JPS59206352A - Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine - Google Patents
Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamineInfo
- Publication number
- JPS59206352A JPS59206352A JP8151483A JP8151483A JPS59206352A JP S59206352 A JPS59206352 A JP S59206352A JP 8151483 A JP8151483 A JP 8151483A JP 8151483 A JP8151483 A JP 8151483A JP S59206352 A JPS59206352 A JP S59206352A
- Authority
- JP
- Japan
- Prior art keywords
- methoxy
- ethyl
- formula
- pyrrolidinemethylamine
- sulfamoylbenzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZOOQKTLLAPMXSL-UHFFFAOYSA-N 3-[2-(ethylaminomethyl)pyrrolidine-1-carbonyl]-4-methoxybenzenesulfonamide Chemical compound CCNCC1CCCN1C(=O)C1=CC(S(N)(=O)=O)=CC=C1OC ZOOQKTLLAPMXSL-UHFFFAOYSA-N 0.000 title abstract 2
- UNRBEYYLYRXYCG-UHFFFAOYSA-N (1-ethylpyrrolidin-2-yl)methanamine Chemical compound CCN1CCCC1CN UNRBEYYLYRXYCG-UHFFFAOYSA-N 0.000 abstract 2
- SQAILWDRVDGLGY-UHFFFAOYSA-N 2-methoxy-5-sulfamoylbenzoic acid Chemical compound COC1=CC=C(S(N)(=O)=O)C=C1C(O)=O SQAILWDRVDGLGY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZWWWLCMDTZFSOO-UHFFFAOYSA-N diethoxyphosphorylformonitrile Chemical compound CCOP(=O)(C#N)OCC ZWWWLCMDTZFSOO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
Abstract
PURPOSE: To obtain the titled compound useful as pharmaceuticals, in one step and high yield, by reacting 2-methoxy-5-sulfamoylbenzoic acid directly with 1- ethyl-2-aminomethylpyrrolidine using diethyl cyanophosphate as a catalyst.
CONSTITUTION: The objective 2-methoxy-5-sulfamoylbenzoyl-(N-ethyl)-2-pyrrolidinemethylamine of formula VI can be prepared by reacting the easily available or producible 2-methoxy-5-sulfamoylbenzoic acid of formula I with 1-ethyl-2- aminomethylpyrrolidine of formula II at room temperature, using diethyl cyanophosphate of formula III as a catalyst.
EFFECT: The objective compound can be prepared in a short time under extremely advantageous condition.
COPYRIGHT: (C)1984,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8151483A JPS59206352A (en) | 1983-05-10 | 1983-05-10 | Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8151483A JPS59206352A (en) | 1983-05-10 | 1983-05-10 | Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS59206352A true JPS59206352A (en) | 1984-11-22 |
Family
ID=13748450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8151483A Pending JPS59206352A (en) | 1983-05-10 | 1983-05-10 | Production of 2-methoxy-5-sulfamoylbenzoyl-(n-ethyl)-2- pyrrolidinemethylamine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59206352A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804265A (en) * | 2012-11-08 | 2014-05-21 | 江苏天士力帝益药业有限公司 | Synthesis and post-processing method of sulpiride or optical isomer thereof |
-
1983
- 1983-05-10 JP JP8151483A patent/JPS59206352A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804265A (en) * | 2012-11-08 | 2014-05-21 | 江苏天士力帝益药业有限公司 | Synthesis and post-processing method of sulpiride or optical isomer thereof |
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