JPS58203382A - Freezing dry warehouse - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a freeze-drying oven into which vials can be automatically pushed. Conventionally, when freeze-drying a drug solution in a container such as an ampoule or a vial, the container after being filled with the drug solution is
It is stored in a tray, and this tray is placed on a shelf in the freeze-drying chamber for drying. This method involves loading and unloading containers into and out of trays, and requires a large number of trays. In addition, cleaning and sterilization of the trays are required, resulting in problems such as manpower, space, tray costs, and contamination inside the refrigerator due to rubbing between the trays and the shelves.

In order to eliminate these drawbacks, the present invention provides an apparatus for directly loading and unloading containers filled with chemical solutions onto the shelves of a freeze-drying storage without using a tray.

To explain the figures, FIG. 1 is a plan view of the pushing device of the present invention, and FIG. 2 is a sectional view taken along line ▲1A in FIG. The containers to be processed, such as, are transported in a line by the conveyor 2 to the front of the freeze-drying warehouse 3. When the vial is pushed from the conveyor 2 through the transfer plate 6, if the drug solution in the container 1 shakes, the drug solution will adhere to the inner wall of the container and cause an unsightly appearance when finishing the product.
In addition, if the container 1 falls over, the chemical liquid will be scattered and a great deal of effort will be required to remove the surrounding containers and clean up afterwards. Therefore, in the embodiment of the pushing device of the present invention, when transferring a container from the conveyor 2 in the right angle direction, a pushing frame 7 is used, the frame 7 surrounds the front and back of the container, and the cylinder 4 applies fluid pressure to the frame 7.
The piston rod 9 fixed to the vial is pushed out and the vials are sequentially pushed out onto the shelf. Frame 7 as shown in Figure 1
is first positioned on the conveyor 2, and the containers transferred on the conveyor are placed one after another into the frame. When the required number of containers are filled within the frame to fill the width of the shelf 5, the stopper 8 moves forward to move the next container. Is the cylinder 4 the piston rod? That is, when the frame 7 moves forward into the refrigerator, inserts the - row of containers to the deepest position on the shelf in the refrigerator, and reaches the predetermined position, the frame 7' in the predetermined position moves into the cylinder 4 as shown in FIG. 7'
It goes to position 7M, is pulled back and goes to position 7M on the conveyor, where it is lowered onto the conveyor. Then, the stopper 8 is pulled out and the suppression operation for the next row is restarted.

Figures 3 and 4 show two sides of the structure of the frame 7;
is a plan view of the first example, and (E) is a side view shown using trigonometry. It has the same structure as the frame shown in FIGS. 1 and 2, and consists only of the frame. It is advantageous to a certain degree. FIG. 4 shows a second example, in which FIG. 4) is a plan view and CB) is a side view, which has a back plate 72, which is advantageous when the width W is from several tens of meters to more than 1 meter.

The shelves 5 are multi-tiered, and when containers are lined up on one shelf, that shelf is lifted upwards and containers are arranged on the shelf one level below in the same way. At this time, as shown in FIG. 5, when the distance between the upper shelf 5' and the shelf 5 on which the containers are arranged is narrow, the holding portion 7a of the pushing frame 7 in front of the container is shortened. Then, when the frame 7 is lifted up to the upper position 7' and returned to the rear as shown in FIG. 5, since the holding portion 7a is short, the amount of lifting can be reduced. Alternatively, as shown in Figure 6, the structure of the frame 7 is formed into a shape having a circular arc in the front, and the cylinder 4a is rotated by protruding the piston rod 9'. It can be removed from the container as shown in the figure).

Note that if containers are pushed into a grid when entering the warehouse, the shelf surface cannot be used effectively, and the alignment may be disrupted starting from the part that was entered first, making it impossible to stock a predetermined number of containers.

