (・(' is 1) li
W [cyst tube lever 500), L protrusion J'154
it(X) to be Jγ11V5 (l or υ1 to h).

24th 'i' button 39 from OFF to ON
If you press down on [;, the second press button: 39 and -・
4) 111 or 1 may be lowered, engage the concave notch 51 with the pressure of the n'l it cyst lever, and then slide (111). Hold the state. The slide l-' 4-41
1F Descending C] - Front R1 -: Swing lever: (For 4 cars)
At -2, there is one disk 19 in one part 4 of the disk chamber 3 with two secrets -1-4.

[When the pressing force of the second push button 39 is divided by 1 with the push button 7, the force of the slide M & 411/Crj spring 11) to return to the direction 1' is 1. , Recessed part 51 of Prepar 501 Slide V4.1
When ζ is engaged (-'-1 year old, the stroke of the elongated hole 50' is exceeded! Free bar 1] side of lever 5G
hI tJ commercial stock lever 50 10i/: W thrust 54V (hit, hit.

It's close to each other. Therefore, the second pushbutton 39
If you press it further than the ON state)-r)"' R
1,,: Free movement of the rotating lever 56, 'l゛ surface is pressed 1
17 Rotate downward e and press the upper end of the stock lever 50 described in Aii with the tip ψ11.1 of the abutting lever 59 (),
Struggle bar movement (-7, recessed part 5 of slide lever J 41
I'fli escapes from 1. After that, press the second push button; (
The pressing force of 9 is slightly 1.

), 2 push buttons outside the sub link 46
The state returns to I+power τOFF. 1st, i11, 1st
Oshihotan 3 8 rJ. Mii Ni. :Tisfu 1
9 is also σ, ·, and the second push button 3 9 &. ls]・Tubble lever 50 and (υ) release 1°! Iih lever 5
6 no. Then press the disc 19 into the test chamber 3 (7) part 1 ((7) to bring it into close contact with each other. , galvanized iron 39 phantom rate-]' Essay J11, and the division i+.1 Uto-4
It is used selectively depending on the chemical components of the blood. [TSU 1 out of 60 1: J measurement start switch, (ifB:
ieil 1st, auto) 22 push button: 3 8, 3
! It closes when you press l...11 Mitsugawa Sui, Qi C.

Next, let's talk about the action υ′.

A flat measuring wheel 14 impregnated with reagents necessary for blood analysis.
As shown in No. 31-1, inside each through hole 18 of the buisfu 10 (
Then Ii*h. Next, the disk chamber 19 was placed in the soil of the constant-temperature room I. Close the IJ11 of 3; When the center hole 2o of the rice/19 is fitted into the head 9' of the rice plate 9, the result is the same as 11. +1 name -, the engagement hole 22 is engaged with the protrusion 21. < L, then the valve cover 19 can be set/(ra, close the opening/closing cover 5 of the disc chamber knee 3 8
4. Insert Bipeno 1 from the opening/closing lid 5 and dispense blood (full surface, it'll be clean, then U). For this dispensing, move the disk 19 manually (dispatch) K J
, and do it one frame at a time. Next, measuring element 1
One sample of the blood dispensed in step 4 is measured, and the filter 28 is moved to the rotating disk 62 by +)i+i/ζ-, the properties of the measuring wheel I14 to be measured
Turn 2 to select 2, and then decide whether to use the constant force method, the entoboint assay, or the 1-assay.
), [111 Nagisa d;,, l+ first push button: 38, the latter v'. 1st, 2nd push hotan 30 蓓Jko - tokeru. By this near 1, J'i+. Small・'Ruba 3
3, 311&J-to! 7II'1 shi, φ'I'1
i tree; through 35 (offer at 7 + 19 rod 7, 'i, bring disk 19 close to the tray part 4 of disk chamber: 3, and i7 (, disk 19 The optical lens 25c is brought into contact with the surface of the cone-shaped cover 25e, and the measuring part llilF is kept at a constant angle of 1°.
iql. irill Akagawa Sui Akako Switch 61
'11, then press switch 60 for measurement star -4
゛koto(/(Light from 2 (1 Emperor 27 studies) Y: 1.-,
, A) Y: Desired measurement with j rice Lter 28 bristles in the source)'(: )Y;
'X'2 25" + condenser lens 25c at 1- measurement part -r1/1σ) blade surface (・(-1.

