JPS5848054B2 - 血小板集合監視装置 - Google Patents
血小板集合監視装置Info
- Publication number
- JPS5848054B2 JPS5848054B2 JP51005509A JP550976A JPS5848054B2 JP S5848054 B2 JPS5848054 B2 JP S5848054B2 JP 51005509 A JP51005509 A JP 51005509A JP 550976 A JP550976 A JP 550976A JP S5848054 B2 JPS5848054 B2 JP S5848054B2
- Authority
- JP
- Japan
- Prior art keywords
- circuit
- amplifier
- platelet
- output
- resistor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000012806 monitoring device Methods 0.000 title claims description 6
- 210000004623 platelet-rich plasma Anatomy 0.000 claims description 27
- 230000003287 optical effect Effects 0.000 claims description 25
- 210000002381 plasma Anatomy 0.000 claims description 17
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 12
- 230000035945 sensitivity Effects 0.000 claims description 4
- 239000003990 capacitor Substances 0.000 description 22
- 230000003321 amplification Effects 0.000 description 10
- 238000003199 nucleic acid amplification method Methods 0.000 description 10
- 239000004020 conductor Substances 0.000 description 9
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 8
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- 230000004931 aggregating effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/10—Photometry, e.g. photographic exposure meter by comparison with reference light or electric value provisionally void
- G01J1/16—Photometry, e.g. photographic exposure meter by comparison with reference light or electric value provisionally void using electric radiation detectors
- G01J1/1626—Arrangements with two photodetectors, the signals of which are compared
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Urology & Nephrology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Indication And Recording Devices For Special Purposes And Tariff Metering Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/542,997 US3989382A (en) | 1975-01-22 | 1975-01-22 | Platelet aggregation monitoring device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5197483A JPS5197483A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-27 |
| JPS5848054B2 true JPS5848054B2 (ja) | 1983-10-26 |
Family
ID=24166171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51005509A Expired JPS5848054B2 (ja) | 1975-01-22 | 1976-01-22 | 血小板集合監視装置 |
Country Status (3)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4135818A (en) * | 1975-01-22 | 1979-01-23 | Bio/Data Corporation | Platelet aggregation monitoring device |
| FR2383444A1 (fr) * | 1977-03-11 | 1978-10-06 | Laborgeraete Analysensyst Gmbh | Mesure du temps de coagulation de sang |
| JPS5451893A (en) * | 1977-09-30 | 1979-04-24 | Sankyo Co | Measuring of blood coagulating time |
| US4309112A (en) * | 1979-05-15 | 1982-01-05 | Sherwood Medical Industries Inc. | Rate measurement analyzer |
| US4327371A (en) | 1979-12-19 | 1982-04-27 | The Singer Company | Method and apparatus calibrating a plurality of preamplifiers |
| US4325706A (en) * | 1980-08-15 | 1982-04-20 | Ortho Diagnostic Systems Inc. | Automated detection of platelets and reticulocytes in whole blood |
| US4591793A (en) * | 1984-06-14 | 1986-05-27 | Freilich Arthur H | Aggregometer electrode structures |
| US5114860A (en) * | 1984-10-09 | 1992-05-19 | Toa Medical Electronics Co., Ltd. | Device of measuring a blood coagulating time |
| US4856906A (en) * | 1986-09-29 | 1989-08-15 | Circuits And Systems, Inc. | Enhanced system for transmission loss comparison |
| US4788139A (en) * | 1987-08-06 | 1988-11-29 | Streck Laboratories, Inc. | Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood |
| WO1989010562A1 (fr) * | 1988-04-20 | 1989-11-02 | Vsesojuzny Kardiologichesky Nauchny Tsentr Akademi | Procede et dispositif pour analyser l'agregation de thrombocytes |
| US5223437A (en) * | 1989-12-01 | 1993-06-29 | Akzo N.V. | Direct fibrinogen assay |
| IE904244A1 (en) * | 1989-12-01 | 1991-06-05 | Akzo Nv | Direct fibrinogen assay |
| US5487112A (en) * | 1990-02-20 | 1996-01-23 | Board Of Regents, The University Of Texas System | Method and apparatus for time-resolved measurements of lymphocyte function and aggregate structure using computer-automated microscopy |
| US6043871A (en) * | 1997-03-03 | 2000-03-28 | Brigham Young University | System and method for measuring blood platelet function |
| WO2009111615A2 (en) * | 2008-03-05 | 2009-09-11 | Thrombovision, Inc. | Systems for measuring properties of a physiological fluid suspension |
| CN109406461B (zh) * | 2018-09-30 | 2021-05-14 | 山东泰利信医疗科技有限公司 | 血小板聚集率测量结果判定方法及血小板聚集仪的标定方法 |
| EP4134658A1 (de) * | 2021-08-10 | 2023-02-15 | Kommanditgesellschaft Behnk Elektronik GmbH & Co. | Verfahren zur erstellung einer datenbank zur ermittlung eines lichttransmissionsaggregometrie-referenzwerts und verfahren und vorrichtung zur durchführung einer lichttransmissionsaggregometrie-messung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089382A (en) * | 1957-07-01 | 1963-05-14 | Shell Oil Co | Method and apparatus for analyzing fluids |
| US3658480A (en) * | 1970-04-13 | 1972-04-25 | Bio Data Corp | Coagulation timing apparatus, and method |
| US3711774A (en) * | 1971-03-01 | 1973-01-16 | Perkin Elmer Corp | Automatic gain calibration |
| SE355414B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-04-05 | 1973-04-16 | Saab Scania Ab | |
| NL7305239A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-04-25 | 1973-10-29 | ||
| US3861877A (en) * | 1974-01-21 | 1975-01-21 | Clinical Technology Inc | Optical analysis of fluids |
-
1975
- 1975-01-22 US US05/542,997 patent/US3989382A/en not_active Expired - Lifetime
-
1976
- 1976-01-22 JP JP51005509A patent/JPS5848054B2/ja not_active Expired
- 1976-06-04 GB GB23214/76A patent/GB1504482A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1504482A (en) | 1978-03-22 |
| US3989382A (en) | 1976-11-02 |
| JPS5197483A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-27 |
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