JPS5899461A - ２３，２５，２６−トリヒドロキシビタミンｄ↓３ - Google Patents
２３，２５，２６−トリヒドロキシビタミンｄ↓３Info
- Publication number
- JPS5899461A JPS5899461A JP19625281A JP19625281A JPS5899461A JP S5899461 A JPS5899461 A JP S5899461A JP 19625281 A JP19625281 A JP 19625281A JP 19625281 A JP19625281 A JP 19625281A JP S5899461 A JPS5899461 A JP S5899461A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- vitamin
- solvent
- product
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 10
- 239000002904 solvent Substances 0.000 abstract description 8
- -1 lithium aluminum hydride Chemical compound 0.000 abstract description 5
- 238000004440 column chromatography Methods 0.000 abstract description 4
- 239000012280 lithium aluminium hydride Substances 0.000 abstract description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 229930003316 Vitamin D Natural products 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052753 mercury Inorganic materials 0.000 abstract description 2
- 235000019166 vitamin D Nutrition 0.000 abstract description 2
- 239000011710 vitamin D Substances 0.000 abstract description 2
- 150000003710 vitamin D derivatives Chemical group 0.000 abstract description 2
- 229940046008 vitamin d Drugs 0.000 abstract description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- ISULLEUFOQSBGY-UHFFFAOYSA-N 4-phenyl-1,2,4-triazole-3,5-dione Chemical compound O=C1N=NC(=O)N1C1=CC=CC=C1 ISULLEUFOQSBGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- JJFYNCJHSCTBPW-TVQCKQBJSA-N cholesta-5,7-dien-3beta,25-diol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H](CCCC(C)(C)O)C)CC[C@H]33)C)C3=CC=C21 JJFYNCJHSCTBPW-TVQCKQBJSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- 150000003704 vitamin D3 derivatives Chemical class 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 description 1
- 150000008046 alkali metal hydrides Chemical class 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19625281A JPS5899461A (ja) | 1981-12-08 | 1981-12-08 | ２３，２５，２６−トリヒドロキシビタミンｄ↓３ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19625281A JPS5899461A (ja) | 1981-12-08 | 1981-12-08 | ２３，２５，２６−トリヒドロキシビタミンｄ↓３ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5899461A true JPS5899461A (ja) | 1983-06-13 |
| JPH0142264B2 JPH0142264B2 (enExample) | 1989-09-11 |
Family
ID=16354711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19625281A Granted JPS5899461A (ja) | 1981-12-08 | 1981-12-08 | ２３，２５，２６−トリヒドロキシビタミンｄ↓３ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5899461A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58109469A (ja) * | 1981-12-23 | 1983-06-29 | Teijin Ltd | ２３，２５，２６−トリヒドロキシビタミンｄ３ |
-
1981
- 1981-12-08 JP JP19625281A patent/JPS5899461A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58109469A (ja) * | 1981-12-23 | 1983-06-29 | Teijin Ltd | ２３，２５，２６−トリヒドロキシビタミンｄ３ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0142264B2 (enExample) | 1989-09-11 |
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