JPS5883614A - Therapeutical composition for bite, sting and wound - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to compositions and methods for treating bites, stings and wounds.

Australian patents t75,036.513.983 and 518,852 all relate to compositions for the treatment of bites and stings containing water-soluble aluminum salts, particularly aluminum sulphate. No. 475.036 describes another detergent ingredient that is the ethyl oxylate of an alcohol having 12 to 15 carbon atoms. Mukuro patent 51398g
are ionic and non-ionic detergents, especially those selected from ammonium salts, substituted ammonium salts, alkali metal salts and alkaline earth metal salts of higher benzene sulfonic acids, higher alkyl sulfates and higher fatty acid monoglyceride sulfates. Detergent ingredients are listed.

Each of the detergent ingredients listed above is useful in removing natural skin oils or other oily substances such as tanning creams, which are commonly used before a bite or sting occurs, resulting in an aluminum salt bite or sting. It can reduce the effect of sting in a young way.

Although the mechanism of action of Al<=rum salts in reducing bites or stings is not completely clear, it is believed that the Al<=R>A ion is capable of producing venom or toxins and other stinging substances that can be removed by live pain-producing agents. It is believed. For example, Chironex Fleekari (Cktrosas Fleekari)
4il111, which is caused by marine stinging organisms such as the murrelet (murrelet), is caused by a positively loaded aluminum ion toxin or a polymeric substance such as white matter that makes up the venom. They are thought to penetrate the complex lattice that exists and modify it;

Said patents 475,036.513,983 and 5IIL8
Although the compositions described in No. 52 are useful in the treatment of bite wounds and If wounds, these compositions are water-based in nature and therefore have limited use while swimming or at the shore. - If it is not V, it will be wired. Also, the water-based aluminum composition has been found to be effective in localized maturation for immediate relief, but it does not last long on the skin and is also easily removed when exposed to water. Due to the fact that it becomes dry due to dryness or thick
Does not provide long-lasting protection against kO stings or wounds.

Therefore, if a swimmer, for example, Chironecchus breraceri (
Chironez Fleekari), PhysaLia Utriculs
a) (Boby daesa W n-t--7-(Por
txgwesa haan-m-war)] or bluebottle (bluebottle j) or the axonemal side or stinging capsule that can sting humans and cause great discomfort with severe symptoms. A need has now arisen for the provision of a protective lotion or balm that can be applied by swimmers to the skin of sea anemones or hydroids before entering the water, which they may encounter.

Iron Wf47 to 036, 513983 and 51 to 852
The composition of the formula is such that, even if people like Ff, 1.
There are no common situations where ointments or lotions are required. Previously, such people had to wear protective clothing, particularly in northern Queensland, Australia during the seasonal months, which was uncomfortable and restrictive in tropical conditions.

It is therefore an object of the present invention to provide articles and methods for the treatment of bites, stings and wounds that can be used in the form of a protective cream, lotion or ointment.

The composition of the present invention contains the following components: (1)2
an aluminum salt in the form of finely divided particles having a large particle size of Qt Chron; and (2) a waterproof shaped chestnut.

The method of the invention includes the step of topically applying the aluminum salt described above to the skin.

Preferably the aluminum salt has a minimum particle size of α5 microns. The aluminum salt is preferably a5~1
．． It has a particle size range of 0 microns.

The aluminum salt passed for use in the present invention is
Aluminum sulfate, aluminum chloride.

It can be selected from aluminum nitrate, aluminum vinegar, aluminum chloride, aluminum citrate, aluminum tartrate, aluminum formate and alum.

Preferably, the production of the aluminum salt in the form of anhydrous finely divided particles is carried out in a l-luminium or other suitable grinding equipment. The quality of the aluminum and nium salts must be of high purity, especially free of heavy metals such as lead and arsenic as impurities.

Prior to milling, the aluminum salt (suitably in the form of aluminum sulfate) can be dried by heating in a hot air oven or other suitable heating device. The grinding operation is preferably carried out using an organic motivating medium such as petroleum ether or ahallita.

Fatty aqueous excipients can also act as carriers for other optional ingredients of the compositions described below. Certain other waterproof carriers may also be used for other components.

