JPS58198414A - Toothpaste - Google Patents

Abstract

PURPOSE:Toothpaste capable of suppressing the irritation of gingiva and preventing periodontosis, obtained by blending a composition base containing calcium hydrogenphosphate treated with magnesium and polyphosphoric acid with epsilon-aminocaproic acid. CONSTITUTION:A toothpaste composition base containing calcium hydrogenphosphate obtained by treating calcium phosphate as an abrasive with magnesium and polyphosphoric acid is blended with 0.01-1.0wt% epsilon-aminocaproic acid having anti-plasmin action. epsilon-Aminocaproic acid is contained and kept in the base in a stable state by the use of the abrasive stabilized with magnesium and polyphosphoric acid, inflammation of paraodontitis, marginal gingivitis, etc. are prevented securely, and the toothpaste has preventing action on hemorrhage of gum during cleaning of teeth.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to tooth brushing that suppresses gingival irritation and prevents periodontal diseases.

In general, the two diseases in the dental field are dental caries and periodontal tissue diseases, and among these, periodontal diseases are the most common diseases, as shown in reports on morbidity and tooth loss, as well as reports on the actual state of dental diseases in Japan. The prevalence of this disease is comparable to that of dental caries, and the effects on teeth are also profound.

However, these factors are not single-N-acting, but are extremely complex, as they are a combination of several factors and are based on individual differences in resistance, but the most important of these factors is It can be said that what must be considered is the local factor of oral hygiene.As for the progression of periodontal disease, the papilla and margins of the gums first become hyperemic, causing edema, swelling, etc.2- Normally, the step ring disappears, the gingival surface becomes swollen, becomes soft and easily bleeds, and then the gingival inflammation spreads and progresses to alveolar pyorrhea. In such a state, when you use a toothbrush or eat fruits such as apples, you tend to bleed easily, discharge pus, and experience bad breath and discomfort.

It is also known that these can cause systemic diseases in the human body; in other words, the above-mentioned simple papillary gingivitis and simple marginal gingivitis are the early symptoms of periodontal disease. In order to prevent periodontal disease, it is important to prevent the occurrence of simple papillary and marginal gingivitis, and for this reason, it is extremely important for dental health to properly perform cleaning and gingival gingival surgery on both days of daily life. As one means of achieving this, it is extremely effective and reasonable to brush with a toothpaste that is effective in removing dental deposits and preventing gingival diseases, so toothpastes containing various drugs have been tried. 5- However, each has its advantages and disadvantages and problems.

For example, an astringent containing aluminum salt produces a bitter and astringent taste.

There are problems with compatibility, and products containing dihydrocholesterin or methyl glycyrrhetinate have problems with compatibility, solubility, stability, resources, and cost. However, there are problems with stability, cost, and blendability with photosensitive elements and azulene, and there are problems with coloration, cost, resource considerations, and solubility. It was not possible to satisfy all conditions such as the effect of preventing periodontal disease and the effect of reducing discomfort in the mouth when waking up.

The object of the present invention is to provide a toothpaste that satisfies and overcomes all of these conventional problems.

Furthermore, the purpose of the present invention is to prevent the development and progression of periodontal disease by utilizing epsilon aminocaproic acid, an anti-plasmin substance that inhibits the action of plasmin, to appropriately prevent periodontal disease, and to improve the ability to remove tooth contaminants. 85B-i98414 (2
) To provide an economical tooth-brushing force which can significantly improve the brushing force and eliminate bad breath, and which can be exerted without reducing the efficacy of epsilon aminocaproic acid.

The present invention provides a composition base comprising an active ingredient for tooth chewing, which contains epsilon aminocaproic acid (hereinafter abbreviated as ε-aminocapro/acid), which has an anti-plasmin effect, and calcium phosphate-hydrogen treated with magnesium-polyphosphoric acid. E 0.
This is a toothpaste composition characterized in that it contains 01 to 1.0% by weight.

