JPS58213714A - Preparation of tablet - Google Patents

Abstract

PURPOSE:To obtain a tablet having improved appearance free from surface unevenness, by melting at least part of an inorganic or organic compound to be tableted and molded and a binder, blending them, cooling, powdering the blend, tableting and molding it. CONSTITUTION:In tableting and molding an inorganic or organic compound such as sodium bicarbonate, sodium sulfate, dichloroisocyanuric acid, etc. substantially containing no water or liberating no water of crystallization at <=50 deg.C, preferably at <=100 deg.C, the whole of the component or at least part of it and a binder component such as polyethylene glycol (2,000-20,000 molecular weight), etc. showing >=40 deg.C melting point are preheated at a temperature higher than the melting point of the binder, melted, blended, cooled, powdered, and, if necessary, the powder is blended with another component (e.g., a substance having high reactivity, a substance having low heat stability), tableted and molded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing tablets. This invention relates to a method for manufacturing tablets by compression molding that does not cause any unevenness on the tablet surface.
' Tablets are generally made by compressing powdered or granular raw materials or multi-component mixtures. At this time, although tablets can be obtained by compressing the powder or granule components as they are, a binder is generally added to improve the hardness and working efficiency of the tablets. Water is generally used as a binder, but if you do not want to add water or if components that are likely to be decomposed by water are added, water cannot be used as a binder. Undesirable.

In this case, a powder of an organic compound having a melting point of 40 U or more is added as a non-aqueous binder and the tablets are compressed. A problem with tabletting in this manner is chipping (a phenomenon in which irregularities occur on the surface and the appearance of the surface deteriorates).

Conventional measures to prevent such chipping have been to add calcium stearate, stearic acid, Merck, etc., but when tablets are dissolved in water and used, these are insoluble in water and float to the surface of the water. , which is undesirable because it causes discomfort.

The present inventors investigated a tableting method that does not cause chipping, and found that an organic compound with a melting point of 4°C or higher to be used as a binder and at least a part of the inorganic or organic compound components to be formed into tablets were mixed in advance. The present invention was achieved by discovering that tableting can be achieved without causing chipping by heating, melting and mixing at a temperature higher than the melting point of the binder, then cooling and pulverizing.

That is, in the present invention, when tabletting an inorganic or organic compound that does not substantially contain water or does not release water of crystallization at less than sor, all or at least a portion of the ingredients to be tableted are After heating and melt-mixing the binder component exhibiting a melting point of A4or or higher at m degrees above the melting point of the binder component, the mixture is cooled and powdered, and other components are added and mixed as necessary to form a tablet. The present invention relates to a method for producing a characteristic tablet.

The ingredient to be tableted by the method of the present invention is a substance that does not substantially contain water, or if water is contained as water of crystallization, water of crystallization is not liberated at temperatures below SaC, preferably below tj: 100-C. These substances include sodium sulfate, sodium carbonate, sodium bicarbonate, sodium pyrophosphate, sodium tripolyphosphate, sodium monophosphate,
Sodium salts such as dibasic sodium phosphate, or their inorganic salts such as potassium salts, calcium salts, and magnesium salts, percarbonate, sodium perborate, potassium monopersulfate double salts (for example, 2So, KH8O,:
double salt with a molar ratio of KH8O1l of 1:2:1), 4 Ha
280. ' 2 Sodium sulfate-chloride such as H2O2.Na0t) +7um Oxygen-based dyes such as monohydrogen peroxide adducts, dichloroisocyanuric acid and its alkali metal salts or alkaline earth metal salts, trichloroisocyanuric acid acid, dichlorodimethylhydantoin, tetrachloroglycoluril, calcium hypochlorite, lithium hypochlorite in an aqueous solution of 1 g of hypochlorite acid or hypochlorite, an organic or inorganic chlorine compound that produces a chlorine salt; Acids, organic acids such as tartaric acid, citric acid, conolinic acid, gluconic acid, adipic acid, or their alkali metal salts or alkaline earth metal salts, etc., and if necessary, fungicides, dyes, pigments, etc. are also used. I can do it.

It is desirable that these substances be substantially anhydrous, but for example, carbonate containing water of crystallization, IJum monohydrate, sodium pyrophosphate decahydrate, sodium tripolyphosphate hexahydrate, etc. , NaBO3.4H20, etc. can also be used.

A preferable substance having a melting point of 40 tl' or more used as a binder is an ethylene oxide adduct;
For example, polyethylene glycol (molecular weight 2000-20
000), polyoxyethylene (number of added moles n=1
5 or more) alkyl (Oa to C22) ethers. Other polyoxyethylene (n=15 or more) fatty acid (0□2~C22) ester, and fatty acid (C2~0
22) etc. can also be used. The addition of these binders 11 is from 0.1 to 1o M of the entire mixture to be tableted, *tib is 2i!
I, preferably 0.5 to 5% by weight.

The ingredients to be heated and melted in advance together with these binders may be all of the ingredients to be made into tablets, or only a portion thereof may be treated.

