JPS59213440A - Tableted deoxidizing agent - Google Patents

Abstract

PURPOSE:To obtain a deoxidizing agent to be suitably used for preservation of medicines contained in a small bottle by impregnating a granular material with a metallic halide, adhering iron powder on the surface of the granular material, and tableting the product. CONSTITUTION:1-60pts.wt. metallic halide (e.g. NaCl) is dissolved in 100pts.wt. solvent, and 20-100pts.wt. said solution is impregnated into 100pts.wt. granular material such as zeolite. Iron powder such as electrolytic iron powder having <=50 mesh particle size is adhered to the granule and the product is formed to tablets. Suitable amt. of the iron powder to be used is usually 30-500, pref. 50-200pts.wt. per 100pts.wt. granular material contg. impregnated metallic halide. The tableted deoxidizing agent obtd. in this way has excellent oxygen absorbing cpacity, and is used suitably for preservation of medicines, etc. contained in a small bottle.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a tablet oxygen absorber. More specifically, the invention relates to a tablet-shaped oxygen scavenger characterized in that it is made into a tablet by impregnating a granular material with a gold halide group and adhering iron powder to the surface thereof.

Recently, oxygen scavengers have become popular for use in preserving foods and medicines. When oxygen absorbers are used for food preservation, oxygen absorbers are generally pressure-packed in sachets, but even with these oxygen absorbers in small sachets, pharmaceuticals are usually packed in small bottles. However, it had the disadvantage that it was too large to be used. The present inventors have completed the present invention as a result of intensive research into small tablet-shaped oxygen scavengers.

In the present invention, particulate materials are substances insoluble in water or Alfur, such as diatomaceous earth, perlite, zeolite, activated alumina, silica gel, activated carbon, activated clay,
means other inorganic particulate matter. The size of these particulate materials is generally between 0.1 and 5 mm, preferably between 0.6 and 3 mm.

In the present invention, metals in the metal halide include alkali metals, alkaline earth metals, copper, zinc, aluminum, tin, manganese, and iron.

At least one metal selected from the group consisting of fuvaldium and nickel can be used, and alkali metals and alkaline earth metals are preferably used. Alkali metals and alkaline earth metals include lithium, sodium, potassium, 1gnesium, calcium1. Barium is preferred. In addition, the halogens in the halogen compound trap include chlorine,
Examples include bromine and iodine, but chlorine is preferred.

Specifically, sodium chloride, magnesium chloride, magnesium chloride, calcium chloride, etc. are preferably used. - When impregnating a granular material with metal halide, use water or an aqueous solution of metal halide dissolved in alfur such as methanol, ethanol, propatool, ethylene glyfur, propylene glyfur, glycerin, or an aqueous solution of these furfurs, or halogenated metal. A metal slurry is used. The amount of metal halide in the solution or slurry of the halogen compound (generally 0.1 to 200 parts, preferably 1 to 200 parts per 100 parts of solvent)
There are 60 copies.

In addition, when impregnating granular materials with metal halide, the amount of liquid is preferably such that some liquid remains on the surface of the granular materials so that the iron powder will adhere well to the granular materials later. Although the amount varies, it is generally 20 to 100 parts, preferably 50 to 70 parts, based on 100 parts of the particulate material.

In the present invention, the granular material is impregnated with a metal halide, and some iron powder is sprinkled on the surface of the granular material. is preferably used. Further, the iron powder does not need to be particularly pure, and it can be used even if it contains various impurities as long as the object 1 of the present invention can be achieved.

The strength of the iron powder in the present invention is generally 5[]mes
h or less, preferably 200 mesh or less.

The amount of iron powder used is 1 granular material impregnated with metal halide.
00 parts, generally 30-500 parts, preferably 50-200 parts.

In the present invention, the granular material coated with iron powder has good fluidity as a whole because the liquid existing on the surface of the granular material is absorbed by the iron powder.

However, in consideration of the next tableting process, it is also possible to mix a filler with low water content if further improvement in fluidity is required. Examples of fillers in this case include activated carbon, diatomaceous earth, perlite, cellulose, zeolite, activated clay, activated alumina, finely divided silica gel, alkaline earth metal sulfates, kaolin, silicon nitride, freutaluminol, talc, bentonite, and silica alumina gel. , anhydrous silica, calcium silicate, asbestos, magnesium oxide, natural graphite, aluminum hydroxide, iron oxide, inorganic powders such as mineral powders, and granules are not used from the above-mentioned granules.

