CA2285012C - Remedy for external application, and use of an oil-in-water emulsion for said remedy - Google Patents
Remedy for external application, and use of an oil-in-water emulsion for said remedy Download PDFInfo
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- CA2285012C CA2285012C CA002285012A CA2285012A CA2285012C CA 2285012 C CA2285012 C CA 2285012C CA 002285012 A CA002285012 A CA 002285012A CA 2285012 A CA2285012 A CA 2285012A CA 2285012 C CA2285012 C CA 2285012C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a remedy for external application, in particular to prevent skin diseases. Said remedy has an oil-in-water emulsion in which minerals are provided, the grain size thereof being so sma ll that the minerals can pass through the skin pores of human skin.
Description
REMEDY FOR EXTERNAL APPLICATION, AND USE OF AN OIL-IN-WATER
EMULSION FOR SAID REMEDY
The present invention relates to a remedy for external application, in particular for the treatment of skin diseases, and to the use of an oil emulsion for producing such a remedy.
A lot of remedies used to cure or relieve skin diseases such as neurodermatitis (scabies), psoriasis (psora), acne, dandruff, itchiness, herpes, shingles, burn wounds, scab, sunburn and phlebalgia in the legs are well known in the art. Not all bring satisfactory results. There is a need for further remedies in this field.
Skin diseases like the above-mentioned are getting more frequent. This is probably due to lots of environmental influences and to modified environmental conditions. Skin diseases are typically involving very troublesome accessory symptoms. Itchiness occurs, which is often unbearable. The disease is often aggravated or other problems occur due to the fact that the smitten parts are too much rubbed or scratched.
This is where the invention comes to bear. Its object is to provide a remedy for external application, in particular for the treatment of skin diseases, with the help of which the clinical picture of the disease heals up soon and which is easy to use.
i ~ ~ i The solution of this object is to provide, on the basis of a remedy of the type mentioned above, an oil-in-water emulsion in which grained minerals are provided, the grain size thereof being so small that the minerals can pass through the skin pores of human skin, in particular amorphous, pyrogenic silicic acid dissolved in oil and emulsified in water with mineral ingredients like silicon, calcium and/or magnesium. The oil-in-water emulsion is preferably polydialkyl-siloxane-in-water emulsion.
The decisive ingredients are the minerals contained in the aqueous oil emulsion where they are extremely finely dispersed. They are dispersed =so finely that their grain size is smaller than the pore d__ameter of human skin. Thus even the tiniest minerals may penetrate the skin. The minerals are so tiny that they are not staying on the surface where they would be filtered, but are absorbed by the skin. Thus, the diseased skin gets the minerals it is lacking.
The oil which proved most effecaive is a mineral oil. In the mineral and oil emulsion, minerals like silicon, calcium and traces of magnesium are extremely finely dispersed. The emulsion is not ionogenic. The pH-value is neutral with 5 to 7. Particular vreferred results have been obtained when these minerals are present in an amount of less than to by weight, prefer;~bly of less than O,lo by weight of the emulsion. Other mi:zerals may also be present, e.g. those belonging to the alaali and/or alkaline earth group. The minerals are not dissolved. They are finely dispersed.
It proved particularly preferable to add an emulsifier to the basic topical composition. Commercial emulsifiers are used.
EMULSION FOR SAID REMEDY
The present invention relates to a remedy for external application, in particular for the treatment of skin diseases, and to the use of an oil emulsion for producing such a remedy.
A lot of remedies used to cure or relieve skin diseases such as neurodermatitis (scabies), psoriasis (psora), acne, dandruff, itchiness, herpes, shingles, burn wounds, scab, sunburn and phlebalgia in the legs are well known in the art. Not all bring satisfactory results. There is a need for further remedies in this field.
Skin diseases like the above-mentioned are getting more frequent. This is probably due to lots of environmental influences and to modified environmental conditions. Skin diseases are typically involving very troublesome accessory symptoms. Itchiness occurs, which is often unbearable. The disease is often aggravated or other problems occur due to the fact that the smitten parts are too much rubbed or scratched.
