JPS579776A - Production of anthracycline - Google Patents

Production of anthracycline

Info

Publication number
JPS579776A
JPS579776A JP8432980A JP8432980A JPS579776A JP S579776 A JPS579776 A JP S579776A JP 8432980 A JP8432980 A JP 8432980A JP 8432980 A JP8432980 A JP 8432980A JP S579776 A JPS579776 A JP S579776A
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
active substance
enzymatically active
acyladriamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8432980A
Other languages
Japanese (ja)
Other versions
JPS5746359B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Kuniaki Tatsuta
Tsutomu Sawa
Hiroshi Osanawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP8432980A priority Critical patent/JPS579776A/en
Publication of JPS579776A publication Critical patent/JPS579776A/en
Publication of JPS5746359B2 publication Critical patent/JPS5746359B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: 14-O-Acyladriamycin is subjected to hydrolytic treatment using an enzymatically active substance that originates from an animal organ and can hydrolyze ester linkages to produce 4'-O-substituted or unsubstituted adriamycin.
CONSTITUTION: A 4'-O-substituted or unsubstituted 14-O-acyladriamycin of formula I (R1 is 1W6C alkyl, benzyl; R2 is H, 3W7C 1-alkoxyalkyl, tetrahydrofuran- 2-yl, 6-substituted or unsubstituted tetrahydropyran-2-yl) is treated with an enzymatically active substance that can hydrolyze ester linkages to produce a 4'-O- substituted or unsubstituted adriamycin of formula II. The above enzymatically active substance originates from an organ or tissue of an animal or from the culture mixture of a microorganism such as a lipase originating from swine pancreas.
USE: Anticancer agent.
COPYRIGHT: (C)1982,JPO&Japio
JP8432980A 1980-06-20 1980-06-20 Production of anthracycline Granted JPS579776A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8432980A JPS579776A (en) 1980-06-20 1980-06-20 Production of anthracycline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8432980A JPS579776A (en) 1980-06-20 1980-06-20 Production of anthracycline

Publications (2)

Publication Number Publication Date
JPS579776A true JPS579776A (en) 1982-01-19
JPS5746359B2 JPS5746359B2 (en) 1982-10-02

Family

ID=13827468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8432980A Granted JPS579776A (en) 1980-06-20 1980-06-20 Production of anthracycline

Country Status (1)

Country Link
JP (1) JPS579776A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61295656A (en) * 1985-06-25 1986-12-26 Toshiba Corp Image sensor
JPS63138944A (en) * 1986-11-27 1988-06-10 旭化成株式会社 Box in which wound lap film is stored
JPH0499441A (en) * 1990-08-17 1992-03-31 Nippon Shokuhin Kogaku Kiyougikai:Kk Yogurt
DE102018100970A1 (en) 2017-01-19 2018-07-19 Toyota Jidosha Kabushiki Kaisha Control for an actuator and steering device

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61295656A (en) * 1985-06-25 1986-12-26 Toshiba Corp Image sensor
JPH0521348B2 (en) * 1985-06-25 1993-03-24 Toshiba Kk
JPS63138944A (en) * 1986-11-27 1988-06-10 旭化成株式会社 Box in which wound lap film is stored
JPH0499441A (en) * 1990-08-17 1992-03-31 Nippon Shokuhin Kogaku Kiyougikai:Kk Yogurt
DE102018100970A1 (en) 2017-01-19 2018-07-19 Toyota Jidosha Kabushiki Kaisha Control for an actuator and steering device

Also Published As

Publication number Publication date
JPS5746359B2 (en) 1982-10-02

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term