JPS58213073A - Solidification of oily substance - Google Patents

Abstract

PURPOSE:To solidify an oily substance to facilitate the administration, without making the volume larger and utilizing injurious org. solvents, by mixing an adsorbent with an emulsion of an oily substance emulsified by the use of surfactants and water. CONSTITUTION:An oily substance (e.g., vitamin A, vitamin E, castor oil) is emulsified by the use of surfactants (e.g., polysorbate, polyoxyl stearate) and water. The resulting oily substance emulsion and an adsorbent (e.g., silica, synthetic aluminum silicate) are mixed and then dried. It is possible to facilitate the administration of an oily substance, and to solidify it without making the volume larger and utilizing injurious org. solvents.

Description

[Detailed description of the invention] The present invention relates to a method for solidifying oily substances.

More specifically, the present invention provides a method for solidifying an oily substance, which is characterized by emulsifying the oily substance using a surfactant and water, mixing the oily substance emulsion with an adsorbent, and then drying the oily substance. It is about law.

Conventionally, methods for solidifying oily substances include, for example, directly adding liquid substances to excipients such as starch, lactose, microcrystalline cellulose, silicic anhydride, calcium citrate, synthetic aluminum silicate, and magnesium oxide. Adsorption methods have been used, but these excipients have insufficient adsorption capacity and fluidity, have too large a volume, or cause mutual changes with the liquid, making them impractical. Moreover, the oily substance is dissolved in an organic solvent such as chloroform, chlorocene, methylene chloride, etc., and the oil is dissolved in an organic solvent such as silicic anhydride, calcium citrate, synthetic aluminum silicate, or oxidized aluminum. A method has been used in which liquid substances are adsorbed onto magnesium, etc., but this method has drawbacks such as the effect of organic solvents on the human body and the complexity of the process during the formulation process.
Special Publication No. 49-46899).

On the other hand, when taking an oily substance directly, it is difficult for the patient to take it, and when the oily substance is emulsified and taken as an emulsion as a way to easily take an oily substance, the emulsion may separate due to long-term storage or If stored for a long time, it will rot and have a negative impact on the human body, and there are problems such as using large amounts of preservatives.

Inventor Akiyoshi ``) 1) In order to solve the additional points of J'11', we found a way to solidify oily substances without using organic solvents that are harmful to the human body. The invention has been completed.

That is, the present invention emulsifies an oily substance using a redundant active agent and water, mixes this oily substance emulsion with an adsorbent, and processes 1. This is a method for solidifying oily substances, which is characterized by drying and stirring after drying.

The oily substances used in the present invention include, for example, vitamin A1, vitamin E acetate, soybean oil, unsaponifiables of soybean oil, castor oil, clofibral-1, gefal/te, linoleic acid, eugenol, and squalane. Examples of natural or synthetic oily substances such as (・)a), 1 and 1) and W surfactants used in the present invention include vorinorbe-1, polyoxyl stearate, lauryl fII11)I, lium, etc. 3) Sexual agents can be cited as surface active agents. Furthermore, the adsorbent used in the present invention includes, for example, silicic anhydride, calcium silicate, synthetic aluminum silicate, calcium citrate, magnesium oxide, light silicic anhydride (trade name: Aerosil), and preferably light silicic anhydride. It is.

The solid oily substance obtained in the present invention can be made into powders, fine granules, and granules by known pulverization and granulation methods, and these powders, fine granules, and granules can be further converted into capsules, It can also be added to tablets, pills, etc.

In addition, the present invention covers powders, which are the final products of the present invention,
In order to improve the quality of fine granules, granules, capsules, tablets, pills, etc., known binders, disintegrants, lubricants, stabilizers, excipients, colorants, etc. may be added. can.

Reference Example The dried product obtained in Example was powdered, 70.9 g of crystalline cellulose and 50 g of carboxymethyl cellulose calcium were added to the powder, mixed, and 600 ml of Ma(4) Crocol 3I and 8() Thimethanol was added and conflated. , granulated, magnesium stearate 20g
was added, spheroidized using a marmerizer, dried, and then filled into capsules to obtain hard capsules.

Next, Example 1+11 of the present invention will be shown. 40()
9, quay/acid 11.9 and ascorbic acid 4g 8
()°C mixed solution was added and emulsified. The emulsion was added to 100 fl of light anhydrous citric acid, kneaded and adsorbed, and the adsorbed material was dried to scrape off the solid matter of unsaponifiable soybean oil.

that's all Applicant Masatoshi Yama 11

Claims (1)

[Claims] A method for solidifying an oily substance, which comprises emulsifying the oily substance using a surfactant and water, mixing the oily substance emulsion with an adsorbent, and then drying the mixture.