This is where the invention comes to bear. Its object is to provide a remedy for external application, in particular for the treatment of skin diseases, with the help of which the clinical picture of the disease heals up soon and which is easy to use.
i ~ ~ i The solution of this object is to provide, on the basis of a remedy of the type mentioned above, an oil-in-water emulsion in which grained minerals are provided, the grain size thereof being so small that the minerals can pass through the skin pores of human skin, in particular amorphous, pyrogenic silicic acid dissolved in oil and emulsified in water with mineral ingredients like silicon, calcium and/or magnesium. The oil-in-water emulsion is preferably polydialkyl-siloxane-in-water emulsion.
The decisive ingredients are the minerals contained in the aqueous oil emulsion where they are extremely finely dispersed. They are dispersed =so finely that their grain size is smaller than the pore d__ameter of human skin. Thus even the tiniest minerals may penetrate the skin. The minerals are so tiny that they are not staying on the surface where they would be filtered, but are absorbed by the skin. Thus, the diseased skin gets the minerals it is lacking.
The oil which proved most effecaive is a mineral oil. In the mineral and oil emulsion, minerals like silicon, calcium and traces of magnesium are extremely finely dispersed. The emulsion is not ionogenic. The pH-value is neutral with 5 to 7. Particular vreferred results have been obtained when these minerals are present in an amount of less than to by weight, prefer;~bly of less than O,lo by weight of the emulsion. Other mi:zerals may also be present, e.g. those belonging to the alaali and/or alkaline earth group. The minerals are not dissolved. They are finely dispersed.
It proved particularly preferable to add an emulsifier to the basic topical composition. Commercial emulsifiers are used.
It proved particularly preferable to add a stabilizer to the basic topical composition. Commercial stabilizers are used, such as for example carboxymethylcellulose preferably used in an amount of from 0.025 to 0.75% by weight of the total composition.
It also proved advantageous to add an anti;;eptic to the emulsion. Tea tree oil is particularly appropriate. On top of its antiseptic property, the composition of tea tree oil also soothes the skin and relieves itchiness. The antiseptic is preferably used in an amount of from 0.001 to 1 % by weight of the total composition.
It further proved advantageous to add a surface-active agent, in particular an anionic surface-active agent 15 to 30%. ~~urface-active agents clean the skin and act as emulsifiers. The surface-active agent is preferably used in an amount of from 0.0001 to 1 % by weight of the total composition.
It proved particularly advantageous to add glycerin to the emulsion. Glycerin is known as a moisture binding material for the skin. It also acts as an emollient.
The glycerin is preferably used in an amount of from 0.001 to 50% by weight of the total composition.
In order to confer a fat-restoring property on the remedy, a fat-restoring additive is added in cases in which restoring fat is desired, thus not for acne for example.
Here, commercial compositions of skin milks for dry skin may be used. The fat-restoring additive particularly contains oils, paraffins, stearates and so on.
The fat-restoring skin milk is preferably used in an amount of from 0.001 to 30%
by weight of the total composition.
Finally, the invention relates to the use of an oil-in-water emulsion containing finest grained minerals for producing a remedy for external application, in particular to prevent skin diseases. In a preferred embodiment, the remedy is so fluid that it may be used in atomizers and sprayed on the skin. For being atomized, the emulsion is preferably coni:aining 0.2-1 % by weight of mineral solution in oil, the rest being water.
It also proved advantageous to add an anti;;eptic to the emulsion. Tea tree oil is particularly appropriate. On top of its antiseptic property, the composition of tea tree oil also soothes the skin and relieves itchiness. The antiseptic is preferably used in an amount of from 0.001 to 1 % by weight of the total composition.
It further proved advantageous to add a surface-active agent, in particular an anionic surface-active agent 15 to 30%. ~~urface-active agents clean the skin and act as emulsifiers. The surface-active agent is preferably used in an amount of from 0.0001 to 1 % by weight of the total composition.
