JPS59122955A - Automatic biochemical analyzing apparatus - Google Patents

Abstract

PURPOSE:To enable accurate analysis by reducing the interfrence of the other reagent and the residual component of an object to be examined, in performing portionwise injection because of the presence of an item to be analyzed after portionwise injection is not performed for a long cycle, by constituting the titled apparatus so as to perform the portionwise injection in the anterior stage thereof. CONSTITUTION:When a plastic cuvet sheet 3 is flowed to the direction shown by the arrow on a reaction line 1 and the first and fifth analytical containers 2 of said cuvet sheet 3 shown by the characters X, Y are subjected to item selection, portionwise injection is also performed to two analytical containers 2 shown by the characters Z, W. That is, even when an item to be analyzed is not selected and the analytical container wherein the item to be analyzed is selected after a predetermined time is moved, portionwise injection is performed. Because this invention is constituted as mentioned above, the interference of the other reagent and the residual component of an object to be examined is reduced and accurate analysis can be carried out.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic biochemical analyzer in which the interference effect of other reagents and the interference effect of residual samples is extremely small in a dispenser with a dispensing mechanism. a dispensing mechanism for dispensing the dividedly weighed sample and each reagent or diluted sample into analysis containers in the reaction line; and a suction nozzle for sucking the dispensed liquid from the analysis containers in the reaction line. , an analyzer for the suction liquid from the suction nozzle, and a control device that processes data from the analyzer and sends operating signals to the above-mentioned dispensing mechanism Ia structure and the suction nozzle. A device characterized in that an activation signal is sent when a selected analytical container moves to a dispensing position and when an analytical container selected for an analysis item moves to a dispensing position after a predetermined time. This relates to automatic chemical analyzers.

In the biochemical automatic analyzer, the dispenser of the dispensing TM structure has a configuration as shown in FIG. 1AB.

The pipettor (a) has a three-layer structure, and is provided with a sample introduction channel (bt) that communicates with the sample at a certain position inside, and the sample is introduced from the sample cup (C) into this introduction channel (bt). ,
As shown in FIG. 1B, it is brought into a sliding state and weighed in parts. Then, it is configured to be dispensed into each reagent or diluted sample channel container. In the conventional method, if the reagent or diluted sample remains in the flow path (small) without selecting an analysis item during a long cycle on the plywood, (D)
Samples from the adjacent channels (reagents flowing through the city and the introduction channel mountain) that seep out between the slide surfaces gradually accumulate in the area, and when the next dispensing is performed in this state, the analysis results will be lost. Interference with reagents and samples in other channels occurs. In addition, although the inlet channel is washed with pure water every time an analysis is performed, if the cycle is long, components such as filibrin (if the sample is serum) may accumulate in the inlet channel. Therefore, the analysis results will also be subject to interference.

Both of the above-mentioned interferences are particularly problematic when analysis is performed using an electrolyte analyzer.

This invention was made to solve the above problems.
If there is an analysis item to be dispensed after dispensing is not performed in a long cycle, the dispensing is performed in the previous step.

The present invention will be described in detail below with reference to the drawings, but the present invention is not limited to the following examples.

Figure 2 shows the overall configuration of the automatic biochemical analyzer.
In the reaction line (1), there are many analytical containers (2
) is being flown.A plastic cuvette sheet (3) with integrally provided (4) is the dispensing mechanism, dispensing machine I
N (41 is a pipettor (5) similar to that shown in Fig. 1, a sample flow path (6) arranged in this pipettor (5), and a reagent or diluted sample flow path ('71). It consists of a solenoid valve (8) and an AC motor (9), which are respectively provided in the flow path (force).
The blade end serves as the nozzle of the dispenser (5). 00) is a suction nozzle, which is movably numbered to correspond to the analysis container (2) and the dummy liquid container (1υ).(I2)
is an electrolyte analyzer that is installed to analyze the suction liquid (mixture of sample and diluted sample since the analyzer is an electrolyte analyzer) from the suction nozzle 00).
2) is connected to the control device 03) for sending analysis data. The control device 03) is further connected to the dispensing mechanism (4) and the suction nozzle 00), and sends activation signals to each of them based on a pre-installed program. The connection with the dispensing mechanism (4) is actually a solenoid valve (8) and an AC
This is done with the motor (9).

