JPS5721346A - Production of farnesylacetic ester - Google Patents

Production of farnesylacetic ester

Info

Publication number
JPS5721346A
JPS5721346A JP9382180A JP9382180A JPS5721346A JP S5721346 A JPS5721346 A JP S5721346A JP 9382180 A JP9382180 A JP 9382180A JP 9382180 A JP9382180 A JP 9382180A JP S5721346 A JPS5721346 A JP S5721346A
Authority
JP
Japan
Prior art keywords
diphenyl
formula
alkyl
naphthalene
nerolidol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9382180A
Other languages
Japanese (ja)
Inventor
Shoichi Kinoshita
Yoshitomo Yonehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawamura Institute of Chemical Research
DIC Corp
Original Assignee
Kawamura Institute of Chemical Research
Dainippon Ink and Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawamura Institute of Chemical Research, Dainippon Ink and Chemicals Co Ltd filed Critical Kawamura Institute of Chemical Research
Priority to JP9382180A priority Critical patent/JPS5721346A/en
Publication of JPS5721346A publication Critical patent/JPS5721346A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: The reaction of nerolidol with a malonic diester is conducted in a specific solvent such as naphthalene, diphenyl or anisole in the presence of a catalyst amount of N-methylpyrrolidone to produce the titled substance economically in a short time, which is used to produce medicines.
CONSTITUTION: The reaction between nerolidol (3,7,11-trimethyl-1,6,10-dodecatriene-3-ol) of formula I and a malonic diester of formula II (R1, R2 are alkyl) is carried out in a solvent selected from the group consisting of aromatic hydrocarbons such as naphthalene, alkyl-substituted naphthalene, diphenyl, alkyl-substituted diphenyl, and aromatic ethers such as diphenyl ether, benzyl ether, anipole, phenetole or veratrol in the presence of N-methylpyrrolidone or hexamethyl phosphoric traiamide to give compounds of formula III and formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP9382180A 1980-07-11 1980-07-11 Production of farnesylacetic ester Pending JPS5721346A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9382180A JPS5721346A (en) 1980-07-11 1980-07-11 Production of farnesylacetic ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9382180A JPS5721346A (en) 1980-07-11 1980-07-11 Production of farnesylacetic ester

Publications (1)

Publication Number Publication Date
JPS5721346A true JPS5721346A (en) 1982-02-04

Family

ID=14093056

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9382180A Pending JPS5721346A (en) 1980-07-11 1980-07-11 Production of farnesylacetic ester

Country Status (1)

Country Link
JP (1) JPS5721346A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271258A (en) * 1991-09-27 1993-10-19 Merck & Co Inc Farnesyl pyrophosphate analog
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271258A (en) * 1991-09-27 1993-10-19 Merck & Co Inc Farnesyl pyrophosphate analog
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

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