It proved particularly advantageous to add glycerin to the emulsion. Glycerin is known as a moisture binding material for the skin. It also acts as an emollient.
The glycerin is preferably used in an amount of from 0.001 to 50% by weight of the total composition.
In order to confer a fat-restoring property on the remedy, a fat-restoring additive is added in cases in which restoring fat is desired, thus not for acne for example.
Here, commercial compositions of skin milks for dry skin may be used. The fat-restoring additive particularly contains oils, paraffins, stearates and so on.
The fat-restoring skin milk is preferably used in an amount of from 0.001 to 30%
by weight of the total composition.
Finally, the invention relates to the use of an oil-in-water emulsion containing finest grained minerals for producing a remedy for external application, in particular to prevent skin diseases. In a preferred embodiment, the remedy is so fluid that it may be used in atomizers and sprayed on the skin. For being atomized, the emulsion is preferably coni:aining 0.2-1 % by weight of mineral solution in oil, the rest being water.
Tea tree oil exists in technical and pharmaceutical grades.
Both have the same effect in the remedy according to the invention. The pharmaceutical embodiment has the advantage to smell a little bit better.
The ingredients of 200 grams tea tree oil are typically the following:
terpinene-4-oil 70 g ~-terpin oil 14 g O-terpinene 46 g ~-terpinene 20 g sigma cymene 20 g 1,8 cineole 20 g ~G-pinene 7 g ~-terpinolene 7 g d-limonene 6 g The remedy assists the body in self-healing. The tissue on which the remedy was sprayed gets warm, since blood circulation is much improved in this area. This also contributes to heal and relieve. This is an advantage constituting a particularity of the remedy according to the invention. The increased blood circulation explains the effect the remedy according to the invention has on for example the treatment of phlebalgia.
E x a m p 1 a s Example l:
An acne treating composition has the following ingredients:
Both have the same effect in the remedy according to the invention. The pharmaceutical embodiment has the advantage to smell a little bit better.
The ingredients of 200 grams tea tree oil are typically the following:
terpinene-4-oil 70 g ~-terpin oil 14 g O-terpinene 46 g ~-terpinene 20 g sigma cymene 20 g 1,8 cineole 20 g ~G-pinene 7 g ~-terpinolene 7 g d-limonene 6 g The remedy assists the body in self-healing. The tissue on which the remedy was sprayed gets warm, since blood circulation is much improved in this area. This also contributes to heal and relieve. This is an advantage constituting a particularity of the remedy according to the invention. The increased blood circulation explains the effect the remedy according to the invention has on for example the treatment of phlebalgia.
E x a m p 1 a s Example l:
An acne treating composition has the following ingredients:
5,000 g Demineralized Water 500 g Mineral Solution, emulsified in oil 200 g Tea Tree Oil g Anionic surface-active agents 15 - 300 500 g Glycerin.
When applied on the skin, particularly when sprayed on it, acne is healing in two stages. The already existing comedos first dry up. Then, the skin effloresces and looks like measles with lots of red spots. This occurs because the 10 hidden sebaceous follicles, which are not yet inflamed, are brought to the surface of the skin. After that, the skin becomes smooth.
Example 2:
For the production of a remedy for the treatment of phlebalgia:
5,000 g Demineralized water 1,000 g Mineral Solution, emulsified in oil 100 g Tea Tree Oil 10 g Anionic Surface-Active Agents 1,000 g Glycerin.
After undergoing surgery on veins, the patient often suffers from burning pain in the legs. By spraying the fluid onto the legs, the pain vanishes. One treatment a day is enough to remain free from pain.
Example 3:
Remedy for the treatment of neurodermatitis:
When applied on the skin, particularly when sprayed on it, acne is healing in two stages. The already existing comedos first dry up. Then, the skin effloresces and looks like measles with lots of red spots. This occurs because the 10 hidden sebaceous follicles, which are not yet inflamed, are brought to the surface of the skin. After that, the skin becomes smooth.
