JPS59214443A - Artificial implant material - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an artificial graft material for bone defect prosthesis or surgery.

BACKGROUND OF THE INVENTION Conventionally, teeth and bone defects caused by various diseases or accidents have been replaced with artificial implants made of metal materials or organic materials. However, artificial implants made of metal have the disadvantage that they are corroded by body fluids and ions in the metal elute into the body (thus irritating the living body.Artificial implant materials made of organic materials) However, these materials have the drawbacks of stimulating the living body and lacking in mechanical strength.Furthermore, since both of the z'A materials described in -1-1 are voluntarily repaired with the bone of an acquainted person, the above-mentioned It is necessary to bind materials to bones.Therefore, in recent years, bioactive substances that spontaneously bind to bones in vivo have been proposed. -145394 Publication and 0 Japanese Patent Publication No. 57-37
Bioactive glasses and ceramics, apatite, calcium phosphate, and the like described in Japanese Patent No. 39 are known as bioactive substances. However, these bioactive substances! It has insufficient strength in shallow areas, so there are some concerns about using it in areas that are subject to heavy loads, such as tooth roots and hip joints.

The present IJI was developed in view of the above-mentioned background, and its purpose is to create a practical artificial implant material that is bioactive and has sufficient mechanical strength even under large loads. It is about providing.

And, in order to achieve the second objective, the artificial implant according to the present invention +
The +Z material comprises a base made of a metal or non-metallic material, at least one bioinert layer made of a bioactive substance covering the base, and a bioinactive layer made of a bioactive substance covering the base. and at least one bioactive layer covering it.

Hereinafter, the present invention will be explained in more detail using the drawings. Figure 1 is a vertical cross-sectional view of the main part showing an example of an artificial transplant, and Figure @2 is a cross-sectional +1ff1 view of the tree.

In both figures, (2) is a substrate made of metal or non-metallic material, (4) is a bioinactive layer covering the substrate (2),
(6) is a bioactive layer covering the bioinactive layer (4).

The substrate 12) is made of stainless steel, titanium, titanium gold, nickel-chromium alloy, cobalt-chromium alloy, cobalt-chromium alloy, etc.
It is made of a material with sufficient mechanical strength, such as a metal material such as a chromium-molybdenum alloy, a cobalt-chromium-nickel alloy, or a nickel-titanium alloy, or a nonmetallic material such as single crystal or polycrystalline aluminum oxide.

The bioinert layer (4) is made of bioinert glass with good chemical durability to prevent corrosion of the base (2) by body fluids! ! , / is made of ceramics. This bioinactive layer f4)ff, the substrate (2) and the bioactive [actual active li′i′1(
In order to alleviate the stress due to the difference in thermal expansion coefficient between 6) and 6), it is preferable that the thickness be increased by 1 inch in consideration of the thermal expansion coefficient.

The bioactive layer (6) consists of bioactive substances such as bioactive glass and ceramics, apatite, calcium phosphate, etc. As a biologically active substance, for biological VC; fjl
j i! I for biological use, such as being carcinogenic or harmful, not irritating to living organisms, and having good compatibility with living organisms.
/1 year old In addition to the basic properties of F, a needle 1 is required that spontaneously integrates with the bone in the living body without the aid of other measuring devices or bonding/IA materials. Bioactive glasses and ceramics are disclosed in Japanese Patent Publications No. 51-8970 and Japanese Patent Publication No. 55-467.
32, JP-A-51'-116809, JP-A-52-94695, JP-A-54-11719
This method is known from Japanese Patent Publication No. 4 and Japanese Unexamined Patent Publication No. 54-138006-zu.

Note that the bioinactive layer (4) and the bioactive layer (6) are not limited to single-layer VC, and may each have a multi-layer structure.

In order to produce the artificial implant of the present invention, first, a substrate (
When using a metal material as 2), this gold 10,000 (the material is pretreated to clean the surface by degreasing, pickling, or blasting, etc.) and the bioactive layer (
6) may be sequentially formed by a dry method using a hollow technique, a wet method, a gas spraying method, a plasma spraying method, or the like. Incidentally, after cleaning the surface of the base (2) made of metal, a suitable oxidation treatment may be performed.

Embodiments of the present invention will be described below: 1.