Waterproof excipient medicine suitable for RTC, xi amount standard 20~8
It is included in the composition within a proportion of 0%. Preferably, the waterproof excipient system comprises 20-70% of the composition. On the other hand, the finely divided aluminum salt contains 50 to 7 &Oi-'' parts of the composition, more preferably 15 to 6 parts of the composition.
It is possible to construct a 0-fold l-.

Most preferably, the aluminum salt is from 15 to 609 of the composition.
6 can be constructed.

Suitable waterproof excipient systems are commercially available silicone polymers, suitably in the form of dimethicones. In particular, mixtures of monolithic and liquid silicones, such as those supplied by Consolidated Silicones Company Limited, can be used. Also.

Mixtures of liquid dimethicones that are finely divided and depleted of mourning silica can also be used.

Other waterproof excipient systems that may be used include petroleum ether, chelite, common petroleum products such as liquid rough-in, petroleum jelly or Fip# rough-in wax. Aluminum, magnesium and calcium metal soaps can also be used. ! Creams, oils such as coconut oil, and higher Harakiri alcohols can also be used. Any suitable water-repellent material that is generally non-toxic to the skin and also serves as a suitable excipient system for the finely divided particles of the al-1-um salt and other components of the compositions of the invention. It can also be used as an excipient. In addition to acting as an excipient system, the waterproofing material can inhibit leaching of the composition from the aluminum salt and other ingredients mentioned herein.

Fatty aqueous vehicles can also prevent the tentacles of marine stinging organisms with phlegmon from adhering to the skin. This feature is important in that it greatly reduces the risk of anything other than small non-lethal sting effects.

Other ingredients that can be used in the compositions of the invention are substances that inhibit the release of phlegmon of marine stinging organisms. This material can be methyl oil. 1' to 30fiii% of this substance in the composition.

More appropriately, it can be operated on the basis of 10 folds fiIii'qk.

Other ingredients that can be used in the compositions of the invention include:

Included are suitable marine stinging repellents that have been found to be disliked by marine stinging organisms or motile poisonous substances such as jellyfish.

A suitable range of proportions in the composition for which menthol has been found to be particularly permeable can be from α5 to 5.0% by weight. Preferred formulations include 15 densitide, other suitable marine repellents such as dichlorobenzene, chlorinated hydrogen chloride, and camphor.

Sunscreen agents that are compatible with the above ingredients can also be used in the compositions of the invention. *Nana Nikko - New drug is from Australia,
PAR8OL sunscreen, supplied by Gilmen Petit Limited of Day Why, Sydney, can be used in 25-120 wt.
A suitable ratio is 7.0 to 7.5 times JIi-.

Appropriate fragrances can be used if desired.

And the appropriate fragrance is Sydney, Australia.

The ratio of Day Why is 7'(:'59019), supplied by Shiman Buchie Limited. A suitable range of proportions is α1 to 1.0, more preferably 0.25 to 1.

Example 1 Industrial grade aluminum sulfate was -dried by heating to 260-250C in a hot air oven for 3 hours. After drying, the aluminum sulfate was ground in a gold mill with an excipient concentration of petroleum ether at a temperature of 30-60C and a water content of less than 0.4%. Meanwhile, dry aluminum sulfate.

At least 2 ml of calcium chloride, shaking occasionally, on a desiccant
It is also possible to grind the shaped concentrate of chelite, which has been previously dried by standing for a week.

Aluminum a-acid is insoluble in both celite or petroleum ether.

The dried aluminum sulfate is ground in a gold mill.
The required particle size of 5-1.0 microns was achieved. The body of the mill is made of smooth, highly polished stainless steel, and the diameter of the mill measures 134 inches. Highly polished or non-corrosive highly polished ball bearings made from other suitable metals may also be used.

The building body was hermetically closed to prevent evaporation of the liquid excipient. Milling was typically carried out for 4 days.

After milling, the liquid was evaporated and the milled product was sieved through a suitable nylon material.

During grinding, the mill body is angled and rotated so that the wheels fall onto the material to be ground.

The required particle size of aluminum sulfate was measured microscopically using an eyepiece and stage micrometer, and the ground product had a sand-like feel when applied to the skin in a suitably reamed form. The most suitable is one that does not give any

Example 8 The following composition examples of the present invention were combined by first determining the electric potential of each component in an evaporation vessel using a vacuum cleaner before mixing, and the mixing operation was continued for 30 minutes. Perform at room temperature.