When a highly reactive substance or a substance with low thermal stability is incorporated into a tablet, other inert ingredients such as sodium bicarbonate or sodium sulfate and a binder may be melted by heating. After the mixing treatment, it is preferable to add the mixture to the cooled powdered system and then tablet.

The tablets obtained by compressing the tablets according to the method of the present invention can be used for detergents, whitening agents, pool disinfectants, bath additives, bath water cleaners, and other uses, depending on the composition of the tablets. A product with an excellent appearance without any unevenness on the surface can be obtained.

Examples of the present invention will be shown below, but the present invention is not limited to these Examples. The blending ratio is m'J1m.

Example 1 For formulations A and B, the raw material powders were mixed as they were. For Formulation C, the mixed system was heated in advance at 65C for 20 minutes using a table kneader (Irie Shokai: Model PNV-1) and then cooled.

The mixed system took on a powder form just by cooling, and no pulverization or sieving was required.

These A, B, and O powders were each compressed into 17 S tablets using a tablet machine (Hata Tekkosho: Model HT-8/1). After 10 tablets of A were compressed, powder adhesion to the rods and whites had already occurred, and unevenness had formed on the surface of the tablets.

In addition, tablet #g1 of B was weak, and the tablet disintegrated when pressed lightly with a finger. The result measured with a bookstore type hardness tester is 5-61Q.
/ It was a lock. Even when 100 tablets of 0a were compressed, there was no adhesion to the rod or white, and there was no change in the surface of the tablets. Further, the hardness was 15 to 23-, showing a sufficient hardness.

From the above, it can be seen that the tableting method according to the present invention not only improves tableting properties, but also requires less amount of binder, making it economical.

The sodium percarbonate tablets of formulation 0 prepared as described above can be added as a date marking agent and used as an adjunct to detergents by adding 3 to 4 tablets at the time of washing the tumor.

Example 2 Potassium dichloroisocyanurate 30 Tartaric acid 30 Sodium bicarbonate 38.5 Polyethylene glycol (
Molecule z40oO) 1.5 The mixed system of sodium heavy acid and polyethylene glycol 4000 in the above reaction was mixed and melted in a table kneader for 10 minutes, and cooled for 1 to 10 minutes, as in the case of formulation 0 in the example. The treated product was in almost the same condition as the original powder. This was mixed with tartaric acid and potassium dichloroisocyanurate, and tableted in the same manner as in Example 1. 1
Even after 00 tablets were compressed, there was no powder adhesion to the rods or whites, and no rc unevenness occurred on the tablet surface.

If you add one tablet of this tablet to your bath at home, it will prevent the growth of fine particles and prevent the bath water from becoming cloudy, slimy, and smelly even after you turn it over twice.

Example 3 Sodium dichloroisocyanurate 50 Sodium tripolyphosphate 48 Myristic acid 2 Sodium tripolyphosphate in the above formulation 1 Jum powder and 1) Stin*fyoc were heated and melted for 10 minutes, cooled and powdered. When sodium dichloroincyanurate was added to this and the tablets were compressed into 5 tons/tablet in the same manner as Tushu 991, there was no powder adhesion to the rod or die even after 100 tablets were compressed. No unevenness occurred on the surface.

Motoichi will use Keyaki whitening agent and L2.

Applicant's agent Kaoru Furuya Procedural amendment (spontaneous) July 21, 1980 Director-General of the Tokuken Agency Kazuo Wakasugi 1, Indication of the case Patent application No. 17-97095 2, Name of the invention Method for manufacturing tablets 3. Relationship with the case of the person making the amendment Patent applicant (091) Kao Soap Co., Ltd. 4 Agent 75 Nakai Building, 1-1 Nihonbashi Yokoyama-cho, Chuo-ku, Tokyo Column 6 of the detailed description of the invention in the specification, Contents of the amendment 88-

Claims (1)

[Claims] 1. When compressing into an IR tablet an inorganic or organic compound that does not substantially contain water or does not release water of crystallization at hsoc or lower, the above-mentioned ji! All or at least some of the components to be molded are heated at a temperature higher than the melting point of the binder component, melt-mixed, and then cooled and powdered, followed by adding other components as necessary. 1. A method for producing tablets, which comprises adding and mixing and compressing into tablets. 2. Ingredients to be formed into tablets are 1 carbonate) IJum. The binder component may be one or more selected from the group consisting of sodium peroxide, sodium nitrate, sodium carbonate, dichloroisocyanuric acid, sodium dichloroisocyanurate, and potassium dichloroisocyanurate. Polyethylene glycol (molecule II 2000~
20,000) or polyethylene glycol alkyl ether (the number of moles of ethylene oxide added is 15 or more, the number of alkyl carbons is 8 to 22), and one or more kinds selected from the group consisting of fatty acids! 'A method for producing a tablet according to item 1. 6 Sodium bicarbonate and molecular weight 2000~toooo. After melting and mixing with polyethylene glycol by heating at 60 to 100 C, cooling and □ powdering, to this is added a mixture of one or more selected from tartaric acid, oxalic acid, citric acid and condensate, or ( and) the method for producing a tablet according to claim 2, which comprises adding sodium dichloroisocyanurate, potassium dichloroisocyanurate, or a mixture thereof and forming the tablet into a tablet.