JPS5920673B2 - Sesquiterpene derivatives and their production method - Google Patents
Sesquiterpene derivatives and their production methodInfo
- Publication number
- JPS5920673B2 JPS5920673B2 JP11036078A JP11036078A JPS5920673B2 JP S5920673 B2 JPS5920673 B2 JP S5920673B2 JP 11036078 A JP11036078 A JP 11036078A JP 11036078 A JP11036078 A JP 11036078A JP S5920673 B2 JPS5920673 B2 JP S5920673B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- production method
- sesquiterpene
- sesquiterpene derivatives
- mathematical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
【発明の詳細な説明】
本発明は、式：
ＣＨ３Ｃ０Ｏｏ
２５Ｈ３Ｃ−０ＣＯＣＨ３
、Ｈ
、
Ｈ３ＣＣＨ３Ｑ、
２０で表わされる新規なセスキテルペン誘導体及びその
製造法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel sesquiterpene derivative represented by the formula: CH3C0Oo 25H3C-0COCH3, H, H3CCH3Q, 20, and a method for producing the same.
本発明によつて得られる上記目的化合物であるジヒドロ
キシ体１３は骨格の類似している天然物のドリマン型セ
スキテルペン誘導体、例えば夜盗２５蛾（Ａｆｒｉｃａ
ｎａｒｍｙｗｏｒｍ）に対する強力な摂食阻止物質作用
を示すバーバガナール（Ｗａｒｂｕｒ−ｇａｎａｌ）〔
Ａ〕、ポリゴジアール（Ｐｏｌｙｇｏ−ｄｉａｌ）〔別
名タデオナール（ Ｔａｄｅｏｎａｌ）〕〔Ｂ〕等へ容
易に誘導可能と考えられ、これら種３０種の生理活性物
質へ変換する際の重要な中間体と考えられる。The dihydroxy compound 13, which is the target compound obtained by the present invention, is a natural product doliman-type sesquiterpene derivative having a similar skeleton, such as the night robin moth (Africa).
Warbur-ganal is a powerful anti-feedant substance against narmyworms.
A], Polygo-dial (also known as Tadeonal) [B], etc., and is considered to be an important intermediate in the conversion to these 30 physiologically active substances.
醗力゜一。The power is one.
ＣＨ３ＣＨ３
例えば、本発明の化合物（Ｂ）からバーバガナール〔Ａ
〕を合成する経路としては、次の工程を挙げることがで
きる。CH3CH3 For example, from the compound (B) of the present invention to barbaganal [A
] The following steps can be mentioned as a route for synthesizing .
本願発明者らは、先にｔ−アビエチン酸から、コンフエ
ルテイフオリン、イソドリメニン（ＩｓＯｄｒｉｍｃｎ
ｉｎ）等の他、種々のセスキテルペン化合物の合成法を
開発したが、（日本薬学会第９６年会（１９７６年）講
演要旨集第分冊第１９７頁、同第９７年会（１９７７年
）講演要旨集第分冊第１９７頁、特願昭５２−３８６２
８号明細書、特開昭５３−３４７６８号公報参照）更に
ｔ−アビエチン酸の他に広く原料を求めて、種々のセス
キテルペン誘導体の合成法について鋭意研究の結果、β
−ヨノン（１）を原料として用いることによつて、種々
のセスキテルペン誘導体を合成しうる知見を得て、本発
明を完成するに至つた。The inventors of the present application have previously discovered that conferteiforin, isodorimenine (IsOdrimcn
In addition, he developed synthetic methods for various sesquiterpene compounds, including (197th page of Abstracts of the 96th Annual Meeting of the Pharmaceutical Society of Japan (1976), Lecture at the 97th Annual Meeting of the Pharmaceutical Society of Japan (1977)). Abstract collection, separate volume, page 197, patent application No. 52-3862
8 specification, JP-A-53-34768) Furthermore, in search of a wide range of raw materials other than t-abietic acid, as a result of intensive research on synthesis methods for various sesquiterpene derivatives, β
By using -ionone (1) as a raw material, we have obtained the knowledge that various sesquiterpene derivatives can be synthesized, and have completed the present invention.
Claims (1)
処理して式：▲数式、化学式、表等があります▼ で表わされる化合物を得ることを特徴とするセスキテル
ペン誘導体の製造法。[Claims] 1. A sesquiterpene derivative represented by the formula: ▲There are mathematical formulas, chemical formulas, tables, etc.▼. 2 Using a compound represented by the formula: ▲Mathematical formula, chemical formula, table, etc.▼ as a starting material, and treating it with an oxidizing agent to obtain a compound represented by the formula: ▲Mathematical formula, chemical formula, table, etc.▼ A method for producing a sesquiterpene derivative characterized by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11036078A JPS5920673B2 (en) | 1978-09-08 | 1978-09-08 | Sesquiterpene derivatives and their production method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11036078A JPS5920673B2 (en) | 1978-09-08 | 1978-09-08 | Sesquiterpene derivatives and their production method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5536442A JPS5536442A (en) | 1980-03-14 |
| JPS5920673B2 true JPS5920673B2 (en) | 1984-05-15 |
Family
ID=14533797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11036078A Expired JPS5920673B2 (en) | 1978-09-08 | 1978-09-08 | Sesquiterpene derivatives and their production method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5920673B2 (en) |
-
1978
- 1978-09-08 JP JP11036078A patent/JPS5920673B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5536442A (en) | 1980-03-14 |
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