JPS5796261A - Preparation of immunoactive particle - Google Patents

Preparation of immunoactive particle

Info

Publication number
JPS5796261A
JPS5796261A JP17256480A JP17256480A JPS5796261A JP S5796261 A JPS5796261 A JP S5796261A JP 17256480 A JP17256480 A JP 17256480A JP 17256480 A JP17256480 A JP 17256480A JP S5796261 A JPS5796261 A JP S5796261A
Authority
JP
Japan
Prior art keywords
particle
immunoactive
polymer
medium
amino group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17256480A
Other languages
Japanese (ja)
Other versions
JPS6315554B2 (en
Inventor
Shuntaro Hosaka
Yasuo Murao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP17256480A priority Critical patent/JPS5796261A/en
Priority to CA000391753A priority patent/CA1177751A/en
Priority to EP81110260A priority patent/EP0054249B2/en
Priority to DE8181110260T priority patent/DE3171273D1/en
Publication of JPS5796261A publication Critical patent/JPS5796261A/en
Priority to US06/757,761 priority patent/US4656144A/en
Publication of JPS6315554B2 publication Critical patent/JPS6315554B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PURPOSE:To obtain an immunoactive particle, by a method wherein an immunoactive substance with an amino group is reacted with a particle obtained by polymerizing glycidyl acrylate or glycidyl methacrylate in a medium which dissolves monomers but allows the produced polymer to precipitate. CONSTITUTION:A polymer in the form of particle with an average diameter of 0.03-10mum is obtained by polymerizing glycidyl acrylate or glycidyl methacrylate in a medium which dissolves monomers but separates out the polymer produced by the polymerization, such as ethyl acetate, n-propyl acetate, isopropyl acetate or the like. Then, a reagent is obtained by fixing an immunoactive substance on a carrier particle by means of a covalent bond between the free epoxy group on the particle-shaped polymer surface and the amino group of the immunoactive substance. According to the present invention, it is possible to produce free-epoxy group-containing carrier particles having a diameter suitable for an immunological inspection as well as having a narrow particle-diameter distribution only in a single stage.
JP17256480A 1980-12-09 1980-12-09 Preparation of immunoactive particle Granted JPS5796261A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP17256480A JPS5796261A (en) 1980-12-09 1980-12-09 Preparation of immunoactive particle
CA000391753A CA1177751A (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing same
EP81110260A EP0054249B2 (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing the same
DE8181110260T DE3171273D1 (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing the same
US06/757,761 US4656144A (en) 1980-12-09 1985-07-22 Immunoparticles and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17256480A JPS5796261A (en) 1980-12-09 1980-12-09 Preparation of immunoactive particle

Publications (2)

Publication Number Publication Date
JPS5796261A true JPS5796261A (en) 1982-06-15
JPS6315554B2 JPS6315554B2 (en) 1988-04-05

Family

ID=15944176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17256480A Granted JPS5796261A (en) 1980-12-09 1980-12-09 Preparation of immunoactive particle

Country Status (1)

Country Link
JP (1) JPS5796261A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919856A (en) * 1982-07-27 1984-02-01 Toray Ind Inc Fine carrier particle for immobilizing amynologically active material
JPS59204601A (en) * 1983-05-09 1984-11-20 Unitika Ltd Manufacture of molded article having physiological activity
JPH0684312B2 (en) * 1987-08-14 1994-10-26 鐘淵化学工業株式会社 Biospecific polymer
JP2015114272A (en) * 2013-12-13 2015-06-22 東ソー株式会社 Polymerizable monomer and application thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919856A (en) * 1982-07-27 1984-02-01 Toray Ind Inc Fine carrier particle for immobilizing amynologically active material
JPH0376426B2 (en) * 1982-07-27 1991-12-05 Toray Industries
JPS59204601A (en) * 1983-05-09 1984-11-20 Unitika Ltd Manufacture of molded article having physiological activity
JPH0684312B2 (en) * 1987-08-14 1994-10-26 鐘淵化学工業株式会社 Biospecific polymer
JP2015114272A (en) * 2013-12-13 2015-06-22 東ソー株式会社 Polymerizable monomer and application thereof

Also Published As

Publication number Publication date
JPS6315554B2 (en) 1988-04-05

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