JPS58213701A - 臓器の保存方法 - Google Patents
臓器の保存方法Info
- Publication number
- JPS58213701A JPS58213701A JP9589682A JP9589682A JPS58213701A JP S58213701 A JPS58213701 A JP S58213701A JP 9589682 A JP9589682 A JP 9589682A JP 9589682 A JP9589682 A JP 9589682A JP S58213701 A JPS58213701 A JP S58213701A
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- organ
- perfusate
- perfusion
- drop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000056 organ Anatomy 0.000 title claims abstract description 64
- 238000004321 preservation Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000007710 freezing Methods 0.000 claims abstract description 35
- 230000008014 freezing Effects 0.000 claims abstract description 30
- 239000008280 blood Substances 0.000 claims abstract description 24
- 210000004369 blood Anatomy 0.000 claims abstract description 24
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
- 210000001367 artery Anatomy 0.000 claims abstract description 14
- 210000003240 portal vein Anatomy 0.000 claims abstract description 14
- 210000003462 vein Anatomy 0.000 claims abstract description 9
- 230000010412 perfusion Effects 0.000 claims description 47
- 239000007798 antifreeze agent Substances 0.000 claims description 15
- 230000006378 damage Effects 0.000 claims description 13
- 238000010257 thawing Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 230000036760 body temperature Effects 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 230000017531 blood circulation Effects 0.000 claims description 4
- 230000008081 blood perfusion Effects 0.000 claims description 4
- 239000002577 cryoprotective agent Substances 0.000 claims description 4
- 210000004204 blood vessel Anatomy 0.000 claims description 3
- 230000035922 thirst Effects 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- 238000001816 cooling Methods 0.000 description 6
- 239000003507 refrigerant Substances 0.000 description 5
- 239000007789 gas Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 229940113601 irrigation solution Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9589682A JPS58213701A (ja) | 1982-06-04 | 1982-06-04 | 臓器の保存方法 |
| CA000429420A CA1200507A (en) | 1982-06-04 | 1983-06-01 | Method of preserving organ and apparatus for preserving the same |
| DE8383303133T DE3366419D1 (en) | 1982-06-04 | 1983-06-01 | Method of preserving organ and apparatus for preserving the same |
| EP83303133A EP0096997B1 (en) | 1982-06-04 | 1983-06-01 | Method of preserving organ and apparatus for preserving the same |
| US06/615,212 US4494385A (en) | 1982-06-04 | 1984-05-20 | Method of preserving organ and apparatus for preserving the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9589682A JPS58213701A (ja) | 1982-06-04 | 1982-06-04 | 臓器の保存方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58213701A true JPS58213701A (ja) | 1983-12-12 |
| JPS6155881B2 JPS6155881B2 (enrdf_load_stackoverflow) | 1986-11-29 |
Family
ID=14150066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9589682A Granted JPS58213701A (ja) | 1982-06-04 | 1982-06-04 | 臓器の保存方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58213701A (enrdf_load_stackoverflow) |
-
1982
- 1982-06-04 JP JP9589682A patent/JPS58213701A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6155881B2 (enrdf_load_stackoverflow) | 1986-11-29 |
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