Example 2:
For the production of a remedy for the treatment of phlebalgia:
5,000 g Demineralized water 1,000 g Mineral Solution, emulsified in oil 100 g Tea Tree Oil 10 g Anionic Surface-Active Agents 1,000 g Glycerin.
After undergoing surgery on veins, the patient often suffers from burning pain in the legs. By spraying the fluid onto the legs, the pain vanishes. One treatment a day is enough to remain free from pain.
Example 3:
Remedy for the treatment of neurodermatitis:
5,000 g Demineralized water 500 g Mineral Solution, emulsified in oil 200 g Tea Tree Oil g Anionic Surface-Active Agents 15 - 300 500 g Glycerin 500 g Skin Milk for dry skin made of water, octyl stearate, paraffin oil, castor oil, sorbitan oleate, dimethicon tocopheryl acetate, heliotropins, phenoxyethanol, magnesium sulphate, zinc sulphate.
The unbearable itchiness accompanying neurodermatitis eases nearly immediately upon applying the remedy. Rubbing and scratching as well as the constant aggravation of the clinical picture they are causing are thus avoided. The diseased skin parts heal very fast, actually within a few days. The diseased, keratinized skin peels off like after severe sunburn. It may also desquamate. The skin appearing underneath is thin and red but normalizes very soon. It is no longer smitten.
Example 4:
For the production of the remedy according to the invention, formulas formulated within the following ranges proved to be advantageous:
5,000 g Water 50-5,000 g Mineral Solution, emulsified in oil 10-2,000 g Tea Tree Oil 1-100 g Anionic Surface-Active Agents and 1-3,000 g Glycerin.
The unbearable itchiness accompanying neurodermatitis eases nearly immediately upon applying the remedy. Rubbing and scratching as well as the constant aggravation of the clinical picture they are causing are thus avoided. The diseased skin parts heal very fast, actually within a few days. The diseased, keratinized skin peels off like after severe sunburn. It may also desquamate. The skin appearing underneath is thin and red but normalizes very soon. It is no longer smitten.
Example 4:
For the production of the remedy according to the invention, formulas formulated within the following ranges proved to be advantageous:
5,000 g Water 50-5,000 g Mineral Solution, emulsified in oil 10-2,000 g Tea Tree Oil 1-100 g Anionic Surface-Active Agents and 1-3,000 g Glycerin.
Preferred amounts of the fat-restoring additive in the composition mentioned in Example 3are between 10 and 2, 000 g.
Example 5:
Novoskin/Dermac Amount Water 7go Glycerin 85% 80 Silicon sediments Silica 2,450 Methyl Cellulose 0,050 Water 2,5%
Calcium sediments Calcium Carbonate 0,74s Methyl Cellulose 0,02a Water 1,24%
Castor Oil 20 Malaleuca Oil 20 Dexpanthenol 10 Magnesium sediments Magnesium Carbonate 0,2%
Methyl Cellulose 0,01%
Water 0,79%
Avocado Oil to Ingredient Amount Function Standard Water 78o Vehicle normal Glycerin 850 8% Emollient Ph. Eur.
Purified Water 4,530 Vehicle Ph. Eur.
Colloidal Silica Anhydride 2,450 Cleanser Ph. Eur.
Example 5:
Novoskin/Dermac Amount Water 7go Glycerin 85% 80 Silicon sediments Silica 2,450 Methyl Cellulose 0,050 Water 2,5%
Calcium sediments Calcium Carbonate 0,74s Methyl Cellulose 0,02a Water 1,24%
Castor Oil 20 Malaleuca Oil 20 Dexpanthenol 10 Magnesium sediments Magnesium Carbonate 0,2%
Methyl Cellulose 0,01%
Water 0,79%
Avocado Oil to Ingredient Amount Function Standard Water 78o Vehicle normal Glycerin 850 8% Emollient Ph. Eur.
