JPS58130046A - Apparatus for preventing coagulation of blood - Google Patents
Apparatus for preventing coagulation of bloodInfo
- Publication number
- JPS58130046A JPS58130046A JP57013838A JP1383882A JPS58130046A JP S58130046 A JPS58130046 A JP S58130046A JP 57013838 A JP57013838 A JP 57013838A JP 1383882 A JP1383882 A JP 1383882A JP S58130046 A JPS58130046 A JP S58130046A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- tube
- blood coagulation
- vivo
- prevention device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は生体内留置物又は生体外血液管および／或轄こ
れに接する血液に血球を破壊しない１Ｍ度の振動管与克
る超音波発振機よりなる血液凝固防止装置に関するもの
である〇
血液６は正常面ｔａｉ以外の與物と接触する時、血小板
６Ｆｉ異物に何着しｌｉ維状足６′を出してｒＭ着し、
血小板相互が凝集して血栓を影成するため、止血上有害
な凝集防止剤或は真向防止剤を使用し血液の性状を変質
した状態においてカテーテルの血管内留雪や体外ａｍを
行う心動かあった。このような薬剤の使用は人体にとっ
てきわめて危険な出血性◆故を併売し易φ状態である。DETAILED DESCRIPTION OF THE INVENTION The present invention provides a blood coagulation prevention device comprising an ultrasonic oscillator that provides a 1 M degree vibrating tube that does not destroy blood cells in an in-vivo indwelling object or an in-vivo blood tube and/or blood in contact with the same. Regarding blood 6, when it comes into contact with an object other than the normal surface, the platelets 6Fi land on the foreign body, the li filamentous feet 6' come out, and the blood 6 lands on the foreign body.
Because platelets aggregate with each other to form a thrombus, cardiac arrest is performed by using catheters in blood vessels or extracorporeal AM in conditions where blood properties have been altered using anti-aggregation agents or direct anti-aggregation agents that are harmful to hemostasis. there were. The use of such drugs makes it easy to sell them together with hemorrhagic ◆, which is extremely dangerous to the human body.
本発明は上記実情に飯みなされたものであって、実験の
結果、血小板の異物＠看に集性能はその苅象物体か静止
物或はゆつくしした移動物９体との間に起り、生物的な
Ｉ＆着凝集能力の限界を越える急進に移動する対象物と
の間で蝶そのａｌ力は消滅してしまうことを発見した。The present invention was developed based on the above-mentioned circumstances, and as a result of experiments, it was found that the ability of platelets to collect foreign substances occurs between them, stationary objects, or loosely moving objects. It has been discovered that the butterfly's al force disappears when it comes in contact with an object that moves rapidly beyond the limits of its biological I&A capacity.
この性能を逆に利用して所定範囲の超音波振動１を与え
ることによって血小板の異物＠看およ′ひ凝集性状か消
滅し１皿液の毛管流動緻抗を軽減することを発見し、こ
れを血液凝固防止装奮に応用するどとをｍ ｅ４ ：ｌ
）１シ：＊ものである。本発明を図面に示す実施例につ
−て説明すると、血Ｉ＃１内の留置物２例えｄカテーテ
ル２′や人工透析における合性樹脂製チューブ又は透析
用軸ｔ（血液’ｆｌ ３ ’）および／又祉これに！１
する血＠５を振動させる超音波発振機４とよりなるもの
である。By utilizing this performance inversely, we discovered that by applying ultrasonic vibrations in a predetermined range, the foreign particles and aggregation properties of platelets disappeared, and the capillary flow resistance of the dish solution was reduced. How can I apply this to anti-coagulant stimulation?
)1shi: *It is a thing. The present invention will be described with reference to the embodiments shown in the drawings.The indwelling object 2 in the blood I#1, for example, d catheter 2', a synthetic resin tube in artificial dialysis, or the dialysis shaft t (blood 'fl3') And/Matoshi this! 1
This device consists of an ultrasonic oscillator 4 that vibrates blood @5.
