JPS59175428A - Cariostatic agent - Google Patents

Abstract

PURPOSE:To provide a drug for oral cavity application, useful as a cariostatic agent free from side effects and having extremely high safety, by using a lactone as an active component. CONSTITUTION:The objective agent contains a lactone (e.g. d-decalactone, d- dodecalactone, d-undecalactone, d-tridecalactone, d-tetradecalactone, etc.) as an active component. The antibacterial activity of lactone to Streptococcus mutans causing caries is relatively low compared with an antibiotic substance, erythromycin; however, there is no side effects (disturbance of the microflora in the body, emergence of resistant strain, etc.) of antibiotic substances because the compound is a high-safety flavor component used widely in food industry, etc., and the agent can be administered continuously for a long period absolutely without problems. Since the agent inhibits the growth of Streptococcus mutans at an extremely low concentration, a cariostatic effect can be attained by the use of only a slight amount of the compound. It is used as a flavor of gargle, troche, dentifrice, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION This invention relates to anti-nodule agents, oral agents that prevent and even arrest the progression of nodules.

In recent years, the prevalence of nodules and tooth decay has increased significantly, and it has developed into a major social problem.

Meanwhile, research into the causes of nodules is also progressing, and the current theory is that the sucrose in food undergoes changes due to the action of nodule-causing bacteria, producing insoluble and sticky glucan. It is said that there is. The glucan thus produced causes nodule-causing bacteria to adhere to the tooth surface and multiply, forming dental plaque. Using this plaque as a base, bacteria within it generate acid through sugar fermentation, and this acid causes nodules to develop. To prevent nodules, there are ways to increase tooth resistance, eliminate sucrose or use sweeteners instead of sucrose, break down insoluble glucan produced from sucrose, or prevent glucan production or nodule. Possible methods include eradicating the causative bacteria. Each of the above methods has its own advantages and disadvantages, but since the essence of nodule is an infection caused by nodule-causing bacteria, eradicating the nodule-causing bacteria is the most effective way to prevent 1st erosion. Conceivable. The above bacteria include Streptococcus mutans
Streptoc
occus Sanguis). Many attempts have been made to eliminate such nodule-causing bacteria in order to prevent nodules. For example, efforts are being made to use antibiotics such as penicillin and erythromycin, cell wall lytic enzymes that dissolve the cell walls of nodule-causing bacteria, and disinfectants such as cyclohexidine. However, these have problems in that they disrupt the natural bacterial balance by disrupting the intraluminal and intestinal flora, and also cause side effects. Since the problem of such side effects has not yet been solved, it has not been widely used. Therefore, the reality is that there is no definitive method for preventing nodules, and no preventive method has been established that is superior to the physical method of cleaning with a towel after meals. It is.

In view of these circumstances, the present inventors (d.
While conducting a series of researches, he got a hint from the fact that certain fragrances have antibacterial effects, and investigated the possibility of using fragrances as binders, targeting a huge number of fragrances and conducting research over a long period of time. We have carried out a series of research over the years. As a result, it was discovered that lactone, which is used as a flavoring agent, has an excellent bactericidal effect on nodule-causing bacteria, and the present invention was achieved. That is, the gist of the present invention is an antidepressant characterized by comprising a lactone.

As described above, the greatest feature of this invention (d) is that an extremely safe fragrance ingredient with no side effects is used as a welding agent.

Next, this invention will be explained in detail.

Heretofore, there have been reports that natural essential oils and some of the active ingredients of natural essential oils have antibacterial effects against Escherichia coli, Shigella, and the like. However, there are few reports regarding the antibacterial properties of flavoring agents such as lactones. Therefore, as a first step, the present inventors measured the antibacterial activity against Streptococcus mutans using a relatively widely used lactone. The antibacterial activity of each lactone is
Add this to heart infusion medium containing 5φ sucrose at a ratio of l/l 00 to 1/1000 (5% alcohol solution (test component)). ) concentration is 1/100 to l/100
Streptococcus mutans RIMD.
8125"001) was punctured and cultured at 37°C for over 72 hours, and the growth of the bacteria in the medium and on the surface of the medium was observed and measured. Those with anti-Streptococcus mutans activity are as shown in the table below. Streptococcus mutans has anti-Streptococcus mutans activity, which means that when the test components are added at a ratio of 171,000 to 171,000 and cultured at 37°C for 72 hours or more, no growth of mutans is observed. Then, the concentration of the test component is gradually diluted, and the reciprocal of the minimum concentration (effective growth inhibitory concentration) at which anti-Streptococcus mutans activity is observed, for example, when the concentration of the test component is 1/1000, the reciprocal is determined. 1000 was shown as the anti-Streptococcus mutans activity value.Similar experiments were conducted using Atsuboku extract, Magnolol, the active ingredient of Atsubaku extract, and erythromycin, an antibiotic that has a bactericidal effect against Streptococcus mutans, as subjects. The lactones listed in the table are equivalent to or better than Koboku extract (see Japanese Patent Application Laid-open No. 57-85319), which is known as an anti-nodule agent. shows B. tans activity.

As described above, the binding agent of the present invention does not cause any side effects because it is made of highly safe flavor components that are widely and actually used in the food industry and the like. That is, the anti-fluxing agent of this invention has a slightly lower anti-nodulation effect than the antibiotic erythromycin, but since the anti-fluxing agent of this invention is not an antibiotic, it does not have the same effect as that found in antibiotics. There are no side effects (disturbance of the body's microflora, appearance of resistant bacteria), and there is no problem at all even when used continuously for a long period of time. Furthermore, since the welding agent of the present invention can inhibit the growth of Streptococcus mutans at an extremely low concentration, a large anti-orchidial corrosion effect can be obtained with a small amount of use.

As described above, the binding agent of the present invention is a fragrance ingredient and can be used in mouthwashes, troches, and toothpastes because it has excellent anti-orchidial effects even when used in a small amount.

It not only adds flavor to chewing gum, but also has an anti-knot effect. Moreover, its use does not cause any side effects unlike those of conventional antibiotics, and it is highly practical as it can withstand long-term continuous use.

Next, examples will be described.

〔Example〕

d-decalactone, d-dodecalactone, d-undecalactone, d-)ridecalactone, d-) listed in the previous table
- When we investigated the effective growth concentration of tetradecalactone against S. mutans, we found that
Its effective growth concentration concentration is. oo (anti-Streptococcus mutans activity 4000). This mixture has a strong milk flavor, and its 5% alcohol solution has a concentration of 10
Even when I added it to my sucrose solution at a ratio of 1 part to 1 part and put it in my mouth, I did not feel any discomfort or irritation. The arithmetic mean anti-Streptococcus mutans activity of the above lactones is 1600, and the anti-Streptococcus mutans activity of the mixture of the above Examples is much higher than that, which indicates a synergistic effect due to the mixture.

Patent applicant Kanebo Foods Co., Ltd.

Claims (2)

[Claims] (1) An anti-nodulation agent characterized by comprising a lactone. (2) The lactone is at least one lactone selected from the group consisting of d-decalactone, d-dodecalactone, d-undecalactone, d-tridecalactone, and d-tetradecalactone. 1
Anti-nodulation agent as described in section.