The e-aminocaproic acid used in the present invention has a structural formula of It has been reported that it has excellent effects as a synthetic anti-plasmin agent that blocks the action of plasmin (a proteolytic enzyme).

However, this C-aminocaproic acid does not contain water-soluble calcium ions in toothpaste compositions.
When C occurs, its efficacy is reduced, and it is not only necessary and important as an active ingredient for preventing bleeding, but also works together with surfactants to improve its dispersibility.
Research has revealed that it is compatible with toothpaste compositions in that it can significantly remove bad breath and can increase and strengthen polishing power without increasing the amount of abrasive.

That is, the following experimental results were obtained regarding the stability of ε-aminocaprodiaic acid during tooth brushing and its effects.

(1) Experiment-1 Anti-plasmin effect of e-aminocaproic acid (I) Experimental method Fibrinolyaia (1yai) using human serum
The inhibitory effect of e-aminocaproic acid in the a time method) was investigated.

6- + 0.5% kxwine fibrinogen
Q, 2mk 1yais measured at 25℃ (Ill results (note) fist phosphate buffer -5aline
(pHl 4) Horizontal bar 1ysis time -7- (2) Experiment-2 Inhibition rate of e-aminocaproic acid-containing toothpaste and stability during toothbrushing 871■ in PBS 8.71d+=Dispersion b: Toothpaste 1087iy containing e-aminocaproic acid α1% (summer i) P
Dispersed in BS 10.87 + 117 C: ε-Aminocaproic acid 0-5% C [I) Toothpaste 90589 PB 89.05ml + = Dispersed '4 猜ll'a58-198414 (3) Fist-inhibition rate @) Probit is used to utilize the fact that the inhibitor log concentration is linearly related (results of experiment-1), and the 1ys of this experiment result is
The inhibition rate and the amount of t-aminocaproic acid in toothpaste were determined from is timθ.

(3) Clinical experiment (summer) experimental method Targeting female junior college students who lived in a dormitory and had relatively the same living environment, we unified the conditions for using toothbrushes, oral cleaning methods, and sample toothpaste.

Examination: Objective and subjective symptoms were observed during the examination immediately before the start of the clinical experiment, and similar examinations were conducted every week, and the clinical experiment was conducted for 4 consecutive weeks, for a total of 5 examinations.

(FF+Results) Compared to dihydrocholesterin-containing products, which are conventionally considered to be highly effective in this type of toothpaste, this product has the following advantages:

1 Marginal periodontitis suppression effect (objective) 19.9% reduction after 1 week of use (12,3chi) 4 weeks
# 57.7chi I (46,8chi)N Papillary gingivitis suppressive effect (objective) 36.5chi decrease after 2 weeks of use (14,85)4
44.4% # (44.4%) 111
Gum bleeding prevention effect (perceived) 652-reduction after 1 week of use (13.3%) 45α0%
＃゛(50,6chi) 1v Effect of reducing discomfort in the mouth when waking up (perceived) 610% reduction after 1 week of use (556%)
) V tooth movement suppression effect 197 slow decrease after 1 week of use (0chi) 4
60,1 liter C66, 7 liter) [However) The value indicates the reduction rate in the dihydrocholesterin-containing product. ] As shown in the above experimental results, the stabilizing combination of ε-aminocaproic acid in toothpaste and the periodontal disease preventive effect of e-aminocaproic acid in toothpaste were confirmed in Experiment 10.

It is recommended that the toothpaste contains 1-aminocaproic acid in a dissolved state at a concentration of at least 0.01% by weight, preferably within the range of about 0.05 to 2.0% by weight, and is used as a toothpaste to prevent periodontal disease. It can also be blended with a surfactant to improve its dispersibility and increase its effectiveness.

In this case, the efficacy of 6-aminocaproic acid is proportional to its concentration, but if the amount is less than 0.01 weight 1*, the desired function cannot be fully exerted, and 2.0 weight t
If the content exceeds t%, the bitterness becomes extremely strong and, unlike temporary products such as medicines, the properties of toothpaste, which is expected to be effective with continuous use, should be avoided, so it should be avoided.