Silicone 3 &Of 52.0 Paraffin-Zeri-11 (l ill Menthol
1.1lBf 10Δrsol
Table St 7.0 Aluminum Sulfate
11 (12α5 fragrance 0.28 f O,!
Silicone 2L2t 3λ7 Paraffin Φ Jelly 22-Of a16 Menthol 1.95F 5.0 Parsol 45F 7.0 Alkenium Sulfate 1a (120,5 Fragrance
α25f O,2 Composition 3 Sili:' 7 11. Of
17.3 Norifin Jelly 3 KOf
52.0 Menthol 195 f
10 Parsol Table S?
? , 0 sulfur aluminum ξ nium 1109 !
α5 fragrance &25f α2
Composition 4 Silicone 4151 49.8
Menthol 165 f &0-
15- Parsol α159 7.
0 aluminum sulfate 35Of 40.
0 fragrance αgst α2
Composition 5 Silicone 415F 34.9 Menthol 139 10 Parsol 7.65? 7.0
Aluminum sulfate 3NOf 45.0
Liquid silicone 445 f a.

Methyl oil nol not yet 19 &9 fragrance (L25f α2 composition 6 silicone use a47 menthol &25t &0 norsol &, '15f 7
．． 0 sulfur aluminum A 5alaBf
4a0 liquid silicone: y-n IL75f
10.1 Fragrance am! f
ai! Composition 7 Composition of silicone 4159 4
5.7 Menthol 2L65 t 17] Lusol 6. -15 f&
4 Altium waxate 3 LOf 3 a
? Methyl oil norl &9F 9.3
Fragrance α251 α2 Each of the above compositions was applied topically to a swimmer in Proservin, Queensland, Australia, and the law was obtained against blue tor stings for 80 minutes before reassuring a new application. There was found.

Ckfo%-2Flaa
kari), when you come into contact with this value creature #
It turned out that only a small sting of 1 mm was caused. It was found that moxibustion and rash on the skin were greatly reduced.

In addition, only a small amount of welts of #1 were produced in the M-lineage cells. - It was also found that the release of poisonous threads from the prefecture into the skin was substantially suppressed. It was also found that the adhesion of such threads to the skin was also substantially reduced.

The above compositions have been applied topically to the skin and have been found to be effective in substantially minimizing pain caused by spider, wasp, snapper, wasp, giant bear beak and force stings. Symptoms such as scars, prurigo, allergic reactions and secondary infections have also been substantially minimized or in some cases completely eliminated.

The above compositions may be used, for example, by John Dory.
ry) or Butterfly C.
It has also been found to be effective in substantially alleviating the pain associated with contact with crawling fish such as A. od. Contact with such refined fish often results in very painful starvation, wounds, or bites.

The above compositions have also been found to be effective in providing protection against stings from round-shafted waxwood and stinging nettle.

Patent applicant Megrath Henderson

Claims (1)

[Claims] 1. B) 2) an aluminum salt in the form of finely divided particles having a maximum dimension of 1 kg; and (2) containing a waterproof excipient system. Anhydrous composition for Ichihara of MLL Association. 2 Particles of aluminum salt have a size within the range 1 of a5 to 1.0 microns.
li1 completed. The proportion of aluminum salts in the composition! L
O~ysjiiM-. Range 1 or [Present 1 composition]. Table: The proportion of aluminum salt contained in the composition is 15
〜5oii*n. The composition according to claim 11, item 3. Fh, the proportion of government-owned waterproofing additives in the composition is 20
~soi@Deruru. 11+λ song 1 of waiting needle i+hX
Or the composition according to item 2. a The proportion of waterproof molding work carried out during assembly is 20%.
~70 irises-, % eaves aS request, section 5, entry 11i
Composition of lc. 7. Furun dipenta-salt is aluminum sulfate. A composition according to any one of claims @l-@. & methyl oil r)-ol. A composition according to any one of claims 1 to MY. Contains silicone polymer as a waterproof material. A composition according to any one of claims 1 to 8. lα The method includes the step of applying the composition described in any one of claims 1 to 9 on the skin. How to treat a strangulation, sting or wound.