JPS5732228A - Preparation of immunoglobulin usable for intravenous injection - Google Patents

Preparation of immunoglobulin usable for intravenous injection

Info

Publication number
JPS5732228A
JPS5732228A JP10736380A JP10736380A JPS5732228A JP S5732228 A JPS5732228 A JP S5732228A JP 10736380 A JP10736380 A JP 10736380A JP 10736380 A JP10736380 A JP 10736380A JP S5732228 A JPS5732228 A JP S5732228A
Authority
JP
Japan
Prior art keywords
fraction
immunoglobulin
polymeric
blood plasma
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10736380A
Other languages
Japanese (ja)
Other versions
JPS6221359B2 (en
Inventor
Yatsuhiro Kamimura
Setsu Goto
Yoshiaki Kano
Satoru Funakoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP10736380A priority Critical patent/JPS5732228A/en
Publication of JPS5732228A publication Critical patent/JPS5732228A/en
Publication of JPS6221359B2 publication Critical patent/JPS6221359B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain an immunoglobulin for intravenous injection useful for the infectious prevention and treatment of an antibody-deficient patient in high purity and yield, by treating a blood plasma or plasmatic fraction obtained by the Cohn method with an acid, and fractionating the resultant plasma or plasmatic fraction with an alkylene oxide polymer or copolymer.
CONSTITUTION: A blood plasma or fraction (I+II+III), fraction (II+III), fraction (II) or fraction (III) obtained by subjecting the blood plasma to the cold alcoholic fractionation by the Cohn method is treated with an acid, e.g. hydrochloric or acetic acid, under the conditions of pH 3.2W5.0 and temperature of 4W15°C for 30W180min to dissociate the polymeric immunoglobulin to a nonpolymeric type. The resultant treated blood plasma or fraction is then fractionated with an alkylene oxide polymer (1W4C alkylene oxide polymer) or a copolymer, e.g. Pluronic, having a molecular weight of 2,000W20,000 at a pH of 4W5.5 in a polymeric concentration of 3W 5W/V% to remove the polymeric immunoglobulin. A polymer is then added to the fraction free from the polymeric immunoglobulin at a pH of 6.0W 8.5 in a polymeric concentration of 6W15W/V% to give the aimed immunoglobulin containing no polymeric type.
COPYRIGHT: (C)1982,JPO&Japio
JP10736380A 1980-08-05 1980-08-05 Preparation of immunoglobulin usable for intravenous injection Granted JPS5732228A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10736380A JPS5732228A (en) 1980-08-05 1980-08-05 Preparation of immunoglobulin usable for intravenous injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10736380A JPS5732228A (en) 1980-08-05 1980-08-05 Preparation of immunoglobulin usable for intravenous injection

Publications (2)

Publication Number Publication Date
JPS5732228A true JPS5732228A (en) 1982-02-20
JPS6221359B2 JPS6221359B2 (en) 1987-05-12

Family

ID=14457176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10736380A Granted JPS5732228A (en) 1980-08-05 1980-08-05 Preparation of immunoglobulin usable for intravenous injection

Country Status (1)

Country Link
JP (1) JPS5732228A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61500972A (en) * 1984-07-07 1986-05-15 アルモア　ファルマ　ゲーエムベーハー Production method of gamma globulin for intravenous injection
JPS63183539A (en) * 1986-05-19 1988-07-28 Green Cross Corp:The Production of immunoglobulin pharmaceutical for intravenous injection
JPS6415785U (en) * 1987-07-17 1989-01-26
JPH09176045A (en) * 1996-08-29 1997-07-08 Green Cross Corp:The Immunoglobulin preparation for intravenous injection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4981519A (en) * 1972-11-27 1974-08-06
JPS5320415A (en) * 1976-08-06 1978-02-24 Coval M L Production of gammaa globlin capaple of administering into vein and gammaagloblin produced by said method
JPS5372816A (en) * 1976-12-03 1978-06-28 Coval M L Improved production of gammaaglobulin for vein injection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4981519A (en) * 1972-11-27 1974-08-06
JPS5320415A (en) * 1976-08-06 1978-02-24 Coval M L Production of gammaa globlin capaple of administering into vein and gammaagloblin produced by said method
JPS5372816A (en) * 1976-12-03 1978-06-28 Coval M L Improved production of gammaaglobulin for vein injection

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61500972A (en) * 1984-07-07 1986-05-15 アルモア　ファルマ　ゲーエムベーハー Production method of gamma globulin for intravenous injection
JPH08319241A (en) * 1984-07-07 1996-12-03 Armour Pharma Gmbh Gamma globulin composition for intravenous injection
JPS63183539A (en) * 1986-05-19 1988-07-28 Green Cross Corp:The Production of immunoglobulin pharmaceutical for intravenous injection
JPS6415785U (en) * 1987-07-17 1989-01-26
JPH09176045A (en) * 1996-08-29 1997-07-08 Green Cross Corp:The Immunoglobulin preparation for intravenous injection

Also Published As

Publication number Publication date
JPS6221359B2 (en) 1987-05-12

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