本発明ではｋＳ１図に示すように血管ｌの内部にカテー
テル２を留置し同面１１１内を通過する血液５又はカテ
ーテル２′に超音波発振機４により振動を与えると血液
５、血＄１およびカテーテル２′はそれぞれ＆絶するが
、その振動は血液６、血管１およびカテーテル２′の質
量の相違に基いて相違し血液５の＆１．はこれに接する
血ｔ１やカテーテル２′の振動と私達するからその接触
境界向において血液５Ｆｉ血管１４Ｆカテーテル２との
間に振動差を発生し、血小板６にもカテーテル２′との
振動差を発生しカテーテル２７えの＠看、凝集性状を失
う。In the present invention, as shown in Fig. kS1, when the catheter 2 is placed inside the blood vessel 1 and the blood 5 or the catheter 2' passing through the same plane 111 is vibrated by the ultrasonic oscillator 4, the blood 5, blood $1 and Each of the catheters 2' oscillates differently based on the difference in mass of the blood 6, the blood vessel 1, and the catheter 2'. generates a vibration difference between the vibration of the blood t1 and catheter 2' that are in contact with it, and the blood 5Fi blood vessel 14F catheter 2 in the direction of the contact boundary, and also generates a vibration difference between the platelet 6 and the catheter 2'. However, the catheter loses its cohesive properties.
又第２図に不すようにビニールチューブ略の血液Ｉ＃３
やその中の流動血液５に上述の機動を与えると血液５ｔ
ｉ管３の内壁との間に相対的に振動差を発生し、ｔ ｓ
の内壁えの＠際凝集性状を失う。この血液５の振動は面
球を破壊する範囲のものであってはならな一〇生体内留
置物２には上に１カテーテル２′の他に血糖又はイオン
感知用ｉｈｂ＃ｈカ・ある。Also, as shown in Figure 2, the vinyl tube omitted is blood I#3.
When the above-mentioned movement is given to the flowing blood 5 in it, the blood 5t
A vibration difference is generated relative to the inner wall of the i-tube 3, and t s
The inner wall of the inner wall loses its cohesive properties. The vibration of the blood 5 must not be within a range that would destroy the sphere.10 The in-vivo indwelling device 2 has an IHB#h for blood sugar or ion sensing in addition to the catheter 2' on the top.
以上は血小板の積極的吸看について述べたかその他の生
体内ゲル様物質の付層を防止するときかできる。The above can be done when talking about the active suction of platelets or when preventing the formation of other in-vivo gel-like substances.
従来血液を血管外に循環させたときの凝固防止１的の研
究として血液の性状を変える凝固防止薬剤混入法と、一
方では血液１＃−の主役を演じる血小板が付層しな一素
材によるチューブを用いる方法か研究されている。Conventional research on prevention of coagulation when blood is circulated outside blood vessels involves a method of incorporating anticoagulant agents that changes the properties of blood, and on the other hand, a tube made of a material that does not contain platelets, which play the main role in blood 1#-. A method using
本発明は生体内留置物２おまひ斗体外皿液管３に接する
血液５の生理的凝固過程の最初のきっかけを防止するこ
とかできる。The present invention can prevent the initial triggering of the physiological coagulation process of the blood 5 in contact with the in-vivo indwelling device 2 and the extracorporeal dish fluid tube 3.
（実施例）
１４１／に示すよう、に透析用透明ヒニールチューブ３
（ｍ径５ ｓｗｓ ）に超音波発振機４がら発振する
指向性のある超音波揚動を一定方向からチューブ７に与
え、その状態にお―て同チューブ３′内に血液５を流通
させると、上記振動を与えた１分７のチューブ内壁には
血液の凝固が発生せず部分的に遮蔽するとその部分社凝
固が起り、魚射部と非照射部との境界８か明瞭に現われ
た・第４図で照射側内１１７′の透明度か大ＣＪＩ伽内
ｌ１１７“では振動エネルギーの低下か斑紋状凝固点９
として詔められた。(Example) As shown in 141/, transparent vinyl tube for dialysis 3
(m diameter 5 sws), a directional ultrasonic lift generated by an ultrasonic oscillator 4 is applied to the tube 7 from a certain direction, and blood 5 is allowed to flow in the tube 3' in this state. Blood coagulation did not occur on the inner wall of the 1/7 tube subjected to the above vibration, but when it was partially shielded, coagulation occurred in that part, and the boundary between the irradiated area and the non-irradiated area 8 clearly appeared. In Figure 4, it is the transparency of the inside 117' on the irradiation side, or the drop in vibrational energy in the large CJI Gayai 117'', or the mottled freezing point 9.