In the present invention, the granular material 1 loaded with iron powder is made into a tuplent shape.
ζ゛ is used. In this case, it is more preferable to use magnesium stearate as the lubricant. The tablet-shaped oxygen scavenger thus obtained has an extremely excellent oxygen absorption ability and can be suitably used for preserving medicines and other articles contained in small bottles.

The tablet-shaped oxygen absorber according to the present invention is provided with a holder part for holding the oxygen absorber on the back side of the cap of a small bottle containing medicines, etc., and a small hole is made in the holder to hold a large part of the medicines, etc. The cleaning is preferably carried out by a method of aerating the inside of the holder and storing the tablet-shaped oxygen scavenger according to the present invention in the holder.

Oxygen absorber tab according to the present invention! The shape of the cover is not particularly limited and may be round or square, and if necessary, it may be used in the form of a breathable envelope 5, such as wrapped in paper.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 100 parts of granular No. Ze-lite with a particle size of o, 5% to 1.0: was impregnated with 60 parts of 20% saline solution, and further 2
50 parts of iron powder of 00-400 mesl-+ was mixed and adhered to the surface of the granules to obtain a granular composition with good fluidity. Further, 5 parts of granular zeolite were added to this granular material and mixed. Tablets with a diameter of 9% and a thickness of 41 were obtained using a second tablet press. There is no clogging in the feeder when compressing tablets.
A good tablet was obtained with no adhesion to the surface.

Comparative Example 1 Powdered zeolite 10 with particle size of 200 mesh or less
0 part is impregnated with 60 parts of 20% salt solution, and further 200~
When 50 parts of 400 mesh iron powder was mixed,
A moist, poorly flowing composition was obtained.

Although 5 parts of powdered zeolite was further added to this composition, the properties did not change, and the composition remained wet and had poor fluidity.

When this composition was applied to a tablet machine to obtain tablets with a diameter of 9 mm and a thickness of 4×, continuous tablet compression was impossible due to poor fluidity and clogging in the feeder. Also, the adhesion of powder to the kine.

Furthermore, water oozes out from the surface of the molded tablet.
This caused problems such as adhesion to the equipment.

Test Example 1 The tablets molded in Example 1 and Comparative Example 1 were each placed in a container containing pharmaceuticals (vitamin C @ 1 oy).
There is 1 piece (
o, s, p), and 6 holes with a diameter of 0.5 J were made in the holder to communicate with the drug storage section, and the drugs were stored by sealing with a cap. An oxygen detector, Ageless Eye, was placed in the bottle to check the oxygen removal status.

As a result, the Ageless Eye in the small bottle containing the tablet of Example 1 turned pink in two days, confirming that it had been deoxidized, but the Ageless Eye in the small bottle containing the tablet of Comparative Example 1 turned pink after two days. The Ageless Eye remained blue even after the first day.

The Ageless Eye turns pink when oxygen is 0 or less than 1%, and turns blue when oxygen is more than 0.5%. o-11~0.5
The color between % is purple.

Example 2 Granular activated alumina 100 with a particle size of 0.6% to 0.7%
20 parts of calcium chloride, 10 parts of glycerin, 50 parts of water
120 parts of iron powder with a particle size of 350 mesh or less was added to the surface of the sample to obtain a granular composition with good fluidity.

Further, 10 parts of powdered silica and 5 parts of talc were added to the granules, and a 12×12×5× square tuplet was obtained using a mixing tablet machine. During tableting, good tablets were obtained with no clogging in the feeder (no cracking, no adhesion to the dough).

Test Example 2 The tablet obtained in Example 2 was wrapped in a breathable paper packaging material.
After that, pour the holder into the cap of the small bottle containing the medicine (vitamin C1 tablet 25I).
I put 1 piece (1, 7,?) inside and saved it in the holder.

When the oxygen detector Ageless Eye was placed in the bottle and the deoxidation status was checked, the Ageless Eye changed from blue to pink after three days, confirming that oxygen had been deoxidized.

Patent applicant: Mitsubishi Gas Chemical Co., Ltd. Representative Kazuyoshi Nagano

Claims (1)

[Claims] A tablet-shaped oxygen scavenger characterized by being made into a tablet by impregnating granular material with a metal halide and adhering iron powder to its surface.