Purified Water 4,530 Vehicle Ph. Eur.
Colloidal Silica Anhydride 2,450 Cleanser Ph. Eur.
Castor Oil 2% Stiffener U.S.N.F.
Malaleuca Oil 2o Fragrance normal Dexpanthenol 1o Provitamin Ph. Eur.
Avocado Oil to Fragrance normal Potassium Carbonate 0,74% Cleanser Ph. Eur.
Magnesium Carbonate 0,2% Cleanser Ph. Eur.
Methyl Cellulose 0, 08 o Suspending Agent Ph.
Eur.
Example 6:
Novoskin forte Water 700 Silicon sediments Silica 4,9%
Methyl Cellulose O,lo Water 5%
Glycerin 850 80 Calcium sediments Calcium Carbonate 1,480 Methyl Cellulose 0,040 Water 2,48%
Magnesium sediments Magnesium Carbonate 0,40 Methyl Cellulose 0,02a Water 1,58%
Castor Oil 2%
Malaleuca Oil 2%
Dexpanthenol 1s Avocado Oil to Ingredient Amount Function Standard Water 70o Vehicle normal Purified Water 9,06 Vehicle Ph. Eur.
o Glycerin 85% 8% Emollient Ph. Eur.
Colloidal Silica Anhydride 4,9% Cleanser Ph. Eur.
Castor Oil 2s Stiffener U.S.N.F.
Malaleuca Oil 2% Fragrance normal Potassium Carbonate 1,48% Cleanser Ph. Eur.
Dexpanthenol to Provitamin Ph. Eur.
Avocado Oil to Fragrance normal Magnesium Carbonate 0,4s Cleanser Ph. Eur.
Methyl Cellulose 0,16% Suspending Agent Ph.
Eur.
Example 7:
Novoskin mild Water 80 0 Glycerin 850 80 Silicon sediments Silica 2,45s Methyl Cellulose 0,050 Water 2,50 Calcium sediments Calcium Carbonate 0,740 Methyl Cellulose 0,02%
Water 1,24%
Castor Oil 20 Dexpanthenol to Magnesium sediments Magnesium Carbonate 0,20 Methyl Cellulose O,Olo Water 1,79%
Avocado Oil 1~
Ingredient Amount Function Standard Water 80o Vehicle normal Glycerin 85% 8o Emollient Ph. Eur.
Purified Water 4,53% Vehicle Ph. Eur.
Colloidal Silica Anhydride 2,45% Cleanser Ph. Eur.
Castor Oil 2o Stiffener U.S.N.F.
Malaleuca Oil 2o Fragrance normal Dexpanthenol 1o Provitamin Ph. Eur.
Avocado Oil to Fragrance normal Potassium Carbonate 0,74% Cleanser Ph. Eur.
Magnesium Carbonate 0,2% Cleanser Ph. Eur.
Methyl Cellulose 0, 08 o Suspending Agent Ph.
Eur.
Example 6:
Novoskin forte Water 700 Silicon sediments Silica 4,9%
Methyl Cellulose O,lo Water 5%
Glycerin 850 80 Calcium sediments Calcium Carbonate 1,480 Methyl Cellulose 0,040 Water 2,48%
Magnesium sediments Magnesium Carbonate 0,40 Methyl Cellulose 0,02a Water 1,58%
Castor Oil 2%
Malaleuca Oil 2%
Dexpanthenol 1s Avocado Oil to Ingredient Amount Function Standard Water 70o Vehicle normal Purified Water 9,06 Vehicle Ph. Eur.
o Glycerin 85% 8% Emollient Ph. Eur.
Colloidal Silica Anhydride 4,9% Cleanser Ph. Eur.
Castor Oil 2s Stiffener U.S.N.F.
Malaleuca Oil 2% Fragrance normal Potassium Carbonate 1,48% Cleanser Ph. Eur.
Dexpanthenol to Provitamin Ph. Eur.
