JPS5920210A - Blend and method of preserving dental pulp - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to formulations and methods for preserving and healing dental pulp.

The dental pulp is a delicate connective tissue that is highly enriched with small blood vessels, unmyelinated nerves, lymph vessels, and embryonic connective tissue cells. In this respect, vAflli is similar in composition to other connective tissues throughout the body in that it responds to bacterial infections or other stimuli that involve an inflammatory response.

However, the dental pulp has some unique anatomical features that change the manner and nature of this response. In particular, the calcified walls of the dentin act as tight inclusions for the pulp connective tissue, limiting the amount of normal tissue expansion that occurs due to inflammatory hyperemia and edema. The 11:+1 canal that supplements the pulp enters the tooth through the fine interapical ["]; once the root has been calcified, it develops through the hardened tooth substance and is unable to penetrate this inflamed tissue. Impossible for collateral vascular supply.

In other connective tissues throughout the body, collateral circulation readily develops in the presence of inflammation. The unresponsiveness of the pulpal connective composition to external treatment generally precluded its continued survival even after minor damage, so much of the pulp was left without truly effective treatment.

Most cases of pulpitis are caused by caries where a bacterial infection of the pulp occurs. ll'i results from radical expansion. Pulpitis can also occur as a result of chemical irritation, as seen in treated pulps that have been treated with drugs. This also occurs in intact pulp beneath deep cavities where irritating filling materials have been inserted.

In such cases, these substances percolate and cross the dental tubules into the tooth item. Pulpitis itself can occur in a variety of circumstances, each producing deleterious effects on tA'x 182. It often occurs in those with large carious lesions or those who lack recovery, and the caries recurs.

Pain is induced at the initial stage of inflammation even when the inflammatory response slows down part of the inflammation.

Cold sensitivity is always most pronounced at 1ffJ, and pain persists even after the heat JItlJ intensity has been removed. Sensitivity to both cold and heat is the same in the presence of any type of pulpitis! It is 11
As the amount of tlii increases, the pain becomes more severe. The pain is t! I! ! Celsius can be severe and even increase sharply with changes in body position, such as bending or lying down. When the pulp of a tooth is tested, it shows extreme sensitivity when compared to neighboring healthy teeth. This condition usually lasts until the pulp becomes necrotic and forms an abscess, until the pulp becomes insensitive when tested.

The severe pain seems to be even more severe when the opening to the pulp is small. Pulp compression increases because there is no way for the inflammatory exudate to escape, and general pulpal inflammation spreads rapidly, causing pain and necrosis.

The tooth is not particularly sensitive to percussion until the necrosis has spread beyond the pulp tissue within the tooth. When the opening to the pulp is large, there is less compression-forming machinery. In such cases, the inflammatory response does not tend to spread rapidly and the pain is dull and periodic.

Prior to the present invention, there were no successful treatments for pulpitis. In fact, the consensus was that once pulpitis occurs, the wound cannot heal and results in abscess formation.

When retaining these teeth, the pulp usually requires removal, thorough cleaning, and filling of the pulp chamber and root canal with suitable material. Many drugs have been tried to preserve diseased pulp tissue. Drug-added cement, calcium hydroxide, 1r oxide! , lead and eugenol, steroids, antibiotics, etc. have been used for this purpose, but the success rate with these drugs is very poor in the short term and cannot be recommended even in the long term.

According to the present invention, by adding a few drops of potassium flllate to a zinc oxide-eugenol paste or other suitable vehicle, the formulation reduces most of the pulp degeneration and 1111% when used for coating the dental pulp. It has now been found that the occurrence of tumor formation is prevented. The inventors have previously discovered the surprising effects of potassium nitrate in the context of the treatment of other dental problems, in this regard US Pat. No. 3,863,006 and US Pat.
Please refer to 111:I. However, prior to the present invention, it was not known that the use of potassium nitrate as one of the essential ingredients in the formulation used for coating lIJ #1flli would prevent the occurrence of most pulp degeneration and abscess formation. . U.S. Patent No. 419175
The Gorga-Dental Mesocin publication cited in No. , has been shown to be secured by temporary filling in the crown cavity. However, the subject matter of the present invention is that once If! Since the formulations and treatments of the present invention have little effect when an ulcer begins to form, the aim is to coat the pulp with a potassium nitrate-containing formulation before abscess formation.

In practicing the present invention, the decayed and pulp-containing tooth is first examined clinically because the teeth treated according to the present invention do not have x-ray visible paraapical lesions and are not clinically sensitive to percussion. Confirmed visually and by X-ray examination. Local anesthesia is administered, the cavity is contoured, and the rot is completely removed. The exposed pulp area and its vicinity are then coated with a formulation containing zinc oxide-eugenol paste with a few drops of a saturated aqueous solution of potassium nitrate. Furthermore, H′
In practice, a mixture containing 5 parts of eugenol and 40 parts by weight of zinc oxide is effective. It has been found that the saturated aqueous solution containing potassium nitrate preferably contains about three parts of the formulation so that when the formulation hardens on the gingiva, a permanent recovery is obtained.

