JPS59151059A - Data processor for chromatograph - Google Patents

Abstract

PURPOSE:To correct a table for qualitative determination in compliance with an analytical condition and to permit easy handling of a data processor for a chromatograph by providing a commander for adjusting a holding time to a control commander and changing the content of a factor table. CONSTITUTION:When a commander 8 for adjusting a holding time provided to a control commander 7, the content of a factor table in a factor table storage 13 in a parameter storge 4 formed preliminarily by a factor table former 12 is changed via a CPU1, a control instruction storage 6, etc. The direct use of the factor table is made possible by the desired correction meeting the analyzing condition of the table for qualitative determination and the data processor for a chromatograph is made easy to handle.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a data processing device for chromatography, and more particularly to a data processing device capable of converting a fixed qualitative table into a flexible European method.

In chromatographic analysis, the analytical column used and its column temperature are constant, and the key y IJ Agus (
In a liquid chromatograph, if the flow rate of the solvent is constant, the retention time of the separated components is always constant. Therefore, the correspondence between retention times and separated component groups can be made into a table and used as a qualitative table. In a chromatographic data processing device, this qualitative table is often used for qualitative purposes under the name of a factor table. However, this factor table promises to equate - components with one time, and expresses it in absolute numbers. That is, to give an example,
Under certain analytical conditions, if the retention time is 1.5 minutes, benzene,
If it takes 3.0 minutes, it will be toluene, etc.

Once this factor table is created, it can be used as long as the analyzer does not deteriorate. However, this holding time may be completely deviated due to various reasons. In this case, p1 cannot be qualitatively determined because it cannot correspond to the factor table. There are various possible causes for this lack of correspondence, but in any case, the retention time of each separated component determined by the data processing device will either become faster or slower. Also, some analyzes have hundreds of components in the l table, and if this factor table becomes unusable, the g
It takes a lot of effort to make one.

The purpose of the present invention is to create a qualitative table that is created in advance.
To provide an easy-to-handle chromatographic data processing device that can be used widely in summer with a slight modification.

An embodiment of the present invention will be explained with reference to FIG. 1 is the central processor, 2 is the peripheral device connector, and 3 is the signal data quality +:i
fl 4 is a parameter store, 5 is a retention time adjuster, 6
is a control command storage, 7 is a control command, 8 is a retention time adjustment command, 9 is an output device, 0 is an A/D converter, 11 is an analysis start command, 12 is a factor table creator, and 13 is a factor table store. A chromatographic data processing device having the above configuration will be explained.

Chromatograph 8 from analytical instrument via A/JJ converter lO
The signal is converted from an analog signal to a digital signal and enters the central processing JM unit IK via the peripheral device connector 2. Then, the retention time of each component is converted into data in a predetermined format according to a command in the control command storage 6, and the data is stored in the signal data storage 3. This operation is repeated until all components in the sample are detected, and a chromatogram as shown in FIG. 2 is obtained.

On the other hand, a qualitative factor table is created by the factor table creator 12 in the control command unit 7 as shown in the factor table 27 in FIG. is stored in The retention time of each separated component is determined by the analysis start command unit 11.
The signal is measured from the starting point, and the time at the best point of the peak height of each separated component is registered as the retention time and stored in the signal data storage 3. When all the components have been separated and the analysis has been completed, the central processor 1 refers to the data in the Fat = number data storage 3 and the factor table in the parameter storage 4 according to the command from the control instruction storage 6, and performs qualitative analysis. Let's do it.

Qualitative determination becomes possible when the retention time in the factor table 27 and the retention time of the separated components match. However, as mentioned above, if the analyst messes up the timing of the start of analysis and the timing of the injection point, for example, as shown in the abnormal chromatogram 24 shown by the dotted line in Fig. 2, the retention time of each separated component will change to the original time. It becomes longer by (TRO' - TRO).

In this embodiment, in such a case, a holding time adjustment command device 8 is used in the control command device 7 shown in FIG.
TRO) input the difference. That is, in the abnormal chromatogram 24 in FIG. 2, the retention times of all components are (T+zo,
Therefore, the factor table 27 shown in the figure can be used as follows.

Retention time BENZENE TRI (TRO'-'I'R
O) TOLUENE '142 (TRO' -T
RO)P XYLENE TJ13-('l'no'
TR0)0-XYLENE T R4('1
1"RO' -T RO) Therefore, the number in parentheses is the first
Input more than the holding time A setting command unit 8 shown in the figure. To adjust the time at this time, enter the number by adding a + (time addition) or - (time subtraction) sign to the number. In addition, there is a retention time adjuster 5 in the control command storage 6 shown in FIG. 1, which adds or subtracts the numerical value set by the retention time adjustment command unit 8 to the factor table for qualitative purposes. It is something. The output device 9 in FIG. 1 performs quantitative calculations based on these qualitative results and outputs the results.

In Fig. 2, 21 is chromadoguzim in normal condition, 22
23 is a data processing start point during normal times, 23 is a sample injection point during normal times, 24 is an abnormal chromatogram, 25 is a data processing start point during abnormal times, and 26 is a sample injection point during abnormal times.

The factor table 27 is created by the retention time adjustment command unit 8VC shown in FIG. 1, and is stored in the factor table storage 13.

According to this embodiment, since the time of the qualitative factor table once created can be corrected and used, analysis can be performed without worrying about the sample injection timing.

As described above, according to the present invention, it is possible to eliminate wasteful analysis due to injection errors, etc. by only correcting the time of the entire table without correcting the individual times of the factor table once created.

[Brief explanation of drawings]

FIG. 21 is a +'4 diagram of the present example, and FIG. 2 is a diagram showing a chromatogram and a factor table. 1...Central processor, 3...Signal data storage device, 6.
...Control command storage, 7.Control command device, 9..Output device, 12..Factor table creator, 13.
...Factor table storage, 24...Abnormal chromatogram, No. /[] /3

Claims (1)

[Claims] 1. A/D converter, central processor, data storage. In a chromatographic data processing device consisting of a control command storage, a control command unit, and an output device, a qualitative table to be used for qualitative analysis is created in advance using the control command unit, and the entire table is analyzed. 1. A data processing device for chromatography, characterized in that an input command device is provided in a control command device for making a variable table according to a state.