Furthermore, calcium carbonate or calcium phosphate, which are commonly blended as one of the toothpaste base materials, elutes and exists in large amounts of water-soluble calcium ions, reducing the efficacy of e-aminocaproic acid. Calcium hydrogen phosphate treated with 11-acid is used. In this case, it is not necessary to increase the blending amount by more than 1.0% by weight (the effect can be sufficiently exhibited in the range of 01 to 10% by weight, but the maximum amount is 2.0% by weight).

As a treatment for stabilizing the calcium hydrogen phosphate, for example, quicklime and water are mixed to form lime milk, phosphoric acid and a small amount of birophosphate and/or magnesium salt are added and reacted, and the mixture is aged. . In this case, a small amount c)) birophosphoric acid and/or magnesium salt may be added during mixed ripening. After aging for a certain period of time (approximately - days), dehydrated and filtered,
Grind after drying. The content of birophosphate and/or magnesilla salt relative to the calcium phosphate thus obtained is preferably less than 2% N and around 1%, and it is effective to use this in the above-mentioned mixing ratio as a toothpaste.

Also, in order to increase the polishing power, it is possible to increase the amount of abrasive or use powder with high polishing power, but in this case, are there any disadvantages such as bleeding in the mouth? '1iKid, j5B-i
98414 (4) However, since ε-aminocaproic acid can remove these defects and prevent bleeding, it can also enhance the polishing power. In addition, when anhydrous calcium phosphate is added to the toothpaste ml base material to improve the ability to remove tooth contaminants, it generally tends to cause inflammation of the gums, but when used in combination with 1-aminocaproic acid, there is no risk of this occurring and the anti-inflammatory effect is maintained. It can easily improve gum health and whiten teeth, and can also be used as a foaming agent to relieve irritation of the oral mucous membranes.

In the toothpaste of the present invention, substances commonly used as toothpaste active ingredients, such as abrasives, humectants, foaming agents, additives, sweeteners, fragrances, surfactants, medicinal agents, and other necessary substances such as water, are added in advance. Calcium phosphate as a polishing agent is treated with magnesium-polyphosphoric acid to obtain calcium phosphate-hydrogen. E-aminocaproic acid is blended into the base material to make toothpaste.

The toothpaste composition containing e-aminocaproic acid of the present invention can accurately prevent inflammation such as marginal periodontitis or papillary odontitis, and also has the effect of preventing gum bleeding during toothbrushing. , eliminates bad breath, effectively exhibits all of the effects of reducing oral discomfort when waking up and suppressing tooth movement, and ε-aminocaproic acid is contained and retained in a stable state in toothpaste. When used, it has the ability to provide these appropriate preventive and inhibitory effects, exhibiting an extremely excellent effect on preventing periodontal disease, and also improving the oral cleaning effect and easily removing tooth contamination. It is superior to conventional toothpastes of this type in terms of resources and cost, and has the advantage of ensuring stable formulation and a refreshing feeling of use.

Next, examples of the present invention will be shown.

Example 1 Fibacteria polishing Calcium hydrogen phosphate (dihydrate) SO, O (1 t% by weight)
) Glycerin 25.0 Carboxymethylcellulose 1.0 Foaming agent
2.0 Saccharin 0.114- Flavor 1.0 (Weight tIb
) Meaminocaproic acid 0.0
5 Water Since ε-aminocaproic acid is slightly soluble in hot ethanol, almost insoluble in other organic solvents, but well soluble in water, dissolve 6-aminocaproic acid in an appropriate amount of water, and then dissolve saccharin. This is added to a solution in which carboxymethyl cellulose is swollen in glycerin and mixed by stirring. A fragrance 2 foaming agent and calcium hydrogen phosphate dihydrate were added to this and mixed in a kneader for 25 minutes to obtain a product.