The overall configuration up to this point is no different from the conventional one, and the operation signal of the control device 03) to the dispensing mechanism (4) and the accompanying operation of the dispensing II mechanism (4) are according to the present invention. This is a characteristic configuration.

Now, the plastic cuvette sheet (3) is flowing in the direction of the arrow in the reaction line (1), and the first and fifth analytical containers (2) shown by XY of the plastic cuvette sheet (3) are the items. If selected, conventionally it was dispensed only to each analysis container (2), but 7
Dispensing is also carried out into 12 analytical containers (2) indicated by W. In other words, even if an analysis item is not selected and an analysis container in which an analysis item is selected moves after a predetermined period of time, the sample is dispensed. In this embodiment, the predetermined time corresponding to the analysis container whose analysis item is selected is set to be continuous at a fixed time interval, and the predetermined time is set to be synchronized with each movement cycle of the analysis container. In the second cycle, Niko's analytical container ZW
Dispensing is performed. By passing the outgoing liquid about twice, the remaining liquid in the channel ('7) is sufficiently flushed and removed. The dispensed liquid in the analysis container (2) is not suctioned by the suction nozzle 00) and is discarded. The suction nozzle (lo) is used for analysis containers (2) for which no analysis item is selected and the inside is not filled with dispensing liquid, and for analysis containers (2) for which the above analysis items are not selected but are filled with dispensing liquid. When the container (a) is sent, and when it passes between the plastic cuvette 1 and the sheet (3), the container (C) is located on the dummy liquid container (11) and sucks the dummy liquid. The time corresponding to the dispensing mechanism (4) and suction nozzle (10) of the container (2) is 1
2 seconds, and during these 12 seconds, the suction nozzle 001
performs suction and operation for 0.9 seconds from the analysis container (2) or dummy liquid container (11).

When using one pipettor as described above and providing a continuous sample flow path within this pipetter, if the above analysis item is not selected, the pipetted liquid will contain the sample and reagent. Or, it will be a mixture of diluted samples, but use multiple pipettes.
If there is no analysis item selection corresponding to a particular dispenser, only the reagent or diluted sample may be dispensed without introducing the specimen into the dispenser.

In addition, when dispensing when no analysis item is selected, it is sufficient to measure using the key plate that pulls into the C motor part, and in terms of washing away the remaining liquid, it is sufficient to dispense a large amount of reagent or diluted sample. .

Furthermore, the present invention can also be applied at the start time of analysis, that is, in the stage before the analysis container that must be dispensed for the first time at the start time, the analysis container or the state where no analysis container exists. Perform dispensing. In this case, sufficient washing can be achieved by dispensing more times than the number of dispensings for washing during analysis, for example, about six times.

Since the present invention is configured as described above, it is possible to perform accurate analysis with less interference from other reagents and sample residues in the dispenser, and is particularly effective in those using an electrolytic analyzer as the analyzer.

In addition, even if the reagent stays in the reagent flow path for a long time and deteriorates, the additional effect is that the deteriorated reagent is discarded before regular dispensing.

[Brief explanation of drawings]

FIGS. 1A and 1B are diagrams illustrating the configuration of a general dispenser that dispenses a specimen and a reagent or diluted sample together, and FIG. 2 is a diagram illustrating the configuration of an embodiment of the automatic biochemical analyzer of the present invention. be. (1)...Reaction line, (2)...Analysis container, (4)...Dispensing mechanism, (To)...Suction nozzle, 0z...Electrolyte analyzer, 03)... ·Control device. 1

Claims (1)

[Scope of Claims] 1. A reaction line, a dispensing mechanism for dispensing the dividedly weighed specimen and each reagent or diluted sample into an analytical container in the reaction line, and It consists of a suction nozzle that aspirates the dispensed liquid, an analyzer for the aspirated liquid from the suction nozzle, and a control device that processes data from the analyzer and sends operating signals to the dispensing structure and the suction nozzle. The device operates the dispensing mechanism when an analysis container with an analysis item selected moves to the dispensing position and when an analysis container with an analysis item selected moves to the dispensing position after a predetermined time. A biochemical automatic analyzer characterized by sending signals. 2. Claim 1, wherein the predetermined time period corresponding to one analytical container in which an analysis item is selected is continuous at a fixed time interval, and the predetermined time period corresponds to each movement cycle of the analytical container. Biochemical automatic analyzer described in Section 1.