81n! The optical edge Kl+2."+ (l ro 1111(.)

The injury was transmitted to the element 29, and it was not small.
J, Window 3 (l IJL minute jcR 1i key) 1, Ru.

This 51, Ming is as shown in 1- below, the first few transparent [bird times-...
Both (1(勺、Sequence fraud/Koraifu 6 Buisk'+<
Inner (1) Rotatable L horizontally (C), C3, Target of one through-hole in the busk - F'& (2, Total of 7 through-holes ζ1
1) し、／こ 115j. ．． A., the main surface of '' (-lill) li', the light ray is IF, the error (-2, irradiation t- fr i-law force', 1', the opposite body from the extended surface,
1.Receiver/optical element tic' Llv. It; -1'
For il river: Rb far i + iii fi, and i
11 Buisk "Disc chamber 1.-i" 111
(υ(-(l-"1 talent/ko←" group, old K'#r
b. =' a 4 pieces of work ΦI + Fq-□ stage ^ deception Qノ Therefore, each through hole i/(, the blood component element to be analyzed (respectively, each reaction) 1, colored sample mulberry LS attack (Cure the measuring element with ・Cure (c) Analysis of chemical components frequently used in blood n maidservants, easy and short 11^li-i) can be 11 times 0, and the normal value does not change.

Photometry of the measuring element n,',+i/(l) is the measurement element that is fitted and the disk is brought into close contact with the tray part of the disk chamber, so the measuring distance is always kept constant and the measurement accuracy is high. In addition to obtaining normal values, we have installed an actuating means in the tray part of the Tisk chamber that allows for extremely close contact, depending on the component to be analyzed. endpoint assay and rate
This has an excellent effect in that the message can be easily selected by simply operating a button.

4 Zuji no Shou 1 Itk Island 1. The clear drawings show one embodiment of the present invention, and Fig. 1 is a perspective view of the external appearance with the opening/closing lid of the disk chamber opened, and Fig. 2 is a cross-sectional perspective view of the measuring element. A perspective view of the disc fitted with the disc, a front sectional view of the disc in the state where the disc is placed in the disc chamber, a perspective view showing the actuating means of the disc in Figure 5, and Figure 6. FIG. 7 is a cross-sectional view showing the relationship between the photometric section and the measuring element, and FIG. 8 is a cross-sectional view of the second push button and its stop lever.

3...Disc chamber, 4...Train part, 9...
Axis +1.14...Measurement size, 18...Through hole.

19...disc, 25...1ftll, sound j
X, 32...Saku ii, ', -T stage, 33.3
4... Swing lever.

;35...Brim body, 38...First push button,;39
...Second push button, 50...Stop lever.

56...Rotating lever.

Patent applicant: Konishiroku Photo Industry Co., Ltd. Neni 1 Figure 3

Claims (1)

[Claims] (+,) A disk in which a plurality of through holes are arranged in parallel on the same circle is placed horizontally in a disk chamber so as to be freely rotatable. Irradiate the underside of one of the through-holes of the disc with a light metering line (-7) on the back side of the measuring element, and measure the reflected light from the back side of the irradiated measuring element. A simple blood analyzer, which is equipped with a photometric section for taking out the light-receiving element, and is equipped with an operating means for temporarily or continuously bringing the disk into close contact with a tray part of the disk chamber. (2+1) The actuating means described in fi locks the free end to the upper surface of a chain body fixed in the middle of a shaft rod that supports the disk in the disk chamber and is freely movable down 1 lx. Consisting of two push buttons that move each swing lever downward, one of the push buttons is equipped with a stop bar that can keep the swing lever in the lower position, and a rotating lever that touches and removes the stop lever. A simplified blood analyzer b0 according to claim (7), item 1