Calcium hydrogen phosphate is treated with magnesium-polyphosphoric acid, and is considered to have the effects of e-aminocaproic acid, making it possible to stably incorporate it into the toothpaste base material.

Example 2 Fibacteria polishing calcium hydrogen phosphate (anhydrous salt) 50.0 (weight vb>calcium hydrogen phosphate (dihydrate) 20.0
-15- Sorbitol 25o (heavy (11
≠) Carboxymethyl hexarurose 1.
0 Foaming agent 2.0 Saccharin 0.1 Fragrance
1.0ε-aminocaproic acid 0.05 water
An appropriate amount of calcium hydrogen phosphate is treated with magnesium-polyphosphoric acid, and the effect of e-aminocaproic acid is taken into consideration, making it possible to stably incorporate it into the toothpaste base material.

Procedural amendment filed on August 19, 1939, by the Commissioner of the Patent Office, Mr. Kazuhiro Sansan ■, Indication of the case, Showa S4, patent application filed 189
No. 8 No. 2, Name of the issue Tomogashi 3, Relationship with the case of the person making the amendment Patent applicant address (residence) 4, Office clerk 6, First stop 8 Valley Amendment as attached Document in the specification of the application t No. page 1st line, 10th page last line - 11th tribute first line, 1st
Page 2, lines 15-16, 14-lines 13-14, 15th
[Magnesium, polyphosphoric acid]toal in lines 8-9 on page 8 and lines 14-15 on page 15 is combined with [magnesium salt and/or
or polyphosphoric acid”.

l Add the following sentence between page 8, line M and line 8.

[Next, in order to confirm the effectiveness of tooth brushing according to the present invention, a clinical experiment will be conducted.'' 5. On page 8, line 12, ``Unifying friends'' should be corrected as follows.

[Unified system, the first group includes toothpaste according to the present invention,
The Nigelup group was asked to use a conventional toothpaste containing dihydrocholesterin and rub the toothpaste on a weekly basis, and compared the procedures. Agency Director Kazuo Wakasugi 1, Incident Display 1978 Patent Application Off 889
6 No. 2, Name of the invention 3. Relationship with the case of the person making the amendment Address (residence) of the person making the amendment 7. Subject of the amendment Short history of the specification 8. Contents of the amendment As per the attached document % application 1973 -78893 Amended Specification 15 Title of the Invention Toothbrushing 2, Detailed Description of the Invention The present invention relates to toothbrushing that suppresses gingival irritation and prevents periodontal disease.

In general, engineering diseases in the field of dentistry are dental caries and periodontal tissue diseases, and among these, periodontal disease is clear from reports on morbidity and tooth loss, as well as reports on the actual state of dental diseases in Japan. Although it is comparable to caries, it shows a high rate, and the effect on teeth is also 8 people.

However, these factors do not act singly; 1. It is extremely complex, as it is a combination of several factors and is also based on differences in the strength and weakness of individual resistance, but among these factors, the one that must be considered the most is the local factor, oral hygiene. Regarding the progression of periodontal disease, first, the mammary and peripheral areas of the gums become hyperemic, edema and swelling occur, and then the stenosoling disappears and the gingival surface becomes swollen. state,
Normally, the gums become soft and bleed easily, and the inflammation of the gums further expands and progresses to alveolar pyorrhea. When I ingest something like an apple, I tend to bleed easily, have pus, and have a strong odor and discomfort.

It is also known that these factors can cause systemic diseases in the human body. In other words, the above-mentioned simple neglectful gingivitis JP munic marginal gingivitis is a V1 stage symptom of periodontal VktX. Therefore, in order to prevent periodontal disease, it is important to prevent the occurrence of simple lactation and marginal gingivitis.
For this reason, it is extremely important for dental health to perform appropriate initial cleanings and gum surgery in daily life.
Brushing with a toothpaste that is effective in removing dental deposits and preventing gum disease is a very effective and consistent way to do this, so toothpastes containing various drugs have been tried. In both cases, there is a long-term knowledge and a long-term understanding.

