JPS57209271A - Indirubin derivative and antitumor agent containing the same - Google Patents
Indirubin derivative and antitumor agent containing the sameInfo
- Publication number
- JPS57209271A JPS57209271A JP9507081A JP9507081A JPS57209271A JP S57209271 A JPS57209271 A JP S57209271A JP 9507081 A JP9507081 A JP 9507081A JP 9507081 A JP9507081 A JP 9507081A JP S57209271 A JPS57209271 A JP S57209271A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor agent
- same
- agent containing
- indirubin
- indirubin derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:The indirubin derivative of formulaI( when R1, R3 and R4 are H, then R2 is CH2, C3H5, C3H7, C4H9, C5H11, C10H21, C14H29, C18H37, group of formula II, COOC2H5, CH2COOH, CH2C6H5, COCH3, or CHO; when both R2 and R3 are CH2C6H5 or C10H21, then R1 and R4 are H; when R1 is CH3 or O H3, then R2-R4 are H; when R2 is C2H5 and R1 is OCH3 or OH, then R3 and R4 are H; when R1 is OH, then R2-R4 are H; when R4 is CH3, then R1-R3 are H). EXAMPLE:N-Ethylindirubin. USE:Antitumor agent. PROCESS:The compound of formulaIwherein R1, R3 and R4 are H and R2 is C2H5 can be prepared e.g. by mixing indirubin of formula III, an aqueous solution of NaOh, and a liquid mixture of benzyl triethyl ammonium chloride and ethyl bromide at room temperature.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9507081A JPS609022B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9507081A JPS609022B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57209271A true JPS57209271A (en) | 1982-12-22 |
JPS609022B2 JPS609022B2 (en) | 1985-03-07 |
Family
ID=14127725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9507081A Expired JPS609022B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS609022B2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061555A1 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Indigoid bisindole derivatives |
WO2000061124A3 (en) * | 1999-04-12 | 2002-05-02 | Heinz Herbert Fiebig | Use off cell membrane penetrating indigoid bisindole derivatives |
JP2016519167A (en) * | 2013-05-28 | 2016-06-30 | ▲チュウ▼洲市洛▲達▼生物科技有限公司 | Benzofuranone-indole / azaindole complex and its preparation and application |
WO2023060268A1 (en) * | 2021-10-08 | 2023-04-13 | Azora Therapeutics, Inc. | Derivatives of aryl hydrocarbon receptor agonists |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5690627B2 (en) * | 2011-03-28 | 2015-03-25 | 積水化成品工業株式会社 | Polymer particles and uses thereof |
-
1981
- 1981-06-19 JP JP9507081A patent/JPS609022B2/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061555A1 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Indigoid bisindole derivatives |
WO2000061124A3 (en) * | 1999-04-12 | 2002-05-02 | Heinz Herbert Fiebig | Use off cell membrane penetrating indigoid bisindole derivatives |
JP2002541189A (en) * | 1999-04-12 | 2002-12-03 | ゲルハルト アイゼンブランド | Use of cell membrane permeable indigoid bisindole derivatives |
US6987092B1 (en) | 1999-04-12 | 2006-01-17 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Indigoid bisindole derivatives |
JP2016519167A (en) * | 2013-05-28 | 2016-06-30 | ▲チュウ▼洲市洛▲達▼生物科技有限公司 | Benzofuranone-indole / azaindole complex and its preparation and application |
WO2023060268A1 (en) * | 2021-10-08 | 2023-04-13 | Azora Therapeutics, Inc. | Derivatives of aryl hydrocarbon receptor agonists |
US11834412B2 (en) | 2021-10-08 | 2023-12-05 | Azora Therapeutics, Inc. | Derivatives of aryl hydrocarbon receptor agonists |
Also Published As
Publication number | Publication date |
---|---|
JPS609022B2 (en) | 1985-03-07 |
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