Zinc polyacrylate cement has also been found to provide an excellent vehicle for the nitrates for pulp coating purposes. Zinc polyacrylate cement is used for the retention of dental crowns and bridges, and also as a thread material under other restorations. The materials are in viscous liquid and powder form. The liquid is a solution of about 40% polyacrylic acid in water and the powder is primarily zinc oxide with a small amount of magnesium dehydride. The polyacrylic acid acts as a binder for the reactive zinc particles. According to the present invention, when a few drops of water-saturated potassium nitrate are added to the cement, the formulation is highly effective in preventing pulp degeneration and abscess formation when the formulation is used as a coating for the pulp. make. The process can be simplified by using a freeze-dried zinc polyacrylate cement, such as Ceramco (trade name of Johnson & Johnson Company). This cement is a freeze-dried polyacrylate (powder), which is added to other powders (mainly zinc oxide). Instead of adding water to the cement, as is conventionally done, the present invention involves adding thereto a small amount of a saturated aqueous solution of potassium nitrate. It is clear that the consistency of the mixture can be controlled by varying the amount of saturated aqueous solution added to it. The above cement, whether freeze-dried or not, has been found to be a very good vehicle for potassium nitrate pulp coating formulations, and it hardens well over many years with ease into the desired location. , becomes immobile when multilayer recovery is achieved. This cement composition, which also contains potassium nitrate, is suitable for use in dental crowns and bridges because it helps keep the pulp healthy and makes the tooth less sensitive to thermal, tactile and chemical stimuli. It is found that it works well as a cement. Of course other suitable non-toxic cement compositions, such as glass ionomers, zinc oxyphosphate, etc., can also be used as vehicles for potassium 11j1 acid.

11. Under filling the formulation and method of the present invention. When used to cover the # side of a living body, a follow-up test showed that there was no evidence of a lesion with the pointed tip.
It has been revealed that the tooth that has been damaged has been preserved alive. The majority of treated teeth became asymptomatic immediately upon treatment and removal of local anesthesia. In some cases, a cold sensitivity is present for a period of time, which disappears by itself or upon application of the potassium nitrate paste described in the aforementioned US Pat. No. 3,863,006 (column).

Applying potassium nitrate, etc. to diseased pulp tissue - Although the exact physiological response that occurs is unknown, potassium nitrate is believed to heal the pulp by restoring fluid balance and the normal electrical charge to the pulp tissue. It will be done.

The inflammatory response that develops when connective tissue undergoes damage is reduced, resulting in restoration of the connective tissue by one tooth width. When pulp tissue is damaged, histamine and other humoral substances are isolated. They are signals of an inflammatory response that begins with capillary dilation and fibrinogen influx. Fibrinogen clumps and closes the wound. This causes swelling of the tissue. In other parts of the body, the edematous connective tissue has chambers for expansion, but this is not the case in the dental pulp,
This is because it is encapsulated by the mineralized wall of the tooth. Tissue that swells within the calcified chamber that encapsulates the pulp tissue increases intrapulpal pressure. If this pressure is not relieved, the pulp tissue becomes necrotic and an abscess ensues. When my tooth had an abscess for 1! 1 day (",
The present invention is very effective in eliminating the destructive inflammation 111" reaction within the dental plaque and restoring the tooth flifj tissue. However, once the alveolar disease has formed, the present invention is not effective. The present invention provides a much better physiological situation for the restoration of pulp health than is the case with more conventional treatments such as calcium hydroxide preparations, which as a nuisance probably stimulate pathological reactions. It turned out that it would be provided.

Embodying the present invention here! Although we have shown the If constant configuration,
It will be readily apparent to those skilled in the art that various modifications and changes of parts may be made without departing from the scope of the invention and that it is not limited to the particular forms shown herein.

Claims (1)

[Claims] 1. (N) removing existing rot; (B) coating the m pulp with a viscous mixture that hardens to a cement-like hardness; potassium nitrate being an essential component of the mixture; (0) A method of treating pulpitis to prevent abscess formation, characterized in that said mixture is substantially hardened, and (D) causes permanent healing on said mixture. 2. Potassium nitrate, said mixture being in the form of an aqueous solution. and a zinc oxide-eugenol paste. 3. Potassium nitrate 3 in the form of a saturated aqueous solution.
3. The method according to claim 2, comprising a 1R claw part, 5 parts of eugenol...1 part, and a powdered zinc oxide 40 claw part. 4. The method of claim 1, wherein said mixture comprises a zinc polyacrylate cement and water-saturated potassium nitrate. 5. The method according to claim 4, wherein the zinc polyacrylate is freeze-dried. 6. A viscosity that can harden to cement-like hardness, containing relatively little fft of potassium nitrate as an essential component.4. (!I
! A cartilage composition containing Nl. 7. The composition of claim 6, wherein said potassium nitrate is in the form of a saturated aqueous solution. 8. The composition according to claim 7, wherein the viscous 4-organic material comprises a zinc oxide-eugenol paste. 9. The composition of claim 8, wherein said mixture comprises about 3 parts by weight of potassium nitrate, 5 parts of eugenol, and 40 parts by weight of powdered zinc oxide in the form of a saturated aqueous solution. 7. The composition of claim 6, wherein the viscous material comprises zinc polyacrylate cement. 11. Composition 0 according to claim 10, wherein the zinc polyacrylate cement is freeze-dried.