JPS579776A - Production of anthracycline - Google Patents
Production of anthracyclineInfo
- Publication number
- JPS579776A JPS579776A JP8432980A JP8432980A JPS579776A JP S579776 A JPS579776 A JP S579776A JP 8432980 A JP8432980 A JP 8432980A JP 8432980 A JP8432980 A JP 8432980A JP S579776 A JPS579776 A JP S579776A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- active substance
- enzymatically active
- acyladriamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: 14-O-Acyladriamycin is subjected to hydrolytic treatment using an enzymatically active substance that originates from an animal organ and can hydrolyze ester linkages to produce 4'-O-substituted or unsubstituted adriamycin.
CONSTITUTION: A 4'-O-substituted or unsubstituted 14-O-acyladriamycin of formula I (R1 is 1W6C alkyl, benzyl; R2 is H, 3W7C 1-alkoxyalkyl, tetrahydrofuran- 2-yl, 6-substituted or unsubstituted tetrahydropyran-2-yl) is treated with an enzymatically active substance that can hydrolyze ester linkages to produce a 4'-O- substituted or unsubstituted adriamycin of formula II. The above enzymatically active substance originates from an organ or tissue of an animal or from the culture mixture of a microorganism such as a lipase originating from swine pancreas.
USE: Anticancer agent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8432980A JPS579776A (en) | 1980-06-20 | 1980-06-20 | Production of anthracycline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8432980A JPS579776A (en) | 1980-06-20 | 1980-06-20 | Production of anthracycline |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS579776A true JPS579776A (en) | 1982-01-19 |
JPS5746359B2 JPS5746359B2 (en) | 1982-10-02 |
Family
ID=13827468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8432980A Granted JPS579776A (en) | 1980-06-20 | 1980-06-20 | Production of anthracycline |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS579776A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61295656A (en) * | 1985-06-25 | 1986-12-26 | Toshiba Corp | Image sensor |
JPS63138944A (en) * | 1986-11-27 | 1988-06-10 | 旭化成株式会社 | Box in which wound lap film is stored |
JPH0499441A (en) * | 1990-08-17 | 1992-03-31 | Nippon Shokuhin Kogaku Kiyougikai:Kk | Yogurt |
DE102018100970A1 (en) | 2017-01-19 | 2018-07-19 | Toyota Jidosha Kabushiki Kaisha | Control for an actuator and steering device |
-
1980
- 1980-06-20 JP JP8432980A patent/JPS579776A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61295656A (en) * | 1985-06-25 | 1986-12-26 | Toshiba Corp | Image sensor |
JPH0521348B2 (en) * | 1985-06-25 | 1993-03-24 | Toshiba Kk | |
JPS63138944A (en) * | 1986-11-27 | 1988-06-10 | 旭化成株式会社 | Box in which wound lap film is stored |
JPH0499441A (en) * | 1990-08-17 | 1992-03-31 | Nippon Shokuhin Kogaku Kiyougikai:Kk | Yogurt |
DE102018100970A1 (en) | 2017-01-19 | 2018-07-19 | Toyota Jidosha Kabushiki Kaisha | Control for an actuator and steering device |
Also Published As
Publication number | Publication date |
---|---|
JPS5746359B2 (en) | 1982-10-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term |