Therefore, in the embodiment of the present invention, as shown in FIG. 7, a stopper pin 12 is moved in and out of the frame 7 by a solenoid 11, and the position of the containers that enter the deepest part of the frame is shifted by half the diameter of the containers in each row. . Figure 8) shows another embodiment, in which a metal fitting 15 is fixed to the frame 7 at the tip of the piston rod 9, and a shaft 14 passes through it.
As shown in the figure, it is locked to shaft stoppers 13.13a fixed to the left and right sides of the shaft. A cylinder 18 is mounted on the bracket of the receiver, and a pin is inserted in and out between it and the shaft stopper 13a, and a spring 16 is inserted between the shaft stopper 13 and the bracket 15 of the receiver. There is. Fig. 8 03) shows a state shifted by half a pitch to the left compared to the state in (A). When the pin 17 is extended from the cylinder 18 and the bearing fitting 15a is pushed to the left, this bearing is moved to the frame 7. Since the frame is fixed to , the entire frame shifts to the left by a half pitch while compressing the spring 16.

When the pin 17 is withdrawn, the spring 16 expands and returns to the state shown in (A).

After the freeze-drying operation is completed, as shown in FIG. 9, in the warehouse 3, the shelves 5 are successively suspended from the receiving position 5' to the crotch of the seams. It is carried out to a take-out conveyor via a conveyor.

FIG. 10 shows an example of a device for driving the extrusion device 21 outside the drying chamber. Supported. A holder 2 is attached to the shaft 27.
6 is fixed to a chino 25 which is driven via 26 holders, a motor 23, a torque limiter 24 and a sprocket 30. Therefore, if the motor 25 drives the chamber left and right, the extrusion device 21 can also be moved left and right within the warehouse via the holder 26 and the slide shaft 27.

FIG. 11 and subsequent figures are explanatory diagrams of an example of means for lifting multi-tiered shelves, with FIG. 11 being a side view and FIG. 12 being a front view. Fix stoppers 51, 52, 53, 54°, etc. to the sides of da, 5', 5-, respectively,
Hanging fittings 41, 42, 45, etc. are fitted therein, and locking portions 61, 62, 65, etc. are formed at the lower ends of each. The length from the head of the hanging fitting 41 to the locking part at the lower end is determined in accordance with the spacing between the shelves when the hanging fitting 41 is lifted.

13 and 14 show the state when the uppermost shelf 5 is lifted up. Multi-level shelf 5.5'.

5'... are initially located below the drying chamber 3, as shown in FIG. 11.12. When the containers are now arranged on the uppermost shelf 5, when the first shelf 5 is pulled up by an appropriate means (not shown as it is a well-known means), the hanging fittings 41 are attached to the stopper 51. Since the head is locked,
The hanging fitting 41 rises together with the shelf 5, and stops when the locking part 61 at the lower end collides with the stopper 52 of the shelf 5' one step below, and '1.::'.

Then, line up the containers on the shelf 5' below. When the shelf 5 is lined up with the shelf 5', when the shelf 5 is raised again, the locking part at the lower end of the hanging fitting 41 collides with the stopper 52 of the shelf 5', so the shelf 5' is also raised at the same time as the shelf 5. Starting from this, the hanging fitting 42 whose head is engaged with the stopper 52 also rises together with the stopper 52.

The lower end locking part 62 of the hanging fitting 42 is the stopper 55 of the shelf 5'.
When the shelf 5 stops rising when it collides with the shelf 5, the shelf 5 and the shelf 5' are lifted up, and a container can be placed on the shelf 5'. In this way, all you have to do is hoist the shelves one after another.

When the containers are to be taken out after the freeze-drying operation, the bottom shelf can be lowered to the removal position and the shelves can be lowered one after the other in reverse, as described in connection with FIG. The shelves from which the containers have been removed are then stacked downward, returning to the state shown in FIG. 12.

FIG. 15 is a schematic diagram to facilitate understanding of the present invention, and is a schematic diagram showing the vial filling and semi-cappering machine 31 to the vial 1. @・
The fist is sent to the front of the freeze-drying warehouse 3 by the conveyor 2, and the cylinder 4 and the pushing frame 7 press the pie □1':: Al1. ... is pushed onto the shelf base. 5' indicates the shelf where the arrangement ends and rises one step higher.

