JPS59206352A - Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine - Google Patents

Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine

Info

Publication number
JPS59206352A
JPS59206352A JP8151483A JP8151483A JPS59206352A JP S59206352 A JPS59206352 A JP S59206352A JP 8151483 A JP8151483 A JP 8151483A JP 8151483 A JP8151483 A JP 8151483A JP S59206352 A JPS59206352 A JP S59206352A
Authority
JP
Japan
Prior art keywords
methoxy
ethyl
formula
pyrrolidinemethylamine
sulfamoylbenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8151483A
Other languages
Japanese (ja)
Inventor
Isao Matsushita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiwa Yakuhin Kogyo Kk
Original Assignee
Daiwa Yakuhin Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiwa Yakuhin Kogyo Kk filed Critical Daiwa Yakuhin Kogyo Kk
Priority to JP8151483A priority Critical patent/JPS59206352A/en
Publication of JPS59206352A publication Critical patent/JPS59206352A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as pharmaceuticals, in one step and high yield, by reacting 2-methoxy-5-sulfamoylbenzoic acid directly with 1- ethyl-2-aminomethylpyrrolidine using diethyl cyanophosphate as a catalyst.
CONSTITUTION: The objective 2-methoxy-5-sulfamoylbenzoyl-(N-ethyl)-2-pyrrolidinemethylamine of formula VI can be prepared by reacting the easily available or producible 2-methoxy-5-sulfamoylbenzoic acid of formula I with 1-ethyl-2- aminomethylpyrrolidine of formula II at room temperature, using diethyl cyanophosphate of formula III as a catalyst.
EFFECT: The objective compound can be prepared in a short time under extremely advantageous condition.
COPYRIGHT: (C)1984,JPO&Japio
JP8151483A 1983-05-10 1983-05-10 Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine Pending JPS59206352A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8151483A JPS59206352A (en) 1983-05-10 1983-05-10 Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8151483A JPS59206352A (en) 1983-05-10 1983-05-10 Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine

Publications (1)

Publication Number Publication Date
JPS59206352A true JPS59206352A (en) 1984-11-22

Family

ID=13748450

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8151483A Pending JPS59206352A (en) 1983-05-10 1983-05-10 Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine

Country Status (1)

Country Link
JP (1) JPS59206352A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804265A (en) * 2012-11-08 2014-05-21 江苏天士力帝益药业有限公司 Synthesis and post-processing method of sulpiride or optical isomer thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804265A (en) * 2012-11-08 2014-05-21 江苏天士力帝益药业有限公司 Synthesis and post-processing method of sulpiride or optical isomer thereof

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