JPS5729950A - Determination method of sugar side chain related to cancer - Google Patents

Determination method of sugar side chain related to cancer

Info

Publication number
JPS5729950A
JPS5729950A JP10478780A JP10478780A JPS5729950A JP S5729950 A JPS5729950 A JP S5729950A JP 10478780 A JP10478780 A JP 10478780A JP 10478780 A JP10478780 A JP 10478780A JP S5729950 A JPS5729950 A JP S5729950A
Authority
JP
Japan
Prior art keywords
lectin
cancer
side chain
sugar side
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10478780A
Other languages
Japanese (ja)
Other versions
JPS6326872B2 (en
Inventor
Shoichi Adachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON KOTAI KENKYUSHO KK
NIPPON KOUTAI KENKYUSHO KK
Original Assignee
NIPPON KOTAI KENKYUSHO KK
NIPPON KOUTAI KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON KOTAI KENKYUSHO KK, NIPPON KOUTAI KENKYUSHO KK filed Critical NIPPON KOTAI KENKYUSHO KK
Priority to JP10478780A priority Critical patent/JPS5729950A/en
Publication of JPS5729950A publication Critical patent/JPS5729950A/en
Publication of JPS6326872B2 publication Critical patent/JPS6326872B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE:To determine a sugar side chain related to cancer and to diagnose precisely various cancers by following procedures that a sugar side chain related to cancer in body fluids in reacted with lectin which has binding ability of L-fucose to form a complex, and an amount of the complex or the residual lectin is. CONSTITUTION:A sugar side chain (briefly expressed as TAG hereafter) which is produced by cancer cells in body liquids of cancer patients is separated from the body liquids, and reacted with lectin which has binding ability to L-fucose, and an amount of the complex or the residual lectin is measured. Otherwise a labeled lectin which is capable of binding to L-fucose is added to a body liquid itself and reacted with the liquid, then the TAG-labeled lectin complex or the unreacted labeled lectin is separated, and TAG in the body liquid is determined by measuring either amount of them.
JP10478780A 1980-07-30 1980-07-30 Determination method of sugar side chain related to cancer Granted JPS5729950A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10478780A JPS5729950A (en) 1980-07-30 1980-07-30 Determination method of sugar side chain related to cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10478780A JPS5729950A (en) 1980-07-30 1980-07-30 Determination method of sugar side chain related to cancer

Publications (2)

Publication Number Publication Date
JPS5729950A true JPS5729950A (en) 1982-02-18
JPS6326872B2 JPS6326872B2 (en) 1988-05-31

Family

ID=14390171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10478780A Granted JPS5729950A (en) 1980-07-30 1980-07-30 Determination method of sugar side chain related to cancer

Country Status (1)

Country Link
JP (1) JPS5729950A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2520877A1 (en) * 1982-01-29 1983-08-05 Otsuka Pharma Co Ltd Specific binding assay for tumour-associated glyco:linkage - using lectin capable of binding N-acetyl-D-galactosamine or L-fucose
WO1983004311A1 (en) * 1982-06-03 1983-12-08 Otsuka Pharmaceutical Co., Ltd. Process for preparing fucose antigen and antibody for distinguishing it, measurement of tumor-associated sugar chain utilizing the same, and kit for the measurement
WO1984000421A1 (en) * 1982-07-16 1984-02-02 Otsuka Pharma Co Ltd Method for assaying tumor-associated antigen-specific immune complex
US4455380A (en) * 1982-01-29 1984-06-19 Otsuka Pharmaceutical Co., Ltd. Process for determining tumor-associated glycolinkage
WO1985001442A1 (en) * 1983-09-28 1985-04-11 Summa Medical Corporation Lectin composition and method for diagnosis of cancer
JPS6120867A (en) * 1984-06-29 1986-01-29 オーソ・ダイアグノステイツク・システムズ・インコーポレーテツド Sandwich test for antibody-lectin

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2520877A1 (en) * 1982-01-29 1983-08-05 Otsuka Pharma Co Ltd Specific binding assay for tumour-associated glyco:linkage - using lectin capable of binding N-acetyl-D-galactosamine or L-fucose
US4455380A (en) * 1982-01-29 1984-06-19 Otsuka Pharmaceutical Co., Ltd. Process for determining tumor-associated glycolinkage
WO1983004311A1 (en) * 1982-06-03 1983-12-08 Otsuka Pharmaceutical Co., Ltd. Process for preparing fucose antigen and antibody for distinguishing it, measurement of tumor-associated sugar chain utilizing the same, and kit for the measurement
WO1984000421A1 (en) * 1982-07-16 1984-02-02 Otsuka Pharma Co Ltd Method for assaying tumor-associated antigen-specific immune complex
WO1985001442A1 (en) * 1983-09-28 1985-04-11 Summa Medical Corporation Lectin composition and method for diagnosis of cancer
JPS6120867A (en) * 1984-06-29 1986-01-29 オーソ・ダイアグノステイツク・システムズ・インコーポレーテツド Sandwich test for antibody-lectin

Also Published As

Publication number Publication date
JPS6326872B2 (en) 1988-05-31

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