Avocado Oil to Fragrance normal Magnesium Carbonate 0,4s Cleanser Ph. Eur.
Methyl Cellulose 0,16% Suspending Agent Ph.
Eur.
Example 7:
Novoskin mild Water 80 0 Glycerin 850 80 Silicon sediments Silica 2,45s Methyl Cellulose 0,050 Water 2,50 Calcium sediments Calcium Carbonate 0,740 Methyl Cellulose 0,02%
Water 1,24%
Castor Oil 20 Dexpanthenol to Magnesium sediments Magnesium Carbonate 0,20 Methyl Cellulose O,Olo Water 1,79%
Avocado Oil 1~
Ingredient Amount Function Standard Water 80o Vehicle normal Glycerin 85% 8o Emollient Ph. Eur.
Purified Water 4,53% Vehicle Ph. Eur.
Colloidal Silica Anhydride 2,45% Cleanser Ph. Eur.
Castor Oil 2o Stiffener U.S.N.F.
10 Dexpanthenol 1o Provitamin Ph. Eur.
Avocado Oil 1% Fragrance normal Potassium Carbonate 0,740 Cleanser Ph. Eur.
Magnesium Carbonate 0,2o Cleanser Ph. Eur.
Methyl Cellulose 0,080 Suspending Agent Ph.
Eur.
The water used may be distilled water or water containing the following ingredients:
Sodium 5,4 mg/1 or ppm Potassium 1,1 mg/1 or ppm Magnesium 24,6 mg/1 or ppm Calcium 49,8 mg/1 or ppm Chlorides 11,4 mg/1 or ppm Sulphate 7,1 mg/1 or ppm Hydrogen Carbonate 253,0 mg/1 or ppm Example 8:
Composition of the oil emulsion with minerals 38 % solids, final size of grain of the minerals in the range between 1 and 100 nanometres, preferably between 1 and 10 nanometres.
- = Quartz Powder, initial size 5 micrometres 30 20%
5 30 14% DolomiteBrick Powder, initial size 2 micrometres - =
1 10 = Magnesium Powder approximately 3 micrometres - 3%
O1 5 = Methyl Cellulose - 1%
10 60 = Castor Oil, Pharmagrad - 38%
2 40 = Water - 22%
10 This blend is first kneaded intensively in a kneading machine at a temperature of approximately 50°C. Then, it is brought - inline - to a colloid mill. The colloid mill has a cross gearing with a device for pumping aver and rotor cooling. In a slow passage, the minerals are ground to the size of 10-9 m. The castor oil emulsifies in the warm water and is stabilized by methyl cellulose. In order to avoid overheating during grinding, it is necessary to cool the grinding body. The thus obtained mineral and oil emulsion is stable and may be further diluted with water and blended.
Avocado Oil 1% Fragrance normal Potassium Carbonate 0,740 Cleanser Ph. Eur.
Magnesium Carbonate 0,2o Cleanser Ph. Eur.
Methyl Cellulose 0,080 Suspending Agent Ph.
Eur.
The water used may be distilled water or water containing the following ingredients:
Sodium 5,4 mg/1 or ppm Potassium 1,1 mg/1 or ppm Magnesium 24,6 mg/1 or ppm Calcium 49,8 mg/1 or ppm Chlorides 11,4 mg/1 or ppm Sulphate 7,1 mg/1 or ppm Hydrogen Carbonate 253,0 mg/1 or ppm Example 8:
Composition of the oil emulsion with minerals 38 % solids, final size of grain of the minerals in the range between 1 and 100 nanometres, preferably between 1 and 10 nanometres.
