JPS58129954A - Preparation of new health food - Google Patents

Abstract

PURPOSE:To prepare a health food effective to maintain the health of aged men, by dissolving vitamin E in a vegetable oil under heating, adding riboflavin butyric acid ester and selenium yeast to the solution, and filling the mixture in a capsule. CONSTITUTION:Vitamin E and if necessary beta-carotin, pigments, etc. are dissolved in a vegetable oil under heating at room temperature -150 deg.C. Riboflavin butyric acid ester and selenium yeasts are dispersed in the solution and filled in a capsule. The selenium yeast is obtained by culturing yeast in a principal medium added with a selenium compound,and drying the cultured yeasts. The riboflavin butyric acid ester is prepared by esterifying water-soluble riboflavin (vitamin B2) with butyric acid thereby making the riboflavin fat-soluble. The ester not only acts as the original vitamin B2 in the body, but also directly attacks and destroys the senility-promoting lipid peroxide.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention involves dissolving or suspending vitamin E, riboflavin butyrate, or β-carotene, pigments, etc., which are sparingly soluble in vegetable oil, and selenium yeast, which is insoluble in vegetable oil, in vegetable oil C.
Furthermore, it relates to a new method for producing health foods that are filled into capsules.

The reasons behind the emergence of conventional health foods on the market are (1) people's growing desire to live long and healthy lives, and (2) existing products such as pesticides, feed, and food additives. (3.
+ Western R due to side effects of medicines - Distrust of medicine and interest in Chinese oriental medicine, which has reevaluated Chinese medicine or traditional medicine. (Reference 1) Therefore, many nutrition and food scientists and knowledgeable people
They believe that if these backgrounds fade, the reason for the existence and value of health foods will disappear. Actually Shini,
Most of the health foods currently on the market are selected from Japanese and Chinese medicines and everyday foods that are believed to have medicinal efficacy through tradition and custom.
The academic basis for the ingredients and essence of these things is weak.

However, in our country, which is heading toward a super-aging society that no comparable country in the world has ever experienced, the inventor of the present invention has developed a new health care system that will help maintain the health of elderly people who are trying to work independently. They believed that developing food products was not only of great significance, but could also contribute to reducing medical costs, which were in a tight situation.

In the past, there were separate theories regarding the causes of aging, such as the free radical theory, the mutation theory, the aging pigment theory, the cholesterol theory, and the peroxide tax (two studies were discussed, and the theories seemed to have fallen apart, but these days, these theories are The theory was moved from a chemical reaction to a biological reaction.

The aging process (the two can be arranged and connected sequentially while having a relationship with each other. Arteriosclerosis is the basis of adult diseases, and the process of arteriosclerosis in living organisms is caused by the generation of radicals (reactive oxygen species). i)? Mk is emitted, and lipid peroxide is generated through radicals of unsaturated fat receptors, which are essential constituents of biological membranes, due to peroxidation reaction C2, and subsequent accumulation of aging pigment (lipofuscin), or radicals and peroxidation. The current established theory is that arteriosclerosis is caused by abnormalities in biological membranes and relaxation of intercellular connections caused directly by substances, and the accumulation of LDL-cholesterol or calcium caused by these factors. (Reference 2) Therefore, the health foods of the future will include (11) those that capture various radicals, (21) those that decompose or convert generated peroxides into harmless compounds, and (3) those that decompose lipofuscin or (4)
)It must contain substances that lower LDL-cholesterol-neutral fat in the blood, (51) substances that increase HDL-cholesterol (anti-arteriosclerotic factor) in the blood, etc.

The three substances that meet the above conditions are selenium (selenium), vitamin E (% ti-tocopherol), and riboflavin butyrate, but considering the mutation of genetic DNA caused by radicals and peroxides, C and β −Carotene (
Provitamin A) is also required.

The present inventor dissolved or suspended in vegetable oil selenium yeast (selenium yeast), vitamin E1 riboflavin butyrate, di-β-carotene, and some pigments, which have different chemical and physical characteristics from vegetable oil. As a result of various studies on filling turnips with selenium compounds, the present invention was achieved.In the present invention f2, selenium yeast is produced by culturing yeast in a basic medium containing 710 selenium compounds and harvesting. , dried.Selenium is better to absorb into animals (plants or microorganisms) and give it as an organic selenium compound than to give it to animals as an inorganic compound. It is known that its utilization efficiency in the body is extremely high.

