JPS59192366A - Artificial heart valve - Google Patents
Artificial heart valveInfo
- Publication number
- JPS59192366A JPS59192366A JP58067389A JP6738983A JPS59192366A JP S59192366 A JPS59192366 A JP S59192366A JP 58067389 A JP58067389 A JP 58067389A JP 6738983 A JP6738983 A JP 6738983A JP S59192366 A JPS59192366 A JP S59192366A
- Authority
- JP
- Japan
- Prior art keywords
- valve
- artificial heart
- heart valve
- valves
- diamond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（イ）技術分野
本発明は抗血栓性に優れかつ長期間の便用に耐える人工
心臓弁に関する。DETAILED DESCRIPTION OF THE INVENTION (a) Technical Field The present invention relates to an artificial heart valve that has excellent antithrombotic properties and can withstand long-term use.
（ロ）技術背景
弁膜症等の症病にて心１藏弁が機能しなくなった場合、
人工心臓弁を使用して円滑な血液の循環を補助すること
は従来より数多く行われている。(b) Technical background When the heart valves stop functioning due to diseases such as valvular heart disease,
Artificial heart valves have been widely used to assist smooth blood circulation.
現在の人工心臓弁は大きく分けて■生体弁と■非きた。Current artificial heart valves can be broadly divided into two types: biological valves and non-biological valves.
生体弁では石灰の沈着により比較的短期間でその機能を
失う場合がある。一方非生体弁では血栓性が問題となっ
ている。非生体弁の究極的な材料としてパイロライトカ
ーホンが、開発され現在では数多く使用されている。し
かしこの弁においては、下記の問題点が指摘されている
。（１）弁の開閉峙に音が発生する。（１１）血液の流
れが、急激に変化して、血管や弁に応力が加わり、弁が
破損する場合もある。（ｉｉｉ）取り付は部分に血栓が
発生する。Bioprosthetic valves may lose their function in a relatively short period of time due to lime deposits. On the other hand, thrombosis is a problem with non-prosthetic valves. Pyrolyte carphone was developed as the ultimate material for non-biological valves and is now widely used. However, the following problems have been pointed out with this valve. (1) Sound is generated when the valve opens and closes. (11) Blood flow changes rapidly and stress is applied to blood vessels and valves, which may damage the valves. (iii) Thrombosis occurs in the attachment area.
これ等の解決の為に、弁の描込を根本的に改良したいわ
ゆる三尖弁を柔軟性のある材料で作ることも；ｉｒ（み
らｎている。この場合材料は、抗血栓性を工夫した高分
子材料（なかんづく、ポリウレタン系の材料）が用いら
れるが、やはり石灰化等の問題は完全に解決したとは言
いがたい。To solve these problems, it is also possible to make a so-called tricuspid valve, which has fundamentally improved valve drawing, from a flexible material. In this case, the material has antithrombotic properties. Although devised polymeric materials (such as polyurethane-based materials) have been used, it is difficult to say that problems such as calcification have been completely solved.
ビ１） 発明の開示
本発明は上述の既存の種々の問題点を解決するため提案
するものである。本発明は高分子材料を基体としダイヤ
モンドもしくは非晶質カーボンを被覆した材料を心ル１
↓弁として使用することにある。ダイヤモンドもしくは
、非晶質カーボン膜は炭化水素ガスをイオン化した蒸着
法で得られる現在公知の手法である。プラズマＣＶ Ｄ
法、イオンビーム蒸着法、スパッタリング法等いづれの
場合ニモ結晶質のダイヤモンドと非晶質のカーボンがで
き得るがこれ等が混合した組成もｉ＋Ｊ能である。B1) Disclosure of the Invention The present invention is proposed to solve the various existing problems mentioned above. The present invention is based on a material made of a polymeric material and coated with diamond or amorphous carbon.
↓It is used as a valve. Diamond or amorphous carbon films are currently known to be obtained by vapor deposition using ionized hydrocarbon gas. plasma CVD
Nimo crystalline diamond and amorphous carbon can be produced by any method such as ion beam evaporation, ion beam evaporation, or sputtering, but a composition in which these are mixed also has i+J properties.
発明者はこれ等の膜は驚くべきことに血栓や石灰沈着に
対し良好な性質を持つことを発見し、本発明に至ったも
のである。The inventors have surprisingly discovered that these membranes have good properties against thrombus and calcification, leading to the present invention.