- = Quartz Powder, initial size 5 micrometres 30 20%
5 30 14% DolomiteBrick Powder, initial size 2 micrometres - =
1 10 = Magnesium Powder approximately 3 micrometres - 3%
O1 5 = Methyl Cellulose - 1%
10 60 = Castor Oil, Pharmagrad - 38%
2 40 = Water - 22%
10 This blend is first kneaded intensively in a kneading machine at a temperature of approximately 50°C. Then, it is brought - inline - to a colloid mill. The colloid mill has a cross gearing with a device for pumping aver and rotor cooling. In a slow passage, the minerals are ground to the size of 10-9 m. The castor oil emulsifies in the warm water and is stabilized by methyl cellulose. In order to avoid overheating during grinding, it is necessary to cool the grinding body. The thus obtained mineral and oil emulsion is stable and may be further diluted with water and blended.
Claims (23)
1. Remedy for external application, characterized in that it comprises the following constituents - an oil-in-water emulsion,.and - grained minerals which are present in ~rhe emulsion, the grain size thereof being so small that the minerals can pass through the skin pores of human skin.
2. Remedy according to claim 1, characterized in that the emulsion comprises a stabilizer.
3. Remedy according to claim 2, characterized in that the stabilizer is carboxymethylcellulose.
4. Remedy according to of claim 3, characterized in that carboxymethylcellulose is present in a range of 0.025 to 0.75% by weight.
5. Remedy according to any one of clairns 1 to 4, characterized in that the emulsion also comprises an antiseptic.
6. Remedy according to claim 5, characterized in that the antiseptic is tea tree oil.
7. Remedy according to any one of claims 5 and 6, characterized in that the antiseptic is present in an amount between 0.001 to 1 % by weight.
8. Remedy according to any one of claims 1 to 7, characterized in that the emulsion also comprises a surface-active agent.
9. Remedy according to claim 8, characterized in that the surface-active agent is an anionic 15-30% surface-active agE:nt.
10. Remedy according to any one of claims 8 and 9, characterized in that the surface-active agent is present in an amount between 0.0001 to 1 % by weight.
11. Remedy according to any one of claims 1 to 10, characterized in that the emulsion further comprises glycerine.
12. Remedy according to claim 11, characterized in that the glycerine is added in an amount between 0.001 to 50% by weight.
13. Remedy according to any one of claims 1 to 12, characterized in that the emulsion also comprises a fat-restoring skin milk.
14. Remedy according to claim 13, characterized in that the fat-restoring skin milk is added in a weight range of 0.001 to 30% by weight.
15. Remedy according to any one of claims 1 to 14, characterized in that the oil-in-water emulsion is a mineral oil-in-water emulsion.
16. Remedy according to any one of claims 1 to 15, characterized in that the oil-in-water emulsion is a polydialkylsiloxane-in-water emulsion.
17. Remedy according to any one of claims 1 to 16, characterized in that the grained minerals are amorphous pyrogenic silicic acid dissolved in oil and emulsified in water with mineral ingredients.
18. Remedy according to claim 17, characfiarized in that the mineral ingredients are silicon, calcium and/or magnesium.
19. Remedy according to any one of claims 1 to 18, characterized in that it is atomized.
20. Remedy according to claim 19, characterized in that, to be atomized, the emulsion contains 0.2 - 1% by weight of mineral solution in oil, the rest is water.
