JPS5721346A - Production of farnesylacetic ester - Google Patents
Production of farnesylacetic esterInfo
- Publication number
- JPS5721346A JPS5721346A JP9382180A JP9382180A JPS5721346A JP S5721346 A JPS5721346 A JP S5721346A JP 9382180 A JP9382180 A JP 9382180A JP 9382180 A JP9382180 A JP 9382180A JP S5721346 A JPS5721346 A JP S5721346A
- Authority
- JP
- Japan
- Prior art keywords
- diphenyl
- formula
- alkyl
- naphthalene
- nerolidol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The reaction of nerolidol with a malonic diester is conducted in a specific solvent such as naphthalene, diphenyl or anisole in the presence of a catalyst amount of N-methylpyrrolidone to produce the titled substance economically in a short time, which is used to produce medicines.
CONSTITUTION: The reaction between nerolidol (3,7,11-trimethyl-1,6,10-dodecatriene-3-ol) of formula I and a malonic diester of formula II (R1, R2 are alkyl) is carried out in a solvent selected from the group consisting of aromatic hydrocarbons such as naphthalene, alkyl-substituted naphthalene, diphenyl, alkyl-substituted diphenyl, and aromatic ethers such as diphenyl ether, benzyl ether, anipole, phenetole or veratrol in the presence of N-methylpyrrolidone or hexamethyl phosphoric traiamide to give compounds of formula III and formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9382180A JPS5721346A (en) | 1980-07-11 | 1980-07-11 | Production of farnesylacetic ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9382180A JPS5721346A (en) | 1980-07-11 | 1980-07-11 | Production of farnesylacetic ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5721346A true JPS5721346A (en) | 1982-02-04 |
Family
ID=14093056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9382180A Pending JPS5721346A (en) | 1980-07-11 | 1980-07-11 | Production of farnesylacetic ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5721346A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05271258A (en) * | 1991-09-27 | 1993-10-19 | Merck & Co Inc | Farnesyl pyrophosphate analog |
US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
-
1980
- 1980-07-11 JP JP9382180A patent/JPS5721346A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05271258A (en) * | 1991-09-27 | 1993-10-19 | Merck & Co Inc | Farnesyl pyrophosphate analog |
US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
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