It was admonished as
尚図中１０は血液凝固部である・In addition, 10 in the figure is the blood coagulation part.
ｔＩｈ１図は本発明の血液凝固防止装置を示す図、第２
（２）は同装置の他の実施例図、第３図は血液凝固状態
図、第４図線実験例示図である。
２・・生体内留置物、３・・生体外血液管、５・・血液
、４・・超音波発振機、ｌ・・カテーテル◎特許出願人
立 花 伊 部Figure tIh1 is a diagram showing the blood coagulation prevention device of the present invention.
(2) is another embodiment of the same apparatus, FIG. 3 is a blood coagulation state diagram, and FIG. 4 is an illustrative diagram of an experiment. 2. In-vivo indwelling object, 3. In-vitro blood tube, 5. Blood, 4. Ultrasonic oscillator, l.. Catheter ◎Patent applicant Ibe Tachibana
Claims (1)
２はこれに接する血液５に血球を破壊しない程度の振動
を与える超音波発振機４よ抄なる血液凝固防止装置〇 （２１生体内留置物２か血管内留置カテーテル２′であ
る特許請求の範囲第１項記載の血液凝固防止装置。 （３１生体外血液管３がａ折用細管である特許請求の範
囲第１項記載の血液凝固防止装置◎（４）生体外血液管
３か体外１ｉＩ１１に用チューブ３である特許請求の範
囲第１項記載の血液凝固防止＠ｐｆＩＩｔ０ （５１生体内情置物２か電−である特許請求の範１１項
記１の血液凝固防止装置◎[Claims] (Violet) In-vivo indwelling device 2 or in-vivo blood tube 3 and/! 6
2 is a blood coagulation prevention device made of an ultrasonic oscillator 4 that applies vibrations to the blood 5 in contact with a degree that does not destroy blood cells (21 claims include an in-vivo indwelling device 2 or an intravascular indwelling catheter 2') The blood coagulation prevention device according to claim 1. (31 The blood coagulation prevention device according to claim 1, wherein the in vitro blood tube 3 is an A-fold tube. The blood coagulation prevention device according to claim 1, which is a tube 3 for blood coagulation @pfIIt0 (51 in-vivo device 2) or the blood coagulation prevention device according to claim 11, which is an electric
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57013838A JPS58130046A (en) | 1982-01-28 | 1982-01-28 | Apparatus for preventing coagulation of blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57013838A JPS58130046A (en) | 1982-01-28 | 1982-01-28 | Apparatus for preventing coagulation of blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS58130046A true JPS58130046A (en) | 1983-08-03 |
Family
ID=11844414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57013838A Pending JPS58130046A (en) | 1982-01-28 | 1982-01-28 | Apparatus for preventing coagulation of blood |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58130046A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63200767A (en) * | 1987-02-17 | 1988-08-19 | 積水化学工業株式会社 | Extracorporeal circulation circuit |
| JPH01129855A (en) * | 1987-11-13 | 1989-05-23 | Green Cross Corp:The | Method and apparatus for treating returning self blood |
-
1982
- 1982-01-28 JP JP57013838A patent/JPS58130046A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63200767A (en) * | 1987-02-17 | 1988-08-19 | 積水化学工業株式会社 | Extracorporeal circulation circuit |
| JPH01129855A (en) * | 1987-11-13 | 1989-05-23 | Green Cross Corp:The | Method and apparatus for treating returning self blood |
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