21. Use of the remedy as defined in any one of claims 1 to 20 for external application.
22. Use of the remedy according to claim 21 wherein the external application is for the treatment of skin diseases.
23. Use of the remedy according to any one of claims 21 and 22, characterized in that the remedy is applied by an atomizer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19611742.9 | 1996-03-25 | ||
| DE19611742 | 1996-03-25 | ||
| PCT/DE1997/000476 WO1997035558A1 (en) | 1996-03-25 | 1997-03-11 | Remedy for external application, and use of an oil-in-water emulsion for said remedy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2285012A1 CA2285012A1 (en) | 1997-10-02 |
| CA2285012C true CA2285012C (en) | 2006-06-20 |
Family
ID=7789349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002285012A Expired - Fee Related CA2285012C (en) | 1996-03-25 | 1997-03-11 | Remedy for external application, and use of an oil-in-water emulsion for said remedy |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0889721B1 (en) |
| AT (1) | ATE216222T1 (en) |
| AU (1) | AU2379997A (en) |
| CA (1) | CA2285012C (en) |
| DE (2) | DE59707063D1 (en) |
| DK (1) | DK0889721T3 (en) |
| ES (1) | ES2174247T3 (en) |
| WO (1) | WO1997035558A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6168794B1 (en) | 1998-11-03 | 2001-01-02 | Safe 'n Sound Solutions, Inc. | Compositions comprising oleum Melaleuca |
| AU2001287918A1 (en) * | 2000-09-20 | 2002-04-02 | Nycomed Pharma As | Preparation of vitamin emulsions and concentrates thereof |
| ITPN20010004A1 (en) * | 2001-01-24 | 2002-07-24 | Giovanna Zuddas | CLEAR PRODUCT - WRINKLES |
| FR2823113B1 (en) * | 2001-04-06 | 2005-12-16 | Oreal | ANTI-WRINKLE COSMETIC COMPOSITION WITH IMMEDIATE EFFECT BASED ON AQUEOUS DISPERSION OF AT LEAST ONE MINERAL LOAD |
| DE10323759A1 (en) * | 2003-05-22 | 2004-12-16 | Bauer, Wulf, Dr. | Remedies for internal use, especially against cancer |
| DE10323758A1 (en) * | 2003-05-22 | 2004-12-16 | Bauer, Wulf, Dr. | Remedies for internal use, especially against cancer |
| ES2245601B1 (en) * | 2004-06-22 | 2007-05-01 | Giovanna Zuddas | Anti-wrinkle cosmetic product for wrinkled skin of face, has tensioning agent mixed with silica water at room temperature, and wetting agents, soothing agents, humidified agents, emollients or cooling agents mixed with silica water |
| DE102007004663A1 (en) * | 2007-01-25 | 2008-07-31 | Bauer, Wulf, Dr. | Wound healing agent has substantial components water and silicon dioxide with particle size 50-200 nm, and amount of silicon dioxide is 1-5 percent by weight |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4917891A (en) * | 1984-12-21 | 1990-04-17 | Revlon, Inc. | Composition having evaporative oil-like material |
| US5169429A (en) * | 1988-10-14 | 1992-12-08 | Monsanto Company | Hybridization of sunflowers and safflowers |
| US5292528A (en) * | 1992-06-19 | 1994-03-08 | Sunstar Kabushiki Kaisha | Oral Composition |
| FR2726187A1 (en) * | 1994-10-26 | 1996-05-03 | Jean Noel Thorel | Topical compsns. contg. calcium chloride |
-
1997
- 1997-03-11 EP EP97919265A patent/EP0889721B1/en not_active Expired - Lifetime
- 1997-03-11 AU AU23799/97A patent/AU2379997A/en not_active Abandoned
- 1997-03-11 ES ES97919265T patent/ES2174247T3/en not_active Expired - Lifetime
- 1997-03-11 DK DK97919265T patent/DK0889721T3/en active
- 1997-03-11 DE DE59707063T patent/DE59707063D1/en not_active Expired - Lifetime
- 1997-03-11 DE DE19780248T patent/DE19780248D2/en not_active Expired - Fee Related
- 1997-03-11 AT AT97919265T patent/ATE216222T1/en active
- 1997-03-11 CA CA002285012A patent/CA2285012C/en not_active Expired - Fee Related
- 1997-03-11 WO PCT/DE1997/000476 patent/WO1997035558A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997035558A1 (en) | 1997-10-02 |
| ES2174247T3 (en) | 2002-11-01 |
| CA2285012A1 (en) | 1997-10-02 |
| EP0889721A1 (en) | 1999-01-13 |
| DE59707063D1 (en) | 2002-05-23 |
| ATE216222T1 (en) | 2002-05-15 |
| AU2379997A (en) | 1997-10-17 |
| DE19780248D2 (en) | 1999-03-11 |
| DK0889721T3 (en) | 2002-08-05 |
| EP0889721B1 (en) | 2002-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130311 |