Although FIG. 16 shows a take-out device, which is installed below the pushing device in FIG. 15, only the take-out device is shown in order to avoid complication of the drawing.

The vials on the shelf 5 are pushed forward by the extrusion device 21, and in the illustrated example, the vials 1°... are placed on the conveyor 22 by the rotary distributor 32 and taken out.

[Brief explanation of drawings]

Fig. 1 is a plan view of the pushing device of the present invention, Fig. 2 is a sectional view taken along the line A-A in Fig. 1, Figs. 3 and 4 are views showing two embodiments of the pushing frame, and Fig. 5 Figure 6 shows the operation of the frame.
Figures (A) and CB) are diagrams showing the operation of a frame with a different configuration, Figure 7 is a plan view showing the operation of the stopper bin, and Figure 8 (A).
), (B) is a diagram showing the operating sequence of another embodiment, No. 9
The figure is a plan view of the extrusion device, FIG. 10 is a diagram showing an example of the drive means of the extrusion device, FIG. 11 is a side view of an example of the shelf upper means, FIG. 12 is a front view, and FIG. FIG. 14 is a side view showing the operating state of the assembly means, and FIG. 15 is a front view as well.
The figure shows an explanatory diagram of the pushing device, and FIG. 16 shows an explanatory diagram of the extruding device. Explanation of symbols 1.0. Vial, 2... Incoming conveyor, 3...
Freeze drying chamber, 4... cylinder, 5... shelf, 6...
Passage board, 7... push frame, 7a conflict... holding part, 8...
...Stopper, 9...Piston rod, 11...Solenoid, 12.Working/stopper bottle, 15...Shaft stopper, 14...Shaft, 15...Bracket is metal fitting, 16...
Spring, 17---pin, 18---cylinder, 21...
-・Extrusion device, 22... Delivery conveyor, 26-・e
Motor, 24... e Torque limiter-125... Cheno, 26... Holder, 27... Slide shaft, 2
8...Bearing, 29...Vacuum seal device, 30...
Sprocket, 31s...Filling, half capping machine, 41...
Hanging fixture, 51. (11 or 3 people) Procedural amendment June 3rd, 1980 Patent Application No. 67153, filed in 1982 2, Name of invention Freeze-drying oven 3, Relationship with the person making the amendment ° Patent application Person's Name (667) Yamanouchi Pharmaceutical Co., Ltd. 7, Scope of Claims Subject to Amendment Scope of Patent Claims 1) A conveyor for conveying Nono-ials, and a conveyor for transporting Nono-ials in a direction perpendicular to the conveyor inside the warehouse. A freeze-drying warehouse characterized by being equipped with a pushing device for pushing onto a shelf. 2) The freeze-drying oven described in the patent, characterized in that the above-mentioned vial pushing device includes a device for mutually shifting the vials to the left and right in the pushing direction for each row. 6) The freeze-drying warehouse according to claim 1, characterized in that it is an extrusion device for extruding vials from the shelf by ['+1C]. 4) The above-mentioned shelves in the refrigerator are multi-tiered, and the shelves are stacked one after another. Li. The freeze-drying warehouse according to claim 1, further comprising a lifting device.

Claims (1)

[Scope of Claims] 1) A freeze-drying warehouse characterized by comprising a conveyor for conveying vials, and a pushing device for pushing a fixed number of vials onto a shelf in the warehouse in a direction perpendicular to the conveyor. 2) The freeze-drying warehouse described in the patent, characterized in that the above-mentioned vial pushing device includes a device that alternately shifts the vials to the left and right in the pushing direction for each row. 3) The freeze-drying warehouse according to claim 1, further comprising an extrusion device for pushing out vials from the shelf into the warehouse. 4) The freeze-drying refrigerator according to claim 1, characterized in that the shelves in the refrigerator are arranged in multiple stages and are equipped with a device for lifting them up one after the other.