Selenium absorbed into the body becomes the 4th component of glutathione peroxidase, and the enzyme captures and detoxifies radicals, so m-selenium has attracted attention in the nutritional science community as an important micronutrient for anti-aging. It is.

In addition, riboflavin butyrate is an ester bond of water-soluble riboflavin (vitamin B2) and butyric acid, making it fat-soluble. It has the effect of directly acting on and destroying certain lipid peroxides. However, riboflavin butyrate,
Oils and fats containing a lot of saturated fatty acids, such as butter, are easily soluble, but their widespread use is hindered because they are poorly soluble in oils, especially vegetable oils, which are effective in treating blood cholesterol problems. It is.

Second, vitamin E (especially matecopherol) acts on various radicals such as hydrogen peroxide, hydroxyl radicals, deuterated oxygen, unsaturated fatty acid radicals, and peroxide radicals, rendering them harmless. It is useful for

It is known that riboflavin butyrate and vitamin E (particularly dartcopherol) have the effect of lowering blood LDL-cholesterol and neutral fat and increasing HDL-cholesterol.

Vegetable oil C: On the other hand, selenium yeast is insoluble, and riboflavin butyrate is also very poorly soluble, so it is necessary to maintain a suspended state after filling the capsule, but depending on the concentration of these two substances in vegetable oil. may easily form a precipitate.

The inventors were able to compensate for such defects in appearance by using β-carotene or pigments (e.g., surfactants).
- Depending on the type of vegetable oil, it is difficult to dissolve carotene or pigments, and in that case, heat and time or surfactants are required to completely dissolve them. 9 of all ingredients
It can prevent atmospheric oxidation or deterioration.
Next, Example M of the present invention will be described.

Example 1 Cottonseed oil 10Kg 12<-tocopherol 3Kg
Add and dissolve with stirring at 4 (1'C), then add 700g of riboflavin butyric acid ester and 3Kgk71D of Len's yeast, stir for 30 minutes to make a yellow uniform suspension oil, fill the capsules (ceratin), and fill the capsules with Iso C2. Contents: approx. 25
2nd Example: 10 kg of cottonseed oil, 4 kg of oc-tocopherol, 2 kg of selenium yeast, 4 kg of riboflavin butyrate and 50 g of caramel.
1, stirred for 1 hour at room temperature (2), suspended in light, filled into capsules with a capsule filling machine, and the contents were approximately 280 m
Obtain brown cap-shaped capsules of g.

3rd example: 1 part olive oil (2 parts eatcopherol per 1 kg)
．． 5Kg, 10g of β-carotene and 110g of paprika (red pepper pigment) and stirred at 50°C for 1 hour to completely dissolve.Next, selenium yeast (32.5Kg containing 7100meg of sere in 1g) and 600g of poflavin butyrate. is added and stirred for 30 minutes to suspend the gelatin.The gelatin capsules are filled into capsules using a capsule filling machine to obtain orange gelatin capsules each containing about 150 mg (content).

4th example 11- Concentrated vitamin E solution in 1 kg of oil 2.
5 kg, weigh 710 g of dense weight and heat at 80°C for 30
After stirring for 1 minute to completely dissolve and bring to room temperature, 9 kg of the first
Add 710 g of 1-build oil and stir, then add 100 g of riboflavin butyrate and 1.5 kg of selenium yeast, stir, and suspend in light. It is then filled into capsules using Iso C2 to obtain yellow gelatin capsules each weighing approximately 180 mg.

References 1, Hiroyuki Iwao: Nutrition Classroom for Health, P72, 1st Publication (19801) 2, Shino (f1hiko: Nutritional Food Approach to Aging Control, New Food Industry 24fll)
,7H1982133

Claims (1)

[Claims] l Vitamin E in vegetable oil, and in some cases further (two rho-
It is characterized by adding chlorine, pigments, etc., dissolving at v0 temperature at a temperature above room temperature and below 150'C, then adding riboflavin butyrate and selenium yeast, stirring and suspending the product, and filling it into capsules. A new method for producing healthy foods. ,