本発明は基材が柔軟性があることが、先述のパイロライ
ト裂人工心１１ｉＡ弁の欠点のいくつかを補うものであ
る。パイロライト製人工心ｊ藏弁の如きバタフライタイ
プとする場合は、音の発生や弁の破損事故を防ぐことが
でき、抗血栓性が単に向上するばかりでなく埋入用金具
が、高分子材料になることによって全体の生体適合性も
向上する。むろん本発明は三尖弁として用いた場合は特
に効果が高い。本発明を実現するにはダイヤモンドもし
くはダイヤモンド状炭素を蒸着する工程が必要とされる
がこの方法は公知のイオンビーム蒸着法、高周波分解法
、ＣＶＤ法等のいづれの方法もその効果に変わりはない
。しかし基材高分子材料そのものに損傷を与えない為に
は基材を高温としない方法が適することはｌ−ｉ”うま
でもない。基材の高分子材料は、元素生体適合性に優れ
たものが好ましい。The flexibility of the base material of the present invention compensates for some of the deficiencies of the Pyrolite Cleft Artificial 11iA valve described above. When using a butterfly type artificial heart made of pyrolite, such as the Kura valve, it is possible to prevent noise and damage to the valve, and not only the antithrombotic properties are improved, but also the implantation fittings are made of polymeric material. This also improves overall biocompatibility. Of course, the present invention is particularly effective when used as a tricuspid valve. In order to realize the present invention, a step of vapor depositing diamond or diamond-like carbon is required, but the effectiveness of this method is the same regardless of the known methods such as ion beam vapor deposition, high frequency decomposition, and CVD. . However, in order not to damage the base polymer material itself, it goes without saying that a method that does not heat the base material to high temperatures is suitable.The base polymer material has excellent elemental biocompatibility. is preferred.
なぜなら長期間の使用によりダイヤモンドもしくはダイ
ヤモンド状炭素に何らかの損１ｖＪが、あっても急激に
弁の使用に支障をきたすことがない方がよいと考えられ
る故である。従ってポリウレタン系、シリコーン、チク
ロン等が好適である。This is because it is thought that even if the diamond or diamond-like carbon has some kind of loss of 1 vJ due to long-term use, it is better not to suddenly impede the use of the valve. Therefore, polyurethane, silicone, Zyklon, etc. are suitable.
実施例１
ポリウレタンにて２５２”）ＪＷ ×４２Ｊ＃ＪＩの円
板を作成し、ポリウレタンで作ったマウントに納めた現
在最も一般的なり一３弁タイプの心１藏弁を作成した。Example 1 A disk of 252"JW x 42J#JI was made of polyurethane, and a 1-heart 1-heart valve of the currently most common 1-3 valve type was created, which was housed in a mount made of polyurethane.
−こ
方ンのポリウレタンを予め部品ごとにＣ２’Ｈ６ガスの
高周波分解法で非晶質炭素膜を約２５μ被覆しておいた
ものを本発明とした。これ等を羊の心臓に埋めこんで耐
久テストを行った。パイロライトカーボン製の１３−３
弁は１１Ｅ＋間の使用で血栓による血流障害が発生した
。これは血栓に対する予防剤を使用しなかった為で、従
来から指摘されている問題である。弁周辺からの血栓の
発生に起因しているとみられた。一方ポリウレクンのみ
の弁は２５日の使用でカルシウム沈着による血流障害が
発生した。これ等に対し本発明品は、１２０日の使用後
も障害はなく弁開閉時の音の発生もパイロライトカーボ
ン製のＢ−５弁に比べほとんど無視できる程であった。- The present invention was made by coating each component of this polyurethane with an amorphous carbon film of about 25 μm using a high-frequency decomposition method using C2'H6 gas. These were implanted into the heart of a sheep and tested for durability. 13-3 made of pyrolite carbon
Blood flow disturbance due to thrombus occurred when the valve was used for 11E+. This is because no preventive agent against blood clots was used, and this is a problem that has been pointed out in the past. It appeared to be caused by thrombus formation from around the valve. On the other hand, a valve made only of polyurethane developed blood flow disturbance due to calcium deposits after 25 days of use. On the other hand, the product of the present invention had no problems even after 120 days of use, and the noise generated when opening and closing the valve was almost negligible compared to the B-5 valve made of pyrolite carbon.
