JPS57209271A - Indirubin derivative and antitumor agent containing the same - Google Patents

Indirubin derivative and antitumor agent containing the same

Info

Publication number
JPS57209271A
JPS57209271A JP9507081A JP9507081A JPS57209271A JP S57209271 A JPS57209271 A JP S57209271A JP 9507081 A JP9507081 A JP 9507081A JP 9507081 A JP9507081 A JP 9507081A JP S57209271 A JPS57209271 A JP S57209271A
Authority
JP
Japan
Prior art keywords
antitumor agent
same
agent containing
indirubin
indirubin derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9507081A
Other languages
Japanese (ja)
Other versions
JPS609022B2 (en
Inventor
Tendou Tsutsumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISUKURA SANGYO KK
Iskra Industry Co Ltd
Original Assignee
ISUKURA SANGYO KK
Iskra Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISUKURA SANGYO KK, Iskra Industry Co Ltd filed Critical ISUKURA SANGYO KK
Priority to JP9507081A priority Critical patent/JPS609022B2/en
Publication of JPS57209271A publication Critical patent/JPS57209271A/en
Publication of JPS609022B2 publication Critical patent/JPS609022B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:The indirubin derivative of formulaI( when R1, R3 and R4 are H, then R2 is CH2, C3H5, C3H7, C4H9, C5H11, C10H21, C14H29, C18H37, group of formula II, COOC2H5, CH2COOH, CH2C6H5, COCH3, or CHO; when both R2 and R3 are CH2C6H5 or C10H21, then R1 and R4 are H; when R1 is CH3 or O H3, then R2-R4 are H; when R2 is C2H5 and R1 is OCH3 or OH, then R3 and R4 are H; when R1 is OH, then R2-R4 are H; when R4 is CH3, then R1-R3 are H). EXAMPLE:N-Ethylindirubin. USE:Antitumor agent. PROCESS:The compound of formulaIwherein R1, R3 and R4 are H and R2 is C2H5 can be prepared e.g. by mixing indirubin of formula III, an aqueous solution of NaOh, and a liquid mixture of benzyl triethyl ammonium chloride and ethyl bromide at room temperature.
JP9507081A 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them Expired JPS609022B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9507081A JPS609022B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9507081A JPS609022B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Publications (2)

Publication Number Publication Date
JPS57209271A true JPS57209271A (en) 1982-12-22
JPS609022B2 JPS609022B2 (en) 1985-03-07

Family

ID=14127725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9507081A Expired JPS609022B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Country Status (1)

Country Link
JP (1) JPS609022B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061555A1 (en) * 1999-04-12 2000-10-19 Gerhard Eisenbrand Indigoid bisindole derivatives
WO2000061124A3 (en) * 1999-04-12 2002-05-02 Heinz Herbert Fiebig Use off cell membrane penetrating indigoid bisindole derivatives
JP2016519167A (en) * 2013-05-28 2016-06-30 ▲チュウ▼洲市洛▲達▼生物科技有限公司 Benzofuranone-indole / azaindole complex and its preparation and application
WO2023060268A1 (en) * 2021-10-08 2023-04-13 Azora Therapeutics, Inc. Derivatives of aryl hydrocarbon receptor agonists

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5690627B2 (en) * 2011-03-28 2015-03-25 積水化成品工業株式会社 Polymer particles and uses thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061555A1 (en) * 1999-04-12 2000-10-19 Gerhard Eisenbrand Indigoid bisindole derivatives
WO2000061124A3 (en) * 1999-04-12 2002-05-02 Heinz Herbert Fiebig Use off cell membrane penetrating indigoid bisindole derivatives
JP2002541189A (en) * 1999-04-12 2002-12-03 ゲルハルト アイゼンブランド Use of cell membrane permeable indigoid bisindole derivatives
US6987092B1 (en) 1999-04-12 2006-01-17 Faustus Forschungs Cie. Translational Cancer Research Gmbh Indigoid bisindole derivatives
JP2016519167A (en) * 2013-05-28 2016-06-30 ▲チュウ▼洲市洛▲達▼生物科技有限公司 Benzofuranone-indole / azaindole complex and its preparation and application
WO2023060268A1 (en) * 2021-10-08 2023-04-13 Azora Therapeutics, Inc. Derivatives of aryl hydrocarbon receptor agonists
US11834412B2 (en) 2021-10-08 2023-12-05 Azora Therapeutics, Inc. Derivatives of aryl hydrocarbon receptor agonists

Also Published As

Publication number Publication date
JPS609022B2 (en) 1985-03-07

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