For example, an astringent containing aluminum salt produces a bitter and astringent taste.

There are problems with compatibility, and products containing dihydrocholesterin or methyl glycyrrhetinate have problems with compatibility, solubility, stability, resources, and cost (B'); Trypsin, streptokinase, etc.) have acid sites in terms of stability, cost, and formulation, and photosensitizers and azulene have problems in terms of coloring, cost, resources, solubility, etc., and both are not suitable for toothpaste. It was not possible to satisfy all of the conditions such as stable and effective formulation, periodontal disease prevention effect, and oral discomfort reduction effect when waking up.

The object of the present invention is to provide a toothpaste that can overcome all of these conventional problems.

History≦2 The purpose of the present invention is to prevent the occurrence of periodontal disease by utilizing epsilon aminocaproic acid, an anti-plasmin substance that blocks the action of plasmin, to improve the prevention of periodontal disease, and to improve the ability to remove tooth contaminants and improve tooth polishing. 1,[-
To provide an economical toothpaste that can eliminate even one odor and exhibit the effectiveness of epsilon aminocaproic acid without diminishing it.

The present invention provides a composition base material consisting of a toothpaste active ingredient containing epsilon aminocaproic acid (hereinafter abbreviated as monoaminocaproic acid), which has an anti-whitening effect, magnenium, and phosphorus-removed calcium treated with polyphosphoric acid.
This is a toothpaste composition characterized in that it contains 10% by weight.

The C-aminocaproic acid used in the present invention is a synthetic substance with the structural formula %, which is highly soluble in water, slightly soluble in hot ethanol, and almost insoluble in other organic solvents, and by itself is a synthetic substance that is soluble in plasmin (proteolytic It has been reported that it has excellent effects as a synthetic anti-plasmin agent that blocks the action of enzymes.

However, the efficacy of C-aminocaproic acid is diminished when water-soluble calcium ions are present in toothpaste compositions, and it is not necessary to use it simply as an active ingredient for preventing bleeding. In addition, it acts together with a surfactant to improve its dispersibility, [] can significantly remove wrinkles, and can increase and strengthen the polishing force without increasing the amount of abrasive. As a result of research, it has become clear that the composition is compatible with I-Mikagi composition.

That is, the following experimental results were obtained regarding the anti-plasmin effect and stability of ε-aminocaproic acid during tooth brushing and the effect of tooth brushing according to the present invention.

m Experiment-1 and - Anti-plusin effect of mucaproic acid (11 experimental methods fzbrxnolysia (1ya
The inhibitory effect of ε-aminocaproic acid in the is time method) was investigated.

+05% bovu1e fibrmogen O, 2m
1y81s tz measurement at 25°C [l result (jiang)
(pH 7,4) (2) Experiment-2 Inhibition rate of ε-aminocaproic acid-containing toothpaste and stability during toothbrushing (1) Experimental method Same as Experiment-1 a: Toothpaste 871~ without t-aminocaproic acid added to P
BS 8.71 yxl t: Dispersed b: g-aminocaproic acid 0.1% (weight) Toothpaste 10
874 dispersed in PBS 10.87 at cog-aminocaproic acid α5% ('&min,) blended toothpaste 905ap dispersed in FB8905ml+= ([l) Result ◆・Kai・Shoshoken・Inhibition rate book） Probit was used to utilize the fact that the logarithmic concentration of the inhibitor was linearly related (results of Experiment 1), and the 1ys of the results of this experiment were
Inhibition rate and ε-amitsukagulonic acid cap during tooth brushing were determined from xs time.

Next, a clinical experiment was conducted to confirm the effectiveness of tooth brushing according to the present invention.

(3) Clinical experiment (Experiment 11) The method of using toothbrushes and the conditions for using the sample toothpaste were standardized on female junior college students whose living environment was relatively the same, such as living in a dormitory.