Example 1 A nickel-chromium alloy was used as the base (2), and O'
(2) As a treatment, it is degreased and pickled with a mixed acid solution of nitric acid and sulfuric acid. As the acid substance for the bioinactive layer 4), 1 ml of chemically durable soda lime glass was used, and the weight ratio was 1 ml of soda lime glass = 100, clay: 5,
Add 0.25% of sodium nitrite, 0.25% of magnesium carbonate, and 50% of water, and mix and grind these to form a slurry. Then, using a wet method, this slurry was sprayed with 2 g of the above-mentioned slurry at a pressure of 9/crl on 2+ rt, dried at 50°C for 30 minutes, and then dried at 950°C for 5 minutes. Baking and bioinactive layer 1
4) is formed to cover the substrate (2). On top of this (spray Abaphyte, dry it, and then heat it to 900 degrees Celsius for 3 minutes to coat it with a bioinactive layer 14) (t
i) form.

As the example base wood 12), stainless steel (5US316L)
]]1j treatment, this is degreased and pickled with a mixed acid solution of nitric acid and cutic acid. Silica glass, which has good chemical durability, is used as the bio-inactive layer (4), and is coated with 100-145. The surface of the substrate (2) is coated with a bioinactive layer (4) by thermal spraying (using 2 materials and gas cutting with oxygen-acetylene combustion gas). Thermal spraying is done using the method of
The substrate (2) coated with the bioinactive layer (4) is further coated with bioactive glass to form a bioactive layer (6).

In both of the above examples, sufficient mechanical strength against the large load of the metal constituting the base body (2) is obtained, and the outermost bioactive layer (6) also provides affinity for the living body. Unfortunately, the fact that the metal constituting the substrate (2) is eaten away by body fluids and the ions in the metal are eluted and stimulate the living body is a biologically inert layer f4) with good chemical durability. Therefore, it is prevented. Furthermore, according to Example 1, a material having a thermal expansion coefficient intermediate between that of the substrate 12) and the biologically active layer (6) is used for the bio-inactive layer (4). The stress caused by the difference in thermal expansion coefficient between the bioactive layer (6) and the bioactive layer (6) can be alleviated. However, as in Example 2, even if a material with a thermal expansion (thread count) outside the above range is applied to the biologically inactive layer (4), cooling of the substrate j2 in the biologically inactive + 141 layer formation step, etc. If you keep the temperature of the material at 7!1j'1 degree (for practical use) and use the completed Jinnoden 1 repair material in areas where there is little temperature change, almost no stress will occur due to the change in quality. Because there is no, there is no interval 1IIfl.

As described below, the artificial implant according to the present invention (type 2) consists of a substrate made of metal or non-metallic material, and glass or ceramic that has good chemical durability and is bioinert. - at least -11-li biologically active outer layer covering the substrate and at least one bioactive layer covering the biologically inactive layer containing a bioactive substance; By configuring it in this way, sufficient mechanical strength from the base and bioactive layer (
Not only can the biological activity 'l']'j'r be obtained, but also the substances constituting the substrate are eaten up by body fluids, and the ions in the substrate are released into the body and stimulate the living body. Irritation is prevented by the fact that the substrate is coated with a highly durable bioinactive layer, which is bioactive and has sufficient mechanical strength against large negative forces. In addition, it is possible to obtain an artificial transplant material that is sufficient for practical use.

In this embodiment, the biologically inactive layer is discarded by a substance having a tensile coefficient M between the substrate and the biologically active layer. Accordingly, stress caused by a difference in thermal expansion coefficient between the base body and the bioactive layer can be alleviated.

4 Brief Description of the Drawings [,y:l Fig. 1 is a vertical cross-sectional view of the main part showing the artificial implant material according to the present invention, and Fig. 2 is a cross-sectional view thereof.

(2); Substrate + t't); Bioinactive layer, ! 6+;
Bioactive layer applicant Minolta Camera Co., Ltd.

Claims (1)

[Claims] 1. A substrate made of a metal or non-metallic material, and at least one layer of glass or ceramics that has good chemical durability and is biologically inert. An artificial implant, an eye, comprising a bioinactive layer and at least one bioactive layer comprising a bioactive substance and covering the bioinactive layer. ? , - The substrate is stainless steel, titanium, titanium alloy,
The artificial implant material according to claim 1, characterized in that it is made of a nickel-chromium alloy, a cobalt-chromium alloy, a cobalt-chromium-molybdenum alloy, a cobalt-chromium-nickel alloy moxibustion-specific thread. 3. The artificial implant according to claim 1, wherein the substrate J1 is made of single crystal or polycrystalline aluminum oxide. 4. The chair according to claims S1 to 3, wherein the bioinactive layer is made of a material having a natural expansion coefficient between that of the base and the bioactive layer. Artificial graft material described in Crab. 5. The artificial implant material according to any one of claims 1 to 4, wherein the bioactive layer is made of bioactive glass or ceramics, apatite, or calcium phosphate.