Claims (1)
被覆して成る人工心１藏弁。 （２、特許請求の範囲第（１）項において該高分子材料
はポリウレタン、テフロンであることを特徴とする人工
心臓弁。(1) An artificial heart made of a polymeric material coated with amorphous carbon or diamond. (2. An artificial heart valve according to claim (1), characterized in that the polymeric material is polyurethane or Teflon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58067389A JPS59192366A (en) | 1983-04-15 | 1983-04-15 | Artificial heart valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58067389A JPS59192366A (en) | 1983-04-15 | 1983-04-15 | Artificial heart valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59192366A true JPS59192366A (en) | 1984-10-31 |
| JPS6344378B2 JPS6344378B2 (en) | 1988-09-05 |
Family
ID=13343579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58067389A Granted JPS59192366A (en) | 1983-04-15 | 1983-04-15 | Artificial heart valve |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59192366A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043790A3 (en) * | 1999-11-10 | 2002-05-02 | St Jude Medical | Medical article with a diamond-like carbon coating |
| US7963942B2 (en) | 2006-09-20 | 2011-06-21 | Boston Scientific Scimed, Inc. | Medical balloons with modified surfaces |
| US9526814B2 (en) | 2006-02-16 | 2016-12-27 | Boston Scientific Scimed, Inc. | Medical balloons and methods of making the same |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06163122A (en) * | 1992-11-26 | 1994-06-10 | Nec Corp | Multi-way connector |
| JPH06163123A (en) * | 1992-11-26 | 1994-06-10 | Nec Corp | Multi-way connector |
| JPH06188048A (en) * | 1992-12-18 | 1994-07-08 | Nec Corp | Multipolar connector |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566358A (en) * | 1978-11-08 | 1980-05-19 | Fydelor Peter John | Surgical plastic material that biologically has compatibility |
-
1983
- 1983-04-15 JP JP58067389A patent/JPS59192366A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566358A (en) * | 1978-11-08 | 1980-05-19 | Fydelor Peter John | Surgical plastic material that biologically has compatibility |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001043790A3 (en) * | 1999-11-10 | 2002-05-02 | St Jude Medical | Medical article with a diamond-like carbon coating |
| US6761736B1 (en) | 1999-11-10 | 2004-07-13 | St. Jude Medical, Inc. | Medical article with a diamond-like carbon coated polymer |
| US9526814B2 (en) | 2006-02-16 | 2016-12-27 | Boston Scientific Scimed, Inc. | Medical balloons and methods of making the same |
| US7963942B2 (en) | 2006-09-20 | 2011-06-21 | Boston Scientific Scimed, Inc. | Medical balloons with modified surfaces |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6344378B2 (en) | 1988-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huang et al. | Hemocompatibility of titanium oxide films | |
| US6761736B1 (en) | Medical article with a diamond-like carbon coated polymer | |
| JP3859712B2 (en) | Prosthetic heart valve with a larger lumen | |
| DE60214513T2 (en) | PROCESS FOR SURFACE MODIFICATION | |
| SCHOEN | Cardiac valve prostheses: pathological and bioengineering considerations | |
| CA2186375A1 (en) | Improved blood contact surfaces using endothelium on a subendothelial extracellular matrix | |
| Clarotti et al. | Modification of the biocompatible and haemocompatible properties of polymer substrates by plasma-deposited fluorocarbon coatings | |
| WO1996007444A1 (en) | Method of making fibrin coated substrates | |
| JP2011152447A (en) | Implant | |
| Parker et al. | The biocompatibility of low temperature diamond-like carbon films: a transmission electron microscopy, scanning electron microscopy and cytotoxicity study | |
| JPS59192366A (en) | Artificial heart valve | |
| Kambe et al. | Short‐term evaluation of thromboresistance of a poly (ether ether ketone)(PEEK) mechanical heart valve with poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC)‐grafted surface in a porcine aortic valve replacement model | |
| Angell et al. | Porcine valves | |
| Sessler et al. | Tribological behavior of TiC thin films grown by pulsed laser deposition (PLD) | |
| Pizzoferrato et al. | In vitro biocompatibility of a polyurethane catheter after deposition of fluorinated film | |
| Fedel | Blood compatibility of diamond-like carbon (DLC) coatings | |
| Bokros | Carbon in medical devices | |
| Tieszer et al. | XPS and SEM detection of surface changes on 64 ureteral stents after human usage | |
| Bambauer et al. | Long‐term catheters for apheresis and dialysis with surface treatment with infection resistance and low thrombogenicity | |
| Mazzocchi et al. | PDMS and DLC‐coated unidirectional valves for artificial urinary sphincters: Opening performance after 126 days of immersion in urine | |
| KR102131101B1 (en) | Method for preparation of ePTFE-based artificial vessels with enhanced hemocompatibility via selective plasma etching | |
| Mhic Iomhair et al. | Effect of film size on production of foreign body sarcoma by perforated film implants | |
| JPH0360B2 (en) | ||
| EP0783328B1 (en) | Method of improving mechanical heart valve prostheses and other medical inserts, and products manufactured in accordance with the method | |
| Suzuki et al. | Ion implantation into collagen for the substrate of small diameter artificial grafts |