The first group received the toothpaste according to the present invention, and the second group received a toothpaste containing dihydrocholesterin, which is a conventional product, for 4 weeks for comparison.

Examination: At the time of examination immediately before the start of the clinical experiment (objective and subjective symptoms were observed, similar examinations were conducted every week, and the clinical experiment was conducted for 4 consecutive weeks, for a total of 5 examinations.

(n) Results Compared to the dihydrocholesterin-containing product, which is conventionally considered to be an effective sieve for tooth brushing, this product is superior in the following points.

I Inhibitory effect on marginal periodontitis (objective) After 1 week of use, r::1q, tpls decreased (12.3%)
) 4 weeks 1 57.7-I (46.8%)
Effect of suppressing lactating gingivitis (objective) 36.5% reduction after 2 weeks of use (148%) 4
#44.4% # (44.4%)1
11 Gum bleeding prevention effect (perceived) 5 after 1 week of use
'5.2-decrease (15,396)4'
50.0% # (50.6%) 1v Effect to reduce discomfort in the mouth when waking up (perceived) 60.0% reduction after 4 weeks of use (55.6%) ■Tooth movement suppression effect after 1 week of stool use 19.7% decrease (Ol)4
#60.1%' (6 & 7%) However, H indicates the reduction rate for dihydrocholesterin-containing products. ] As shown in the above experimental results, the stabilizing combination of ε-aminocaproic acid in toothpaste and the periodontal disease preventive effect of 6-aminocaproic acid in toothpaste have been experimentally established.

It is recommended to use toothpaste C2 containing ξ-aminocaproic acid in a dissolved state in a minimum amount of 001%, preferably within a concentration range of about 0.05 to 2.0% by weight, as a disease prevention toothpaste. At the same time, it is also possible to add ζ2 to a surfactant to improve its dispersibility and increase its effect.

In this case, the efficacy of ε-ami7cabronic acid is proportional to its degree, but if the amount is less than 0.01% by weight, it will not be able to fully demonstrate its intended function. , 0
If the amount is more than 100%, the bitterness becomes extremely bitter and the properties as a toothpaste, which is expected to have an effect with continuous use, unlike those of temporary medicines, should be avoided, so it should be avoided.

Furthermore, calcium carbonate or calcium phosphate, which are commonly blended as one of the toothpaste base materials, elutes and exists in large amounts of water-soluble calcium ions, reducing the efficacy of ε-aminocaproic acid. To prevent this, magnesium and polyphosphoric acid treatments are applied. It is a phosphoric acid-hydrogen calcium hydroxide. In this case, the amount of violet to be mixed does not need to be more than i, o weight %, and the effect can be sufficiently exhibited by adding 0.0 i to 10 times the amount of violet, but the maximum pH is 20i4+.

In the present invention, magnesium and polyphosphate treatment refers to the treatment of homogeneous dicalcium phosphate (phosphoric acid) by reacting a phosphoric acid solution with a calcium compound in the presence of a magnesium compound.
It means the process of generating . That is, the phosphoric acid-
As a treatment for stabilizing hydrogen calcium, for example, quicklime and water are mixed to make lime milk, and phosphoric acid and a small amount of birophosphate and a magnesium salt as a magnesium compound such as magnesium chloride, basic magnesium carbonate, etc. are added to this. Add and react, and mix and ripen. In this case, a small amount of birophosphoric acid and/or magnesium salt may be added during mixed ripening. After aging for a certain period of time (approximately - days), it is dehydrated, passed through once, dried, and then crushed. The birophosphate or magnesium salt sensitivity to calcium phosphate thus obtained is preferably 2-2 or less, around 11s, and it is effective to use it in the above-mentioned blending ratio as a toothpaste.

Also, in order to increase the kJ'r@ force, it is possible to increase the amount of abrasive or use powder with less abrasive power, but in this case, disadvantages such as bleeding in the mouth will appear, but ε-aminocaproic acid Since these defects can be removed and prevented, the polishing power can also be enhanced.Also, when anhydrous calcium phosphate is added to the base material of toothpaste to improve the ability to remove tooth contaminants, it generally causes inflammation of the gums. However, when used in combination with ε-amitsukagulonic acid, there is no risk of this happening, and anti-inflammatory effects, gum health, and excellent tooth whitening can be easily achieved, and it can also be used to alleviate the oral mucosal irritation caused by foaming agents. It is.

In the toothpaste of the present invention, a combination of toothpaste active ingredients and other necessary substances such as commonly used substances such as polishing agents, humectants, foaming agents, glues, sweeteners, fragrances, surfactants and medicinal agents, and water ( 2) Calcium phosphate as an abrasive is treated with magnesium and polyphosphoric acid to form a phosphoric acid-hydrogen hydroxide/umium composition. Epsilon-aminocaprone is blended into the base material to make a toothpaste.

The toothpaste composition containing 6-aminocaproic acid of the present invention can accurately prevent inflammation such as marginal periodontitis or lactation, and also has the effect of preventing gum protrusion during toothbrushing. Aminocaproic acid is contained and retained in a stable state in the toothpaste base material, which eliminates bad breath, reduces the discomfort in the mouth when waking up, and effectively exhibits all of the effects of suppressing tooth movement. It is now possible to provide these appropriate preventive and inhibitory effects during use, exhibiting an extremely excellent effect on preventing periodontal disease, and at the same time improving the oral cleaning effect and easily removing tooth contamination. It is superior in terms of resources and cost compared to conventional in-and-out containers of this type, and has the advantage of guaranteeing stable blendability and a refreshing feeling of use.

Next, examples of the present invention will be shown.

Example 1 Line drawing polishing calcium hydrogen phosphate (dihydrate) 5 [J, D
(11% by weight) Glycerin 250 Carboxymethylcellulose 10 Foaming agent 20 Saccharin 01 Fragrance
1.0 and-aminocaproic acid 005 water
An appropriate amount of ε-aminocaproic acid is slightly soluble in hot ethanol, almost insoluble in other organic solvents, but highly soluble in water, so that C-aminocaproic acid and saccharin are dissolved in an appropriate amount of water. This was added to the solution in which glycerin 1 dicarboxymethyl cellulose was swollen, and the mixture was stirred and mixed. To this, fragrance 1 foaming agent and calcium hydrogen phosphate 2 permanent were added and mixed for 25A1 minute in a Ni-Goo to obtain a product.

Calcium hydrogen phosphate is treated with magnesium and polyphosphoric acid, and is designed to have the effects of e-aminocaproic acid, so that it can be stably incorporated into the toothpaste base material.

Example 2. Line drawing polishing calcium hydrogen phosphate (anhydrous salt) 300 C-
#Kan fb) Calcium hydrogen phosphate (dihydrate) 20
．． 0 norbitol 25.0
Carboxymethyl cellulose 10 Foaming agent 2.0 Saccharin 01 Fragrance
1.0 ε-amitsukagron @ 0.05 water Appropriate amount Calcium hydrogen phosphate is treated with magnesium and polyphosphoric acid. This makes it possible to mix and match.

3. Scope of Patent Request 1 A toothpaste characterized in that epsilon aminocaproic acid is blended in a coulometric base of 001 to 1.0 to a composition base consisting of a toothpaste active ingredient containing magnesium and calcium hydrogen phosphate treated with polyphosphoric acid. .

Patent applicant Lion Corporation Sub-Agent Patent Attorney Thousand 1) Neji

Claims (1)

[Claims] 1. Epsilon aminocaproic acid, magnesium-
Composition base material consisting of a toothpaste active ingredient containing calcium phosphate-hydrogen treated with polyphosphoric acid 0.01 to 1.0 weight i
A toothpaste characterized by containing TS.